Inflammation-associated activation of coagulation and immune regulation by the protein C pathway. Thromb Res 2014 May;133 Suppl 1(0 1):S32-4
Date
04/25/2014Pubmed ID
24759138Pubmed Central ID
PMC4060429DOI
10.1016/j.thromres.2014.03.015Scopus ID
2-s2.0-84898951284 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
The inflammation-induced activation of the protein C pathway provides negative feedback inhibition of coagulation and exerts coagulation-independent anti-inflammatory and cytoprotective effects. The balance between these activities of aPC modulates the outcome of diverse inflammatory diseases such as encephalitis, diabetes, and sepsis; and is affected by naturally occurring aPC-resistance of coagulation factor V Leiden.
Author List
Weiler HMESH terms used to index this publication - Major topics in bold
Activated Protein C ResistanceAnimals
Blood Coagulation
Brain Diseases
Diabetes Complications
Encephalitis
Factor V
Hashimoto Disease
Humans
Inflammation
Protein C
Sepsis
Signal Transduction
