Ure(k)a! Sirtuins Regulate Mitochondria. Cell 2009 May 01;137(3):404-6
Date
05/05/2009Pubmed ID
19410538Pubmed Central ID
PMC3310393DOI
10.1016/j.cell.2009.04.036Scopus ID
2-s2.0-65249164893 (requires institutional sign-in at Scopus site) 16 CitationsAbstract
Increasing evidence suggests that multiple metabolic pathways are regulated by sirtuin-dependent protein deacetylation in the mitochondria. In this issue, Nakagawa et al. (2009) show that the sirtuin SIRT5 deacetylates and activates a mitochondrial enzyme, carbamoyl phosphate synthetase 1, which mediates the first step in the urea cycle.
Author List
Hallows WC, Smith BC, Lee S, Denu JMAuthor
Brian C. Smith PhD Associate Professor in the Biochemistry department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCarbamoyl-Phosphate Synthase (Ammonia)
Enzyme Activation
Humans
Mice
Mitochondria
Mitochondrial Proteins
Sirtuins
