Medical College of Wisconsin
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Brian C. Smith PhD

Brian C. Smith PhD profile photo picture

Associate Professor

Institution: Medical College of Wisconsin
Department: Biochemistry

image of /images/ORCIDiD_icon16x16.png   https://orcid.org/0000-0001-6330-2768

Member of the Cancer Center
Member of the Cardiovascular Research Center
Member of the Center for Disease Prevention Research (CDPR)


I am willing to collaborate on research projects.
I am willing to mentor a junior faculty member.

View Curriculum Vitae

Research Experience

  • Amino Acids, Peptides, and Proteins
  • Binding Sites
  • Biochemistry
  • Catalysis
  • Deuterium Exchange Measurement
  • Enzyme Activators
  • Enzyme Inhibitors
  • Enzymes and Coenzymes
  • Histone Code
  • Histone Deacetylases
  • Mass Spectrometry
  • Molecular Probes
  • Molecular Structure
  • Nitric Oxide Donors
  • Nitric Oxide Synthase
  • Peptide Library
  • Peptides
  • Protein Binding
  • Proteins
  • Proteomics
  • Reducing Agents
  • Sirtuins
  • Structure-Activity Relationship
  • Substrate Specificity

    • Methodologies and Techniques

  • Biochemistry
  • Biological Assay
  • Chromatography, Affinity
  • Electrophoresis
  • Mass Spectrometry
  • Models, Chemical
  • Models, Molecular
  • Mutagenesis
  • Nuclear Magnetic Resonance, Biomolecular
  • Peptide Library
  • Protein Array Analysis
  • Proteomics
  • chemical synthesis
  • enzymology

    • Leadership Positions

  • Associate Director, Program in Chemical Biology
  • Associate Director, Structural Genomics Unit, Mellowes Center for Genomic Sciences and Precision Medicine

    • MCW Program / Core Facilities

  • Redox Biology
  • Biochemistry

    • Publications (83)

  • BET bromodomain inhibitors attenuate transcription of a subset of IL-1-induced NF-κB targets that promote inflammation in β-cells. (Nord JA, Makowski SJ, Sidlowski PFW, Bursch KL, Corbett JA, Smith BC) J Biol Chem 2025 Jun 10:110358 PMID: 40505864 06/13/2025    
  • Oxidized LDL stimulates PKM2-mediated mtROS production and phagocytosis. (Zhang J, Chang J, Chen V, Beg MA, Huang W, Vick L, Wang Y, Zhang H, Yttre E, Gupta A, Castleberry M, Zhang Z, Dai W, Zhu J, Song S, Yang M, Brown AK, Xu Z, Ma YQ, Smith BC, Zielonka J, Traylor JG Jr, Ben Dhaou C, Orr AW, Cui W, Chen Y) J Lipid Res 2025 May;66(5):100809 PMID: 40250804 PMCID: PMC12142535 SCOPUS ID: 2-s2.0-105006766220 04/19/2025    
  • Mitigation of Injury from Myocardial Infarction by Pentamidine, an Inhibitor of the Acetyltransferase Tip60. (Wang X, Harty KR, Wan TC, Qu Z, Smith BC, Lough JW, Auchampach JA) Cardiovasc Drugs Ther 2025 Apr 09 PMID: 40202550 SCOPUS ID: 2-s2.0-105002184326 04/09/2025    
  • Reutericyclin, a specialized metabolite of Limosilactobacillus reuteri, mitigates risperidone-induced weight gain in mice. (Aboulalazm FA, Kazen AB, deLeon O, Müller S, Saravia FL, Lozada-Fernandez V, Hadiono MA, Keyes RF, Smith BC, Kellogg SL, Grobe JL, Kindel TL, Kirby JR) Gut Microbes 2025 Dec;17(1):2477819 PMID: 40190120 PMCID: PMC11980487 SCOPUS ID: 2-s2.0-105002217346 04/07/2025       2 Citations
  • Role of SIRT3 in the regulation of Gadd45α expression and DNA repair in β-cells. (Naatz A, Bohl KS, Jones Lipinski RA, Nord JA, Gehant AL, Hansen PA, Smith BC, Corbett JA) J Biol Chem 2025 May;301(5):108451 PMID: 40147772 PMCID: PMC12051128 SCOPUS ID: 2-s2.0-105003152914 03/28/2025    
  • Multivalent nucleosome scaffolding by bromodomain and extraterminal domain tandem bromodomains. (Olp MD, Bursch KL, Wynia-Smith SL, Nuñez R, Goetz CJ, Jackson V, Smith BC) J Biol Chem 2025 Mar;301(3):108289 PMID: 39938804 PMCID: PMC11930079 SCOPUS ID: 2-s2.0-85219493438 02/13/2025    
  • The TRIM33 Bromodomain Recognizes Histone Lysine Lactylation. (Nuñez R, Sidlowski PFW, Steen EA, Wynia-Smith SL, Sprague DJ, Keyes RF, Smith BC) ACS Chem Biol 2024 Dec 20;19(12):2418-2428 PMID: 39556662 PMCID: PMC11706526 SCOPUS ID: 2-s2.0-85209707761 11/18/2024       2 Citations
  • Inhibition of Sirtuin Deacylase Activity by Peroxynitrite. (Bohl K, Wynia-Smith SL, Jones Lipinski RA, Smith BC) Biochemistry 2024 Oct 01;63(19):2463-2476 PMID: 39256054 PMCID: PMC11524680 SCOPUS ID: 2-s2.0-85205075999 09/11/2024       2 Citations
  • Oxidized LDL regulates efferocytosis through the CD36-PKM2-mtROS pathway. (Zhang J, Chang J, Chen V, Beg MA, Huang W, Vick L, Wang Y, Zhang H, Yttre E, Gupta A, Castleberry M, Zhang Z, Dai W, Song S, Zhu J, Yang M, Brown AK, Xu Z, Ma YQ, Smith BC, Zielonka J, Traylor JG, Dhaou CB, Orr AW, Cui W, Zheng Z, Chen Y) bioRxiv 2024 Jul 15 PMID: 39071358 PMCID: PMC11275753 07/29/2024    
  • Lipid Trolling to Optimize A3 Adenosine Receptor-Positive Allosteric Modulators (PAMs). (Pradhan B, Pavan M, Fisher CL, Salmaso V, Wan TC, Keyes RF, Rollison N, Suresh RR, Kumar TS, Gao ZG, Smith BC, Auchampach JA, Jacobson KA) J Med Chem 2024 Jul 25;67(14):12221-12247 PMID: 38959401 PMCID: PMC11636968 SCOPUS ID: 2-s2.0-85197620924 07/03/2024       4 Citations
  • Zinc-chelating BET bromodomain inhibitors equally target islet endocrine cell types. (Jones Lipinski RA, Stancill JS, Nuñez R, Wynia-Smith SL, Sprague DJ, Nord JA, Bird A, Corbett JA, Smith BC) Am J Physiol Regul Integr Comp Physiol 2024 Jun 01;326(6):R515-R527 PMID: 38618911 PMCID: PMC11381023 SCOPUS ID: 2-s2.0-85194976711 04/15/2024       1 Citation
  • Current Trends in Sirtuin Activator and Inhibitor Development. (Bursch KL, Goetz CJ, Smith BC) Molecules 2024 Mar 06;29(5) PMID: 38474697 PMCID: PMC10934002 SCOPUS ID: 2-s2.0-85187801042 03/13/2024       17 Citations
  • Cancer-associated polybromo-1 bromodomain 4 missense variants variably impact bromodomain ligand binding and cell growth suppression. (Bursch KL, Goetz CJ, Jiao G, Nuñez R, Olp MD, Dhiman A, Khurana M, Zimmermann MT, Urrutia RA, Dykhuizen EC, Smith BC) J Biol Chem 2024 Apr;300(4):107146 PMID: 38460939 PMCID: PMC11002309 SCOPUS ID: 2-s2.0-85189184192 03/10/2024       2 Citations
  • Extrahelical Binding Site for a 1H-Imidazo[4,5-c]quinolin-4-amine A3 Adenosine Receptor Positive Allosteric Modulator on Helix 8 and Distal Portions of Transmembrane Domains 1 and 7. (Fisher CL, Pavan M, Salmaso V, Keyes RF, Wan TC, Pradhan B, Gao ZG, Smith BC, Jacobson KA, Auchampach JA) Mol Pharmacol 2024 Feb 15;105(3):213-223 PMID: 38182432 PMCID: PMC10877738 SCOPUS ID: 2-s2.0-85185222449 01/06/2024       6 Citations
  • Identification of Protein Targets of S-Nitroso-Coenzyme A-Mediated S-Nitrosation Using Chemoproteomics. (Falco JA, Wynia-Smith SL, McCoy J, Smith BC, Weerapana E) ACS Chem Biol 2024 Jan 19;19(1):193-207 PMID: 38159293 PMCID: PMC11154738 SCOPUS ID: 2-s2.0-85181803360 01/02/2024       1 Citation
  • Deep computational phenotyping of genomic variants impacting the SET domain of KMT2C reveal molecular mechanisms for their dysfunction. (Jorge SD, Chi YI, Mazaba JL, Haque N, Wagenknecht J, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R) Front Genet 2023;14:1291307 PMID: 38090150 PMCID: PMC10715303 SCOPUS ID: 2-s2.0-85179362461 12/13/2023       3 Citations
  • A multi-layered computational structural genomics approach enhances domain-specific interpretation of Kleefstra syndrome variants in EHMT1. (Chi YI, Jorge SD, Jensen DR, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R) Comput Struct Biotechnol J 2023;21:5249-5258 PMID: 37954151 PMCID: PMC10632586 SCOPUS ID: 2-s2.0-85174744984 11/13/2023    
  • Fragment-based screening by protein-detected NMR spectroscopy. (Kerber PJ, Nuñez R, Jensen DR, Zhou AL, Peterson FC, Hill RB, Volkman BF, Smith BC) Methods Enzymol 2023;690:285-310 PMID: 37858532 PMCID: PMC10657026 SCOPUS ID: 2-s2.0-85166280504 10/20/2023       5 Citations
  • Analysis of continuous enzyme kinetic data using ICEKAT. (Bursch KL, Olp MD, Smith BC) Methods Enzymol 2023;690:109-129 PMID: 37858527 PMCID: PMC10691744 SCOPUS ID: 2-s2.0-85166356880 10/20/2023       3 Citations
  • Beyond structural bioinformatics for genomics with dynamics characterization of an expanded KRAS mutational landscape. (Ratnasinghe BD, Haque N, Wagenknecht JB, Jensen DR, Valdivia Esparza GK, Leverence EN, Milech De Assuncao T, Mathison AJ, Lomberk G, Smith BC, Volkman BF, Urrutia R, Zimmermann MT) Comput Struct Biotechnol J 2023;21:4790-4803 PMID: 37841325 PMCID: PMC10570560 SCOPUS ID: 2-s2.0-85173171942 10/16/2023       5 Citations
  • A Multi-Layered Computational Structural Genomics Approach Enhances Domain-Specific Interpretation of Kleefstra Syndrome Variants in EHMT1. (Chi YI, Jorge SD, Jensen DR, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R) bioRxiv 2023 Sep 07 PMID: 37786696 PMCID: PMC10541560 10/03/2023    
  • Synthesis of fluorinated triphenylphosphonium analogs that improve cancer cell selectivity and in vivo detection. (Keyes RF, McAllister D, Dwinell MB, Smith BC) STAR Protoc 2023 Sep 15;4(3):102437 PMID: 37552599 PMCID: PMC10424135 SCOPUS ID: 2-s2.0-85175638505 08/08/2023    
  • Rational Design and Development of Selective BRD7 Bromodomain Inhibitors and Their Activity in Prostate Cancer. (Ordonez-Rubiano SC, Maschinot CA, Wang S, Sood S, Baracaldo-Lancheros LF, Strohmier BP, McQuade AJ, Smith BC, Dykhuizen EC) J Med Chem 2023 Aug 24;66(16):11250-11270 PMID: 37552884 PMCID: PMC10641717 SCOPUS ID: 2-s2.0-85168344957 08/08/2023       8 Citations
  • Cysteine and methionine oxidation in thrombotic disorders. (Yang M, Smith BC) Curr Opin Chem Biol 2023 Oct;76:102350 PMID: 37331217 PMCID: PMC10527720 SCOPUS ID: 2-s2.0-85162072148 06/19/2023       8 Citations
  • Beyond Structural Bioinformatics for Genomics with Dynamics Characterization of an Expanded KRAS Mutational Landscape. (Ratnasinghe BD, Haque N, Wagenknecht JB, Jensen DR, Esparza GV, Leverence EN, De Assuncao TM, Mathison AJ, Lomberk G, Smith BC, Volkman BF, Urrutia R, Zimmermann MT) bioRxiv 2023 Apr 28 PMID: 37207265 PMCID: PMC10189839 05/19/2023    
  • Sulfenylation links oxidative stress to protein disulfide isomerase oxidase activity and thrombus formation. (Yang M, Chiu J, Scartelli C, Ponzar N, Patel S, Patel A, Ferreira RB, Keyes RF, Carroll KS, Pozzi N, Hogg PJ, Smith BC, Flaumenhaft R) J Thromb Haemost 2023 Aug;21(8):2137-2150 PMID: 37037379 PMCID: PMC10657653 SCOPUS ID: 2-s2.0-85158843043 04/11/2023       9 Citations
  • Harnessing the Noncanonical Keap1-Nrf2 Pathway for Human Cytomegalovirus Control. (Ghosh AK, Su YP, Forman M, Keyes RF, Smith BC, Hu X, Ferrer M, Arav-Boger R) J Virol 2023 Apr 27;97(4):e0016023 PMID: 36939350 PMCID: PMC10134830 SCOPUS ID: 2-s2.0-85159161803 03/21/2023       2 Citations
  • Fragment-based drug discovery of small molecule ligands for the human chemokine CCL28. (Zhou AL, Jensen DR, Peterson FC, Thomas MA, Schlimgen RR, Dwinell MB, Smith BC, Volkman BF) SLAS Discov 2023 Jun;28(4):163-169 PMID: 36841432 PMCID: PMC10339762 SCOPUS ID: 2-s2.0-85149845436 02/26/2023       3 Citations
  • Fluorinated triphenylphosphonium analogs improve cell selectivity and in vivo detection of mito-metformin. (AbuEid M, Keyes RF, McAllister D, Peterson F, Kadamberi IP, Sprague DJ, Chaluvally-Raghavan P, Smith BC, Dwinell MB) iScience 2022 Dec 22;25(12):105670 PMID: 36567718 PMCID: PMC9768319 SCOPUS ID: 2-s2.0-85143723525 12/27/2022       7 Citations
  • Pharmacological inhibition of the acetyltransferase Tip60 mitigates myocardial infarction injury. (Wang X, Wan TC, Kulik KR, Lauth A, Smith BC, Lough JW, Auchampach JA) Dis Model Mech 2023 May 01;16(5) PMID: 36341679 PMCID: PMC9672930 SCOPUS ID: 2-s2.0-85141362492 11/08/2022       9 Citations
  • Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening. (Shishodia S, Nuñez R, Strohmier BP, Bursch KL, Goetz CJ, Olp MD, Jensen DR, Fenske TG, Ordonez-Rubiano SC, Blau ME, Roach MK, Peterson FC, Volkman BF, Dykhuizen EC, Smith BC) J Med Chem 2022 Oct 27;65(20):13714-13735 PMID: 36227159 PMCID: PMC9630929 SCOPUS ID: 2-s2.0-85140311972 10/14/2022       16 Citations
  • N-terminal BET bromodomain inhibitors disrupt a BRD4-p65 interaction and reduce inducible nitric oxide synthase transcription in pancreatic β-cells. (Nord JA, Wynia-Smith SL, Gehant AL, Jones Lipinski RA, Naatz A, Rioja I, Prinjha RK, Corbett JA, Smith BC) Front Endocrinol (Lausanne) 2022;13:923925 PMID: 36176467 PMCID: PMC9513428 SCOPUS ID: 2-s2.0-85138892468 10/01/2022       9 Citations
  • Characterization of Dual-Acting A3 Adenosine Receptor Positive Allosteric Modulators That Preferentially Enhance Adenosine-Induced Gαi3 and GαoA Isoprotein Activation. (Fisher CL, Fallot LB, Wan TC, Keyes RF, Suresh RR, Rothwell AC, Gao ZG, McCorvy JD, Smith BC, Jacobson KA, Auchampach JA) ACS Pharmacol Transl Sci 2022 Aug 12;5(8):625-641 PMID: 35983277 PMCID: PMC9380209 SCOPUS ID: 2-s2.0-85135593508 08/20/2022       11 Citations
  • Oral and Inhaled Fosamprenavir Reverses Pepsin-Induced Damage in a Laryngopharyngeal Reflux Mouse Model. (Johnston N, Samuels TL, Goetz CJ, Arnold LA, Smith BC, Seabloom D, Wuertz B, Ondrey F, Wiedmann TS, Vuksanovic N, Silvaggi NR, MacKinnon AC, Miller J, Bock J, Blumin JH) Laryngoscope 2023 Jan;133 Suppl 1(Suppl 1):S1-S11 PMID: 35678265 PMCID: PMC9732152 SCOPUS ID: 2-s2.0-85131512635 06/10/2022       13 Citations
  • Structural bioinformatics enhances the interpretation of somatic mutations in KDM6A found in human cancers. (Chi YI, Stodola TJ, De Assuncao TM, Leverence EN, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R) Comput Struct Biotechnol J 2022;20:2200-2211 PMID: 35615018 PMCID: PMC9111933 SCOPUS ID: 2-s2.0-85130080827 05/27/2022       9 Citations
  • Chemical Regulation of the Protein Quality Control E3 Ubiquitin Ligase C-Terminus of Hsc70 Interacting Protein (CHIP). (Kanack AJ, Olp MD, Newsom OJ, Scaglione JB, Gooden DM, McMahon K, Smith BC, Scaglione KM) Chembiochem 2022 Mar 18;23(6):e202100633 PMID: 35061295 PMCID: PMC9016715 SCOPUS ID: 2-s2.0-85124142518 01/22/2022       4 Citations
  • Sirtuin Oxidative Post-translational Modifications. (Kalous KS, Wynia-Smith SL, Smith BC) Front Physiol 2021;12:763417 PMID: 34899389 PMCID: PMC8652059 SCOPUS ID: 2-s2.0-85120877526 12/14/2021       15 Citations
  • Trisubstituted 1,3,5-Triazines: The First Ligands of the sY12-Binding Pocket on Chemokine CXCL12. (Sprague DJ, Getschman AE, Fenske TG, Volkman BF, Smith BC) ACS Med Chem Lett 2021 Nov 11;12(11):1773-1782 PMID: 34795867 PMCID: PMC8592115 SCOPUS ID: 2-s2.0-85118771967 11/20/2021       3 Citations
  • Computational modeling reveals key molecular properties and dynamic behavior of disruptor of telomeric silencing 1-like (DOT1L) and partnering complexes involved in leukemogenesis. (Stodola TJ, Chi YI, De Assuncao TM, Leverence EN, Tripathi S, Dsouza NR, Mathison AJ, Volkman BF, Smith BC, Lomberk G, Zimmermann MT, Urrutia R) Proteins 2022 Jan;90(1):282-298 PMID: 34414607 PMCID: PMC8671179 SCOPUS ID: 2-s2.0-85114677469 08/21/2021       3 Citations
  • Correction to: Molecular mechanics and dynamic simulations of well-known Kabuki syndrome-associated KDM6A variants reveal putative mechanisms of dysfunction. (Chi YI, Stodola TJ, De Assuncao TM, Leverence EN, Tripathi S, Dsouza NR, Mathison AJ, Basel DG, Volkman BF, Smith BC, Lomberk G, Zimmermann MT, Urrutia R) Orphanet J Rare Dis 2021 Jun 01;16(1):247 PMID: 34074320 PMCID: PMC8170813 SCOPUS ID: 2-s2.0-85107273180 06/03/2021    
  • Molecular docking-guided synthesis of NSAID-glucosamine bioconjugates and their evaluation as COX-1/COX-2 inhibitors with potentially reduced gastric toxicity. (Jones Lipinski RA, Thillier Y, Morisseau C, Sebastiano CS Jr, Smith BC, Hall CD, Katritzky AR) Chem Biol Drug Des 2021 Jul;98(1):102-113 PMID: 33955172 PMCID: PMC8281356 SCOPUS ID: 2-s2.0-85106558172 05/07/2021       12 Citations
  • Molecular mechanics and dynamic simulations of well-known Kabuki syndrome-associated KDM6A variants reveal putative mechanisms of dysfunction. (Chi YI, Stodola TJ, De Assuncao TM, Leverence EN, Tripathi S, Dsouza NR, Mathison AJ, Basel DG, Volkman BF, Smith BC, Lomberk G, Zimmermann MT, Urrutia R) Orphanet J Rare Dis 2021 Feb 05;16(1):66 PMID: 33546721 PMCID: PMC7866879 SCOPUS ID: 2-s2.0-85100579633 02/07/2021       12 Citations
  • Cysteine sulfenylation by CD36 signaling promotes arterial thrombosis in dyslipidemia. (Yang M, Li W, Harberg C, Chen W, Yue H, Ferreira RB, Wynia-Smith SL, Carroll KS, Zielonka J, Flaumenhaft R, Silverstein RL, Smith BC) Blood Adv 2020 Sep 22;4(18):4494-4507 PMID: 32946569 PMCID: PMC7509873 SCOPUS ID: 2-s2.0-85092260584 09/19/2020       25 Citations
  • Development of activity-based probes for the protein deacylase Sirt1. (Goetz CJ, Sprague DJ, Smith BC) Bioorg Chem 2020 Nov;104:104232 PMID: 32911193 PMCID: PMC7686039 SCOPUS ID: 2-s2.0-85090347297 09/11/2020       7 Citations
  • ICEKAT: an interactive online tool for calculating initial rates from continuous enzyme kinetic traces. (Olp MD, Kalous KS, Smith BC) BMC Bioinformatics 2020 May 14;21(1):186 PMID: 32410570 PMCID: PMC7222511 SCOPUS ID: 2-s2.0-85084786097 05/16/2020       40 Citations
  • Human sirtuins are differentially sensitive to inhibition by nitrosating agents and other cysteine oxidants. (Kalous KS, Wynia-Smith SL, Summers SB, Smith BC) J Biol Chem 2020 Jun 19;295(25):8524-8536 PMID: 32371394 PMCID: PMC7307208 SCOPUS ID: 2-s2.0-85086777279 05/07/2020       20 Citations
  • Validation and Characterization of Five Distinct Novel Inhibitors of Human Cytomegalovirus. (Kapoor A, Ghosh AK, Forman M, Hu X, Ye W, Southall N, Marugan J, Keyes RF, Smith BC, Meyers DJ, Ferrer M, Arav-Boger R) J Med Chem 2020 Apr 23;63(8):3896-3907 PMID: 32191456 PMCID: PMC7386824 SCOPUS ID: 2-s2.0-85084027851 03/20/2020       9 Citations
  • Covalent-Fragment Screening of BRD4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites. (Olp MD, Sprague DJ, Goetz CJ, Kathman SG, Wynia-Smith SL, Shishodia S, Summers SB, Xu Z, Statsyuk AV, Smith BC) ACS Chem Biol 2020 Apr 17;15(4):1036-1049 PMID: 32149490 PMCID: PMC7271629 SCOPUS ID: 2-s2.0-85083621949 03/10/2020       39 Citations
  • Non-sedating benzodiazepines cause paralysis and tissue damage in the parasitic blood fluke Schistosoma mansoni. (McCusker P, Mian MY, Li G, Olp MD, Tiruveedhula VVNPB, Rashid F, Golani LK, Verma RS, Smith BC, Cook JM, Chan JD) PLoS Negl Trop Dis 2019 Nov;13(11):e0007826 PMID: 31730614 PMCID: PMC6881066 SCOPUS ID: 2-s2.0-85075815012 11/16/2019       6 Citations
  • Mitochondrial Metabolic Reprogramming by CD36 Signaling Drives Macrophage Inflammatory Responses. (Chen Y, Yang M, Huang W, Chen W, Zhao Y, Schulte ML, Volberding P, Gerbec Z, Zimmermann MT, Zeighami A, Demos W, Zhang J, Knaack DA, Smith BC, Cui W, Malarkannan S, Sodhi K, Shapiro JI, Xie Z, Sahoo D, Silverstein RL) Circ Res 2019 Dec 06;125(12):1087-1102 PMID: 31625810 PMCID: PMC6921463 SCOPUS ID: 2-s2.0-85076330129 10/19/2019       168 Citations
  • Comparative and integrative metabolomics reveal that S-nitrosation inhibits physiologically relevant metabolic enzymes. (Bruegger JJ, Smith BC, Wynia-Smith SL, Marletta MA) J Biol Chem 2018 Apr 27;293(17):6282-6296 PMID: 29483187 PMCID: PMC5925818 SCOPUS ID: 2-s2.0-85046036655 02/28/2018       17 Citations
  • Calmodulin-induced Conformational Control and Allostery Underlying Neuronal Nitric Oxide Synthase Activation. (Hanson QM, Carley JR, Gilbreath TJ, Smith BC, Underbakke ES) J Mol Biol 2018 Mar 30;430(7):935-947 PMID: 29458127 SCOPUS ID: 2-s2.0-85042563266 02/20/2018       19 Citations
  • Nitric oxide antagonism to glioblastoma photodynamic therapy and mitigation thereof by BET bromodomain inhibitor JQ1. (Fahey JM, Stancill JS, Smith BC, Girotti AW) J Biol Chem 2018 Apr 06;293(14):5345-5359 PMID: 29440272 PMCID: PMC5892570 SCOPUS ID: 2-s2.0-85045064956 02/15/2018       50 Citations
  • Development and Validation of 2D Difference Intensity Analysis for Chemical Library Screening by Protein-Detected NMR Spectroscopy. (Egner JM, Jensen DR, Olp MD, Kennedy NW, Volkman BF, Peterson FC, Smith BC, Hill RB) Chembiochem 2018 Mar 02;19(5):448-458 PMID: 29239081 PMCID: PMC5844354 SCOPUS ID: 2-s2.0-85041064927 12/15/2017       11 Citations
  • Metabolically Derived Lysine Acylations and Neighboring Modifications Tune the Binding of the BET Bromodomains to Histone H4. (Olp MD, Zhu N, Smith BC) Biochemistry 2017 Oct 17;56(41):5485-5495 PMID: 28945351 PMCID: PMC5970795 SCOPUS ID: 2-s2.0-85031686253 09/26/2017       21 Citations
  • Mechanism of Sirt1 NAD+-dependent Protein Deacetylase Inhibition by Cysteine S-Nitrosation. (Kalous KS, Wynia-Smith SL, Olp MD, Smith BC) J Biol Chem 2016 Dec 02;291(49):25398-25410 PMID: 27756843 PMCID: PMC5207242 SCOPUS ID: 2-s2.0-85001969732 10/21/2016       45 Citations
  • Nitrosothiol formation and S-nitrosation signaling through nitric oxide synthases. (Wynia-Smith SL, Smith BC) Nitric Oxide 2017 Feb 28;63:52-60 PMID: 27720836 SCOPUS ID: 2-s2.0-85002112699 10/11/2016       53 Citations
  • Chemoproteomic Strategy to Quantitatively Monitor Transnitrosation Uncovers Functionally Relevant S-Nitrosation Sites on Cathepsin D and HADH2. (Zhou Y, Wynia-Smith SL, Couvertier SM, Kalous KS, Marletta MA, Smith BC, Weerapana E) Cell Chem Biol 2016 Jun 23;23(6):727-37 PMID: 27291402 PMCID: PMC4920707 SCOPUS ID: 2-s2.0-84976439988 06/14/2016       39 Citations
  • Reply: To PMID 25479138. (Shteyer E, Smith B) Gastroenterology 2015 Jul;149(1):261-2 PMID: 26025311 SCOPUS ID: 2-s2.0-84931432533 05/31/2015    
  • Nitric Oxide Mediates Biofilm Formation and Symbiosis in Silicibacter sp. Strain TrichCH4B. (Rao M, Smith BC, Marletta MA) mBio 2015 May 05;6(3):e00206-15 PMID: 25944856 PMCID: PMC4436077 SCOPUS ID: 2-s2.0-84936933376 05/07/2015       31 Citations
  • Truncating mutation in the nitric oxide synthase 1 gene is associated with infantile achalasia. (Shteyer E, Edvardson S, Wynia-Smith SL, Pierri CL, Zangen T, Hashavya S, Begin M, Yaacov B, Cinamon Y, Koplewitz BZ, Vromen A, Elpeleg O, Smith BC) Gastroenterology 2015 Mar;148(3):533-536.e4 PMID: 25479138 SCOPUS ID: 2-s2.0-84924061735 12/06/2014       37 Citations
  • Nitric oxide signaling (Surmeli NB, Underbakke ES, Smith BC, Wynia-Smith SL, Marletta MA) Comprehensive Inorganic Chemistry Vol. 3, 241-262 10/29/2014    
  • Molecular architecture of mammalian nitric oxide synthases. (Campbell MG, Smith BC, Potter CS, Carragher B, Marletta MA) Proc Natl Acad Sci U S A 2014 Sep 02;111(35):E3614-23 PMID: 25125509 PMCID: PMC4156747 SCOPUS ID: 2-s2.0-84907227897 08/16/2014       92 Citations
  • Nitric oxide synthase domain interfaces regulate electron transfer and calmodulin activation. (Smith BC, Underbakke ES, Kulp DW, Schief WR, Marletta MA) Proc Natl Acad Sci U S A 2013 Sep 17;110(38):E3577-86 PMID: 24003111 PMCID: PMC3780838 SCOPUS ID: 2-s2.0-84884294241 09/05/2013       87 Citations
  • Mechanisms of S-nitrosothiol formation and selectivity in nitric oxide signaling. (Smith BC, Marletta MA) Curr Opin Chem Biol 2012 Dec;16(5-6):498-506 PMID: 23127359 PMCID: PMC3518608 SCOPUS ID: 2-s2.0-84872277775 11/07/2012       223 Citations
  • Mechanism and kinetics of inducible nitric oxide synthase auto-S-nitrosation and inactivation. (Smith BC, Fernhoff NB, Marletta MA) Biochemistry 2012 Feb 07;51(5):1028-40 PMID: 22242685 PMCID: PMC3277664 SCOPUS ID: 2-s2.0-84863406254 01/17/2012       31 Citations
  • Structural and kinetic isotope effect studies of nicotinamidase (Pnc1) from Saccharomyces cerevisiae. (Smith BC, Anderson MA, Hoadley KA, Keck JL, Cleland WW, Denu JM) Biochemistry 2012 Jan 10;51(1):243-56 PMID: 22229411 PMCID: PMC3257521 SCOPUS ID: 2-s2.0-84863395503 01/11/2012       13 Citations
  • Hydrolysis of O-acetyl-ADP-ribose isomers by ADP-ribosylhydrolase 3. (Kasamatsu A, Nakao M, Smith BC, Comstock LR, Ono T, Kato J, Denu JM, Moss J) J Biol Chem 2011 Jun 17;286(24):21110-7 PMID: 21498885 PMCID: PMC3122172 SCOPUS ID: 2-s2.0-79958764081 04/19/2011       41 Citations
  • Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction. (Hallows WC, Yu W, Smith BC, Devries MK, Ellinger JJ, Someya S, Shortreed MR, Prolla T, Markley JL, Smith LM, Zhao S, Guan KL, Denu JM) Mol Cell 2011 Jan 21;41(2):139-49 PMID: 21255725 PMCID: PMC3101115 SCOPUS ID: 2-s2.0-78651468707 01/25/2011       331 Citations
  • SIRT3 substrate specificity determined by peptide arrays and machine learning. (Smith BC, Settles B, Hallows WC, Craven MW, Denu JM) ACS Chem Biol 2011 Feb 18;6(2):146-57 PMID: 20945913 PMCID: PMC3042044 SCOPUS ID: 2-s2.0-79951906633 10/16/2010       67 Citations
  • A continuous microplate assay for sirtuins and nicotinamide-producing enzymes. (Smith BC, Hallows WC, Denu JM) Anal Biochem 2009 Nov 01;394(1):101-9 PMID: 19615966 PMCID: PMC2752052 SCOPUS ID: 2-s2.0-69249206539 07/21/2009       121 Citations
  • Ure(k)a! Sirtuins Regulate Mitochondria. (Hallows WC, Smith BC, Lee S, Denu JM) Cell 2009 May 01;137(3):404-6 PMID: 19410538 PMCID: PMC3310393 SCOPUS ID: 2-s2.0-65249164893 05/05/2009       16 Citations
  • Mechanisms and molecular probes of sirtuins. (Smith BC, Hallows WC, Denu JM) Chem Biol 2008 Oct 20;15(10):1002-13 PMID: 18940661 PMCID: PMC2626554 SCOPUS ID: 2-s2.0-53649086367 10/23/2008       134 Citations
  • Chemical mechanisms of histone lysine and arginine modifications. (Smith BC, Denu JM) Biochim Biophys Acta 2009 Jan;1789(1):45-57 PMID: 18603028 PMCID: PMC2642981 SCOPUS ID: 2-s2.0-59349115177 07/08/2008       326 Citations
  • Mechanism-based inhibition of Sir2 deacetylases by thioacetyl-lysine peptide. (Smith BC, Denu JM) Biochemistry 2007 Dec 18;46(50):14478-86 PMID: 18027980 SCOPUS ID: 2-s2.0-37349110743 11/22/2007       130 Citations
  • Acetyl-lysine analog peptides as mechanistic probes of protein deacetylases. (Smith BC, Denu JM) J Biol Chem 2007 Dec 21;282(51):37256-65 PMID: 17951578 SCOPUS ID: 2-s2.0-37549067781 10/24/2007       122 Citations
  • Linking SIRT2 to Parkinson's disease. (Garske AL, Smith BC, Denu JM) ACS Chem Biol 2007 Aug 17;2(8):529-32 PMID: 17708669 SCOPUS ID: 2-s2.0-34548570794 08/22/2007       62 Citations
  • Sir2 deacetylases exhibit nucleophilic participation of acetyl-lysine in NAD+ cleavage. (Smith BC, Denu JM) J Am Chem Soc 2007 May 09;129(18):5802-3 PMID: 17439123 PMCID: PMC2568996 SCOPUS ID: 2-s2.0-34248595983 04/19/2007       70 Citations
  • Sirtuins caught in the act. (Smith BC, Denu JM) Structure 2006 Aug;14(8):1207-8 PMID: 16905094 SCOPUS ID: 2-s2.0-33746854376 08/15/2006       11 Citations
  • Sir2 protein deacetylases: evidence for chemical intermediates and functions of a conserved histidine. (Smith BC, Denu JM) Biochemistry 2006 Jan 10;45(1):272-82 PMID: 16388603 PMCID: PMC2519119 SCOPUS ID: 2-s2.0-30144431571 01/04/2006       93 Citations
  • Small molecule regulation of Sir2 protein deacetylases. (Grubisha O, Smith BC, Denu JM) FEBS J 2005 Sep;272(18):4607-16 PMID: 16156783 SCOPUS ID: 2-s2.0-25444484672 09/15/2005       123 Citations
  • Mechanism of human SIRT1 activation by resveratrol. (Borra MT, Smith BC, Denu JM) J Biol Chem 2005 Apr 29;280(17):17187-95 PMID: 15749705 SCOPUS ID: 2-s2.0-20444444649 03/08/2005       979 Citations
  • Coenzyme specificity of Sir2 protein deacetylases: implications for physiological regulation. (Schmidt MT, Smith BC, Jackson MD, Denu JM) J Biol Chem 2004 Sep 17;279(38):40122-9 PMID: 15269219 SCOPUS ID: 2-s2.0-4544243684 07/23/2004       141 Citations
    • Last update: 06/28/2025