Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids. Prostaglandins Other Lipid Mediat 2007 Jan;82(1-4):19-29
Date
12/14/2006Pubmed ID
17164129DOI
10.1016/j.prostaglandins.2006.05.025Scopus ID
2-s2.0-33845313333 (requires institutional sign-in at Scopus site) 46 CitationsAbstract
Arachidonic acid (AA) is an essential fatty acid that is metabolized by cyclooxygenase (COX), lipoxygenase (LOX) or cytochrome P450 (CYP) enzymes to generate eicosanoids which in turn mediate a number of biological activities including regulation of angiogenesis. While much information on the effects of COX and LOX products is known, the physiological relevance of the CYP-derived products of AA are less well understood. CYP enzymes are highly expressed in the liver and kidney, but have also been detected at lower levels in the brain, heart and vasculature. A number of these enzymes, including members of the CYP 4 family, predominantly catalyze conversion of AA to 20-hydroxyeicosatetraenoic acid (20-HETE) while the CYP epoxygenases generate mainly epoxyeicosatrienoic acids (EETs). This review will focus on the emerging roles of inhibitors of eicosanoid production with emphasis on the CYP pathways, in the regulation of angiogenesis and tumor growth. We also discuss current observations describing the protective effects of EETs for survival of the endothelium.
Author List
Medhora M, Dhanasekaran A, Gruenloh SK, Dunn LK, Gabrilovich M, Falck JR, Harder DR, Jacobs ER, Pratt PFMESH terms used to index this publication - Major topics in bold
8,11,14-Eicosatrienoic AcidActins
Animals
Apoptosis
Arachidonate 12-Lipoxygenase
Arachidonic Acid
Cytochrome P-450 CYP4A
Cytochrome P-450 Enzyme System
Eicosanoids
Epoxy Compounds
Humans
Kidney
Neovascularization, Pathologic
Neovascularization, Physiologic
