Faculty Collaboration Database

The Rat Genome Database, update 2007--easing the path from disease to data and back again. Nucleic Acids Res 2007 Jan;35(Database issue):D658-62

Date

12/08/2006

Pubmed ID

17151068

Pubmed Central ID

PMC1761441

DOI

10.1093/nar/gkl988

Scopus ID

2-s2.0-33846111969 (requires institutional sign-in at Scopus site)   109 Citations

Abstract

The Rat Genome Database (RGD, http://rgd.mcw.edu) is one of the core resources for rat genomics and recent developments have focused on providing support for disease-based research using the rat model. Recognizing the importance of the rat as a disease model we have employed targeted curation strategies to curate genes, QTL and strain data for neurological and cardiovascular disease areas. This work has centered on rat but also includes data for mouse and human to create 'disease portals' that provide a unified view of the genes, QTL and strain models for these diseases across the three species. The disease curation efforts combined with normal curation activities have served to greatly increase the content of the database, particularly for biological information, including gene ontology, disease, pathway and phenotype ontology annotations. In addition to improving the features and database content, community outreach has been expanded to demonstrate how investigators can leverage the resources at RGD to facilitate their research and to elicit suggestions and needs for future developments. We have published a number of papers that provide additional information on the ontology annotations and the tools at RGD for data mining and analysis to better enable researchers to fully utilize the database.

Author List

Twigger SN, Shimoyama M, Bromberg S, Kwitek AE, Jacob HJ, RGD Team

Author

Anne E. Kwitek PhD Professor in the Physiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Cardiovascular Diseases
Chromosome Mapping
Databases, Genetic
Disease Models, Animal
Genomics
Humans
Internet
Mice
Nervous System Diseases
Quantitative Trait Loci
Rats
User-Computer Interface