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Anne E. Kwitek PhD

Anne E. Kwitek PhD profile photo picture

Associate Professor

Institution: Medical College of Wisconsin
Department: Physiology

Member of the Cardiovascular Center


Publications (108)

  • Single-Nucleus RNA Sequencing of the Hypothalamic Arcuate Nucleus of C57BL/6J Mice After Prolonged Diet-Induced Obesity. (Deng G, Morselli LL, Wagner VA, Balapattabi K, Sapouckey SA, Knudtson KL, Rahmouni K, Cui H, Sigmund CD, Kwitek AE, Grobe JL) Hypertension 2020 Aug;76(2):589-597 PMID: 32507042 PMCID: PMC7347451 SCOPUS ID: 2-s2.0-85087901067 06/09/2020    
  • Reduced mRNA Expression of RGS2 (Regulator of G Protein Signaling-2) in the Placenta Is Associated With Human Preeclampsia and Sufficient to Cause Features of the Disorder in Mice. (Perschbacher KJ, Deng G, Sandgren JA, Walsh JW, Witcher PC, Sapouckey SA, Owens CE, Zhang SY, Scroggins SM, Pearson NA, Devor EJ, Sebag JA, Pierce GL, Fisher RA, Kwitek AE, Santillan DA, Gibson-Corley KN, Sigmund CD, Santillan MK, Grobe JL) Hypertension 2020 Feb;75(2):569-579 PMID: 31865781 PMCID: PMC7027931 SCOPUS ID: 2-s2.0-85077761676 12/24/2019    
  • Targeted broad-based genetic testing by next-generation sequencing informs diagnosis and facilitates management in patients with kidney diseases. (Mansilla MA, Sompallae RR, Nishimura CJ, Kwitek AE, Kimble MJ, Freese ME, Campbell CA, Smith RJ, Thomas CP) Nephrol Dial Transplant 2019 Nov 18 PMID: 31738409 11/19/2019    
  • The Year of the Rat: The Rat Genome Database at 20: a multi-species knowledgebase and analysis platform. (Smith JR, Hayman GT, Wang SJ, Laulederkind SJF, Hoffman MJ, Kaldunski ML, Tutaj M, Thota J, Nalabolu HS, Ellanki SLR, Tutaj MA, De Pons JL, Kwitek AE, Dwinell MR, Shimoyama ME) Nucleic Acids Res 2020 01 08;48(D1):D731-D742 PMID: 31713623 PMCID: PMC7145519 SCOPUS ID: 2-s2.0-85077666371 11/13/2019       4 Citations
  • Rat Models of Metabolic Syndrome. (Kwitek AE) Methods Mol Biol 2019;2018:269-285 PMID: 31228162 PMCID: PMC7315404 06/23/2019    
  • Cervical vagal nerve stimulation impairs glucose tolerance and suppresses insulin release in conscious rats. (Stauss HM, Stangl H, Clark KC, Kwitek AE, Lira VA) Physiol Rep 2018 12;6(24):e13953 PMID: 30569658 PMCID: PMC6300710 12/21/2018       7 Citations
  • Genome variation and conserved regulation identify genomic regions responsible for strain specific phenotypes in rat. (Martín-Gálvez D, Dunoyer de Segonzac D, Ma MCJ, Kwitek AE, Thybert D, Flicek P) BMC Genomics 2017 12 22;18(1):986 PMID: 29272997 PMCID: PMC5741965 12/24/2017    
  • Contribution of independent and pleiotropic genetic effects in the metabolic syndrome in a hypertensive rat. (Ma MCJ, Pettus JM, Jakoubek JA, Traxler MG, Clark KC, Mennie AK, Kwitek AE) PLoS One 2017;12(8):e0182650 PMID: 28792545 PMCID: PMC5549746 08/10/2017       3 Citations
  • Screening of Living Kidney Donors for Genetic Diseases Using a Comprehensive Genetic Testing Strategy. (Thomas CP, Mansilla MA, Sompallae R, Mason SO, Nishimura CJ, Kimble MJ, Campbell CA, Kwitek AE, Darbro BW, Stewart ZA, Smith RJ) Am J Transplant 2017 02;17(2):401-410 PMID: 27434427 PMCID: PMC5297870 07/20/2016       7 Citations
  • Systems biology with high-throughput sequencing reveals genetic mechanisms underlying the metabolic syndrome in the Lyon hypertensive rat. (Wang J, Ma MC, Mennie AK, Pettus JM, Xu Y, Lin L, Traxler MG, Jakoubek J, Atanur SS, Aitman TJ, Xing Y, Kwitek AE) Circ Cardiovasc Genet 2015 Apr;8(2):316-26 PMID: 25573024 PMCID: PMC4406788 01/13/2015       9 Citations
  • An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge. (Brownstein CA, Beggs AH, Homer N, Merriman B, Yu TW, Flannery KC, DeChene ET, Towne MC, Savage SK, Price EN, Holm IA, Luquette LJ, Lyon E, Majzoub J, Neupert P, McCallie D Jr, Szolovits P, Willard HF, Mendelsohn NJ, Temme R, Finkel RS, Yum SW, Medne L, Sunyaev SR, Adzhubey I, Cassa CA, de Bakker PI, Duzkale H, Dworzyński P, Fairbrother W, Francioli L, Funke BH, Giovanni MA, Handsaker RE, Lage K, Lebo MS, Lek M, Leshchiner I, MacArthur DG, McLaughlin HM, Murray MF, Pers TH, Polak PP, Raychaudhuri S, Rehm HL, Soemedi R, Stitziel NO, Vestecka S, Supper J, Gugenmus C, Klocke B, Hahn A, Schubach M, Menzel M, Biskup S, Freisinger P, Deng M, Braun M, Perner S, Smith RJ, Andorf JL, Huang J, Ryckman K, Sheffield VC, Stone EM, Bair T, Black-Ziegelbein EA, Braun TA, Darbro B, DeLuca AP, Kolbe DL, Scheetz TE, Shearer AE, Sompallae R, Wang K, Bassuk AG, Edens E, Mathews K, Moore SA, Shchelochkov OA, Trapane P, Bossler A, Campbell CA, Heusel JW, Kwitek A, Maga T, Panzer K, Wassink T, Van Daele D, Azaiez H, Booth K, Meyer N, Segal MM, Williams MS, Tromp G, White P, Corsmeier D, Fitzgerald-Butt S, Herman G, Lamb-Thrush D, McBride KL, Newsom D, Pierson CR, Rakowsky AT, Maver A, Lovrečić L, Palandačić A, Peterlin B, Torkamani A, Wedell A, Huss M, Alexeyenko A, Lindvall JM, Magnusson M, Nilsson D, Stranneheim H, Taylan F, Gilissen C, Hoischen A, van Bon B, Yntema H, Nelen M, Zhang W, Sager J, Zhang L, Blair K, Kural D, Cariaso M, Lennon GG, Javed A, Agrawal S, Ng PC, Sandhu KS, Krishna S, Veeramachaneni V, Isakov O, Halperin E, Friedman E, Shomron N, Glusman G, Roach JC, Caballero J, Cox HC, Mauldin D, Ament SA, Rowen L, Richards DR, San Lucas FA, Gonzalez-Garay ML, Caskey CT, Bai Y, Huang Y, Fang F, Zhang Y, Wang Z, Barrera J, Garcia-Lobo JM, González-Lamuño D, Llorca J, Rodriguez MC, Varela I, Reese MG, De La Vega FM, Kiruluta E, Cargill M, Hart RK, Sorenson JM, Lyon GJ, Stevenson DA, Bray BE, Moore BM, Eilbeck K, Yandell M, Zhao H, Hou L, Chen X, Yan X, Chen M, Li C, Yang C, Gunel M, Li P, Kong Y, Alexander AC, Albertyn ZI, Boycott KM, Bulman DE, Gordon PM, Innes AM, Knoppers BM, Majewski J, Marshall CR, Parboosingh JS, Sawyer SL, Samuels ME, Schwartzentruber J, Kohane IS, Margulies DM) Genome Biol 2014 Mar 25;15(3):R53 PMID: 24667040 PMCID: PMC4073084 03/29/2014       66 Citations
  • Genomic structure of nucleotide diversity among Lyon rat models of metabolic syndrome. (Ma MC, Atanur SS, Aitman TJ, Kwitek AE) BMC Genomics 2014 Mar 14;15:197 PMID: 24628878 PMCID: PMC4003853 03/19/2014       6 Citations
  • A novel otoferlin splice-site mutation in siblings with auditory neuropathy spectrum disorder. (Runge CL, Erbe CB, McNally MT, Van Dusen C, Friedland DR, Kwitek AE, Kerschner JE) Audiol Neurootol 2013;18(6):374-82 PMID: 24135434 PMCID: PMC3877672 SCOPUS ID: 2-s2.0-84885522606 10/19/2013       9 Citations
  • Genome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory rat. (Atanur SS, Diaz AG, Maratou K, Sarkis A, Rotival M, Game L, Tschannen MR, Kaisaki PJ, Otto GW, Ma MC, Keane TM, Hummel O, Saar K, Chen W, Guryev V, Gopalakrishnan K, Garrett MR, Joe B, Citterio L, Bianchi G, McBride M, Dominiczak A, Adams DJ, Serikawa T, Flicek P, Cuppen E, Hubner N, Petretto E, Gauguier D, Kwitek A, Jacob H, Aitman TJ) Cell 2013 Aug 01;154(3):691-703 PMID: 23890820 PMCID: PMC3732391 07/31/2013    
  • Allele-specific expression of angiotensinogen in human subcutaneous adipose tissue. (Park S, Lu KT, Liu X, Chatterjee TK, Rudich SM, Weintraub NL, Kwitek AE, Sigmund CD) Hypertension 2013 Jul;62(1):41-7 PMID: 23648704 PMCID: PMC3718031 SCOPUS ID: 2-s2.0-84880725776 05/08/2013       7 Citations
  • BB rat Gimap gene expression in sorted lymphoid T and B cells. (Moralejo DH, Fuller JM, Rutledge EA, Van Yserloo B, Ettinger RA, Jensen R, Osborne W, Kwitek A, Lernmark A) Life Sci 2011 Nov 07;89(19-20):748-54 PMID: 21925515 PMCID: PMC3264544 09/20/2011       4 Citations
  • Differential effects of leptin receptor mutation on male and female BBDR Gimap5-/Gimap5- spontaneously diabetic rats. (Moralejo DH, Hansen CT, Treuting P, Hessner MJ, Fuller JM, Van Yserloo B, Jensen R, Osborne W, Kwitek AE, Lernmark A) Physiol Genomics 2010 Mar 03;41(1):9-20 PMID: 19996157 PMCID: PMC2841494 SCOPUS ID: 2-s2.0-77949660725 12/10/2009       7 Citations
  • Implication of chromosome 13 on hypertension and associated disorders in Lyon hypertensive rats. (Gilibert S, Bataillard A, Nussberger J, Sassard J, Kwitek AE) J Hypertens 2009 Jun;27(6):1186-93 PMID: 19462495 PMCID: PMC2915542 05/23/2009       12 Citations
  • Sequence variation and expression of the Gimap gene family in the BB rat. (Rutledge EA, Fuller JM, Van Yserloo B, Moralejo DH, Ettinger RA, Gaur P, Hoehna JL, Peterson MR, Jensen R, Kwitek AE, Lernmark A) Exp Diabetes Res 2009;2009:835650 PMID: 19421422 PMCID: PMC2676327 05/08/2009       8 Citations
  • Genetic dissection reveals diabetes loci proximal to the gimap5 lymphopenia gene. (Fuller JM, Bogdani M, Tupling TD, Jensen RA, Pefley R, Manavi S, Cort L, Blankenhorn EP, Mordes JP, Lernmark A, Kwitek AE) Physiol Genomics 2009 Jun 10;38(1):89-97 PMID: 19351909 PMCID: PMC2696149 04/09/2009       13 Citations
  • Congenic strains provide evidence that four mapped loci in chromosomes 2, 4, and 16 influence hypertension in the SHR. (Aneas I, Rodrigues MV, Pauletti BA, Silva GJ, Carmona R, Cardoso L, Kwitek AE, Jacob HJ, Soler JM, Krieger JE) Physiol Genomics 2009 Mar 03;37(1):52-7 PMID: 19126752 01/08/2009       15 Citations
  • Genetically hypertensive Brown Norway congenic rat strains suggest intermediate traits underlying genetic hypertension. (Bilusić M, Moreno C, Barreto NE, Tschannen MR, Harris EL, Porteous WK, Thompson CM, Grigor MR, Weder A, Boerwinkle E, Hunt SC, Curb JD, Jacob HJ, Kwitek AE) Croat Med J 2008 Oct;49(5):586-99 PMID: 18925692 PMCID: PMC2582351 10/18/2008       6 Citations
  • Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5. (Schulteis RD, Chu H, Dai X, Chen Y, Edwards B, Haribhai D, Williams CB, Malarkannan S, Hessner MJ, Glisic-Milosavljevic S, Jana S, Kerschen EJ, Ghosh S, Wang D, Kwitek AE, Lernmark A, Gorski J, Weiler H) Blood 2008 Dec 15;112(13):4905-14 PMID: 18796632 PMCID: PMC2597598 SCOPUS ID: 2-s2.0-58149376483 09/18/2008       44 Citations
  • Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease. (Mattson DL, Dwinell MR, Greene AS, Kwitek AE, Roman RJ, Jacob HJ, Cowley AW Jr) Am J Physiol Renal Physiol 2008 Sep;295(3):F837-42 PMID: 18653478 PMCID: PMC2536867 SCOPUS ID: 2-s2.0-54449084434 07/26/2008       74 Citations
  • Using multiple ontologies to integrate complex biological data. (Shimoyama M, Petri V, Pasko D, Bromberg S, Wu W, Chen J, Nenasheva N, Kwitek A, Twigger S, Jacob H) Comp Funct Genomics 2005;6(7-8):373-8 PMID: 18629202 PMCID: PMC2447497 07/17/2008    
  • Progress and prospects in rat genetics: a community view. (Aitman TJ, Critser JK, Cuppen E, Dominiczak A, Fernandez-Suarez XM, Flint J, Gauguier D, Geurts AM, Gould M, Harris PC, Holmdahl R, Hubner N, Izsvák Z, Jacob HJ, Kuramoto T, Kwitek AE, Marrone A, Mashimo T, Moreno C, Mullins J, Mullins L, Olsson T, Pravenec M, Riley L, Saar K, Serikawa T, Shull JD, Szpirer C, Twigger SN, Voigt B, Worley K) Nat Genet 2008 May;40(5):516-22 PMID: 18443588 SCOPUS ID: 2-s2.0-42649111665 04/30/2008       207 Citations
  • Molecular networks in Dahl salt-sensitive hypertension based on transcriptome analysis of a panel of consomic rats. (Liang M, Lee NH, Wang H, Greene AS, Kwitek AE, Kaldunski ML, Luu TV, Frank BC, Bugenhagen S, Jacob HJ, Cowley AW Jr) Physiol Genomics 2008 Jun 12;34(1):54-64 PMID: 18430809 SCOPUS ID: 2-s2.0-47249097572 04/24/2008       37 Citations
  • Comparative genomics for detecting human disease genes. (Moreno C, Lazar J, Jacob HJ, Kwitek AE) Adv Genet 2008;60:655-97 PMID: 18358336 03/25/2008       16 Citations
  • Effects of chromosome 17 on features of the metabolic syndrome in the Lyon hypertensive rat. (Gilibert S, Kwitek AE, Hubner N, Tschannen M, Jacob HJ, Sassard J, Bataillard A) Physiol Genomics 2008 Apr 22;33(2):212-7 PMID: 18285521 02/21/2008       16 Citations
  • Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats. (Mattson DL, Dwinell MR, Greene AS, Kwitek AE, Roman RJ, Cowley AW Jr, Jacob HJ) Am J Physiol Renal Physiol 2007 Dec;293(6):F1905-14 PMID: 17898042 SCOPUS ID: 2-s2.0-36549060031 09/28/2007       39 Citations
  • Epistatic interaction between haplotypes of the ghrelin ligand and receptor genes influence susceptibility to myocardial infarction and coronary artery disease. (Baessler A, Fischer M, Mayer B, Koehler M, Wiedmann S, Stark K, Doering A, Erdmann J, Riegger G, Schunkert H, Kwitek AE, Hengstenberg C) Hum Mol Genet 2007 Apr 15;16(8):887-99 PMID: 17324965 02/28/2007       35 Citations
  • Model Systems - The Rat (Cuppen E, Hübner N, Jacob HJ, Kwitek AE (senior author)) (2007) in Genetic Variation: A Laboratory Manual, CSHL Press, Cold Spring Harbor, NY. ISBN 978-087969780-8 01/01/2007    
  • The Rat Genome Database, update 2007--easing the path from disease to data and back again. (Twigger SN, Shimoyama M, Bromberg S, Kwitek AE, Jacob HJ, RGD Team) Nucleic Acids Res 2007 Jan;35(Database issue):D658-62 PMID: 17151068 PMCID: PMC1761441 SCOPUS ID: 2-s2.0-33846111969 12/08/2006       104 Citations
  • Introgression of F344 rat genomic DNA on BB rat chromosome 4 generates diabetes-resistant lymphopenic BB rats. (Fuller JM, Kwitek AE, Hawkins TJ, Moralejo DH, Lu W, Tupling TD, Macmurray AJ, Borchardt G, Hasinoff M, Lernmark A) Diabetes 2006 Dec;55(12):3351-7 PMID: 17130479 11/30/2006       15 Citations
  • Evidence of a functional role for mast cells in the development of type 1 diabetes mellitus in the BioBreeding rat. (Geoffrey R, Jia S, Kwitek AE, Woodliff J, Ghosh S, Lernmark A, Wang X, Hessner MJ) J Immunol 2006 Nov 15;177(10):7275-86 PMID: 17082646 SCOPUS ID: 2-s2.0-33750840512 11/04/2006       53 Citations
  • The application of microarray analysis to pediatric diseases. (Hessner MJ, Liang M, Kwitek AE) Pediatr Clin North Am 2006 Aug;53(4):579-90 PMID: 16872994 SCOPUS ID: 2-s2.0-33746189506 07/29/2006       2 Citations
  • Sequence analysis of the complete mitochondrial DNA in 10 commonly used inbred rat strains. (Schlick NE, Jensen-Seaman MI, Orlebeke K, Kwitek AE, Jacob HJ, Lazar J) Am J Physiol Cell Physiol 2006 Dec;291(6):C1183-92 PMID: 16855218 07/21/2006       34 Citations
  • Consomic strategies to localize genomic regions related to vascular reactivity in the Dahl salt-sensitive rat. (Kunert MP, Drenjancevic-Peric I, Dwinell MR, Lombard JH, Cowley AW Jr, Greene AS, Kwitek AE, Jacob HJ) Physiol Genomics 2006 Aug 16;26(3):218-25 PMID: 16772359 SCOPUS ID: 2-s2.0-33747330104 06/15/2006       23 Citations
  • Association of the Ghrelin receptor gene region with left ventricular hypertrophy in the general population: results of the MONICA/KORA Augsburg Echocardiographic Substudy. (Baessler A, Kwitek AE, Fischer M, Koehler M, Reinhard W, Erdmann J, Riegger G, Doering A, Schunkert H, Hengstenberg C) Hypertension 2006 May;47(5):920-7 PMID: 16567594 03/29/2006       22 Citations
  • BN phenome: detailed characterization of the cardiovascular, renal, and pulmonary systems of the sequenced rat. (Kwitek AE, Jacob HJ, Baker JE, Dwinell MR, Forster HV, Greene AS, Kunert MP, Lombard JH, Mattson DL, Pritchard KA Jr, Roman RJ, Tonellato PJ, Cowley AW Jr) Physiol Genomics 2006 Apr 13;25(2):303-13 PMID: 16478827 SCOPUS ID: 2-s2.0-33645761913 02/16/2006       27 Citations
  • Physiogenomic resources for rat models of heart, lung and blood disorders. (Malek RL, Wang HY, Kwitek AE, Greene AS, Bhagabati N, Borchardt G, Cahill L, Currier T, Frank B, Fu X, Hasinoff M, Howe E, Letwin N, Luu TV, Saeed A, Sajadi H, Salzberg SL, Sultana R, Thiagarajan M, Tsai J, Veratti K, White J, Quackenbush J, Jacob HJ, Lee NH) Nat Genet 2006 Feb;38(2):234-9 PMID: 16415889 01/18/2006       44 Citations
  • Characterization of blood pressure and renal function in chromosome 5 congenic strains of Dahl S rats. (Roman RJ, Hoagland KM, Lopez B, Kwitek AE, Garrett MR, Rapp JP, Lazar J, Jacob HJ, Sarkis A) Am J Physiol Renal Physiol 2006 Jun;290(6):F1463-71 PMID: 16396943 01/07/2006       23 Citations
  • Impact of Genomics on Research in the Rat (Lazar, J, Moreno, C, Jacob, HJ, Kwitek, AE) (2006) in Genomes, (ed. HE Sussman and MA Smit), pp. 281-311, CSHL Press, Cold Spring Harbor, NY. 01/01/2006    
  • Impact of genomics on research in the rat. (Lazar J, Moreno C, Jacob HJ, Kwitek AE) Genome Res 2005 Dec;15(12):1717-28 PMID: 16339370 12/13/2005       50 Citations
  • Fine mapping of Lvm1: a quantitative trait locus controlling heart size independently of blood pressure. (Di Nicolantonio R, Kostka V, Kwitek A, Jacob H, Thomas WG, Harrap SB) Pulm Pharmacol Ther 2006;19(1):70-3 PMID: 16286240 11/16/2005       6 Citations
  • Tools and strategies for physiological genomics: the Rat Genome Database. (Twigger SN, Pasko D, Nie J, Shimoyama M, Bromberg S, Campbell D, Chen J, dela Cruz N, Fan C, Foote C, Harris G, Hickmann B, Ji Y, Jin W, Li D, Mathis J, Nenasheva N, Nigam R, Petri V, Reilly D, Ruotti V, Schauberger E, Seiler K, Slyper R, Smith J, Wang W, Wu W, Zhao L, Zuniga-Meyer A, Tonellato PJ, Kwitek AE, Jacob HJ) Physiol Genomics 2005 Oct 17;23(2):246-56 PMID: 16106031 PMCID: PMC4505745 SCOPUS ID: 2-s2.0-28844446021 08/18/2005       21 Citations
  • In silico analysis of 2085 clones from a normalized rat vestibular periphery 3' cDNA library. (Roche JP, Wackym PA, Cioffi JA, Kwitek AE, Erbe CB, Popper P) Audiol Neurootol 2005 Nov-Dec;10(6):310-22 PMID: 16103642 PMCID: PMC1421512 08/17/2005       7 Citations
  • Genetic linkage and association of the growth hormone secretagogue receptor (ghrelin receptor) gene in human obesity. (Baessler A, Hasinoff MJ, Fischer M, Reinhard W, Sonnenberg GE, Olivier M, Erdmann J, Schunkert H, Doering A, Jacob HJ, Comuzzie AG, Kissebah AH, Kwitek AE) Diabetes 2005 Jan;54(1):259-67 PMID: 15616037 PMCID: PMC2793077 12/24/2004       79 Citations
  • The Rat Genome Database (RGD): developments towards a phenome database. (de la Cruz N, Bromberg S, Pasko D, Shimoyama M, Twigger S, Chen J, Chen CF, Fan C, Foote C, Gopinath GR, Harris G, Hughes A, Ji Y, Jin W, Li D, Mathis J, Nenasheva N, Nie J, Nigam R, Petri V, Reilly D, Wang W, Wu W, Zuniga-Meyer A, Zhao L, Kwitek A, Tonellato P, Jacob H) Nucleic Acids Res 2005 Jan 01;33(Database issue):D485-91 PMID: 15608243 PMCID: PMC540004 SCOPUS ID: 2-s2.0-13444273396 12/21/2004       45 Citations
  • Mapping the genetic determinants of hypertension, metabolic diseases, and related phenotypes in the lyon hypertensive rat. (Bilusic M, Bataillard A, Tschannen MR, Gao L, Barreto NE, Vincent M, Wang T, Jacob HJ, Sassard J, Kwitek AE) Hypertension 2004 Nov;44(5):695-701 PMID: 15452030 SCOPUS ID: 2-s2.0-7444254076 09/29/2004       46 Citations
  • Transgenic rescue demonstrates involvement of the Ian5 gene in T cell development in the rat. (Michalkiewicz M, Michalkiewicz T, Ettinger RA, Rutledge EA, Fuller JM, Moralejo DH, Van Yserloo B, MacMurray AJ, Kwitek AE, Jacob HJ, Lander ES, Lernmark A) Physiol Genomics 2004 Oct 04;19(2):228-32 PMID: 15328390 08/26/2004       30 Citations
  • Integrative genomics: in silico coupling of rat physiology and complex traits with mouse and human data. (Twigger SN, Nie J, Ruotti V, Yu J, Chen D, Li D, Mathis J, Narayanasamy V, Gopinath GR, Pasko D, Shimoyama M, De La Cruz N, Bromberg S, Kwitek AE, Jacob HJ, Tonellato PJ) Genome Res 2004 Apr;14(4):651-60 PMID: 15060006 PMCID: PMC383309 SCOPUS ID: 2-s2.0-3042536890 04/03/2004       17 Citations
  • High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. (Kwitek AE, Gullings-Handley J, Yu J, Carlos DC, Orlebeke K, Nie J, Eckert J, Lemke A, Andrae JW, Bromberg S, Pasko D, Chen D, Scheetz TE, Casavant TL, Soares MB, Sheffield VC, Tonellato PJ, Jacob HJ) Genome Res 2004 Apr;14(4):750-7 PMID: 15060019 PMCID: PMC383322 04/03/2004       31 Citations
  • Genome sequence of the Brown Norway rat yields insights into mammalian evolution. (Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium) Nature 2004 Apr 01;428(6982):493-521 PMID: 15057822 04/02/2004       1482 Citations
  • Genetic determinants of obesity-related lipid traits. (Sonnenberg GE, Krakower GR, Martin LJ, Olivier M, Kwitek AE, Comuzzie AG, Blangero J, Kissebah AH) J Lipid Res 2004 Apr;45(4):610-5 PMID: 14754912 PMCID: PMC2771634 02/03/2004       32 Citations
  • Expression of G-protein alpha subunit genes in the vestibular periphery of Rattus norvegicus and their chromosomal mapping. (Cioffi JA, Erbe CB, Raphael R, Kwitek AE, Tiwari UK, Jacob HJ, Popper P, Wackym PA) Acta Otolaryngol 2003 Dec;123(9):1027-34 PMID: 14710903 01/09/2004       7 Citations
  • Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat. (Moralejo DH, Park HA, Speros SJ, MacMurray AJ, Kwitek AE, Jacob HJ, Lander ES, Lernmark A) J Autoimmun 2003 Dec;21(4):315-24 PMID: 14624755 PMCID: PMC7126882 11/20/2003       30 Citations
  • Consomic rats for the identification of genes and pathways underlying cardiovascular disease. (Roman RJ, Cowley AW Jr, Greene A, Kwitek AE, Tonellato PJ, Jacob HJ) Cold Spring Harb Symp Quant Biol 2002;67:309-15 PMID: 12858554 07/16/2003       18 Citations
  • Assessing unmodified 70-mer oligonucleotide probe performance on glass-slide microarrays. (Wang HY, Malek RL, Kwitek AE, Greene AS, Luu TV, Behbahani B, Frank B, Quackenbush J, Lee NH) Genome Biol 2003;4(1):R5 PMID: 12540297 PMCID: PMC151289 01/24/2003       119 Citations
  • Physiological Genomics (Kwitek, AE) (2003) in Physiology Secrets, 2nd edition (ed. H Raff), pp. 57-62, Hanley and Belfus, Inc, Philadelphia, PA. 01/01/2003    
  • Radiation hybrid mapping of five muscarinic acetylcholine receptor subtype genes in Rattus norvegicus. (Tseng J, Erbe CB, Kwitek AE, Jacob HJ, Popper P, Wackym PA) Hear Res 2002 Dec;174(1-2):86-92 PMID: 12433399 11/16/2002       4 Citations
  • Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene. (MacMurray AJ, Moralejo DH, Kwitek AE, Rutledge EA, Van Yserloo B, Gohlke P, Speros SJ, Snyder B, Schaefer J, Bieg S, Jiang J, Ettinger RA, Fuller J, Daniels TL, Pettersson A, Orlebeke K, Birren B, Jacob HJ, Lander ES, Lernmark A) Genome Res 2002 Jul;12(7):1029-39 PMID: 12097339 PMCID: PMC186618 07/05/2002       178 Citations
  • Radiation hybrid mapping of 70 rat genes from a data set of differentially expressed genes. (Wallace CA, Ali S, Glazier AM, Norsworthy PJ, Carlos DC, Scott J, Freeman TC, Stanton LW, Kwitek AE, Aitman TJ) Mamm Genome 2002 Apr;13(4):194-7 PMID: 11956762 04/17/2002       7 Citations
  • Rat genetics: attaching physiology and pharmacology to the genome. (Jacob HJ, Kwitek AE) Nat Rev Genet 2002 Jan;3(1):33-42 PMID: 11823789 02/02/2002       199 Citations
  • Rat Genome Database (RGD): mapping disease onto the genome. (Twigger S, Lu J, Shimoyama M, Chen D, Pasko D, Long H, Ginster J, Chen CF, Nigam R, Kwitek A, Eppig J, Maltais L, Maglott D, Schuler G, Jacob H, Tonellato PJ) Nucleic Acids Res 2002 Jan 01;30(1):125-8 PMID: 11752273 PMCID: PMC99132 SCOPUS ID: 2-s2.0-18444394318 12/26/2001       79 Citations
  • Automated construction of high-density comparative maps between rat, human, and mouse. (Kwitek AE, Tonellato PJ, Chen D, Gullings-Handley J, Cheng YS, Twigger S, Scheetz TE, Casavant TL, Stoll M, Nobrega MA, Shiozawa M, Soares MB, Sheffield VC, Jacob HJ) Genome Res 2001 Nov;11(11):1935-43 PMID: 11691858 PMCID: PMC311144 11/03/2001       33 Citations
  • The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome. (Comuzzie AG, Funahashi T, Sonnenberg G, Martin LJ, Jacob HJ, Black AE, Maas D, Takahashi M, Kihara S, Tanaka S, Matsuzawa Y, Blangero J, Cohen D, Kissebah A) J Clin Endocrinol Metab 2001 Sep;86(9):4321-5 PMID: 11549668 SCOPUS ID: 2-s2.0-17944362243 09/11/2001       268 Citations
  • Radiation hybrid mapping of 11 alpha and beta nicotinic acetylcholine receptor genes in Rattus norvegicus. (Tseng J, Kwitek-Black AE, Erbe CB, Popper P, Jacob HJ, Wackym PA) Brain Res Mol Brain Res 2001 Jul 13;91(1-2):169-73 PMID: 11457506 07/18/2001       10 Citations
  • The role of rats in functional genomics. (Kwitek-Black AE) Lab Anim (NY) 2000 Mar;29(3):44-8 PMID: 11375646 05/26/2001    
  • Positional cloning of a novel gene on chromosome 16q causing Bardet-Biedl syndrome (BBS2). (Nishimura DY, Searby CC, Carmi R, Elbedour K, Van Maldergem L, Fulton AB, Lam BL, Powell BR, Swiderski RE, Bugge KE, Haider NB, Kwitek-Black AE, Ying L, Duhl DM, Gorman SW, Heon E, Iannaccone A, Bonneau D, Biesecker LG, Jacobson SG, Stone EM, Sheffield VC) Hum Mol Genet 2001 Apr 01;10(8):865-74 PMID: 11285252 04/04/2001       192 Citations
  • Generation of a high-density rat EST map. (Scheetz TE, Raymond MR, Nishimura DY, McClain A, Roberts C, Birkett C, Gardiner J, Zhang J, Butters N, Sun C, Kwitek-Black A, Jacob H, Casavant TL, Soares MB, Sheffield VC) Genome Res 2001 Mar;11(3):497-502 PMID: 11230173 PMCID: PMC311028 03/07/2001       29 Citations
  • The use of designer rats in the genetic dissection of hypertension. (Kwitek-Black AE, Jacob HJ) Curr Hypertens Rep 2001 Feb;3(1):12-8 PMID: 11177702 02/15/2001       35 Citations
  • Retinoic acid-induced tissue transglutaminase and apoptosis in vascular smooth muscle cells. (Ou H, Haendeler J, Aebly MR, Kelly LA, Cholewa BC, Koike G, Kwitek-Black A, Jacob HJ, Berk BC, Miano JM) Circ Res 2000 Nov 10;87(10):881-7 PMID: 11073883 11/14/2000       52 Citations
  • High-throughput scanning of the rat genome using interspersed repetitive sequence-PCR markers. (Gösele C, Hong L, Kreitler T, Rossmann M, Hieke B, Gross U, Kramer M, Himmelbauer H, Bihoreau MT, Kwitek-Black AE, Twigger S, Tonellato PJ, Jacob HJ, Schalkwyk LC, Lindpaintner K, Ganten D, Lehrach H, Knoblauch M) Genomics 2000 Nov 01;69(3):287-94 PMID: 11056046 11/01/2000       12 Citations
  • New target regions for human hypertension via comparative genomics. (Stoll M, Kwitek-Black AE, Cowley AW Jr, Harris EL, Harrap SB, Krieger JE, Printz MP, Provoost AP, Sassard J, Jacob HJ) Genome Res 2000 Apr;10(4):473-82 PMID: 10779487 PMCID: PMC310887 04/26/2000       197 Citations
  • Molecular cloning, tissue-specific expression, and chromosomal localization of a novel nerve growth factor-regulated G-protein- coupled receptor, nrg-1. (Glickman M, Malek RL, Kwitek-Black AE, Jacob HJ, Lee NH) Mol Cell Neurosci 1999 Aug;14(2):141-52 PMID: 10532805 10/26/1999       67 Citations
  • A high-density integrated genetic linkage and radiation hybrid map of the laboratory rat. (Steen RG, Kwitek-Black AE, Glenn C, Gullings-Handley J, Van Etten W, Atkinson OS, Appel D, Twigger S, Muir M, Mull T, Granados M, Kissebah M, Russo K, Crane R, Popp M, Peden M, Matise T, Brown DM, Lu J, Kingsmore S, Tonellato PJ, Rozen S, Slonim D, Young P, Jacob HJ) Genome Res 1999 Jun;9(6):AP1-8, insert PMID: 10400928 07/13/1999       177 Citations
  • Gene-Environment Interactions (Kwitek-Black, AE, Jacob, H) (1999) in Hypertension Primer: The Essentials of High Blood Pressure, 2nd edition (ed. JL Izzo and HR Black), pp. 222-223, Lippincott, Williams & Wilkins, Baltimore, MD. ISBN-13: 978-0683307061 01/02/1999    
  • Usher syndrome in the Samaritans: strengths and limitations of using inbred isolated populations to identify genes causing recessive disorders. (Bonné-Tamir B, Nystuen A, Seroussi E, Kalinsky H, Kwitek-Black AE, Korostishevsky M, Adato A, Sheffield VC) Am J Phys Anthropol 1997 Oct;104(2):193-200 PMID: 9386826 12/05/1997       11 Citations
  • Use of a DNA pooling strategy to identify a human obesity syndrome locus on chromosome 15. (Carmi R, Rokhlina T, Kwitek-Black AE, Elbedour K, Nishimura D, Stone EM, Sheffield VC) Hum Mol Genet 1995 Jan;4(1):9-13 PMID: 7711739 01/01/1995       159 Citations
  • Identification of a Bardet-Biedl syndrome locus on chromosome 3 and evaluation of an efficient approach to homozygosity mapping. (Sheffield VC, Carmi R, Kwitek-Black A, Rokhlina T, Nishimura D, Duyk GM, Elbedour K, Sunden SL, Stone EM) Hum Mol Genet 1994 Aug;3(8):1331-5 PMID: 7987310 08/01/1994       181 Citations
  • Linkage of Bardet-Biedl syndrome to chromosome 16q and evidence for non-allelic genetic heterogeneity. (Kwitek-Black AE, Carmi R, Duyk GM, Buetow KH, Elbedour K, Parvari R, Yandava CN, Stone EM, Sheffield VC) Nat Genet 1993 Dec;5(4):392-6 PMID: 8298649 12/01/1993       147 Citations
  • The sensitivity of single-strand conformation polymorphism analysis for the detection of single base substitutions. (Sheffield VC, Beck JS, Kwitek AE, Sandstrom DW, Stone EM) Genomics 1993 May;16(2):325-32 PMID: 8314571 05/01/1993       561 Citations
  • Clinical features and linkage analysis of a family with autosomal dominant juvenile glaucoma. (Johnson AT, Drack AV, Kwitek AE, Cannon RL, Stone EM, Alward WL) Ophthalmology 1993 Apr;100(4):524-9 PMID: 8479711 04/01/1993       91 Citations
  • A denaturing gradient gel electrophoresis assay for sensitive detection of p53 mutations. (Beck JS, Kwitek AE, Cogen PH, Metzger AK, Duyk GM, Sheffield VC) Hum Genet 1993 Mar;91(1):25-30 PMID: 8454284 03/01/1993       40 Citations
  • Linkage of Rieger syndrome to the region of the epidermal growth factor gene on chromosome 4. (Murray JC, Bennett SR, Kwitek AE, Small KW, Schinzel A, Alward WL, Weber JL, Bell GI, Buetow KH) Nat Genet 1992 Sep;2(1):46-9 PMID: 1303248 09/01/1992    
  • Mapping of human chromosome 5 microsatellite DNA polymorphisms. (Weber JL, Polymeropoulos MH, May PE, Kwitek AE, Xiao H, McPherson JD, Wasmuth JJ) Genomics 1991 Nov;11(3):695-700 PMID: 1774070 11/01/1991       77 Citations
  • Linkage mapping of D21S171 to the distal long arm of human chromosome 21 using a polymorphic (AC)n dinucleotide repeat. (Petersen MB, Weber JL, Slaugenhaupt SA, Kwitek AE, McInnis MG, Chakravarti A, Antonarakis SE) Hum Genet 1991 Aug;87(4):401-4 PMID: 1879826 08/01/1991       12 Citations
  • Dinucleotide repeat polymorphism at the D6S105 locus. (Weber JL, Kwitek AE, May PE, Zoghbi HY) Nucleic Acids Res 1991 Feb 25;19(4):968 PMID: 2017389 PMCID: PMC333759 02/25/1991       58 Citations
  • Linkage mapping of the highly informative DNA marker D21S156 to human chromosome 21 using a polymorphic GT dinucleotide repeat. (Lewis JG, Weber JL, Petersen MB, Slaugenhaupt SA, Kwitek A, May PE, Warren AC, Chakravarti A, Antonarakis SE) Genomics 1990 Oct;8(2):400-2 PMID: 1979059 10/01/1990       17 Citations
  • Dinucleotide repeat polymorphisms at the D17S250 and D17S261 loci. (Weber JL, Kwitek AE, May PE, Wallace MR, Collins FS, Ledbetter DH) Nucleic Acids Res 1990 Aug 11;18(15):4640 PMID: 2388867 PMCID: PMC331336 08/11/1990    
  • Dinucleotide repeat polymorphism at the D15S87 locus. (Weber JL, Kwitek AE, May PE) Nucleic Acids Res 1990 Aug 11;18(15):4640 PMID: 2388866 PMCID: PMC331335 08/11/1990       138 Citations
  • Dinucleotide repeat polymorphism at the D19S75 locus. (Weber JL, Kappel C, May PE, Kwitek AE) Nucleic Acids Res 1990 Aug 11;18(15):4639 PMID: 2388864 PMCID: PMC331333 08/11/1990       14 Citations
  • Dinucleotide repeat polymorphism at the D14S34 locus. (Weber JL, Kwitek AE, May PE) Nucleic Acids Res 1990 Aug 11;18(15):4638 PMID: 2388863 PMCID: PMC331332 08/11/1990    
  • Dinucleotide repeat polymorphism at the D13S71 locus. (Weber JL, Kwitek AE, May PE) Nucleic Acids Res 1990 Aug 11;18(15):4638 PMID: 2388862 PMCID: PMC331331 08/11/1990       19 Citations
  • Dinucleotide repeat polymorphism at the D12S43 locus. (Weber JL, Kwitek AE, May PE, Polymeropoulos M) Nucleic Acids Res 1990 Aug 11;18(15):4637 PMID: 2388861 PMCID: PMC331330 08/11/1990       56 Citations
  • Dinucleotide repeat polymorphism at the D6S87 locus. (Weber JL, Kwitek AE, May PE) Nucleic Acids Res 1990 Aug 11;18(15):4636 PMID: 2388859 PMCID: PMC331328 08/11/1990       31 Citations
  • Dinucleotide repeat polymorphism at the D4S174 locus. (Weber JL, Kwitek AE, May PE, Killary AM) Nucleic Acids Res 1990 Aug 11;18(15):4636 PMID: 2388858 PMCID: PMC331327 08/11/1990       31 Citations
  • Dinucleotide repeat polymorphism at the CRP locus. (Weber JL, Kwitek AE, May PE) Nucleic Acids Res 1990 Aug 11;18(15):4635 PMID: 2388856 PMCID: PMC331325 08/11/1990       23 Citations
  • Dinucleotide repeat polymorphisms at the D7S435 and D7S440 loci. (Weber JL, Kwitek AE, May PE) Nucleic Acids Res 1990 Jul 11;18(13):4039 PMID: 1973841 PMCID: PMC331152 07/11/1990       34 Citations
  • Dinucleotide repeat polymorphisms at the D8S85, D8S87, and D8S88 loci. (Weber JL, Kwitek AE, May PE, Patterson D, Drabkin H) Nucleic Acids Res 1990 Jul 11;18(13):4038 PMID: 1973840 PMCID: PMC331151 07/11/1990       39 Citations
  • Dinucleotide repeat polymorphisms at the DXS453, DXS454 and DXS458 loci. (Weber JL, Kwitek AE, May PE, Polymeropoulos MH, Ledbetter S) Nucleic Acids Res 1990 Jul 11;18(13):4037 PMID: 1973839 PMCID: PMC331150 07/11/1990       45 Citations
  • Dinucleotide repeat polymorphisms at the D11S419 and CD3D loci. (Weber JL, Kwitek AE, May PE) Nucleic Acids Res 1990 Jul 11;18(13):4036 PMID: 1973838 PMCID: PMC331149 07/11/1990       22 Citations
  • Dinucleotide repeat polymorphisms at the D5S107, D5S108, D5S111, D5S117 and D5S118 loci. (Weber JL, Kwitek AE, May PE) Nucleic Acids Res 1990 Jul 11;18(13):4035 PMID: 1973837 PMCID: PMC331148 07/11/1990       34 Citations
  • Dinucleotide repeat polymorphisms at the D16S260, D16S261, D16S265, D16S266, and D16S267 loci. (Weber JL, Kwitek AE, May PE) Nucleic Acids Res 1990 Jul 11;18(13):4034 PMID: 1973836 PMCID: PMC331147 07/11/1990       31 Citations
  • Dinucleotide repeat polymorphism at the D1S104 locus. (Weber JL, Kwitek AE, May PE) Nucleic Acids Res 1990 May 11;18(9):2835 PMID: 1971099 PMCID: PMC330796 05/11/1990       17 Citations
  • Dinucleotide repeat polymorphism at the D1S103 locus. (Weber JL, Kwitek AE, May PE) Nucleic Acids Res 1990 Apr 25;18(8):2199 PMID: 1970879 PMCID: PMC330726 04/25/1990    
  • Dinucleotide repeat polymorphism at the D1S102 locus. (Weber JL, Kwitek AE, May PE) Nucleic Acids Res 1990 Apr 25;18(8):2199 PMID: 1970878 PMCID: PMC330725 04/25/1990       19 Citations
  • Last update: 09/17/2020
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