Nuclear migration during retinal development. Brain Res 2008 Feb 04;1192:29-36
Date
06/15/2007Pubmed ID
17560964Pubmed Central ID
PMC2674389DOI
10.1016/j.brainres.2007.05.021Scopus ID
2-s2.0-38849104859 (requires institutional sign-in at Scopus site) 109 CitationsAbstract
In this review we focus on the mechanisms, regulation, and cellular consequences of nuclear migration in the developing retina. In the nervous system, nuclear migration is prominent during both proliferative and post-mitotic phases of development. Interkinetic nuclear migration is the process where the nucleus oscillates from the apical to basal surfaces in proliferative neuroepithelia. Proliferative nuclear movement occurs in step with the cell cycle, with M-phase being confined to the apical surface and G1-, S-, and G2-phases occurring at more basal locations. Later, following cell cycle exit, some neuron precursors migrate by nuclear translocation. In this mode of cellular migration, nuclear movement is the driving force for motility. Following discussion of the key components and important regulators for each of these processes, we present an emerging model where interkinetic nuclear migration functions to distinguish cell fates among retinal neuroepithelia.
Author List
Baye LM, Link BAAuthor
Brian A. Link PhD Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCell Cycle
Cell Lineage
Cell Movement
Cell Nucleus
Humans
Models, Biological
Neuroepithelial Cells
Neurons
Retina
Stem Cells
