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Brian A. Link PhD

Professor

Institution: Medical College of Wisconsin
Department: Cell Biology, Neurobiology and Anatomy
Program: Administration

Member of the Cardiovascular Center
Member of the Neuroscience Research Center

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Publications (97)

The tunicamycin derivative TunR2 exhibits potent antibiotic properties with low toxicity in an in vivo Mycobacterium marinum-zebrafish TB infection model. (Nonarath HJT, Jackson MA, Penoske RM, Zahrt TC, Price NPJ, Link BA) J Antibiot (Tokyo) 2024 Apr;77(4):245-256 PMID: 38238588 SCOPUS ID: 2-s2.0-85182630226 01/19/2024

Mesenchymal Stromal Cells Facilitate Tip Cell Fusion Downstream of BMP-Mediated Venous Angiogenesis-Brief Report. (Eisa-Beygi S, Hu MM, Kumar SN, Jeffery BE, Collery RF, Vo NJ, Lamichanne BS, Yost HJ, Veldman MB, Link BA) Arterioscler Thromb Vasc Biol 2023 Jul;43(7):e231-e237 PMID: 37128914 PMCID: PMC10330147 SCOPUS ID: 2-s2.0-85163499929 05/02/2023

Myofibroblast Ccn3 is regulated by Yap and Wwtr1 and contributes to adverse cardiac outcomes. (Flinn MA, Alvarez-Argote S, Knas MC, Almeida VA, Paddock SJ, Zhou X, Buddell T, Jamal A, Taylor R, Liu P, Drnevich J, Patterson M, Link BA, O'Meara CC) Front Cardiovasc Med 2023;10:1142612 PMID: 36998974 PMCID: PMC10043314 SCOPUS ID: 2-s2.0-85150879131 04/01/2023 1 Citation

Endothelial cilia dysfunction in pathogenesis of hereditary hemorrhagic telangiectasia. (Eisa-Beygi S, Burrows PE, Link BA) Front Cell Dev Biol 2022;10:1037453 PMID: 36438574 PMCID: PMC9686338 SCOPUS ID: 2-s2.0-85142632800 11/29/2022 1 Citation

Ablation of mpeg+ Macrophages Exacerbates mfrp-Related Hyperopia. (Brandt ZJ, Collery RF, Besharse JC, Link BA) Invest Ophthalmol Vis Sci 2021 Dec 01;62(15):13 PMID: 34913948 PMCID: PMC8684298 SCOPUS ID: 2-s2.0-85122380090 12/17/2021 1 Citation

Retinal Gene Therapy for Usher Syndrome: Current Developments, Challenges, and Perspectives. (Dinculescu A, Link BA, Saperstein DA) Int Ophthalmol Clin 2021 Oct 01;61(4):109-124 PMID: 34584048 PMCID: PMC8478317 SCOPUS ID: 2-s2.0-85117357508 09/30/2021 4 Citations

RhoA activation-mediated vascular permeability in capillary malformation-arteriovenous malformation syndrome: a hypothesis (Eisa-Beygi S, Vo N(, Link BA) Drug Discovery Today August 2021;26(8):1790-1793 SCOPUS ID: 2-s2.0-85098655506 08/01/2021 1 Citation

Dynamic Polarization of Rab11a Modulates Crb2a Localization and Impacts Signaling to Regulate Retinal Neurogenesis. (Clark BS, Miesfeld JB, Flinn MA, Collery RF, Link BA) Front Cell Dev Biol 2020;8:608112 PMID: 33634099 PMCID: PMC7900515 SCOPUS ID: 2-s2.0-85101223534 02/27/2021 5 Citations

Complementary and divergent functions of zebrafish Tango1 and Ctage5 in tissue development and homeostasis. (Clark EM, Link BA) Mol Biol Cell 2021 Mar 01;32(5):391-401 PMID: 33439675 PMCID: PMC8098853 SCOPUS ID: 2-s2.0-85101912245 01/14/2021 8 Citations

RhoA activation-mediated vascular permeability in capillary malformation-arteriovenous malformation syndrome: a hypothesis. (Eisa-Beygi S, Vo NJ, Link BA) Drug Discov Today 2021 Aug;26(8):1790-1793 PMID: 33358701 SCOPUS ID: 2-s2.0-85098655506 12/29/2020 1 Citation

Interplay of MPP5a with Rab11 synergistically builds epithelial apical polarity and zonula adherens. (Hao Y, Zhou Y, Yu Y, Zheng M, Weng K, Kou Z, Liang J, Zhang Q, Tang X, Xu P, Link BA, Yao K, Zou J) Development 2020 Nov 19;147(22) PMID: 33060129 SCOPUS ID: 2-s2.0-85096508420 10/17/2020 1 Citation

Llgl1 regulates zebrafish cardiac development by mediating Yap stability in cardiomyocytes. (Flinn MA, Otten C, Brandt ZJ, Bostrom JR, Kenarsary A, Wan TC, Auchampach JA, Abdelilah-Seyfried S, O'Meara CC, Link BA) Development 2020 Aug 25;147(16) PMID: 32843528 PMCID: PMC7473637 SCOPUS ID: 2-s2.0-85089923843 08/28/2020 7 Citations

Core Hippo pathway components act as a brake on Yap and Taz in the development and maintenance of the biliary network. (Brandt ZJ, Echert AE, Bostrom JR, North PN, Link BA) Development 2020 Jun 22;147(12) PMID: 32439761 PMCID: PMC7328147 SCOPUS ID: 2-s2.0-85087440712 05/23/2020 6 Citations

Establishment and validation of an endoplasmic reticulum stress reporter to monitor zebrafish ATF6 activity in development and disease. (Clark EM, Nonarath HJT, Bostrom JR, Link BA) Dis Model Mech 2020 Jan 28;13(1) PMID: 31852729 PMCID: PMC6994954 SCOPUS ID: 2-s2.0-85079534293 12/20/2019 20 Citations

Upstream regulation of the Hippo-Yap pathway in cardiomyocyte regeneration. (Flinn MA, Link BA, O'Meara CC) Semin Cell Dev Biol 2020 Apr;100:11-19 PMID: 31606277 PMCID: PMC7263368 SCOPUS ID: 2-s2.0-85073003673 10/14/2019 32 Citations

Precise Short Sequence Insertion in Zebrafish Using a CRISPR/Cas9 Approach to Generate a Constitutively Soluble Lrp2 Protein. (Collery RF, Link BA) Front Cell Dev Biol 2019;7:167 PMID: 31457013 PMCID: PMC6700241 SCOPUS ID: 2-s2.0-85072723134 08/29/2019 3 Citations

Somatic Mutations of lats2 Cause Peripheral Nerve Sheath Tumors in Zebrafish. (Brandt ZJ, North PN, Link BA) Cells 2019 Aug 25;8(9) PMID: 31450674 PMCID: PMC6770745 SCOPUS ID: 2-s2.0-85084889096 08/28/2019 10 Citations

The Roles of Hippo Signaling Transducers Yap and Taz in Chromatin Remodeling. (Hillmer RE, Link BA) Cells 2019 May 24;8(5) PMID: 31137701 PMCID: PMC6562424 SCOPUS ID: 2-s2.0-85076223119 05/30/2019 43 Citations

Regeneration of the zebrafish retinal pigment epithelium after widespread genetic ablation. (Hanovice NJ, Leach LL, Slater K, Gabriel AE, Romanovicz D, Shao E, Collery R, Burton EA, Lathrop KL, Link BA, Gross JM) PLoS Genet 2019 Jan;15(1):e1007939 PMID: 30695061 PMCID: PMC6368336 SCOPUS ID: 2-s2.0-85061272556 01/30/2019 34 Citations

The Hippo Pathway Regulates Caveolae Expression and Mediates Flow Response via Caveolae. (Rausch V, Bostrom JR, Park J, Bravo IR, Feng Y, Hay DC, Link BA, Hansen CG) Curr Biol 2019 Jan 21;29(2):242-255.e6 PMID: 30595521 PMCID: PMC6345631 SCOPUS ID: 2-s2.0-85060027631 01/01/2019 53 Citations

Kif17 phosphorylation regulates photoreceptor outer segment turnover. (Lewis TR, Kundinger SR, Link BA, Insinna C, Besharse JC) BMC Cell Biol 2018 Nov 20;19(1):25 PMID: 30458707 PMCID: PMC6245759 SCOPUS ID: 2-s2.0-85056802940 11/22/2018 26 Citations

Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth. (Cox AG, Tsomides A, Yimlamai D, Hwang KL, Miesfeld J, Galli GG, Fowl BH, Fort M, Ma KY, Sullivan MR, Hosios AM, Snay E, Yuan M, Brown KK, Lien EC, Chhangawala S, Steinhauser ML, Asara JM, Houvras Y, Link B, Vander Heiden MG, Camargo FD, Goessling W) EMBO J 2018 Nov 15;37(22) PMID: 30348863 PMCID: PMC6236334 SCOPUS ID: 2-s2.0-85055253100 10/24/2018 70 Citations

Yap is required for scar formation but not myocyte proliferation during heart regeneration in zebrafish. (Flinn MA, Jeffery BE, O'Meara CC, Link BA) Cardiovasc Res 2019 Mar 01;115(3):570-577 PMID: 30295714 SCOPUS ID: 2-s2.0-85061983162 10/09/2018 28 Citations

Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography. (Lapierre-Landry M, Huckenpahler AL, Link BA, Collery RF, Carroll J, Skala MC) Transl Vis Sci Technol 2018;7(5):4 PMID: 30197836 PMCID: PMC6126953 SCOPUS ID: 2-s2.0-85053899557 09/11/2018 32 Citations

SRCP1 Conveys Resistance to Polyglutamine Aggregation. (Santarriaga S, Haver HN, Kanack AJ, Fikejs AS, Sison SL, Egner JM, Bostrom JR, Seminary ER, Hill RB, Link BA, Ebert AD, Scaglione KM) Mol Cell 2018 Jul 19;71(2):216-228.e7 PMID: 30029002 PMCID: PMC6091221 SCOPUS ID: 2-s2.0-85049861465 07/22/2018 12 Citations

Repeatability and Reproducibility of In Vivo Cone Density Measurements in the Adult Zebrafish Retina. (Huckenpahler A, Wilk M, Link B, Carroll J, Collery R) Adv Exp Med Biol 2018;1074:151-156 PMID: 29721939 PMCID: PMC6363109 SCOPUS ID: 2-s2.0-85046645800 05/04/2018 5 Citations

Feedback between tissue packing and neurogenesis in the zebrafish neural tube. (Hiscock TW, Miesfeld JB, Mosaliganti KR, Link BA, Megason SG) Development 2018 May 04;145(9) PMID: 29678815 PMCID: PMC5992593 SCOPUS ID: 2-s2.0-85046850961 04/22/2018 14 Citations

PITX2 deficiency and associated human disease: insights from the zebrafish model. (Hendee KE, Sorokina EA, Muheisen SS, Reis LM, Tyler RC, Markovic V, Cuturilo G, Link BA, Semina EV) Hum Mol Genet 2018 May 15;27(10):1675-1695 PMID: 29506241 PMCID: PMC5932568 SCOPUS ID: 2-s2.0-85046996401 03/06/2018 45 Citations

Characterization of Coding/Noncoding Variants for SHROOM3 in Patients with CKD. (Prokop JW, Yeo NC, Ottmann C, Chhetri SB, Florus KL, Ross EJ, Sosonkina N, Link BA, Freedman BI, Coppola CJ, McDermott-Roe C, Leysen S, Milroy LG, Meijer FA, Geurts AM, Rauscher FJ 3rd, Ramaker R, Flister MJ, Jacob HJ, Mendenhall EM, Lazar J) J Am Soc Nephrol 2018 May;29(5):1525-1535 PMID: 29476007 PMCID: PMC5967772 SCOPUS ID: 2-s2.0-85046380339 02/25/2018 32 Citations

Cone myoid elongation involves unidirectional microtubule movement mediated by dynein-1. (Lewis TR, Zareba M, Link BA, Besharse JC) Mol Biol Cell 2018 Jan 15;29(2):180-190 PMID: 29142075 PMCID: PMC5909930 SCOPUS ID: 2-s2.0-85040967232 11/17/2017 9 Citations

Imaging the adult zebrafish cone mosaic using optical coherence tomography-CORRIGENDUM. (Huckenpahler AL, Wilk MA, Cooper RF, Moehring F, Link BA, Carroll J, Collery RF) Vis Neurosci 2017 Jan;34:E005 PMID: 28965523 PMCID: PMC8054337 SCOPUS ID: 2-s2.0-85057402023 10/03/2017

The Effect of Retinal Melanin on Optical Coherence Tomography Images. (Wilk MA, Huckenpahler AL, Collery RF, Link BA, Carroll J) Transl Vis Sci Technol 2017 Apr;6(2):8 PMID: 28392975 PMCID: PMC5381330 04/11/2017

Cos2/Kif7 and Osm-3/Kif17 regulate onset of outer segment development in zebrafish photoreceptors through distinct mechanisms. (Lewis TR, Kundinger SR, Pavlovich AL, Bostrom JR, Link BA, Besharse JC) Dev Biol 2017 May 15;425(2):176-190 PMID: 28341548 PMCID: PMC5558849 SCOPUS ID: 2-s2.0-85016498928 03/28/2017 21 Citations

Producing tissue specific stem cells for regeneration: how YAP/TAZ may prove useful. (Henle SJ, Link BA) Stem Cell Investig 2017;4:16 PMID: 28275646 PMCID: PMC5334554 03/10/2017

Imaging the adult zebrafish cone mosaic using optical coherence tomography. (Huckenpahler AL, Wilk MA, Cooper RF, Moehring F, Link BA, Carroll J, Collery RF) Vis Neurosci 2016 Jan;33:E011 PMID: 28177275 PMCID: PMC5659228 SCOPUS ID: 2-s2.0-85020503535 02/09/2017 11 Citations

Loss of Zebrafish Mfrp Causes Nanophthalmia, Hyperopia, and Accumulation of Subretinal Macrophages. (Collery RF, Volberding PJ, Bostrom JR, Link BA, Besharse JC) Invest Ophthalmol Vis Sci 2016 Dec 01;57(15):6805-6814 PMID: 28002843 PMCID: PMC5215506 SCOPUS ID: 2-s2.0-85007349845 12/22/2016 30 Citations

Lmx1b is required for the glutamatergic fates of a subset of spinal cord neurons. (Hilinski WC, Bostrom JR, England SJ, Juárez-Morales JL, de Jager S, Armant O, Legradi J, Strähle U, Link BA, Lewis KE) Neural Dev 2016 Aug 23;11(1):16 PMID: 27553035 PMCID: PMC4995821 SCOPUS ID: 2-s2.0-84988447879 08/25/2016 11 Citations

Zebrafish Models of Retinal Disease. (Link BA, Collery RF) Annu Rev Vis Sci 2015 Nov 24;1:125-153 PMID: 28532376 11/24/2015

Yap and Taz regulate retinal pigment epithelial cell fate. (Miesfeld JB, Gestri G, Clark BS, Flinn MA, Poole RJ, Bader JR, Besharse JC, Wilson SW, Link BA) Development 2015 Sep 01;142(17):3021-32 PMID: 26209646 PMCID: PMC4582179 SCOPUS ID: 2-s2.0-84940754780 07/26/2015 113 Citations

YAP is essential for tissue tension to ensure vertebrate 3D body shape. (Porazinski S, Wang H, Asaoka Y, Behrndt M, Miyamoto T, Morita H, Hata S, Sasaki T, Krens SFG, Osada Y, Asaka S, Momoi A, Linton S, Miesfeld JB, Link BA, Senga T, Shimizu N, Nagase H, Matsuura S, Bagby S, Kondoh H, Nishina H, Heisenberg CP, Furutani-Seiki M) Nature 2015 May 14;521(7551):217-221 PMID: 25778702 PMCID: PMC4720436 SCOPUS ID: 2-s2.0-84929315796 03/18/2015 185 Citations

Rapid, accurate, and non-invasive measurement of zebrafish axial length and other eye dimensions using SD-OCT allows longitudinal analysis of myopia and emmetropization. (Collery RF, Veth KN, Dubis AM, Carroll J, Link BA) PLoS One 2014;9(10):e110699 PMID: 25334040 PMCID: PMC4205002 SCOPUS ID: 2-s2.0-84908190382 10/22/2014 44 Citations

Loss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamics. (Paulus JD, Link BA) PLoS One 2014;9(10):e109922 PMID: 25329564 PMCID: PMC4199637 SCOPUS ID: 2-s2.0-84908045074 10/21/2014 20 Citations

Shroom3 contributes to the maintenance of the glomerular filtration barrier integrity. (Yeo NC, O'Meara CC, Bonomo JA, Veth KN, Tomar R, Flister MJ, Drummond IA, Bowden DW, Freedman BI, Lazar J, Link BA, Jacob HJ) Genome Res 2015 Jan;25(1):57-65 PMID: 25273069 PMCID: PMC4317173 SCOPUS ID: 2-s2.0-84920650331 10/03/2014 56 Citations

Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. (Tang Y, Gholamin S, Schubert S, Willardson MI, Lee A, Bandopadhayay P, Bergthold G, Masoud S, Nguyen B, Vue N, Balansay B, Yu F, Oh S, Woo P, Chen S, Ponnuswami A, Monje M, Atwood SX, Whitson RJ, Mitra S, Cheshier SH, Qi J, Beroukhim R, Tang JY, Wechsler-Reya R, Oro AE, Link BA, Bradner JE, Cho YJ) Nat Med 2014 Jul;20(7):732-40 PMID: 24973920 PMCID: PMC4108909 SCOPUS ID: 2-s2.0-84904036266 06/30/2014 251 Citations

Establishment of transgenic lines to monitor and manipulate Yap/Taz-Tead activity in zebrafish reveals both evolutionarily conserved and divergent functions of the Hippo pathway. (Miesfeld JB, Link BA) Mech Dev 2014 Aug;133:177-88 PMID: 24560909 PMCID: PMC4138299 SCOPUS ID: 2-s2.0-84908158843 02/25/2014 42 Citations

Mirror-symmetric microtubule assembly and cell interactions drive lumen formation in the zebrafish neural rod. (Buckley CE, Ren X, Ward LC, Girdler GC, Araya C, Green MJ, Clark BS, Link BA, Clarke JD) EMBO J 2013 Jan 09;32(1):30-44 PMID: 23202854 PMCID: PMC3545300 SCOPUS ID: 2-s2.0-84872861885 12/04/2012 53 Citations

Integrin α5/fibronectin1 and focal adhesion kinase are required for lens fiber morphogenesis in zebrafish. (Hayes JM, Hartsock A, Clark BS, Napier HR, Link BA, Gross JM) Mol Biol Cell 2012 Dec;23(24):4725-38 PMID: 23097490 PMCID: PMC3521681 SCOPUS ID: 2-s2.0-84871191358 10/26/2012 31 Citations

Loss of Llgl1 in retinal neuroepithelia reveals links between apical domain size, Notch activity and neurogenesis. (Clark BS, Cui S, Miesfeld JB, Klezovitch O, Vasioukhin V, Link BA) Development 2012 May;139(9):1599-610 PMID: 22492354 PMCID: PMC3317966 SCOPUS ID: 2-s2.0-84859297815 04/12/2012 60 Citations

Generation of Rab-based transgenic lines for in vivo studies of endosome biology in zebrafish. (Clark BS, Winter M, Cohen AR, Link BA) Dev Dyn 2011 Nov;240(11):2452-65 PMID: 21976318 PMCID: PMC3197968 SCOPUS ID: 2-s2.0-80054832731 10/07/2011 71 Citations

The ciliopathy gene cc2d2a controls zebrafish photoreceptor outer segment development through a role in Rab8-dependent vesicle trafficking. (Bachmann-Gagescu R, Phelps IG, Stearns G, Link BA, Brockerhoff SE, Moens CB, Doherty D) Hum Mol Genet 2011 Oct 15;20(20):4041-55 PMID: 21816947 PMCID: PMC3177654 SCOPUS ID: 2-s2.0-80053166268 08/06/2011 92 Citations

Cell biological regulation of division fate in vertebrate neuroepithelial cells. (Willardsen MI, Link BA) Dev Dyn 2011 Aug;240(8):1865-79 PMID: 21761474 PMCID: PMC3140019 SCOPUS ID: 2-s2.0-79960366363 07/16/2011 29 Citations

The visual system of zebrafish and its use to model human ocular diseases. (Gestri G, Link BA, Neuhauss SC) Dev Neurobiol 2012 Mar;72(3):302-27 PMID: 21595048 PMCID: PMC3202066 SCOPUS ID: 2-s2.0-84856959269 05/20/2011 128 Citations

Loss of Lrp2 in zebrafish disrupts pronephric tubular clearance but not forebrain development. (Kur E, Christa A, Veth KN, Gajera CR, Andrade-Navarro MA, Zhang J, Willer JR, Gregg RG, Abdelilah-Seyfried S, Bachmann S, Link BA, Hammes A, Willnow TE) Dev Dyn 2011 Jun;240(6):1567-77 PMID: 21455927 PMCID: PMC3278082 SCOPUS ID: 2-s2.0-79955720762 04/02/2011 36 Citations

Mutations in zebrafish lrp2 result in adult-onset ocular pathogenesis that models myopia and other risk factors for glaucoma. (Veth KN, Willer JR, Collery RF, Gray MP, Willer GB, Wagner DS, Mullins MC, Udvadia AJ, Smith RS, John SW, Gregg RG, Link BA) PLoS Genet 2011 Feb;7(2):e1001310 PMID: 21379331 PMCID: PMC3040661 SCOPUS ID: 2-s2.0-79952256057 03/08/2011 83 Citations

Dynamic smad-mediated BMP signaling revealed through transgenic zebrafish. (Collery RF, Link BA) Dev Dyn 2011 Mar;240(3):712-22 PMID: 21337469 PMCID: PMC3072245 SCOPUS ID: 2-s2.0-79951663595 02/22/2011 70 Citations

In vivo development of dendritic orientation in wild-type and mislocalized retinal ganglion cells. (Choi JH, Law MY, Chien CB, Link BA, Wong RO) Neural Dev 2010 Nov 02;5:29 PMID: 21044295 PMCID: PMC2988773 SCOPUS ID: 2-s2.0-77958617157 11/04/2010 22 Citations

Potential novel mechanism for Axenfeld-Rieger syndrome: deletion of a distant region containing regulatory elements of PITX2. (Volkmann BA, Zinkevich NS, Mustonen A, Schilter KF, Bosenko DV, Reis LM, Broeckel U, Link BA, Semina EV) Invest Ophthalmol Vis Sci 2011 Mar;52(3):1450-9 PMID: 20881290 PMCID: PMC3101680 SCOPUS ID: 2-s2.0-79955934874 10/01/2010 41 Citations

Erratu to Analysis of a zebrafish dync1h1 mutant reveals multiple functions for cytoplasmic dynein 1 during retinal photoreceptor development [Neural Development, (2010), 5, 12] (Insinna C, Baye LM, Amsterdam A, Besharse JC, Link BA) Neural Development 6 August 2010;5(1) SCOPUS ID: 2-s2.0-77955206608 08/06/2010 2 Citations

Analysis of a zebrafish dync1h1 mutant reveals multiple functions for cytoplasmic dynein 1 during retinal photoreceptor development. (Insinna C, Baye LM, Amsterdam A, Besharse JC, Link BA) Neural Dev 2010 Apr 22;5:12 PMID: 20412557 PMCID: PMC2880287 SCOPUS ID: 2-s2.0-77951076167 04/24/2010 47 Citations

Actomyosin is the main driver of interkinetic nuclear migration in the retina. (Norden C, Young S, Link BA, Harris WA) Cell 2009 Sep 18;138(6):1195-208 PMID: 19766571 PMCID: PMC2791877 SCOPUS ID: 2-s2.0-70149124068 09/22/2009 204 Citations

Lmx1b is essential for survival of periocular mesenchymal cells and influences Fgf-mediated retinal patterning in zebrafish. (McMahon C, Gestri G, Wilson SW, Link BA) Dev Biol 2009 Aug 15;332(2):287-98 PMID: 19500562 PMCID: PMC2716413 SCOPUS ID: 2-s2.0-67650960647 06/09/2009 51 Citations

FoxC1 is essential for vascular basement membrane integrity and hyaloid vessel morphogenesis. (Skarie JM, Link BA) Invest Ophthalmol Vis Sci 2009 Nov;50(11):5026-34 PMID: 19458328 PMCID: PMC3651675 SCOPUS ID: 2-s2.0-78649436084 05/22/2009 54 Citations

Apical membrane maturation and cellular rosette formation during morphogenesis of the zebrafish lateral line. (Hava D, Forster U, Matsuda M, Cui S, Link BA, Eichhorst J, Wiesner B, Chitnis A, Abdelilah-Seyfried S) J Cell Sci 2009 Mar 01;122(Pt 5):687-95 PMID: 19208766 PMCID: PMC3188803 SCOPUS ID: 2-s2.0-65449130159 02/12/2009 42 Citations

Analysis of IFT kinesins in developing zebrafish cone photoreceptor sensory cilia. (Insinna C, Luby-Phelps K, Link BA, Besharse JC) Methods Cell Biol 2009;93:219-34 PMID: 20409820 SCOPUS ID: 2-s2.0-77954674137 01/01/2009 8 Citations

Retinal development: An overview (Napier HRL, Link BA) Encyclopedia of Neuroscience 2009:195-202 SCOPUS ID: 2-s2.0-84882859060 01/01/2009

The aqueous humor outflow pathway of zebrafish. (Gray MP, Smith RS, Soules KA, John SW, Link BA) Invest Ophthalmol Vis Sci 2009 Apr;50(4):1515-21 PMID: 19060283 PMCID: PMC3642099 SCOPUS ID: 2-s2.0-64049089838 12/09/2008 29 Citations

Zebrafish as a model for development (Link BA, Megason SG) Source Book of Models for Biomedical Research 2008:103-112 SCOPUS ID: 2-s2.0-78549287672 12/01/2008 14 Citations

Regulation of neurogenesis by interkinetic nuclear migration through an apical-basal notch gradient. (Del Bene F, Wehman AM, Link BA, Baier H) Cell 2008 Sep 19;134(6):1055-65 PMID: 18805097 PMCID: PMC2628487 SCOPUS ID: 2-s2.0-51749083057 09/23/2008 258 Citations

Factorial microarray analysis of zebrafish retinal development. (Leung YF, Ma P, Link BA, Dowling JE) Proc Natl Acad Sci U S A 2008 Sep 02;105(35):12909-14 PMID: 18753621 PMCID: PMC2529063 SCOPUS ID: 2-s2.0-51349127378 08/30/2008 37 Citations

The primary open-angle glaucoma gene WDR36 functions in ribosomal RNA processing and interacts with the p53 stress-response pathway. (Skarie JM, Link BA) Hum Mol Genet 2008 Aug 15;17(16):2474-85 PMID: 18469340 PMCID: PMC2722886 SCOPUS ID: 2-s2.0-48249142323 05/13/2008 90 Citations

FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A. (Berry FB, Skarie JM, Mirzayans F, Fortin Y, Hudson TJ, Raymond V, Link BA, Walter MA) Hum Mol Genet 2008 Feb 15;17(4):490-505 PMID: 17993506 SCOPUS ID: 2-s2.0-38849094466 11/13/2007 85 Citations

Interkinetic nuclear migration and the selection of neurogenic cell divisions during vertebrate retinogenesis. (Baye LM, Link BA) J Neurosci 2007 Sep 19;27(38):10143-52 PMID: 17881520 PMCID: PMC6672676 SCOPUS ID: 2-s2.0-34548862024 09/21/2007 146 Citations

Nuclear migration during retinal development. (Baye LM, Link BA) Brain Res 2008 Feb 04;1192:29-36 PMID: 17560964 PMCID: PMC2674389 SCOPUS ID: 2-s2.0-38849104859 06/15/2007 105 Citations

The disarrayed mutation results in cell cycle and neurogenesis defects during retinal development in zebrafish. (Baye LM, Link BA) BMC Dev Biol 2007 Apr 05;7:28 PMID: 17411431 PMCID: PMC1854893 SCOPUS ID: 2-s2.0-34247398665 04/07/2007 19 Citations

Analysis of aPKClambda and aPKCzeta reveals multiple and redundant functions during vertebrate retinogenesis. (Cui S, Otten C, Rohr S, Abdelilah-Seyfried S, Link BA) Mol Cell Neurosci 2007 Mar;34(3):431-44 PMID: 17223574 PMCID: PMC2700298 SCOPUS ID: 2-s2.0-33847311778 01/16/2007 40 Citations

FGF19 is a target for FOXC1 regulation in ciliary body-derived cells. (Tamimi Y, Skarie JM, Footz T, Berry FB, Link BA, Walter MA) Hum Mol Genet 2006 Nov 01;15(21):3229-40 PMID: 17000708 SCOPUS ID: 2-s2.0-33750216514 09/27/2006 39 Citations

Mutations in laminin alpha 1 result in complex, lens-independent ocular phenotypes in zebrafish. (Semina EV, Bosenko DV, Zinkevich NC, Soules KA, Hyde DR, Vihtelic TS, Willer GB, Gregg RG, Link BA) Dev Biol 2006 Nov 01;299(1):63-77 PMID: 16973147 SCOPUS ID: 2-s2.0-33749507648 09/16/2006 59 Citations

laminin alpha 1 gene is essential for normal lens development in zebrafish. (Zinkevich NS, Bosenko DV, Link BA, Semina EV) BMC Dev Biol 2006 Mar 07;6:13 PMID: 16522196 PMCID: PMC1450269 SCOPUS ID: 2-s2.0-33646367199 03/09/2006 40 Citations

Cell migration (Godinho L, Link B) Retinal Development 1 January 2006:59-74 SCOPUS ID: 2-s2.0-38849193234 01/01/2006 5 Citations

Morphogenesis of the anterior segment in the zebrafish eye. (Soules KA, Link BA) BMC Dev Biol 2005 Jun 28;5:12 PMID: 15985175 PMCID: PMC1183199 SCOPUS ID: 2-s2.0-23944494639 06/30/2005 129 Citations

Analysis of the Zebrafish perplexed mutation reveals tissue-specific roles for de novo pyrimidine synthesis during development. (Willer GB, Lee VM, Gregg RG, Link BA) Genetics 2005 Aug;170(4):1827-37 PMID: 15937129 PMCID: PMC1449754 SCOPUS ID: 2-s2.0-25444508919 06/07/2005 39 Citations

Staggered cell-intrinsic timing of ath5 expression underlies the wave of ganglion cell neurogenesis in the zebrafish retina. (Kay JN, Link BA, Baier H) Development 2005 Jun;132(11):2573-85 PMID: 15857917 SCOPUS ID: 2-s2.0-21244503529 04/29/2005 101 Citations

dazed gene is necessary for late cell type development and retinal cell maintenance in the zebrafish retina. (Perkins BD, Nicholas CS, Baye LM, Link BA, Dowling JE) Dev Dyn 2005 Jun;233(2):680-94 PMID: 15844196 SCOPUS ID: 2-s2.0-19544370700 04/22/2005 17 Citations

Intraocular pressure in zebrafish: comparison of inbred strains and identification of a reduced melanin mutant with raised IOP. (Link BA, Gray MP, Smith RS, John SW) Invest Ophthalmol Vis Sci 2004 Dec;45(12):4415-22 PMID: 15557450 SCOPUS ID: 2-s2.0-9444223950 11/24/2004 52 Citations

Using zebrafish to study the complex genetics of glaucoma. (McMahon C, Semina EV, Link BA) Comp Biochem Physiol C Toxicol Pharmacol 2004 Jul;138(3):343-50 PMID: 15533792 SCOPUS ID: 2-s2.0-7944231499 11/10/2004 52 Citations

Positional cloning of the young mutation identifies an essential role for the Brahma chromatin remodeling complex in mediating retinal cell differentiation. (Gregg RG, Willer GB, Fadool JM, Dowling JE, Link BA) Proc Natl Acad Sci U S A 2003 May 27;100(11):6535-40 PMID: 12748389 PMCID: PMC164481 SCOPUS ID: 2-s2.0-0038312996 05/16/2003 84 Citations

Suppression of lens growth by alphaA-crystallin promoter-driven expression of diphtheria toxin results in disruption of retinal cell organization in zebrafish. (Kurita R, Sagara H, Aoki Y, Link BA, Arai K, Watanabe S) Dev Biol 2003 Mar 01;255(1):113-27 PMID: 12618137 SCOPUS ID: 2-s2.0-0037334528 03/06/2003 97 Citations

Evidence for directed mitotic cleavage plane reorientations during retinal development within the zebrafish. (Link BA) Biol Bull 2001 Oct;201(2):254-5 PMID: 11687408 SCOPUS ID: 2-s2.0-0034764170 11/01/2001 2 Citations

The perplexed and confused mutations affect distinct stages during the transition from proliferating to post-mitotic cells within the zebrafish retina. (Link BA, Kainz PM, Ryou T, Dowling JE) Dev Biol 2001 Aug 15;236(2):436-53 PMID: 11476583 SCOPUS ID: 2-s2.0-0035881588 07/31/2001 25 Citations

Genetic analysis of initial and ongoing retinogenesis in the zebrafish: comparing the central neuroepithelium and marginal zone. (Link BA, Darland T) Prog Brain Res 2001;131:565-77 PMID: 11420971 SCOPUS ID: 2-s2.0-0035783955 06/26/2001 13 Citations

Small molecule developmental screens reveal the logic and timing of vertebrate development. (Peterson RT, Link BA, Dowling JE, Schreiber SL) Proc Natl Acad Sci U S A 2000 Nov 21;97(24):12965-9 PMID: 11087852 PMCID: PMC27161 SCOPUS ID: 2-s2.0-0034700166 11/23/2000 456 Citations

The zebrafish young mutation acts non-cell-autonomously to uncouple differentiation from specification for all retinal cells. (Link BA, Fadool JM, Malicki J, Dowling JE) Development 2000 May;127(10):2177-88 PMID: 10769241 SCOPUS ID: 2-s2.0-0034082512 04/19/2000 98 Citations

Development of the avian iris and ciliary body: mechanisms of cellular differentiation during the smooth-to-striated muscle transition. (Link BA, Nishi R) Dev Biol 1998 Nov 01;203(1):163-76 PMID: 9806781 SCOPUS ID: 2-s2.0-0032211630 11/10/1998 23 Citations

Development of the avian iris and ciliary body: the role of activin and follistatin in coordination of the smooth-to-striated muscle transition. (Link BA, Nishi R) Dev Biol 1998 Jul 15;199(2):226-34 PMID: 9698442 SCOPUS ID: 2-s2.0-0032528456 08/12/1998 17 Citations

Opposing effects of activin A and follistatin on developing skeletal muscle cells. (Link BA, Nishi R) Exp Cell Res 1997 Jun 15;233(2):350-62 PMID: 9194497 SCOPUS ID: 2-s2.0-0031570780 06/15/1997 52 Citations

Expression of activin A and follistatin in the developing iris and choroid layer (Darland DC, Link BA, Nishi R) Investigative Ophthalmology and Visual Science 15 February 1996;37(3) SCOPUS ID: 2-s2.0-2542419424 02/15/1996 1 Citation

Activin A and follistatin expression in developing targets of ciliary ganglion neurons suggests a role in regulating neurotransmitter phenotype. (Darland DC, Link BA, Nishi R) Neuron 1995 Oct;15(4):857-66 PMID: 7576634 SCOPUS ID: 2-s2.0-0028805976 10/01/1995 46 Citations

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Brian A. Link PhD

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Publications (97)