Systemic arterial blood pH servocontrol of mechanical ventilation. Anesthesiology 1978 Sep;49(3):201-4
Date
09/01/1978Pubmed ID
28683DOI
10.1097/00000542-197809000-00010Scopus ID
2-s2.0-0018120975 (requires institutional sign-in at Scopus site) 21 CitationsAbstract
Servocontrol of mechanical ventilation using systemic arterial blood pH, measured by a dual-function pH/PCO2 intra-arterial sensor, as the controlled variable uas carried out in 30 dogs anesthetized with pentobarbital, 30 mg/kg. The control loop consisted of the animal, an intra-arterial dual-function pH/PCO2 sensor and sensor amplifier, a controller, and a Siemans-Elema 900 servoventilator. The system responded appropriately to changes in set-point pH from 7.30 to 7.50, as well as to infusions of lactic acid, which, with the control loop open, decreased systemic arterial blood pH 0.1 TO 0.2 PH units. Long-term (16 hr) ventilation of one dog with the systemic arterial blood pH servocontrol ventilator was shown to be feasible.
Author List
Coon RL, Zuperku EJ, Kampine JPAuthor
Edward J. Zuperku PhD, MS Emeritus Professor in the Anesthesiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Acid-Base EquilibriumAnimals
Arteries
Blood
Dogs
Electrodes
Feedback
Hydrogen-Ion Concentration
Ventilators, Mechanical
