Faculty Collaboration Database

Allergic reactions to E. coli L-asparaginase do not affect outcome in childhood B-precursor acute lymphoblastic leukemia: a Children's Oncology Group Study. J Pediatr Hematol Oncol 2007 Sep;29(9):627-32

Date

09/07/2007

Pubmed ID

17805038

DOI

10.1097/MPH.0b013e3181483df1

Scopus ID

2-s2.0-34548387897 (requires institutional sign-in at Scopus site)   33 Citations

Abstract

We describe the outcome of children with B-precursor acute lymphoblastic leukemia registered on Pediatric Oncology Group 8602 who switched to Erwinia asparaginase (ASP) due to an allergy to the Escherichia coli product. Between February 1986 and January 1991, children in complete remission after induction that included intramuscular E. coli ASP (6000 U/m2x6) were randomized for consolidation. One regimen included intensive weekly intramuscular E. coli ASP (25,000 U/m2/wkx24). In case of an allergic reaction to E. coli ASP, Erwinia ASP was substituted at the same dose and schedule. Of the 540 eligible patients, 408 switched to Erwinia ASP due to an allergic reaction. Allergic reactions were significantly associated with younger age, white race, and standard-risk acute lymphoblastic leukemia. Multivariate Cox analysis adjusting for these factors demonstrated no correlation between the switch per se or the timing of the switch and event-free survival.

Author List

Wacker P, Land VJ, Camitta BM, Kurtzberg J, Pullen J, Harris MB, Shuster JJ, Children's Oncology Study Group

MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Asparaginase
Bacterial Proteins
Burkitt Lymphoma
Child
Child, Preschool
Erwinia
Escherichia coli
Humans
Hypersensitivity
Infant
Male
Treatment Outcome