Faculty Collaboration Database

Signal transducer and activator of transcription 5A/B in prostate and breast cancers. Endocr Relat Cancer 2008 Jun;15(2):367-90

Date

05/30/2008

Pubmed ID

18508994

Pubmed Central ID

PMC6036917

DOI

10.1677/ERC-08-0013

Scopus ID

2-s2.0-45849116295 (requires institutional sign-in at Scopus site)   100 Citations

Abstract

Protein kinase signaling pathways, such as Janus kinase 2-Signal transducer and activator of transcription 5A/B (JAK2-STAT5A/B), are of significant interest in the search for new therapeutic strategies in both breast and prostate cancers. In prostate cancer, the components of the JAK2-STAT5A/B signaling pathway provide molecular targets for small-molecule inhibition of survival and growth signals of the cells. At the same time, new evidence suggests that the STAT5A/B signaling pathway is involved in the transition of organ-confined prostate cancer to hormone-refractory disease. This implies that the active JAK2-STAT5A/B signaling pathway potentially provides the means for pharmacological intervention of clinical prostate cancer progression. In addition, active STAT5A/B may serve as a prognostic marker for identification of those primary prostate cancers that are likely to progress to aggressive disease. In breast cancer, the role of STAT5A/B is more complex. STAT5A/B may have a dual role in the regulation of malignant mammary epithelium. Data accumulated from mouse models of breast cancer suggest that in early stages of breast cancer STAT5A/B may promote malignant transformation and enhance growth of the tumor. This is in contrast to established breast cancer, where STAT5A/B may mediate the critical cues for maintaining the differentiation of mammary epithelium. In addition, present data suggest that activation of STAT5A/B in breast cancer predicts favorable clinical outcome. The dual nature of STAT5A/B action in breast cancer makes the therapeutic use of STAT5 A/B more complex.

Author List

Tan SH, Nevalainen MT

MESH terms used to index this publication - Major topics in bold

Breast Neoplasms
Female
Humans
Male
Prostatic Neoplasms
STAT5 Transcription Factor
Signal Transduction
Tumor Suppressor Proteins