Prolactin activates protein kinase C and stimulates growth-related gene expression in rat liver. Mol Cell Endocrinol 1991 Aug;79(1-3):29-35
Date
08/01/1991Pubmed ID
1718797DOI
10.1016/0303-7207(91)90092-7Scopus ID
2-s2.0-0025826725 (requires institutional sign-in at Scopus site) 45 CitationsAbstract
We have examined the effect of prolactin (PRL) on growth-related gene expression, protein kinase C (PKC) activity and diacylglycerol (DAG) mass in rat liver. Hepatic levels of messenger (m)RNA for c-myc, ornithine decarboxylase (ODC) and beta-actin increased in a dose-dependent manner within 1 h after PRL administration. Prolactin also caused a transient elevation of liver DAG levels and particulate-associated PKC activity. The PRL-provoked increases in DAG mass and particulate PKC activity were coincident and maximal at 20 min and began declining toward control levels by 30 min. These results suggest a temporal relationship between PRL-stimulated DAG accumulation and PKC activation. Furthermore, the subsequent rapid induction of growth-related gene expression provides new information on the role of PRL as a hepatic mitogen.
Author List
Crowe PD, Buckley AR, Zorn NE, Rui HMESH terms used to index this publication - Major topics in bold
ActinsAging
Animals
DNA Probes
Diglycerides
Enzyme Activation
Gene Expression
Genes, myc
Histones
Kinetics
Liver
Male
Ornithine Decarboxylase
Prolactin
Protein Kinase C
RNA
RNA, Messenger
Rats
Rats, Inbred Strains
