Faculty Collaboration Database

Case report: hypercalcemia with inappropriate 1,25-dihydroxyvitamin D in Wegener's granulomatosis. Am J Med Sci 1994 Aug;308(2):115-8

Date

08/01/1994

Pubmed ID

8042652

DOI

10.1097/00000441-199408000-00011

Scopus ID

2-s2.0-0028050172 (requires institutional sign-in at Scopus site)   27 Citations

Abstract

Hypercalcemia associated with the extrarenal production of 1,25-dihydroxyvitamin D (1,25(OH)2D) has been reported in several disorders, most notably granulomatous diseases such as sarcoidosis. The authors describe a woman with hypercalcemia, renal insufficiency, microscopic hematuria, and anemia. The circulating 1,25(OH)2D level was higher than appropriate for the ambient conditions (renal insufficiency, suppressed intact parathyroid hormone, and hypercalcemia). A kidney biopsy was consistent with Wegener's granulomatosis, and treatment with prednisone and cyclophosphamide was associated with normalization of serum calcium levels, improved renal function, a marked decrease in serum 1,25(OH)2D levels, and increased serum intact parathyroid hormone levels. These findings are consistent with the unregulated production of 1,25(OH)2D by inflammatory cells associated with Wegener's granulomatosis.

Author List

Shaker JL, Redlin KC, Warren GV, Findling JW

Authors

James W. Findling MD Professor in the Medicine department at Medical College of Wisconsin
Joseph L. Shaker MD Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Aged
Anemia
Calcitriol
Calcium
Creatinine
Cyclophosphamide
Female
Granulomatosis with Polyangiitis
Hematuria
Humans
Hypercalcemia
Parathyroid Hormone
Phosphorus
Prednisone
Renal Insufficiency
Serum Albumin