Mechanical control of tissue and organ development. Development 2010 May;137(9):1407-20
Date
04/15/2010Pubmed ID
20388652Pubmed Central ID
PMC2853843DOI
10.1242/dev.024166Scopus ID
2-s2.0-77951228475 (requires institutional sign-in at Scopus site) 734 CitationsAbstract
Many genes and molecules that drive tissue patterning during organogenesis and tissue regeneration have been discovered. Yet, we still lack a full understanding of how these chemical cues induce the formation of living tissues with their unique shapes and material properties. Here, we review work based on the convergence of physics, engineering and biology that suggests that mechanical forces generated by living cells are as crucial as genes and chemical signals for the control of embryological development, morphogenesis and tissue patterning.
Author List
Mammoto T, Ingber DEAuthor
Tadanori Mammoto PhD Associate Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBiomechanical Phenomena
Embryonic Development
Humans
Models, Biological
Morphogenesis
Organogenesis
Signal Transduction
