Faculty Collaboration Database

Intravenous anesthetic, propofol inhibits invasion of cancer cells. Cancer Lett 2002 Oct 28;184(2):165-70

Date

07/20/2002

Pubmed ID

12127688

DOI

10.1016/s0304-3835(02)00210-0

Scopus ID

2-s2.0-0037190808 (requires institutional sign-in at Scopus site)   153 Citations

Abstract

Intravenous anesthetic, propofol (2,6-diisopropylphenol), is extensively used for general anesthesia without knowing the effects on cancer. We found here that clinically relevant concentrations of propofol (1-5 microg/ml) decreased the invasion ability of human cancer cells (HeLa, HT1080, HOS and RPMI-7951). In the HeLa cells treated with propofol, formation of actin stress fibers as well as focal adhesion were inhibited, and propofol had little effect on the invasion ability of the HeLa cells with active Rho A (Val(14)-Rho A). In addition, continuous infusion of propofol inhibited pulmonary metastasis of murine osteosarcoma (LM 8) cells in mice. These results suggest that propofol inhibits the invasion ability of cancer cells by modulating Rho A and this agent might be an ideal anesthetic for cancer surgery.

Author List

Mammoto T, Mukai M, Mammoto A, Yamanaka Y, Hayashi Y, Mashimo T, Kishi Y, Nakamura H

Authors

Akiko Mammoto MD, PhD Associate Professor in the Pediatrics department at Medical College of Wisconsin
Tadanori Mammoto MD, PhD Associate Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Actins
Anesthetics, Intravenous
Animals
Bone Neoplasms
Cell Adhesion
HeLa Cells
Humans
Lung Neoplasms
Mice
Neoplasm Invasiveness
Osteosarcoma
Propofol
Tumor Cells, Cultured