Selective immunoglobulin M (IgM) deficiency in two immunodeficient adults with recurrent staphylococcal pyoderma. Am J Med 1976 Apr;60(4):486-94
Date
04/01/1976Pubmed ID
1274982DOI
10.1016/0002-9343(76)90714-2Scopus ID
2-s2.0-0017232260 (requires institutional sign-in at Scopus site) 27 CitationsAbstract
Two adult men with recurrent pyoderma due to Staphylococcus aureus and a selective deficiency of immunoglobulin M (IgM) antibody synthesis are described. An analysis of each patient's polymorphonuclear leukocyte chemotaxis, phagocytosis and killing of Staph. aureus, serum opsonizaiton of Staph. aureus, and serum and lymphocyte-mediated responses to antigenic stimulation was performed. Family studies revealed a possible autosomal dominant inheritance pattern with heterogenetic expression of various dysgammaglobulinemic states in each patient's first degree relatives. In vivo studies of delayed hypersensitivity and in vitro studies of polymorphonuclear leukocyte and lymphocyte function were normal. A defect in IgM, but not in IgG (immunoglobulin G), antibody synthesis to a number of antigens, and a mild decrease in serum opsonic activity to Staph. aureus correctable by heat inactivated normal human serum were found in each patient. In these patients, the recurrent staphulococcal pyoderma prompted an investigation of host defense mechanisms and revealed low to absent IgM levels and a defect in IgM antibody synthesis.
Author List
Yocum MW, Strong DM, Chusid MJ, Lakin JDMESH terms used to index this publication - Major topics in bold
AdultAntibodies, Bacterial
Complement System Proteins
Dysgammaglobulinemia
Humans
Immunity, Cellular
Immunoglobulin M
Immunoglobulins
Immunologic Deficiency Syndromes
Leukocytes
Lymphocytes
Male
Pyoderma
Recurrence
Staphylococcal Infections
Staphylococcus aureus
