Medical College of Wisconsin
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MyD88-dependent, superoxide-initiated inflammation is necessary for flow-mediated inward remodeling of conduit arteries. J Exp Med 2008 Dec 22;205(13):3159-71

Date

12/10/2008

Pubmed ID

19064699

Pubmed Central ID

PMC2605224

DOI

10.1084/jem.20081298

Scopus ID

2-s2.0-59649088315 (requires institutional sign-in at Scopus site)   58 Citations

Abstract

Vascular remodeling normalizes abnormal hemodynamic stresses through structural changes affecting vessel size and wall thickness. We investigated the role of inflammation in flow-mediated vascular remodeling using a murine model of partial outflow reduction without flow cessation or neointima formation. Common carotid arteries decreased in size after ipsilateral external carotid artery ligation in wild-type mice, but not in myeloid differentiation protein-88 (MyD88)-deficient mice. Inward remodeling was associated with MyD88-dependent and superoxide-initiated cytokine and chemokine production, as well as transient adventitial macrophage accumulation and activation. Macrophage depletion prevented flow-mediated inward vascular remodeling. Expression of MyD88 by intrinsic vascular cells was necessary for cytokine and chemokine production and changes in vessel size, whereas MyD88 expression by bone marrow-derived cells was obligatory for changes in vessel size. We conclude that there are at least two distinct roles for MyD88 in flow-mediated inward remodeling of conduit arteries. Our findings suggest that inflammation is necessary for vascular adaptation to changes in hemodynamic forces.

Author List

Tang PC, Qin L, Zielonka J, Zhou J, Matte-Martone C, Bergaya S, van Rooijen N, Shlomchik WD, Min W, Sessa WC, Pober JS, Tellides G

Author

Jacek M. Zielonka PhD Assistant Professor in the Biophysics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Carotid Artery Diseases
Carotid Artery, Common
Carotid Stenosis
Chemokines
Cytokines
Hemodynamics
Inflammation
Macrophages
Mice
Mice, Inbred C57BL
Mice, Knockout
Myeloid Differentiation Factor 88
Regional Blood Flow
Superoxides