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Jacek M. Zielonka PhD

Jacek M. Zielonka PhD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Biophysics
Program: Research

Member of the Cancer Center
Member of the Cardiovascular Center
Member of the Center for Disease Prevention Research (CDPR)

View Curriculum Vitae

Research Experience

  • Antioxidants
  • Boronic Acids
  • Cell Line, Tumor
  • Cell Proliferation
  • Cyclic N-Oxides
  • Cytochromes c
  • Energy Metabolism
  • Enzyme Inhibitors
  • Ethidium
  • Fluorescent Dyes
  • Free Radical Scavengers
  • Free Radicals
  • Glutathione
  • Glycolysis
  • HL-60 Cells
  • High-Throughput Screening Assays
  • Hydrogen Peroxide
  • Hypochlorous Acid
  • Kinetics
  • Mitochondria
  • Molecular Probes
  • NADPH Oxidase 2
  • NADPH Oxidases
  • Nitric Oxide
  • Nitrogen Oxides
  • Oxidants
  • Oxidation-Reduction
  • Oxidative Stress
  • Oxygen Consumption
  • Paraquat
  • Peroxidase
  • Peroxynitrous Acid
  • Phenanthridines
  • Pyridines
  • Reactive Nitrogen Species
  • Reactive Oxygen Species
  • Superoxides
  • Xanthine Oxidase

    • Methodologies and Techniques

  • Blotting, Western
  • Chromatography, High Pressure Liquid
  • Electron Spin Resonance Spectroscopy
  • Fluorescence
  • Fluorometry
  • High-Throughput Screening Assays
  • Luminescence
  • Luminescent Measurements
  • Mass Spectrometry
  • Pulse Radiolysis
  • Spectrophotometry
  • Spectrophotometry, Ultraviolet
  • Spin Trapping

    • Publications (132)

  • Synthesis and characterization of the reactivity of new far-red fluorescent dyes and a boronate probe containing a tricyanopyrroline skeleton (Szala M, Grzelakowska A, Michalski R, Dębowska K, Modrzejewska J, Adamczyk M, Siarkiewicz P, Sikora A, Zielonka J, Podsiadły R) Dyes and Pigments March 2024;222 SCOPUS ID: 2-s2.0-85181163298 03/01/2024    
  • Regulation of immunomodulatory networks by Nrf2-activation in immune cells: Redox control and therapeutic potential in inflammatory diseases. (Pant T, Uche N, Juric M, Zielonka J, Bai X) Redox Biol 2024 Apr;70:103077 PMID: 38359749 PMCID: PMC10877431 SCOPUS ID: 2-s2.0-85185554817 02/16/2024       1 Citation
  • Health position paper and redox perspectives - Disease burden by transportation noise. (Sørensen M, Pershagen G, Thacher JD, Lanki T, Wicki B, Röösli M, Vienneau D, Cantuaria ML, Schmidt JH, Aasvang GM, Al-Kindi S, Osborne MT, Wenzel P, Sastre J, Fleming I, Schulz R, Hahad O, Kuntic M, Zielonka J, Sies H, Grune T, Frenis K, Münzel T, Daiber A) Redox Biol 2024 Feb;69:102995 PMID: 38142584 PMCID: PMC10788624 SCOPUS ID: 2-s2.0-85180606610 12/25/2023       5 Citations
  • Evaluation of a novel pyridinium cation-linked styryl-based boronate probe for the detection of selected inflammation-related oxidants. (Siarkiewicz P, Luzak B, Michalski R, Artelska A, Szala M, Przygodzki T, Sikora A, Zielonka J, Grzelakowska A, Podsiadły R) Free Radic Biol Med 2024 Feb 20;212:255-270 PMID: 38122872 SCOPUS ID: 2-s2.0-85181830257 12/21/2023    
  • Novel NADPH Oxidase-2 Inhibitors as Potential Anti-Inflammatory and Neuroprotective Agents. (Juric M, Rawat V, Amaradhi R, Zielonka J, Ganesh T) Antioxidants (Basel) 2023 Aug 23;12(9) PMID: 37759963 PMCID: PMC10525516 SCOPUS ID: 2-s2.0-85172273336 09/28/2023       2 Citations
  • Novel NADPH Oxidase-2 Inhibitors as Potential Anti-Inflammatory and Neuroprotective Agents (Juric M, Rawat V, Amaradhi R, Zielonka J, Ganesh T) Antioxidants September 2023;12(9) SCOPUS ID: 2-s2.0-85172273336 09/01/2023       2 Citations
  • Carvedilol Phenocopies PGC-1α Overexpression to Alleviate Oxidative Stress, Mitochondrial Dysfunction and Prevent Doxorubicin-Induced Toxicity in Human iPSC-Derived Cardiomyocytes. (Uche N, Dai Q, Lai S, Kolander K, Thao M, Schibly E, Sendaydiego X, Zielonka J, Benjamin IJ) Antioxidants (Basel) 2023 Aug 09;12(8) PMID: 37627583 PMCID: PMC10451268 SCOPUS ID: 2-s2.0-85169136890 08/26/2023    
  • Boronate-Based Oxidant-Responsive Derivatives of Acetaminophen as Proinhibitors of Myeloperoxidase. (Pierzchała K, Pięta J, Pięta M, Rola M, Zielonka J, Sikora A, Marcinek A, Michalski R) Chem Res Toxicol 2023 Aug 21;36(8):1398-1408 PMID: 37534491 PMCID: PMC10445283 SCOPUS ID: 2-s2.0-85168427662 08/03/2023       1 Citation
  • Nitric oxide synthase and reduced arterial tone contribute to arteriovenous malformation. (Huang L, Cheng F, Zhang X, Zielonka J, Nystoriak MA, Xiang W, Raygor K, Wang S, Lakshmanan A, Jiang W, Yuan S, Hou KS, Zhang J, Wang X, Syed AU, Juric M, Takahashi T, Navedo MF, Wang RA) Sci Adv 2023 May 26;9(21):eade7280 PMID: 37235659 PMCID: PMC10219588 SCOPUS ID: 2-s2.0-85160378118 05/26/2023       2 Citations
  • Methods to Measure Reactive Oxygen Species Production by NADPH Oxidases (Zielonka J, Juric M) NADPH Oxidases Revisited: From Function to Structure 1 January 2023:323-341 SCOPUS ID: 2-s2.0-85171013888 01/01/2023       1 Citation
  • High-Dose IV Hydroxocobalamin (Vitamin B12) in Septic Shock: A Double-Blind, Allocation-Concealed, Placebo-Controlled Single-Center Pilot Randomized Controlled Trial (The Intravenous Hydroxocobalamin in Septic Shock Trial). (Patel JJ, Willoughby R, Peterson J, Carver T, Zelten J, Markiewicz A, Spiegelhoff K, Hipp LA, Canales B, Szabo A, Heyland DK, Stoppe C, Zielonka J, Freed JK) Chest 2023 Feb;163(2):303-312 PMID: 36174744 SCOPUS ID: 2-s2.0-85146132356 09/30/2022       12 Citations
  • The Chemistry of HNO: Mechanisms and Reaction Kinetics. (Michalski R, Smulik-Izydorczyk R, Pięta J, Rola M, Artelska A, Pierzchała K, Zielonka J, Kalyanaraman B, Sikora AB) Front Chem 2022;10:930657 PMID: 35864868 PMCID: PMC9294461 SCOPUS ID: 2-s2.0-85134235413 07/23/2022       3 Citations
  • Measurement of Tetrahydrobiopterin in Animal Tissue Samples by HPLC with Electrochemical Detection-Protocol Optimization and Pitfalls. (Vujacic-Mirski K, Oelze M, Kuntic I, Kuntic M, Kalinovic S, Li H, Zielonka J, Münzel T, Daiber A) Antioxidants (Basel) 2022 Jun 16;11(6) PMID: 35740082 PMCID: PMC9228106 SCOPUS ID: 2-s2.0-85132015382 06/25/2022       3 Citations
  • Fluorescein clearance kinetics in blood and bile indicates hepatic ischemia-reperfusion injury in rats. (Kim J, Yang Y, Hong SK, Zielonka J, Dash RK, Audi SH, Kumar SN, Joshi A, Zimmerman MA, Hong JC) Am J Physiol Gastrointest Liver Physiol 2022 Aug 01;323(2):G126-G133 PMID: 35700191 SCOPUS ID: 2-s2.0-85134761396 06/15/2022       1 Citation
  • Fluorescent probes for monitoring myeloperoxidase-derived hypochlorous acid: a comparative study. (Pierzchała K, Pięta M, Rola M, Świerczyńska M, Artelska A, Dębowska K, Podsiadły R, Pięta J, Zielonka J, Sikora A, Marcinek A, Michalski R) Sci Rep 2022 Jun 03;12(1):9314 PMID: 35660769 PMCID: PMC9166712 SCOPUS ID: 2-s2.0-85131624486 06/07/2022       8 Citations
  • Measurement of Tetrahydrobiopterin in Animal Tissue Samples by HPLC with Electrochemical Detection—Protocol Optimization and Pitfalls (Vujacic-Mirski K, Oelze M, Kuntic I, Kuntic M, Kalinovic S, Li H, Zielonka J, Münzel T, Daiber A) Antioxidants June 2022;11(6) SCOPUS ID: 2-s2.0-85132015382 06/01/2022       3 Citations
  • Water-soluble cationic boronate probe based on coumarin imidazolium scaffold: Synthesis, characterization, and application to cellular peroxynitrite detection. (Grzelakowska A, Modrzejewska J, Kolińska J, Szala M, Zielonka M, Dębowska K, Zakłos-Szyda M, Sikora A, Zielonka J, Podsiadły R) Free Radic Biol Med 2022 Feb 01;179:34-46 PMID: 34923103 SCOPUS ID: 2-s2.0-85121730594 12/20/2021       17 Citations
  • Novel Boronate Probe Based on 3-Benzothiazol-2-yl-7-hydroxy-chromen-2-one for the Detection of Peroxynitrite and Hypochlorite. (Modrzejewska J, Szala M, Grzelakowska A, Zakłos-Szyda M, Zielonka J, Podsiadły R) Molecules 2021 Sep 30;26(19) PMID: 34641484 PMCID: PMC8512868 SCOPUS ID: 2-s2.0-85116571011 10/14/2021       8 Citations
  • On the chemical reactivity of tricyanofuran(TCF)-based near-infrared fluorescent redox probes – Effects of glutathione on the probe response and product fluorescence (Siarkiewicz P, Michalski R, Sikora A, Smulik-Izydorczyk R, Szala M, Grzelakowska A, Modrzejewska J, Bailey A, Nycz JE, Kalyanaraman B, Malecki JG, Zielonka J, Podsiadły R) Dyes and Pigments August 2021;192 SCOPUS ID: 2-s2.0-85105322458 08/01/2021       12 Citations
  • Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression. (AbuEid M, McAllister DM, McOlash L, Harwig MC, Cheng G, Drouillard D, Boyle KA, Hardy M, Zielonka J, Johnson BD, Hill RB, Kalyanaraman B, Dwinell MB) iScience 2021 Jun 25;24(6):102653 PMID: 34189432 PMCID: PMC8220235 SCOPUS ID: 2-s2.0-85107963806 07/01/2021       18 Citations
  • Identification of Peroxynitrite by Profiling Oxidation and Nitration Products from Mitochondria-Targeted Arylboronic Acid. (Zielonka J, Sikora A, Podsiadly R, Hardy M, Kalyanaraman B) Methods Mol Biol 2021;2275:315-327 PMID: 34118047 PMCID: PMC9245525 SCOPUS ID: 2-s2.0-85108205869 06/13/2021       8 Citations
  • Radiation Increases Bioavailability of Lisinopril, a Mitigator of Radiation-Induced Toxicities. (Medhora M, Phadnis P, Narayanan J, Gasperetti T, Zielonka J, Moulder JE, Fish BL, Szabo A) Front Pharmacol 2021;12:646076 PMID: 33986677 PMCID: PMC8111401 SCOPUS ID: 2-s2.0-85105645466 05/15/2021       1 Citation
  • Two-photon fluorescent probe for cellular peroxynitrite: Fluorescence detection, imaging, and identification of peroxynitrite-specific products. (Grzelakowska A, Zielonka M, Dębowska K, Modrzejewska J, Szala M, Sikora A, Zielonka J, Podsiadły R) Free Radic Biol Med 2021 Jun;169:24-35 PMID: 33862158 SCOPUS ID: 2-s2.0-85104378450 04/17/2021       20 Citations
  • Detection of extracellular superoxide in isolated human immune cells and in an animal model of arterial hypertension using hydropropidine probe and HPLC analysis. (Kalinovic S, Stamm P, Oelze M, Steven S, Kröller-Schön S, Kvandova M, Zielonka J, Münzel T, Daiber A) Free Radic Biol Med 2021 May 20;168:214-225 PMID: 33823245 SCOPUS ID: 2-s2.0-85103958152 04/07/2021       8 Citations
  • Characterization of the reactivity of luciferin boronate - A probe for inflammatory oxidants with improved stability (Szala M, Grzelakowska A, Modrzejewska J, Siarkiewicz P, Słowiński D, Świerczyńska M, Zielonka J, Podsiadły R) Dyes and Pigments December 2020;183 SCOPUS ID: 2-s2.0-85089199002 12/01/2020       17 Citations
  • Oxidation of ethidium-based probes by biological radicals: mechanism, kinetics and implications for the detection of superoxide. (Michalski R, Thiebaut D, Michałowski B, Ayhan MM, Hardy M, Ouari O, Rostkowski M, Smulik-Izydorczyk R, Artelska A, Marcinek A, Zielonka J, Kalyanaraman B, Sikora A) Sci Rep 2020 Oct 29;10(1):18626 PMID: 33122809 PMCID: PMC7596101 SCOPUS ID: 2-s2.0-85094638056 10/31/2020       13 Citations
  • Boronate-Based Probes for Biological Oxidants: A Novel Class of Molecular Tools for Redox Biology. (Sikora A, Zielonka J, Dębowska K, Michalski R, Smulik-Izydorczyk R, Pięta J, Podsiadły R, Artelska A, Pierzchała K, Kalyanaraman B) Front Chem 2020;8:580899 PMID: 33102447 PMCID: PMC7545953 SCOPUS ID: 2-s2.0-85092384929 10/27/2020       45 Citations
  • Mitochondria-targeted magnolol inhibits OXPHOS, proliferation, and tumor growth via modulation of energetics and autophagy in melanoma cells. (Cheng G, Hardy M, Zielonka J, Weh K, Zielonka M, Boyle KA, Abu Eid M, McAllister D, Bennett B, Kresty LA, Dwinell MB, Kalyanaraman B) Cancer Treat Res Commun 2020;25:100210 PMID: 32987287 PMCID: PMC7883397 SCOPUS ID: 2-s2.0-85091576205 09/29/2020       19 Citations
  • Cysteine sulfenylation by CD36 signaling promotes arterial thrombosis in dyslipidemia. (Yang M, Li W, Harberg C, Chen W, Yue H, Ferreira RB, Wynia-Smith SL, Carroll KS, Zielonka J, Flaumenhaft R, Silverstein RL, Smith BC) Blood Adv 2020 Sep 22;4(18):4494-4507 PMID: 32946569 PMCID: PMC7509873 SCOPUS ID: 2-s2.0-85092260584 09/19/2020       21 Citations
  • Alcohol-induced CYP2E1, mitochondrial dynamics and retrograde signaling in human hepatic 3D organoids. (Angireddy R, Chowdhury AR, Zielonka J, Ruthel G, Kalyanaraman B, Avadhani NG) Free Radic Biol Med 2020 Nov 01;159:1-14 PMID: 32738395 SCOPUS ID: 2-s2.0-85089013403 08/02/2020       15 Citations
  • Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: A dose-dependent phenomenon. (Chowdhury AR, Zielonka J, Kalyanaraman B, Hartley RC, Murphy MP, Avadhani NG) Redox Biol 2020 Sep;36:101606 PMID: 32604037 PMCID: PMC7327929 SCOPUS ID: 2-s2.0-85086919803 07/01/2020       57 Citations
  • Magnolia extract is effective for the chemoprevention of oral cancer through its ability to inhibit mitochondrial respiration at complex I. (Zhang Q, Cheng G, Pan J, Zielonka J, Xiong D, Myers CR, Feng L, Shin SS, Kim YH, Bui D, Hu M, Bennett B, Schmainda K, Wang Y, Kalyanaraman B, You M) Cell Commun Signal 2020 Apr 07;18(1):58 PMID: 32264893 PMCID: PMC7140380 SCOPUS ID: 2-s2.0-85083071315 04/09/2020       18 Citations
  • Tracking isotopically labeled oxidants using boronate-based redox probes. (Rios N, Radi R, Kalyanaraman B, Zielonka J) J Biol Chem 2020 May 08;295(19):6665-6676 PMID: 32217693 PMCID: PMC7212653 SCOPUS ID: 2-s2.0-85084721806 03/29/2020       17 Citations
  • Increased formation of reactive oxygen species during tumor growth: Ex vivo low-temperature EPR and in vivo bioluminescence analyses. (Cheng G, Pan J, Podsiadly R, Zielonka J, Garces AM, Dias Duarte Machado LG, Bennett B, McAllister D, Dwinell MB, You M, Kalyanaraman B) Free Radic Biol Med 2020 Feb 01;147:167-174 PMID: 31874251 PMCID: PMC6948008 SCOPUS ID: 2-s2.0-85076857582 12/25/2019       16 Citations
  • SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer. (He C, Danes JM, Hart PC, Zhu Y, Huang Y, de Abreu AL, O'Brien J, Mathison AJ, Tang B, Frasor JM, Wakefield LM, Ganini D, Stauder E, Zielonka J, Gantner BN, Urrutia RA, Gius D, Bonini MG) Proc Natl Acad Sci U S A 2019 Nov 19;116(47):23534-23541 PMID: 31591207 PMCID: PMC6876149 SCOPUS ID: 2-s2.0-85075260452 10/09/2019       51 Citations
  • Synergistic inhibition of tumor cell proliferation by metformin and mito-metformin in the presence of iron chelators. (Cheng G, Zielonka J, Hardy M, Ouari O, Chitambar CR, Dwinell MB, Kalyanaraman B) Oncotarget 2019 May 28;10(37):3518-3532 PMID: 31191823 PMCID: PMC6544408 SCOPUS ID: 2-s2.0-85089087803 06/14/2019       14 Citations
  • Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals. (Besson E, Gastaldi S, Bloch E, Zielonka J, Zielonka M, Kalyanaraman B, Aslan S, Karoui H, Rockenbauer A, Ouari O, Hardy M) Analyst 2019 Jul 21;144(14):4194-4203 PMID: 31180410 SCOPUS ID: 2-s2.0-85068588717 06/11/2019       18 Citations
  • High-Throughput Screening of NOX Inhibitors. (Zielonka J, Zielonka M, Cheng G, Hardy M, Kalyanaraman B) Methods Mol Biol 2019;1982:429-446 PMID: 31172487 PMCID: PMC6953630 SCOPUS ID: 2-s2.0-85067079084 06/07/2019       10 Citations
  • HPLC-Based Monitoring of Oxidation of Hydroethidine for the Detection of NADPH Oxidase-Derived Superoxide Radical Anion. (Zielonka J, Zielonka M, Kalyanaraman B) Methods Mol Biol 2019;1982:243-258 PMID: 31172476 PMCID: PMC6953631 SCOPUS ID: 2-s2.0-85066970086 06/07/2019       7 Citations
  • Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis. (Cheng G, Zhang Q, Pan J, Lee Y, Ouari O, Hardy M, Zielonka M, Myers CR, Zielonka J, Weh K, Chang AC, Chen G, Kresty L, Kalyanaraman B, You M) Nat Commun 2019 May 17;10(1):2205 PMID: 31101821 PMCID: PMC6525201 SCOPUS ID: 2-s2.0-85065824371 05/19/2019       149 Citations
  • Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity. (Pan J, Lee Y, Cheng G, Zielonka J, Zhang Q, Bajzikova M, Xiong D, Tsaih SW, Hardy M, Flister M, Olsen CM, Wang Y, Vang O, Neuzil J, Myers CR, Kalyanaraman B, You M) iScience 2018 May 25;3:192-207 PMID: 30428319 PMCID: PMC6137433 SCOPUS ID: 2-s2.0-85063413951 11/15/2018       42 Citations
  • Foreword to the Free Radical Biology and Medicine Special Issue on ¨Current fluorescence and chemiluminescence approaches in free radical and redox biology¨. (Radi R, Denicola A, Morgan B, Zielonka J) Free Radic Biol Med 2018 Nov 20;128:1-2 PMID: 30293645 SCOPUS ID: 2-s2.0-85054283618 10/09/2018       6 Citations
  • Low-Temperature EPR Spectroscopy as a Probe-Free Technique for Monitoring Oxidants Formed in Tumor Cells and Tissues: Implications in Drug Resistance and OXPHOS-Targeted Therapies. (Kalyanaraman B, Cheng G, Zielonka J, Bennett B) Cell Biochem Biophys 2019 Mar;77(1):89-98 PMID: 30259334 PMCID: PMC6430651 SCOPUS ID: 2-s2.0-85054023520 09/28/2018       11 Citations
  • Detection of mitochondria-generated reactive oxygen species in cells using multiple probes and methods: Potentials, pitfalls, and the future. (Cheng G, Zielonka M, Dranka B, Kumar SN, Myers CR, Bennett B, Garces AM, Dias Duarte Machado LG, Thiebaut D, Ouari O, Hardy M, Zielonka J, Kalyanaraman B) J Biol Chem 2018 Jun 29;293(26):10363-10380 PMID: 29739855 PMCID: PMC6028982 SCOPUS ID: 2-s2.0-85049623107 05/10/2018       76 Citations
  • Kindlin-3 negatively regulates the release of neutrophil extracellular traps. (Xu Z, Ni B, Cao Z, Zielonka J, Gao J, Chen F, Kalyanaraman B, White GC, Ma YQ) J Leukoc Biol 2018 Sep;104(3):597-602 PMID: 29656482 PMCID: PMC6113072 SCOPUS ID: 2-s2.0-85045414281 04/16/2018       12 Citations
  • Small-molecule luminescent probes for the detection of cellular oxidizing and nitrating species. (Zielonka J, Kalyanaraman B) Free Radic Biol Med 2018 Nov 20;128:3-22 PMID: 29567392 PMCID: PMC6146080 SCOPUS ID: 2-s2.0-85054207129 03/24/2018       57 Citations
  • Corrigendum to 'A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds' [REDOX 14C (2017) 316-327]. (Kalyanaraman B, Cheng G, Hardy M, Ouari O, Lopez M, Joseph J, Zielonka J, Dwinell MB) Redox Biol 2018 Jun;16:426-427 PMID: 29548725 PMCID: PMC5952812 SCOPUS ID: 2-s2.0-85043469209 03/20/2018       6 Citations
  • Teaching the basics of reactive oxygen species and their relevance to cancer biology: Mitochondrial reactive oxygen species detection, redox signaling, and targeted therapies. (Kalyanaraman B, Cheng G, Hardy M, Ouari O, Bennett B, Zielonka J) Redox Biol 2018 May;15:347-362 PMID: 29306792 PMCID: PMC5756055 SCOPUS ID: 2-s2.0-85039930921 01/08/2018       157 Citations
  • Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162]. (Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, Petry A, Schulz R, Vina J, Winyard P, Abbas K, Ademowo OS, Afonso CB, Andreadou I, Antelmann H, Antunes F, Aslan M, Bachschmid MM, Barbosa RM, Belousov V, Berndt C, Bernlohr D, Bertrán E, Bindoli A, Bottari SP, Brito PM, Carrara G, Casas AI, Chatzi A, Chondrogianni N, Conrad M, Cooke MS, Costa JG, Cuadrado A, My-Chan Dang P, De Smet B, Debelec-Butuner B, Dias IHK, Dunn JD, Edson AJ, El Assar M, El-Benna J, Ferdinandy P, Fernandes AS, Fladmark KE, Förstermann U, Giniatullin R, Giricz Z, Görbe A, Griffiths H, Hampl V, Hanf A, Herget J, Hernansanz-Agustín P, Hillion M, Huang J, Ilikay S, Jansen-Dürr P, Jaquet V, Joles JA, Kalyanaraman B, Kaminskyy D, Karbaschi M, Kleanthous M, Klotz LO, Korac B, Korkmaz KS, Koziel R, Kračun D, Krause KH, Křen V, Krieg T, Laranjinha J, Lazou A, Li H, Martínez-Ruiz A, Matsui R, McBean GJ, Meredith SP, Messens J, Miguel V, Mikhed Y, Milisav I, Milković L, Miranda-Vizuete A, Mojović M, Monsalve M, Mouthuy PA, Mulvey J, Münzel T, Muzykantov V, Nguyen ITN, Oelze M, Oliveira NG, Palmeira CM, Papaevgeniou N, Pavićević A, Pedre B, Peyrot F, Phylactides M, Pircalabioru GG, Pitt AR, Poulsen HE, Prieto I, Rigobello MP, Robledinos-Antón N, Rodríguez-Mañas L, Rolo AP, Rousset F, Ruskovska T, Saraiva N, Sasson S, Schröder K, Semen K, Seredenina T, Shakirzyanova A, Smith GL, Soldati T, Sousa BC, Spickett CM, Stancic A, Stasia MJ, Steinbrenner H, Stepanić V, Steven S, Tokatlidis K, Tuncay E, Turan B, Ursini F, Vacek J, Vajnerova O, Valentová K, Van Breusegem F, Varisli L, Veal EA, Yalçın AS, Yelisyeyeva O, Žarković N, Zatloukalová M, Zielonka J, Touyz RM, Papapetropoulos A, Grune T, Lamas S, Schmidt HHHW, Di Lisa F, Daiber A) Redox Biol 2018 Apr;14:694-696 PMID: 29107648 PMCID: PMC5975209 SCOPUS ID: 2-s2.0-85032289195 11/07/2017       10 Citations
  • Detection and Characterization of Reactive Oxygen and Nitrogen Species in Biological Systems by Monitoring Species-Specific Products. (Hardy M, Zielonka J, Karoui H, Sikora A, Michalski R, Podsiadły R, Lopez M, Vasquez-Vivar J, Kalyanaraman B, Ouari O) Antioxid Redox Signal 2018 May 20;28(15):1416-1432 PMID: 29037049 PMCID: PMC5910052 SCOPUS ID: 2-s2.0-85045516114 10/19/2017       66 Citations
  • A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds. (Kalyanaraman B, Cheng G, Hardy M, Ouari O, Lopez M, Joseph J, Zielonka J, Dwinell MB) Redox Biol 2018 Apr;14:316-327 PMID: 29017115 PMCID: PMC5633086 SCOPUS ID: 2-s2.0-85030681499 10/11/2017       165 Citations
  • Recent Developments in the Probes and Assays for Measurement of the Activity of NADPH Oxidases. (Zielonka J, Hardy M, Michalski R, Sikora A, Zielonka M, Cheng G, Ouari O, Podsiadły R, Kalyanaraman B) Cell Biochem Biophys 2017 Dec;75(3-4):335-349 PMID: 28660426 PMCID: PMC5693611 SCOPUS ID: 2-s2.0-85025160609 07/01/2017       22 Citations
  • Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications. (Zielonka J, Joseph J, Sikora A, Hardy M, Ouari O, Vasquez-Vivar J, Cheng G, Lopez M, Kalyanaraman B) Chem Rev 2017 Aug 09;117(15):10043-10120 PMID: 28654243 PMCID: PMC5611849 SCOPUS ID: 2-s2.0-85027303022 06/28/2017       1035 Citations
  • European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). (Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, Petry A, Schulz R, Vina J, Winyard P, Abbas K, Ademowo OS, Afonso CB, Andreadou I, Antelmann H, Antunes F, Aslan M, Bachschmid MM, Barbosa RM, Belousov V, Berndt C, Bernlohr D, Bertrán E, Bindoli A, Bottari SP, Brito PM, Carrara G, Casas AI, Chatzi A, Chondrogianni N, Conrad M, Cooke MS, Costa JG, Cuadrado A, My-Chan Dang P, De Smet B, Debelec-Butuner B, Dias IHK, Dunn JD, Edson AJ, El Assar M, El-Benna J, Ferdinandy P, Fernandes AS, Fladmark KE, Förstermann U, Giniatullin R, Giricz Z, Görbe A, Griffiths H, Hampl V, Hanf A, Herget J, Hernansanz-Agustín P, Hillion M, Huang J, Ilikay S, Jansen-Dürr P, Jaquet V, Joles JA, Kalyanaraman B, Kaminskyy D, Karbaschi M, Kleanthous M, Klotz LO, Korac B, Korkmaz KS, Koziel R, Kračun D, Krause KH, Křen V, Krieg T, Laranjinha J, Lazou A, Li H, Martínez-Ruiz A, Matsui R, McBean GJ, Meredith SP, Messens J, Miguel V, Mikhed Y, Milisav I, Milković L, Miranda-Vizuete A, Mojović M, Monsalve M, Mouthuy PA, Mulvey J, Münzel T, Muzykantov V, Nguyen ITN, Oelze M, Oliveira NG, Palmeira CM, Papaevgeniou N, Pavićević A, Pedre B, Peyrot F, Phylactides M, Pircalabioru GG, Pitt AR, Poulsen HE, Prieto I, Rigobello MP, Robledinos-Antón N, Rodríguez-Mañas L, Rolo AP, Rousset F, Ruskovska T, Saraiva N, Sasson S, Schröder K, Semen K, Seredenina T, Shakirzyanova A, Smith GL, Soldati T, Sousa BC, Spickett CM, Stancic A, Stasia MJ, Steinbrenner H, Stepanić V, Steven S, Tokatlidis K, Tuncay E, Turan B, Ursini F, Vacek J, Vajnerova O, Valentová K, Van Breusegem F, Varisli L, Veal EA, Yalçın AS, Yelisyeyeva O, Žarković N, Zatloukalová M, Zielonka J, Touyz RM, Papapetropoulos A, Grune T, Lamas S, Schmidt HHHW, Di Lisa F, Daiber A) Redox Biol 2017 Oct;13:94-162 PMID: 28577489 PMCID: PMC5458069 SCOPUS ID: 2-s2.0-85020032301 06/04/2017       245 Citations
  • Modified Metformin as a More Potent Anticancer Drug: Mitochondrial Inhibition, Redox Signaling, Antiproliferative Effects and Future EPR Studies. (Kalyanaraman B, Cheng G, Hardy M, Ouari O, Sikora A, Zielonka J, Dwinell MB) Cell Biochem Biophys 2017 Dec;75(3-4):311-317 PMID: 28429253 PMCID: PMC5680142 SCOPUS ID: 2-s2.0-85018513016 04/22/2017       20 Citations
  • Green fluorescent proteins induce oxidative stress in cells: A worrisome new wrinkle in the application of the GFP reporter system to biological systems? (Kalyanaraman B, Zielonka J) Redox Biol 2017 Aug;12:755-757 PMID: 28415040 PMCID: PMC5397015 SCOPUS ID: 2-s2.0-85017433209 04/18/2017       15 Citations
  • Mitochondria-targeted metformins: anti-tumour and redox signalling mechanisms. (Kalyanaraman B, Cheng G, Hardy M, Ouari O, Sikora A, Zielonka J, Dwinell M) Interface Focus 2017 Apr 06;7(2):20160109 PMID: 28382202 PMCID: PMC5311906 SCOPUS ID: 2-s2.0-85013194895 04/07/2017       23 Citations
  • Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice. (Langley M, Ghosh A, Charli A, Sarkar S, Ay M, Luo J, Zielonka J, Brenza T, Bennett B, Jin H, Ghaisas S, Schlichtmann B, Kim D, Anantharam V, Kanthasamy A, Narasimhan B, Kalyanaraman B, Kanthasamy AG) Antioxid Redox Signal 2017 Nov 10;27(14):1048-1066 PMID: 28375739 PMCID: PMC5651937 SCOPUS ID: 2-s2.0-85019331880 04/05/2017       94 Citations
  • Detection of Nitric Oxide and Peroxynitrite in Biological Systems: A State-of-the-Art Review (Hogg N, Zielonka J, Kalyanaraman B) Nitric Oxide: Biology and Pathobiology: Third Edition 1 January 2017:23-44 SCOPUS ID: 2-s2.0-85032168005 01/01/2017       13 Citations
  • A Critical Review of Methodologies to Detect Reactive Oxygen and Nitrogen Species Stimulated by NADPH Oxidase Enzymes: Implications in Pesticide Toxicity. (Kalyanaraman B, Hardy M, Zielonka J) Curr Pharmacol Rep 2016 Aug;2(4):193-201 PMID: 27774407 PMCID: PMC5070669 SCOPUS ID: 2-s2.0-85012255350 10/25/2016       29 Citations
  • On the use of peroxy-caged luciferin (PCL-1) probe for bioluminescent detection of inflammatory oxidants in vitro and in vivo - Identification of reaction intermediates and oxidant-specific minor products. (Zielonka J, Podsiadły R, Zielonka M, Hardy M, Kalyanaraman B) Free Radic Biol Med 2016 Oct;99:32-42 PMID: 27458121 PMCID: PMC5107150 SCOPUS ID: 2-s2.0-84979887634 10/23/2016       42 Citations
  • Recent developments in detection of superoxide radical anion and hydrogen peroxide: Opportunities, challenges, and implications in redox signaling. (Kalyanaraman B, Hardy M, Podsiadly R, Cheng G, Zielonka J) Arch Biochem Biophys 2017 Mar 01;617:38-47 PMID: 27590268 PMCID: PMC5318280 SCOPUS ID: 2-s2.0-84995422269 09/04/2016       101 Citations
  • Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells. (Cheng G, Zielonka J, Ouari O, Lopez M, McAllister D, Boyle K, Barrios CS, Weber JJ, Johnson BD, Hardy M, Dwinell MB, Kalyanaraman B) Cancer Res 2016 Jul 01;76(13):3904-15 PMID: 27216187 PMCID: PMC4930686 SCOPUS ID: 2-s2.0-84977588183 05/25/2016       153 Citations
  • Mechanism of oxidative conversion of Amplex® Red to resorufin: Pulse radiolysis and enzymatic studies. (Dębski D, Smulik R, Zielonka J, Michałowski B, Jakubowska M, Dębowska K, Adamus J, Marcinek A, Kalyanaraman B, Sikora A) Free Radic Biol Med 2016 Jun;95:323-32 PMID: 27021961 PMCID: PMC5697983 SCOPUS ID: 2-s2.0-84963657120 03/30/2016       107 Citations
  • Mitigation of NADPH Oxidase 2 Activity as a Strategy to Inhibit Peroxynitrite Formation. (Zielonka J, Zielonka M, VerPlank L, Cheng G, Hardy M, Ouari O, Ayhan MM, Podsiadły R, Sikora A, Lambeth JD, Kalyanaraman B) J Biol Chem 2016 Mar 25;291(13):7029-44 PMID: 26839313 PMCID: PMC4807286 SCOPUS ID: 2-s2.0-84964907042 02/04/2016       56 Citations
  • Toward selective detection of reactive oxygen and nitrogen species with the use of fluorogenic probes--Limitations, progress, and perspectives. (Debowska K, Debski D, Hardy M, Jakubowska M, Kalyanaraman B, Marcinek A, Michalski R, Michalowski B, Ouari O, Sikora A, Smulik R, Zielonka J) Pharmacol Rep 2015 Aug;67(4):756-64 PMID: 26321278 PMCID: PMC5793900 SCOPUS ID: 2-s2.0-84940462191 09/01/2015       47 Citations
  • Antiproliferative effects of mitochondria-targeted cationic antioxidants and analogs: Role of mitochondrial bioenergetics and energy-sensing mechanism. (Cheng G, Zielonka J, McAllister D, Hardy M, Ouari O, Joseph J, Dwinell MB, Kalyanaraman B) Cancer Lett 2015 Aug 28;365(1):96-106 PMID: 26004344 PMCID: PMC4476640 SCOPUS ID: 2-s2.0-84930823628 05/26/2015       61 Citations
  • Detection and differentiation between peroxynitrite and hydroperoxides using mitochondria-targeted arylboronic acid. (Zielonka J, Sikora A, Adamus J, Kalyanaraman B) Methods Mol Biol 2015;1264:171-81 PMID: 25631013 PMCID: PMC4451192 SCOPUS ID: 2-s2.0-84958629324 01/30/2015       28 Citations
  • Nitroxyl (HNO) reacts with molecular oxygen and forms peroxynitrite at physiological pH. Biological Implications. (Smulik R, Dębski D, Zielonka J, Michałowski B, Adamus J, Marcinek A, Kalyanaraman B, Sikora A) J Biol Chem 2014 Dec 19;289(51):35570-81 PMID: 25378389 PMCID: PMC4271240 SCOPUS ID: 2-s2.0-84919475251 11/08/2014       64 Citations
  • A novel mitochondrially-targeted apocynin derivative prevents hyposmia and loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic mouse model of Parkinson's disease. (Dranka BP, Gifford A, McAllister D, Zielonka J, Joseph J, O'Hara CL, Stucky CL, Kanthasamy AG, Kalyanaraman B) Neurosci Lett 2014 Nov 07;583:159-64 PMID: 25263790 PMCID: PMC4253647 SCOPUS ID: 2-s2.0-84907997127 09/30/2014       41 Citations
  • Real-time measurements of amino acid and protein hydroperoxides using coumarin boronic acid. (Michalski R, Zielonka J, Gapys E, Marcinek A, Joseph J, Kalyanaraman B) J Biol Chem 2014 Aug 08;289(32):22536-53 PMID: 24928516 PMCID: PMC4139259 SCOPUS ID: 2-s2.0-84905844117 06/15/2014       61 Citations
  • H2O2 generation by bacillus Calmette-Guérin induces the cellular oxidative stress response required for bacillus Calmette-Guérin direct effects on urothelial carcinoma biology. (Shah G, Zielonka J, Chen F, Zhang G, Cao Y, Kalyanaraman B, See W) J Urol 2014 Oct;192(4):1238-48 PMID: 24928267 PMCID: PMC5798233 SCOPUS ID: 2-s2.0-84921941445 06/15/2014       19 Citations
  • Mitochondria-targeted spin traps: synthesis, superoxide spin trapping, and mitochondrial uptake. (Hardy M, Poulhés F, Rizzato E, Rockenbauer A, Banaszak K, Karoui H, Lopez M, Zielonka J, Vasquez-Vivar J, Sethumadhavan S, Kalyanaraman B, Tordo P, Ouari O) Chem Res Toxicol 2014 Jul 21;27(7):1155-65 PMID: 24890552 PMCID: PMC5452977 SCOPUS ID: 2-s2.0-84904659978 06/04/2014       25 Citations
  • Profiling and targeting of cellular bioenergetics: inhibition of pancreatic cancer cell proliferation. (Cheng G, Zielonka J, McAllister D, Tsai S, Dwinell MB, Kalyanaraman B) Br J Cancer 2014 Jul 08;111(1):85-93 PMID: 24867695 PMCID: PMC4090735 SCOPUS ID: 2-s2.0-84904114424 05/29/2014       68 Citations
  • High-throughput assays for superoxide and hydrogen peroxide: design of a screening workflow to identify inhibitors of NADPH oxidases. (Zielonka J, Cheng G, Zielonka M, Ganesh T, Sun A, Joseph J, Michalski R, O'Brien WJ, Lambeth JD, Kalyanaraman B) J Biol Chem 2014 Jun 06;289(23):16176-89 PMID: 24764302 PMCID: PMC4047388 SCOPUS ID: 2-s2.0-84902206908 04/26/2014       63 Citations
  • Inducible nitric oxide synthase is key to peroxynitrite-mediated, LPS-induced protein radical formation in murine microglial BV2 cells. (Kumar A, Chen SH, Kadiiska MB, Hong JS, Zielonka J, Kalyanaraman B, Mason RP) Free Radic Biol Med 2014 Aug;73:51-9 PMID: 24746617 PMCID: PMC4111989 SCOPUS ID: 2-s2.0-84901763503 04/22/2014       72 Citations
  • Detection and identification of oxidants formed during •NO/O2•⁻ reaction: a multi-well plate CW-EPR spectroscopy combined with HPLC analyses. (Koto T, Michalski R, Zielonka J, Joseph J, Kalyanaraman B) Free Radic Res 2014 Apr;48(4):478-86 PMID: 24460755 PMCID: PMC4780754 SCOPUS ID: 2-s2.0-84895739300 01/28/2014       6 Citations
  • On the use of fluorescence lifetime imaging and dihydroethidium to detect superoxide in intact animals and ex vivo tissues: a reassessment. (Michalski R, Michalowski B, Sikora A, Zielonka J, Kalyanaraman B) Free Radic Biol Med 2014 Feb;67:278-84 PMID: 24200598 PMCID: PMC4275029 SCOPUS ID: 2-s2.0-84889578332 11/10/2013       49 Citations
  • On the use of L-012, a luminol-based chemiluminescent probe, for detecting superoxide and identifying inhibitors of NADPH oxidase: a reevaluation. (Zielonka J, Lambeth JD, Kalyanaraman B) Free Radic Biol Med 2013 Dec;65:1310-1314 PMID: 24080119 PMCID: PMC4274999 SCOPUS ID: 2-s2.0-84886048542 10/02/2013       106 Citations
  • Mito-tempol and dexrazoxane exhibit cardioprotective and chemotherapeutic effects through specific protein oxidation and autophagy in a syngeneic breast tumor preclinical model. (Dickey JS, Gonzalez Y, Aryal B, Mog S, Nakamura AJ, Redon CE, Baxa U, Rosen E, Cheng G, Zielonka J, Parekh P, Mason KP, Joseph J, Kalyanaraman B, Bonner W, Herman E, Shacter E, Rao VA) PLoS One 2013;8(8):e70575 PMID: 23940596 PMCID: PMC3734284 SCOPUS ID: 2-s2.0-84881115392 08/14/2013       57 Citations
  • Real-time monitoring of reactive oxygen and nitrogen species in a multiwell plate using the diagnostic marker products of specific probes. (Zielonka J, Joseph J, Sikora A, Kalyanaraman B) Methods Enzymol 2013;526:145-57 PMID: 23791099 PMCID: PMC6941666 SCOPUS ID: 2-s2.0-84879763530 06/26/2013       22 Citations
  • Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death. (Cheng G, Zielonka J, McAllister DM, Mackinnon AC Jr, Joseph J, Dwinell MB, Kalyanaraman B) BMC Cancer 2013 Jun 13;13:285 PMID: 23764021 PMCID: PMC3686663 SCOPUS ID: 2-s2.0-84878817212 06/15/2013       106 Citations
  • Diapocynin prevents early Parkinson's disease symptoms in the leucine-rich repeat kinase 2 (LRRK2R¹⁴⁴¹G) transgenic mouse. (Dranka BP, Gifford A, Ghosh A, Zielonka J, Joseph J, Kanthasamy AG, Kalyanaraman B) Neurosci Lett 2013 Aug 09;549:57-62 PMID: 23721786 PMCID: PMC3729885 SCOPUS ID: 2-s2.0-84880750830 06/01/2013       31 Citations
  • HPLC-based monitoring of products formed from hydroethidine-based fluorogenic probes--the ultimate approach for intra- and extracellular superoxide detection. (Kalyanaraman B, Dranka BP, Hardy M, Michalski R, Zielonka J) Biochim Biophys Acta 2014 Feb;1840(2):739-44 PMID: 23668959 PMCID: PMC3858408 SCOPUS ID: 2-s2.0-84890117297 05/15/2013       92 Citations
  • Reaction between peroxynitrite and triphenylphosphonium-substituted arylboronic acid isomers: identification of diagnostic marker products and biological implications. (Sikora A, Zielonka J, Adamus J, Debski D, Dybala-Defratyka A, Michalowski B, Joseph J, Hartley RC, Murphy MP, Kalyanaraman B) Chem Res Toxicol 2013 Jun 17;26(6):856-67 PMID: 23611338 PMCID: PMC3700382 SCOPUS ID: 2-s2.0-84879154470 04/25/2013       42 Citations
  • Hydropropidine: a novel, cell-impermeant fluorogenic probe for detecting extracellular superoxide. (Michalski R, Zielonka J, Hardy M, Joseph J, Kalyanaraman B) Free Radic Biol Med 2013 Jan;54:135-47 PMID: 23051008 PMCID: PMC3711142 SCOPUS ID: 2-s2.0-84871920872 10/12/2012       42 Citations
  • Boronate probes as diagnostic tools for real time monitoring of peroxynitrite and hydroperoxides. (Zielonka J, Sikora A, Hardy M, Joseph J, Dranka BP, Kalyanaraman B) Chem Res Toxicol 2012 Sep 17;25(9):1793-9 PMID: 22731669 PMCID: PMC3501381 SCOPUS ID: 2-s2.0-84866386085 06/27/2012       198 Citations
  • Alterations in bioenergetic function induced by Parkinson's disease mimetic compounds: lack of correlation with superoxide generation. (Dranka BP, Zielonka J, Kanthasamy AG, Kalyanaraman B) J Neurochem 2012 Sep;122(5):941-51 PMID: 22708893 PMCID: PMC3423581 SCOPUS ID: 2-s2.0-84865321842 06/20/2012       51 Citations
  • Mitochondria-targeted drugs synergize with 2-deoxyglucose to trigger breast cancer cell death. (Cheng G, Zielonka J, Dranka BP, McAllister D, Mackinnon AC Jr, Joseph J, Kalyanaraman B) Cancer Res 2012 May 15;72(10):2634-44 PMID: 22431711 PMCID: PMC3700358 SCOPUS ID: 2-s2.0-84861158967 03/21/2012       200 Citations
  • Global profiling of reactive oxygen and nitrogen species in biological systems: high-throughput real-time analyses. (Zielonka J, Zielonka M, Sikora A, Adamus J, Joseph J, Hardy M, Ouari O, Dranka BP, Kalyanaraman B) J Biol Chem 2012 Jan 27;287(5):2984-95 PMID: 22139901 PMCID: PMC3270955 SCOPUS ID: 2-s2.0-84856248241 12/06/2011       155 Citations
  • Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy. (Mukhopadhyay P, Horváth B, Zsengellér Z, Zielonka J, Tanchian G, Holovac E, Kechrid M, Patel V, Stillman IE, Parikh SM, Joseph J, Kalyanaraman B, Pacher P) Free Radic Biol Med 2012 Jan 15;52(2):497-506 PMID: 22120494 PMCID: PMC3253235 SCOPUS ID: 2-s2.0-84855448154 11/29/2011       177 Citations
  • Mitochondria-targeted nitroxides exacerbate fluvastatin-mediated cytostatic and cytotoxic effects in breast cancer cells. (Cheng G, Lopez M, Zielonka J, Hauser AD, Joseph J, McAllister D, Rowe JJ, Sugg SL, Williams CL, Kalyanaraman B) Cancer Biol Ther 2011 Oct 15;12(8):707-17 PMID: 21799303 PMCID: PMC3218525 SCOPUS ID: 2-s2.0-80054116454 07/30/2011       26 Citations
  • Reaction between peroxynitrite and boronates: EPR spin-trapping, HPLC Analyses, and quantum mechanical study of the free radical pathway. (Sikora A, Zielonka J, Lopez M, Dybala-Defratyka A, Joseph J, Marcinek A, Kalyanaraman B) Chem Res Toxicol 2011 May 16;24(5):687-97 PMID: 21434648 PMCID: PMC3743543 SCOPUS ID: 2-s2.0-84962440502 03/26/2011       86 Citations
  • The iron-chelating drug triapine causes pronounced mitochondrial thiol redox stress. (Myers JM, Antholine WE, Zielonka J, Myers CR) Toxicol Lett 2011 Mar 05;201(2):130-6 PMID: 21195754 SCOPUS ID: 2-s2.0-79651473123 01/05/2011       21 Citations
  • Erratum: Role of heat shock protein 90 and endothelial nitric oxide synthase during early anesthetic and ischemic preconditioning (Anesthesiology (2009) 110 (317-325)) (Amour J, Brzezinska AK, Weihrauch D, Billstrom AR, Zielonka J, Krolikowski JG, Bienengraeber MW, Warltier DC, Pratt PF, Kersten JR) Anesthesiology August 2011;115(2):452 SCOPUS ID: 2-s2.0-79961093467 01/01/2011    
  • The antioxidant transcription factor Nrf2 negatively regulates autophagy and growth arrest induced by the anticancer redox agent mitoquinone. (Rao VA, Klein SR, Bonar SJ, Zielonka J, Mizuno N, Dickey JS, Keller PW, Joseph J, Kalyanaraman B, Shacter E) J Biol Chem 2010 Nov 05;285(45):34447-59 PMID: 20805228 PMCID: PMC2966059 SCOPUS ID: 2-s2.0-78049398265 09/02/2010       122 Citations
  • Reply to Jourd'heuil: Peroxynitrite is the major species formed from different flux ratios of co-generated nitric oxide and superoxide (Zielonka J, Sikora A, Joseph J, Kalyanaraman B) Journal of Biological Chemistry 27 August 2010;285(35) SCOPUS ID: 2-s2.0-77956241159 08/27/2010       14 Citations
  • Peroxynitrite is the major species formed from different flux ratios of co-generated nitric oxide and superoxide: direct reaction with boronate-based fluorescent probe. (Zielonka J, Sikora A, Joseph J, Kalyanaraman B) J Biol Chem 2010 May 07;285(19):14210-6 PMID: 20194496 PMCID: PMC2863194 SCOPUS ID: 2-s2.0-77951988104 03/03/2010       179 Citations
  • Hydroethidine- and MitoSOX-derived red fluorescence is not a reliable indicator of intracellular superoxide formation: another inconvenient truth. (Zielonka J, Kalyanaraman B) Free Radic Biol Med 2010 Apr 15;48(8):983-1001 PMID: 20116425 PMCID: PMC3587154 SCOPUS ID: 2-s2.0-77950515980 02/02/2010       408 Citations
  • Corrigendum to "HPLC study of oxidation products of hydroethidine in chemical and biological systems: Ramifications in superoxide measurements" [Free Radic. Biol. Med. 46 (2009) 329-338] (DOI:10.1016/j.freeradbiomed.2008.10.031) (Zielonka J, Hardy M, Kalyanaraman B) Free Radical Biology and Medicine 15 January 2010;48(2):373 SCOPUS ID: 2-s2.0-73049086802 01/15/2010    
  • Direct oxidation of boronates by peroxynitrite: mechanism and implications in fluorescence imaging of peroxynitrite. (Sikora A, Zielonka J, Lopez M, Joseph J, Kalyanaraman B) Free Radic Biol Med 2009 Nov 15;47(10):1401-7 PMID: 19686842 PMCID: PMC3375817 SCOPUS ID: 2-s2.0-70350028730 08/19/2009       291 Citations
  • Doxorubicin inactivates myocardial cytochrome c oxidase in rats: cardioprotection by Mito-Q. (Chandran K, Aggarwal D, Migrino RQ, Joseph J, McAllister D, Konorev EA, Antholine WE, Zielonka J, Srinivasan S, Avadhani NG, Kalyanaraman B) Biophys J 2009 Feb 18;96(4):1388-98 PMID: 19217856 PMCID: PMC2717244 SCOPUS ID: 2-s2.0-62649160560 02/17/2009       159 Citations
  • Role of heat shock protein 90 and endothelial nitric oxide synthase during early anesthetic and ischemic preconditioning. (Amour J, Brzezinska AK, Weihrauch D, Billstrom AR, Zielonka J, Krolikowski JG, Bienengraeber MW, Warltier DC, Pratt PF Jr, Kersten JR) Anesthesiology 2009 Feb;110(2):317-25 PMID: 19194158 PMCID: PMC2730207 SCOPUS ID: 2-s2.0-61549089097 02/06/2009       55 Citations
  • MyD88-dependent, superoxide-initiated inflammation is necessary for flow-mediated inward remodeling of conduit arteries. (Tang PC, Qin L, Zielonka J, Zhou J, Matte-Martone C, Bergaya S, van Rooijen N, Shlomchik WD, Min W, Sessa WC, Pober JS, Tellides G) J Exp Med 2008 Dec 22;205(13):3159-71 PMID: 19064699 PMCID: PMC2605224 SCOPUS ID: 2-s2.0-59649088315 12/10/2008       58 Citations
  • The effect of neighboring methionine residue on tyrosine nitration and oxidation in peptides treated with MPO, H2O2, and NO2(-) or peroxynitrite and bicarbonate: role of intramolecular electron transfer mechanism? (Zhang H, Zielonka J, Sikora A, Joseph J, Xu Y, Kalyanaraman B) Arch Biochem Biophys 2009 Apr 15;484(2):134-45 PMID: 19056332 PMCID: PMC2874256 SCOPUS ID: 2-s2.0-64749106532 12/06/2008       21 Citations
  • HPLC study of oxidation products of hydroethidine in chemical and biological systems: ramifications in superoxide measurements. (Zielonka J, Hardy M, Kalyanaraman B) Free Radic Biol Med 2009 Feb 01;46(3):329-38 PMID: 19026738 PMCID: PMC3375818 SCOPUS ID: 2-s2.0-58149168842 11/26/2008       131 Citations
  • "ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis"--a critical commentary. (Zielonka J, Kalyanaraman B) Free Radic Biol Med 2008 Nov 01;45(9):1217-9 PMID: 18789385 PMCID: PMC3595710 SCOPUS ID: 2-s2.0-53449090706 09/16/2008       50 Citations
  • Cytokines and lipopolysaccharides induce inducible nitric oxide synthase but not enzyme activity in adult rat cardiomyocytes. (Vásquez-Vivar J, Whitsett J, Ionova I, Konorev E, Zielonka J, Kalyanaraman B, Shi Y, Pieper GM) Free Radic Biol Med 2008 Oct 01;45(7):994-1001 PMID: 18634867 PMCID: PMC2578873 SCOPUS ID: 2-s2.0-51349157985 07/19/2008       14 Citations
  • Radical scavenging properties of nicotinamide and its metabolites (Sikora A, Szajerski P, Piotrowski Ł, Zielonka J, Adamus J, Marcinek A, Gebicki J) Radiation Physics and Chemistry March 2008;77(3):259-266 SCOPUS ID: 2-s2.0-37349050298 03/01/2008       12 Citations
  • 20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cells. (Medhora M, Chen Y, Gruenloh S, Harland D, Bodiga S, Zielonka J, Gebremedhin D, Gao Y, Falck JR, Anjaiah S, Jacobs ER) Am J Physiol Lung Cell Mol Physiol 2008 May;294(5):L902-11 PMID: 18296498 PMCID: PMC2586843 SCOPUS ID: 2-s2.0-45849122077 02/26/2008       65 Citations
  • Detection of 2-hydroxyethidium in cellular systems: a unique marker product of superoxide and hydroethidine. (Zielonka J, Vasquez-Vivar J, Kalyanaraman B) Nat Protoc 2008;3(1):8-21 PMID: 18193017 SCOPUS ID: 2-s2.0-38149142769 01/15/2008       327 Citations
  • Cytochrome c-mediated oxidation of hydroethidine and mito-hydroethidine in mitochondria: identification of homo- and heterodimers. (Zielonka J, Srinivasan S, Hardy M, Ouari O, Lopez M, Vasquez-Vivar J, Avadhani NG, Kalyanaraman B) Free Radic Biol Med 2008 Mar 01;44(5):835-46 PMID: 18155177 PMCID: PMC2692199 SCOPUS ID: 2-s2.0-39149083084 12/25/2007       92 Citations
  • Hydrogen peroxide induces nitric oxide and proteosome activity in endothelial cells: a bell-shaped signaling response. (Thomas S, Kotamraju S, Zielonka J, Harder DR, Kalyanaraman B) Free Radic Biol Med 2007 Apr 01;42(7):1049-61 PMID: 17349932 PMCID: PMC2692187 SCOPUS ID: 2-s2.0-33847619217 03/14/2007       78 Citations
  • Pulse radiolysis and steady-state analyses of the reaction between hydroethidine and superoxide and other oxidants. (Zielonka J, Sarna T, Roberts JE, Wishart JF, Kalyanaraman B) Arch Biochem Biophys 2006 Dec 01;456(1):39-47 PMID: 17081495 PMCID: PMC2270254 SCOPUS ID: 2-s2.0-33751438500 11/04/2006       54 Citations
  • Radical scavenging and NO-releasing properties of selected beta-adrenoreceptor antagonists. (Szajerski P, Zielonka J, Sikora A, Adamus J, Marcinek A, Gebicki J, Kozlovski VI, Drelicharz L, Chłopicki S) Free Radic Res 2006 Jul;40(7):741-52 PMID: 16984001 SCOPUS ID: 2-s2.0-37349088295 09/21/2006       16 Citations
  • The confounding effects of light, sonication, and Mn(III)TBAP on quantitation of superoxide using hydroethidine. (Zielonka J, Vasquez-Vivar J, Kalyanaraman B) Free Radic Biol Med 2006 Oct 01;41(7):1050-7 PMID: 16962930 SCOPUS ID: 2-s2.0-33748291680 09/12/2006       50 Citations
  • Anthralin: primary products of its redox reactions. (Czerwinska M, Sikora A, Szajerski P, Zielonka J, Adamus J, Marcinek A, Piech K, Bednarek P, Bally T) J Org Chem 2006 Jul 07;71(14):5312-9 PMID: 16808521 SCOPUS ID: 2-s2.0-33745685226 07/01/2006       17 Citations
  • Effect of heparin on viologen-stimulated enzymatic NADH depletion. (Zielonka J, Rybak M, Celińska J, Adamus J, Marcinek A, Gebicki J) Chem Res Toxicol 2006 May;19(5):668-73 PMID: 16696569 SCOPUS ID: 2-s2.0-33744454394 05/16/2006       13 Citations
  • Cyclooxygenase 2 rescues LNCaP prostate cancer cells from sanguinarine-induced apoptosis by a mechanism involving inhibition of nitric oxide synthase activity. (Huh J, Liepins A, Zielonka J, Andrekopoulos C, Kalyanaraman B, Sorokin A) Cancer Res 2006 Apr 01;66(7):3726-36 PMID: 16585199 SCOPUS ID: 2-s2.0-33645734867 04/06/2006       57 Citations
  • Mechanistic similarities between oxidation of hydroethidine by Fremy's salt and superoxide: stopped-flow optical and EPR studies. (Zielonka J, Zhao H, Xu Y, Kalyanaraman B) Free Radic Biol Med 2005 Oct 01;39(7):853-63 PMID: 16140206 SCOPUS ID: 2-s2.0-33644628456 09/06/2005       88 Citations
  • The relationship between the electrochemical and photochemical reduction of some azo dyes derived from 2-aminobenzothiazole (Podsiadły R, Sokołowska J, Marcinek A, Zielonka J, Socha A, Kaźmierska M) Journal of Photochemistry and Photobiology A: Chemistry 15 April 2005;171(1):69-76 SCOPUS ID: 2-s2.0-15044354596 04/15/2005       10 Citations
  • Transient species in the stepwise interconversion of NADH and NAD+. (Gebicki J, Marcinek A, Zielonka J) Acc Chem Res 2004 Jun;37(6):379-86 PMID: 15196047 SCOPUS ID: 2-s2.0-2942637485 06/16/2004       137 Citations
  • Color changes accompanying one-electron reduction and oxidation of the zero dyes (Zielonka J, Podsiad R, Czerwińska M, Sikora A, Sokołowska J, Marcinek A) Journal of Photochemistry and Photobiology A: Chemistry 21 May 2004;163(3):373-379 SCOPUS ID: 2-s2.0-2342473838 05/21/2004       15 Citations
  • 1-Methyl-3-nitropyridine: an efficient oxidant of NADH in non-enzymatic and enzyme-mediated processes. (Wieczorkowska M, Zielonka J, Celińska J, Adamus J, Ciesielska E, Marcinek A, Szmigiero L, Gebicki J) Free Radic Res 2003 Nov;37(11):1157-62 PMID: 14703727 SCOPUS ID: 2-s2.0-0142149059 01/06/2004       7 Citations
  • Direct observation of NADH radical cation generated in reactions with one-electron oxidants (Zielonka J, Marcinek A, Adamus J, Gȩbicki J) Journal of Physical Chemistry A 20 November 2003;107(46):9860-9864 SCOPUS ID: 2-s2.0-0345134773 11/20/2003       30 Citations
  • Radical scavenging properties of genistein. (Zielonka J, Gebicki J, Grynkiewicz G) Free Radic Biol Med 2003 Oct 15;35(8):958-65 PMID: 14556860 SCOPUS ID: 2-s2.0-0141749466 10/15/2003       95 Citations
  • In search for new drugs: From basic research to market product (Gȩbicki J, Adamus J, Marcinek A, Zielonka J, Sysa-Jȩdrzejowska A, Woźniacka A, Denys A, Ciebiada I, Szmigiero L, Ciesielska E, Wieczorkowska M) Przemysl Chemiczny 2003;82(8-9):507-510 SCOPUS ID: 2-s2.0-0141729340 10/09/2003       1 Citation
  • 1-Methylnicotinamide: a potent anti-inflammatory agent of vitamin origin. (Gebicki J, Sysa-Jedrzejowska A, Adamus J, Woźniacka A, Rybak M, Zielonka J) Pol J Pharmacol 2003;55(1):109-12 PMID: 12856834 SCOPUS ID: 2-s2.0-12444253946 07/15/2003       75 Citations
  • Benzopinacol radical cation (Rogowski J, Zielonka J, Marcinek A, Gȩbicki J, Bednarek P) Journal of Physical Chemistry A 13 February 2003;107(6):810-814 SCOPUS ID: 2-s2.0-0037434671 02/13/2003       6 Citations
  • Electrochemical and photochemical reduction of a series of azobenzene dyes in protic and aprotic solvents (Podsiady R, Sokoowska J, Marcinek A, Zielonka J, Chrześcijańska E, Socha A) Coloration Technology 2003;119(5):269-274 SCOPUS ID: 2-s2.0-0242574904 01/01/2003       4 Citations
  • Ionic liquids: Novel media for characterization of radical ions (Marcinek A, Zielonka J, Gȩbicki J, Gordon CM, Dunkin IR) Journal of Physical Chemistry A 11 October 2001;105(40):9305-9309 SCOPUS ID: 2-s2.0-0035846413 10/11/2001       110 Citations
  • Direct characterization of radical species generated on one-electron oxidation of 3,6-diamino-10-methylacridan (Marcinek A, Zielonka J, Adamus J, Gȩbicki J, Platz MS) Journal of Physical Chemistry A 8 February 2001;105(5):875-879 SCOPUS ID: 2-s2.0-0035249594 02/08/2001       11 Citations
    • Last update: 04/03/2024