Association of elevated mutagenesis in the spleen with genetic susceptibility to induced plasmacytoma development in mice. Cancer Res 1998 Apr 15;58(8):1616-9
Date
05/01/1998Pubmed ID
9563470Scopus ID
2-s2.0-0032522886 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
Using the phage lambdaLIZ-based transgenic in vivo mutagenesis assay, mean mutant rates were determined in the spleen of mice exposed to sustained oxidative stress and were found to be increased approximately 3-fold in plasmacytoma-susceptible BALB/c and C.D2-Idh1-Pep3 mice, but not in plasmacytoma-resistant DBA/2N mice. This finding suggests a correlation between the genetic susceptibility to inflammation-induced peritoneal plasmacytomagenesis and the phenotype of increased mutagenesis in lymphoid tissues, raising the possibility that plasmacytoma resistance genes may inhibit tumor development by minimizing oxidative mutagenesis in B cells.
Author List
Felix K, Kelliher K, Bornkamm GW, Janz SAuthor
Siegfried Janz MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsButhionine Sulfoximine
Carcinogens
Disease Susceptibility
Glutathione
Mice
Mice, Inbred BALB C
Mice, Inbred Strains
Mutagenesis
Oxidative Stress
Plasmacytoma
Spleen
Terpenes
