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Siegfried Janz MD

Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Hematology and Oncology - Medicine
Program: Bone Marrow Transplant

Member of the Cancer Center

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Publications (178)

Bispecific BCMA/CD24 CAR-T cells control multiple myeloma growth. (Sun F, Cheng Y, Wanchai V, Guo W, Mery D, Xu H, Gai D, Siegel E, Bailey C, Ashby C, Al Hadidi S, Schinke C, Thanendrarajan S, Ma Y, Yi Q, Orlowski RZ, Zangari M, van Rhee F, Janz S, Bishop G, Tricot G, Shaughnessy JD Jr, Zhan F) Nat Commun 2024 Jan 19;15(1):615 PMID: 38242888 PMCID: PMC10798961 SCOPUS ID: 2-s2.0-85182665152 01/20/2024 1 Citation

Chimeric antigen receptor and bispecific T-cell engager therapies in multiple myeloma patients with prior allogeneic transplantation. (Hammons L, Haider S, Portuguese AJ, Banerjee R, Szabo A, Pasquini M, Chhabra S, Radhakrishnan S, Mohan M, Narra R, Dong J, Janz S, Shah NN, Hamadani M, D'Souza A, Hari P, Dhakal B) Br J Haematol 2024 Mar;204(3):887-891 PMID: 38054558 SCOPUS ID: 2-s2.0-85178904872 12/06/2023 1 Citation

Identification of novel loci for multiple myeloma when comparing with its precursor condition monoclonal gammopathy of unknown significance. (Buradagunta CS, Arsang-Jang S, Massat B, Thapa B, Patek V, D'Souza A, Auer P, Urrutia R, Janz S, Dhakal B, Hari P, Dong J) Leukemia 2024 Feb;38(2):383-385 PMID: 37919604 SCOPUS ID: 2-s2.0-85175540732 11/03/2023

Blood and marrow transplant within 4 weeks of SARS-CoV-2 infection is associated with increased risk of mortality: a National COVID Cohort Collaborative (N3C) Study. (Mohan M, Kothari A, Verhagen N, Shreenivas A, Radhakrishnan SV, Dhakal B, Figueroa-Castro C, Chhabra S, Janz S, Pasquini M, Hamadani M, Szabo A, D'Souza A, N3C consortium) Bone Marrow Transplant 2024 Jan;59(1):121-124 PMID: 37803198 SCOPUS ID: 2-s2.0-85173730029 10/07/2023

High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma. (Cheng Y, Sun F, Alapat DV, Wanchai V, Mery D, Guo W, Cao H, Zhu Y, Ashby C, Bauer MA, Nookaew I, Siegel ER, Ying J, Chen JR, Gai D, Peng B, Xu H, Bailey C, Al Hadidi S, Schinke C, Thanendrarajan S, Zangari M, Chesi M, Bergsagel PL, van Rhee F, Janz S, Tricot G, Shaughnessy JD Jr, Zhan F) Cell Rep Med 2023 Oct 17;4(10):101214 PMID: 37794587 PMCID: PMC10591052 SCOPUS ID: 2-s2.0-85173718596 10/05/2023 1 Citation

The changing spectrum of infection with BCMA and GPRC5D targeting bispecific antibody (bsAb) therapy in patients with relapsed refractory multiple myeloma. (Hammons L, Szabo A, Janardan A, Bhatlapenumarthi V, Annyapu E, Dhakal B, Al Hadidi S, Radhakrishnan SV, Narra R, Bhutani D, Thanendrarajan S, Janz S, Zangari M, Lentzsch S, Van Rhee F, Crescencio JCR, D'Souza A, Chakraborty R, Mohan M, Schinke C) Haematologica 2024 Mar 01;109(3):906-914 PMID: 37646658 PMCID: PMC10905074 SCOPUS ID: 2-s2.0-85178101970 08/30/2023 6 Citations

IL6Myc mouse is an immunocompetent model for the development of aggressive multiple myeloma. (Pisano MD, Sun F, Cheng Y, Parashar D, Zhou V, Jing X, Sompallae R, Abrudan J, Zimmermann MT, Mathison A, Janz S, Pufall MA) Haematologica 2023 Dec 01;108(12):3372-3383 PMID: 37439384 PMCID: PMC10690922 SCOPUS ID: 2-s2.0-85178652041 07/13/2023

A gene signature can predict risk of MGUS progressing to multiple myeloma. (Sun F, Cheng Y, Ying J, Mery D, Al Hadidi S, Wanchai V, Siegel ER, Xu H, Gai D, Ashby TC, Bailey C, Chen JR, Schinke C, Thanendrarajan S, Zangari M, Janz S, Barlogie B, Van Rhee F, Tricot G, Shaughnessy JD Jr, Zhan F) J Hematol Oncol 2023 Jun 29;16(1):70 PMID: 37386588 PMCID: PMC10308756 SCOPUS ID: 2-s2.0-85163879552 06/30/2023 1 Citation

Increased CXCL10 is seen at 1-year after autologous hematopoietic cell transplantation in multiple myeloma patients on maintenance lenalidomide therapy. (Mohan M, Janz S, Brazauskas R, Dwinell MB, Teng BQ, Yun G, Dong J, Pasquini MC, Giralt S, Landau H, Stadtmauer E, Krishnan A, D'Souza A) Bone Marrow Transplant 2023 Aug;58(8):953-955 PMID: 37149674 PMCID: PMC10555486 SCOPUS ID: 2-s2.0-85158126520 05/07/2023

A timeline of genetic variant enrichment: from multiple myeloma diagnosis to myeloma-associated myeloid malignancy. (Kleman A, Singavi A, Pommert L, Mathison AJ, Hari P, Dhakal B, Mohan M, Janz S, Knight JM, Shah MV, Schinke C, Burns R, Steinhardt GF, Rao S, Carlson K) Blood Adv 2023 Sep 26;7(18):5549-5553 PMID: 36724511 PMCID: PMC10514068 SCOPUS ID: 2-s2.0-85164933174 02/02/2023 1 Citation

Clinical outcome of patients with relapsed refractory multiple myeloma listed for BCMA directed commercial CAR-T therapy. (Al Hadidi S, Szabo A, Esselmann J, Hammons L, Hussain M, Ogunsesan Y, Thalambedu N, Khan F, Sethi J, Janardan A, Radhakrishnan SV, Thanendrarajan S, Schinke C, Dhakal B, Janz S, Chhabra S, D'Souza A, Zangari M, van Rhee F, Mohan M) Bone Marrow Transplant 2023 Apr;58(4):443-445 PMID: 36550200 SCOPUS ID: 2-s2.0-85144572498 12/23/2022 11 Citations

DNA methylation in circulating leukocytes is a novel biomarker in multiple myeloma. (D'Souza A, Brazauskas R, Teng BQ, Yun G, Uttley H, Dong J, Dwinell MB, Pasquini MC, Giralt S, Landau H, Stadtmauer E, Krishnan A, Janz S) Bone Marrow Transplant 2023 Mar;58(3):334-336 PMID: 36460820 SCOPUS ID: 2-s2.0-85143207078 12/03/2022

Corneal toxicity with belantamab mafodotin: Multi-institutional real-life experience. (Mohan M, Rein LE, Thalambedu N, Ogunsesan Y, Hussain M, Sethi J, Khan F, Gundarlapalli S, Yarlagadda L, Dhakal B, Price M, Shirey M, Warner D, Thanendrarajan S, Janz S, Radhakrishnan SV, Al Hadidi S, Szabo A, D'Souza A, Zangari M, van Rhee F, Chhabra S, Schinke C) Am J Hematol 2022 Dec;97(12):E451-E453 PMID: 36097868 SCOPUS ID: 2-s2.0-85139019826 09/14/2022 5 Citations

NAT10 promotes cell proliferation by acetylating CEP170 mRNA to enhance translation efficiency in multiple myeloma. (Wei R, Cui X, Min J, Lin Z, Zhou Y, Guo M, An X, Liu H, Janz S, Gu C, Wang H, Yang Y) Acta Pharm Sin B 2022 Aug;12(8):3313-3325 PMID: 35967285 PMCID: PMC9366180 SCOPUS ID: 2-s2.0-85126085456 08/16/2022 25 Citations

NAT10 promotes cell proliferation by acetylating CEP170 mRNA to enhance translation efficiency in multiple myeloma (Wei R, Cui X, Min J, Lin Z, Zhou Y, Guo M, An X, Liu H, Janz S, Gu C, Wang H, Yang Y) Acta Pharmaceutica Sinica B August 2022;12(8):3313-3325 SCOPUS ID: 2-s2.0-85126085456 08/01/2022 25 Citations

FOXM1 regulates glycolysis and energy production in multiple myeloma. (Cheng Y, Sun F, Thornton K, Jing X, Dong J, Yun G, Pisano M, Zhan F, Kim SH, Katzenellenbogen JA, Katzenellenbogen BS, Hari P, Janz S) Oncogene 2022 Aug;41(32):3899-3911 PMID: 35794249 PMCID: PMC9355869 SCOPUS ID: 2-s2.0-85133568311 07/07/2022 17 Citations

Socioeconomic disadvantage contributes to ethnic disparities in multiple myeloma survival: a matched cohort study. (Buradagunta CS, Garacci Z, D'Souza A, Dhakal B, Devata S, Janz S, Thrift AP, Hari P, Stolley M, Dong J) Blood Cancer J 2022 May 25;12(5):82 PMID: 35614050 PMCID: PMC9132975 SCOPUS ID: 2-s2.0-85130720530 05/26/2022 3 Citations

Black patients with multiple myeloma have better survival than white patients when treated equally: a matched cohort study. (Dong J, Garacci Z, Buradagunta CS, D'Souza A, Mohan M, Cunningham A, Janz S, Dhakal B, Thrift AP, Hari P) Blood Cancer J 2022 Feb 24;12(2):34 PMID: 35210395 PMCID: PMC8873507 SCOPUS ID: 2-s2.0-85125303734 02/26/2022 19 Citations

Critical Role for Cap-Independent c-MYC Translation in Progression of Multiple Myeloma. (Shi Y, Sun F, Cheng Y, Holmes B, Dhakal B, Gera JF, Janz S, Lichtenstein A) Mol Cancer Ther 2022 Apr 01;21(4):502-510 PMID: 35086951 PMCID: PMC8983490 SCOPUS ID: 2-s2.0-85128145497 01/29/2022 3 Citations

WDR26 and MTF2 are therapeutic targets in multiple myeloma. (Sun F, Cheng Y, Riordan JD, Dupuy A, Dubois W, Pisano M, Dong J, Mock B, Zhan F, Hari P, Janz S) J Hematol Oncol 2021 Dec 07;14(1):203 PMID: 34876184 PMCID: PMC8650373 SCOPUS ID: 2-s2.0-85120899924 12/09/2021 7 Citations

CHEK1 and circCHEK1_246aa evoke chromosomal instability and induce bone lesion formation in multiple myeloma (Gu C, Wang W, Tang X, Xu T, Zhang Y, Guo M, Wei R, Wang Y, Jurczyszyn A, Janz S, Beksac M, Zhan F, Seckinger A, Hose D, Pan J, Yang Y) Molecular Cancer December 2021;20(1) SCOPUS ID: 2-s2.0-85107366864 12/01/2021 33 Citations

Laboratory Mice - A Driving Force in Immunopathology and Immunotherapy Studies of Human Multiple Myeloma. (Pisano M, Cheng Y, Sun F, Dhakal B, D'Souza A, Chhabra S, Knight JM, Rao S, Zhan F, Hari P, Janz S) Front Immunol 2021;12:667054 PMID: 34149703 PMCID: PMC8206561 SCOPUS ID: 2-s2.0-85108140164 06/22/2021 2 Citations

CHEK1 and circCHEK1_246aa evoke chromosomal instability and induce bone lesion formation in multiple myeloma. (Gu C, Wang W, Tang X, Xu T, Zhang Y, Guo M, Wei R, Wang Y, Jurczyszyn A, Janz S, Beksac M, Zhan F, Seckinger A, Hose D, Pan J, Yang Y) Mol Cancer 2021 Jun 05;20(1):84 PMID: 34090465 PMCID: PMC8178856 SCOPUS ID: 2-s2.0-85107366864 06/07/2021 33 Citations

TRIP13 modulates protein deubiquitination and accelerates tumor development and progression of B cell malignancies. (Li C, Xia J, Franqui-Machin R, Chen F, He Y, Ashby TC, Teng F, Xu H, Liu D, Gai D, Johnson SK, van Rhee F, Janz S, Shaughnessy JD Jr, Tricot G, Frech I, Zhan F) J Clin Invest 2021 Jul 15;131(14) PMID: 34061780 PMCID: PMC8279583 SCOPUS ID: 2-s2.0-85110299073 06/02/2021 11 Citations

HNRNPA2B1 promotes multiple myeloma progression by increasing AKT3 expression via m6A-dependent stabilization of ILF3 mRNA. (Jiang F, Tang X, Tang C, Hua Z, Ke M, Wang C, Zhao J, Gao S, Jurczyszyn A, Janz S, Beksac M, Zhan F, Gu C, Yang Y) J Hematol Oncol 2021 Apr 01;14(1):54 PMID: 33794982 PMCID: PMC8017865 SCOPUS ID: 2-s2.0-85103537142 04/03/2021 69 Citations

Suppression of steroid 5α-reductase type I promotes cellular apoptosis and autophagy via PI3K/Akt/mTOR pathway in multiple myeloma. (Dou R, Qian J, Wu W, Zhang Y, Yuan Y, Guo M, Wei R, Yang S, Jurczyszyn A, Janz S, Beksac M, Gu C, Yang Y) Cell Death Dis 2021 Feb 24;12(2):206 PMID: 33627630 PMCID: PMC7904855 SCOPUS ID: 2-s2.0-85101499978 02/26/2021 12 Citations

Autonomic nervous system control of multiple myeloma. (Cheng Y, Sun F, D'Souza A, Dhakal B, Pisano M, Chhabra S, Stolley M, Hari P, Janz S) Blood Rev 2021 Mar;46:100741 PMID: 32807576 PMCID: PMC7876165 SCOPUS ID: 2-s2.0-85089534779 08/19/2020 12 Citations

Prevalence and significance of sarcopenia in multiple myeloma patients undergoing autologous hematopoietic cell transplantation. (Williams A, Baruah D, Patel J, Szabo A, Chhabra S, Dhakal B, Hari P, Janz S, Stolley M, D'Souza A) Bone Marrow Transplant 2021 Jan;56(1):225-231 PMID: 32732941 PMCID: PMC7855279 SCOPUS ID: 2-s2.0-85088830942 08/01/2020 20 Citations

Trends in the use of therapeutic plasma exchange in multiple myeloma. (Dhakal B, Miller S, Rein L, Pathak LK, Gloria L, Szabo A, Giri S, Chhabra S, Hamadani M, Paner A, Padmanabhan A, Janz S, D'Souza A, Hari P) J Clin Apher 2020 Aug;35(4):307-315 PMID: 32516865 SCOPUS ID: 2-s2.0-85086092696 06/10/2020 3 Citations

MYC needs MNT to drive B cells over the edge. (Janz S) Blood 2020 Mar 26;135(13):977-978 PMID: 32219348 PMCID: PMC7099328 SCOPUS ID: 2-s2.0-85082561383 03/29/2020 1 Citation

Association of adverse events and associated cost with efficacy for approved relapsed and/or refractory multiple myeloma regimens: A Bayesian network meta-analysis of phase 3 randomized controlled trials. (Dhakal B, Narra RK, Giri S, Szabo A, Smunt TL, Ghose S, Pathak LK, Aryal M, Hamadani M, Chhabra S, Janz S, D'Souza A, Hari PN) Cancer 2020 Jun 15;126(12):2791-2801 PMID: 32154922 SCOPUS ID: 2-s2.0-85081273628 03/11/2020 5 Citations

Correction to: Upregulation of FOXM1 leads to diminished drug sensitivity in myeloma. (Gu C, Jing X, Holman C, Sompallae R, Zhan F, Tricot G, Yang Y, Janz S) BMC Cancer 2019 Dec 20;19(1):1238 PMID: 31862002 PMCID: PMC6923850 SCOPUS ID: 2-s2.0-85077075750 12/22/2019 2 Citations

Coactivation of NF-κB and Notch signaling is sufficient to induce B-cell transformation and enables B-myeloid conversion. (Xiu Y, Dong Q, Fu L, Bossler A, Tang X, Boyce B, Borcherding N, Leidinger M, Sardina JL, Xue HH, Li Q, Feldman A, Aifantis I, Boccalatte F, Wang L, Jin M, Khoury J, Wang W, Hu S, Yuan Y, Wang E, Yuan J, Janz S, Colgan J, Habelhah H, Waldschmidt T, Müschen M, Bagg A, Darbro B, Zhao C) Blood 2020 Jan 09;135(2):108-120 PMID: 31697816 PMCID: PMC6952829 SCOPUS ID: 2-s2.0-85077760977 11/08/2019 16 Citations

Identification and Characterization of Tumor-Initiating Cells in Multiple Myeloma. (Gao M, Bai H, Jethava Y, Wu Y, Zhu Y, Yang Y, Xia J, Cao H, Franqui-Machin R, Nadiminti K, Thomas GS, Salama ME, Altevogt P, Bishop G, Tomasson M, Janz S, Shi J, Chen L, Frech I, Tricot G, Zhan F) J Natl Cancer Inst 2020 May 01;112(5):507-515 PMID: 31406992 PMCID: PMC7225664 SCOPUS ID: 2-s2.0-85084784202 08/14/2019 31 Citations

Myeloma sleeper agent in myeloid disguise. (Dhakal B, Janz S) Blood 2019 Jul 04;134(1):3-4 PMID: 31273002 SCOPUS ID: 2-s2.0-85069268458 07/06/2019 2 Citations

Osteolytic disease in IL-6 and Myc dependent mouse model of human myeloma. (Sun F, Cheng Y, Walsh SA, Acevedo MR, Jing X, Han SS, Pisano MD, Tomasson MH, Lichtenstein AK, Zhan F, Hari P, Janz S) Haematologica 2020 Mar;105(3):e111-e115 PMID: 31221780 PMCID: PMC7049347 SCOPUS ID: 2-s2.0-85080963194 06/22/2019 4 Citations

Germline Risk Contribution to Genomic Instability in Multiple Myeloma. (Janz S, Zhan F, Sun F, Cheng Y, Pisano M, Yang Y, Goldschmidt H, Hari P) Front Genet 2019;10:424 PMID: 31139207 PMCID: PMC6518313 SCOPUS ID: 2-s2.0-85067859695 05/30/2019 13 Citations

Chronic intermittent hypoxia enhances disease progression in myeloma-resistant mice. (Ali M, Kowkuntla S, Delloro DJ, Galambos C, Hathi D, Janz S, Shokeen M, Tripathi C, Xu H, Yuk J, Zhan F, Tomasson MH, Bates ML) Am J Physiol Regul Integr Comp Physiol 2019 May 01;316(5):R678-R686 PMID: 30892915 PMCID: PMC6589607 SCOPUS ID: 2-s2.0-85066056744 03/21/2019 8 Citations

New wrinkle on deubiquitination in B-cell lymphoma. (Janz S) Blood 2018 Dec 13;132(24):2529-2530 PMID: 30545891 SCOPUS ID: 2-s2.0-85058444199 12/14/2018

Upregulation of FOXM1 leads to diminished drug sensitivity in myeloma. (Gu C, Jing X, Holman C, Sompallae R, Zhan F, Tricot G, Yang Y, Janz S) BMC Cancer 2018 Nov 21;18(1):1152 PMID: 30463534 PMCID: PMC6249818 SCOPUS ID: 2-s2.0-85056964781 11/23/2018 17 Citations

Upregulation of FOXM1 in a subset of relapsed myeloma results in poor outcome. (Gu C, Holman C, Sompallae R, Jing X, Tomasson M, Hose D, Seckinger A, Zhan F, Tricot G, Goldschmidt H, Yang Y, Janz S) Blood Cancer J 2018 Feb 15;8(2):22 PMID: 29449574 PMCID: PMC5814454 SCOPUS ID: 2-s2.0-85042179699 02/17/2018 16 Citations

Chromosomal instability and acquired drug resistance in multiple myeloma. (Wang W, Zhang Y, Chen R, Tian Z, Zhai Y, Janz S, Gu C, Yang Y) Oncotarget 2017 Sep 29;8(44):78234-78244 PMID: 29100463 PMCID: PMC5652852 SCOPUS ID: 2-s2.0-85030310890 11/05/2017 20 Citations

NEK2 induces osteoclast differentiation and bone destruction via heparanase in multiple myeloma. (Hao M, Franqui-Machin R, Xu H, Shaughnessy J Jr, Barlogie B, Roodman D, Quelle DE, Janz S, Tomasson MH, Sanderson RD, Qiu L, Frech I, Tricot G, Zhan F) Leukemia 2017 Jul;31(7):1648-1650 PMID: 28400617 PMCID: PMC5508075 SCOPUS ID: 2-s2.0-85021748993 04/13/2017 25 Citations

Transgenic mouse model of IgM⁺ lymphoproliferative disease mimicking Waldenström macroglobulinemia. (Tompkins VS, Sompallae R, Rosean TR, Walsh S, Acevedo M, Kovalchuk AL, Han SS, Jing X, Holman C, Rehg JE, Herms S, Sunderland JS, Morse HC, Janz S) Blood Cancer J 2016 Nov 04;6(11):e488 PMID: 27813533 PMCID: PMC5148059 SCOPUS ID: 2-s2.0-84994631132 11/05/2016 3 Citations

Mouse model of MYD88L265P-dependent DLBCL. (Janz S) Blood 2016 Jun 02;127(22):2660-1 PMID: 27257177 SCOPUS ID: 2-s2.0-84974588396 06/04/2016 1 Citation

PIAS1 Promotes Lymphomagenesis through MYC Upregulation. (Rabellino A, Melegari M, Tompkins VS, Chen W, Van Ness BG, Teruya-Feldstein J, Conacci-Sorrell M, Janz S, Scaglioni PP) Cell Rep 2016 Jun 07;15(10):2266-2278 PMID: 27239040 PMCID: PMC4899214 SCOPUS ID: 2-s2.0-84969800844 05/31/2016 36 Citations

KSHV-encoded vIL-6 collaborates with deregulated c-Myc to drive plasmablastic neoplasms in mice. (Rosean TR, Holman CJ, Tompkins VS, Jing X, Krasowski MD, Rose-John S, Janz S) Blood Cancer J 2016 Feb 26;6(2):e398 PMID: 26918362 PMCID: PMC4771969 SCOPUS ID: 2-s2.0-85010733599 02/27/2016 16 Citations

FOXM1 is a therapeutic target for high-risk multiple myeloma. (Gu C, Yang Y, Sompallae R, Xu H, Tompkins VS, Holman C, Hose D, Goldschmidt H, Tricot G, Zhan F, Janz S) Leukemia 2016 Apr;30(4):873-82 PMID: 26648534 PMCID: PMC4826574 SCOPUS ID: 2-s2.0-84955608036 12/10/2015 40 Citations

Cancer stem cells are the cause of drug resistance in multiple myeloma: fact or fiction? (Franqui-Machin R, Wendlandt EB, Janz S, Zhan F, Tricot G) Oncotarget 2015 Dec 01;6(38):40496-506 PMID: 26415231 PMCID: PMC4747348 SCOPUS ID: 2-s2.0-84950996666 09/29/2015 39 Citations

Adoptive B-cell transfer mouse model of human myeloma. (Tompkins VS, Rosean TR, Holman CJ, DeHoedt C, Olivier AK, Duncan KM, Jing X, Foor SD, Acevedo MR, Walsh SA, Tricot G, Zhan F, Janz S) Leukemia 2016 Apr;30(4):962-6 PMID: 26202932 PMCID: PMC4821809 SCOPUS ID: 2-s2.0-84938902459 07/24/2015 5 Citations

RIP1 Cleavage in the Kinase Domain Regulates TRAIL-Induced NF-κB Activation and Lymphoma Survival. (Zhang L, Blackwell K, Workman LM, Chen S, Pope MR, Janz S, Habelhah H) Mol Cell Biol 2015 Oct;35(19):3324-38 PMID: 26195820 PMCID: PMC4561725 SCOPUS ID: 2-s2.0-84941046993 07/22/2015 27 Citations

CDKN1A and FANCD2 are potential oncotargets in Burkitt lymphoma and multiple myeloma. (Han SS, Tompkins VS, Son DJ, Han S, Yun H, Kamberos NL, Dehoedt CL, Gu C, Holman C, Tricot G, Zhan F, Janz S) Exp Hematol Oncol 2015;4:9 PMID: 25838973 PMCID: PMC4383050 SCOPUS ID: 2-s2.0-84978023684 04/04/2015 11 Citations

Bruton tyrosine kinase is a therapeutic target in stem-like cells from multiple myeloma. (Yang Y, Shi J, Gu Z, Salama ME, Das S, Wendlandt E, Xu H, Huang J, Tao Y, Hao M, Franqui R, Levasseur D, Janz S, Tricot G, Zhan F) Cancer Res 2015 Feb 01;75(3):594-604 PMID: 25589346 PMCID: PMC4384656 SCOPUS ID: 2-s2.0-84961289380 01/16/2015 64 Citations

NIAM-deficient mice are predisposed to the development of proliferative lesions including B-cell lymphomas. (Reed SM, Hagen J, Muniz VP, Rosean TR, Borcherding N, Sciegienka S, Goeken JA, Naumann PW, Zhang W, Tompkins VS, Janz S, Meyerholz DK, Quelle DE) PLoS One 2014;9(11):e112126 PMID: 25393878 PMCID: PMC4231569 SCOPUS ID: 2-s2.0-84911493985 11/14/2014 7 Citations

The tumor microenvironment is the main source of IL-6 for plasma cell tumor development in mice. (Rosean TR, Tompkins VS, Olivier AK, Sompallae R, Norian LA, Morse HC 3rd, Waldschmidt TJ, Janz S) Leukemia 2015 Jan;29(1):233-7 PMID: 25257990 PMCID: PMC4286499 SCOPUS ID: 2-s2.0-84920653683 09/27/2014 16 Citations

NEK2 mediates ALDH1A1-dependent drug resistance in multiple myeloma. (Yang Y, Zhou W, Xia J, Gu Z, Wendlandt E, Zhan X, Janz S, Tricot G, Zhan F) Oncotarget 2014 Dec 15;5(23):11986-97 PMID: 25230277 PMCID: PMC4322982 SCOPUS ID: 2-s2.0-84920054095 09/18/2014 53 Citations

Forkhead box M1 regulates quiescence-associated radioresistance of human head and neck squamous carcinoma cells. (Eckers JC, Kalen AL, Sarsour EH, Tompkins VS, Janz S, Son JM, Doskey CM, Buettner GR, Goswami PC) Radiat Res 2014 Oct;182(4):420-9 PMID: 25229973 PMCID: PMC4221113 SCOPUS ID: 2-s2.0-84922041422 09/18/2014 19 Citations

Preclinical validation of interleukin 6 as a therapeutic target in multiple myeloma. (Rosean TR, Tompkins VS, Tricot G, Holman CJ, Olivier AK, Zhan F, Janz S) Immunol Res 2014 Aug;59(1-3):188-202 PMID: 24845460 PMCID: PMC4209159 SCOPUS ID: 2-s2.0-84905747312 05/23/2014 46 Citations

A new model of LMP1-MYC interaction in B cell lymphoma. (Ontiveros EP, Halwani A, Stunz LL, Kamberos N, Olivier AK, Janz S, Bishop GA) Leuk Lymphoma 2014 Dec;55(12):2917-23 PMID: 24605938 PMCID: PMC4207734 SCOPUS ID: 2-s2.0-84919448221 03/13/2014 5 Citations

ALDH1 activity identifies tumor-initiating cells and links to chromosomal instability signatures in multiple myeloma. (Zhou W, Yang Y, Gu Z, Wang H, Xia J, Wu X, Zhan X, Levasseur D, Zhou Y, Janz S, Tricot G, Shi J, Zhan F) Leukemia 2014 May;28(5):1155-8 PMID: 24365790 PMCID: PMC4018236 SCOPUS ID: 2-s2.0-84899964003 12/25/2013 58 Citations

(18)F-FDG-PET/CT imaging in an IL-6- and MYC-driven mouse model of human multiple myeloma affords objective evaluation of plasma cell tumor progression and therapeutic response to the proteasome inhibitor ixazomib. (Duncan K, Rosean TR, Tompkins VS, Olivier A, Sompallae R, Zhan F, Tricot G, Acevedo MR, Ponto LL, Walsh SA, Tygrett LT, Berger AJ, Waldschmidt T, Morse HC 3rd, Sunderland JJ, Janz S) Blood Cancer J 2013 Nov 29;3(11):e165 PMID: 24292417 PMCID: PMC3880444 SCOPUS ID: 2-s2.0-84888393068 12/03/2013 23 Citations

Identification of candidate B-lymphoma genes by cross-species gene expression profiling. (Tompkins VS, Han SS, Olivier A, Syrbu S, Bair T, Button A, Jacobus L, Wang Z, Lifton S, Raychaudhuri P, Morse HC 3rd, Weiner G, Link B, Smith BJ, Janz S) PLoS One 2013;8(10):e76889 PMID: 24130802 PMCID: PMC3793908 SCOPUS ID: 2-s2.0-84885126448 10/17/2013 11 Citations

Waldenström macroglobulinemia: clinical and immunological aspects, natural history, cell of origin, and emerging mouse models. (Janz S) ISRN Hematol 2013 Sep 09;2013:815325 PMID: 24106612 PMCID: PMC3782845 10/10/2013

Piperlongumine inhibits LMP1/MYC-dependent mouse B-lymphoma cells. (Han SS, Tompkins VS, Son DJ, Kamberos NL, Stunz LL, Halwani A, Bishop GA, Janz S) Biochem Biophys Res Commun 2013 Jul 12;436(4):660-5 PMID: 23764397 PMCID: PMC3749779 SCOPUS ID: 2-s2.0-84880040845 06/15/2013 23 Citations

Reduced CXCR4 expression is associated with extramedullary disease in a mouse model of myeloma and predicts poor survival in multiple myeloma patients treated with bortezomib. (Stessman HA, Mansoor A, Zhan F, Janz S, Linden MA, Baughn LB, Van Ness B) Leukemia 2013 Oct;27(10):2075-7 PMID: 23728080 PMCID: PMC4053943 SCOPUS ID: 2-s2.0-84885595409 06/04/2013 43 Citations

Profiling bortezomib resistance identifies secondary therapies in a mouse myeloma model. (Stessman HA, Baughn LB, Sarver A, Xia T, Deshpande R, Mansoor A, Walsh SA, Sunderland JJ, Dolloff NG, Linden MA, Zhan F, Janz S, Myers CL, Van Ness BG) Mol Cancer Ther 2013 Jun;12(6):1140-50 PMID: 23536725 PMCID: PMC4076840 SCOPUS ID: 2-s2.0-84879293601 03/29/2013 62 Citations

Piperlongumine inhibits proliferation and survival of Burkitt lymphoma in vitro. (Han SS, Son DJ, Yun H, Kamberos NL, Janz S) Leuk Res 2013 Feb;37(2):146-54 PMID: 23237561 PMCID: PMC3551475 SCOPUS ID: 2-s2.0-84872374148 12/15/2012 46 Citations

The feed-forward loop between YB-1 and MYC is essential for multiple myeloma cell survival. (Bommert KS, Effenberger M, Leich E, Küspert M, Murphy D, Langer C, Moll R, Janz S, Mottok A, Weissbach S, Rosenwald A, Bargou R, Bommert K) Leukemia 2013 Feb;27(2):441-50 PMID: 22772059 PMCID: PMC4047128 SCOPUS ID: 2-s2.0-84873570632 07/10/2012 44 Citations

Characterization of ARF-BP1/HUWE1 interactions with CTCF, MYC, ARF and p53 in MYC-driven B cell neoplasms. (Qi CF, Kim YS, Xiang S, Abdullaev Z, Torrey TA, Janz S, Kovalchuk AL, Sun J, Chen D, Cho WC, Gu W, Morse Iii HC) Int J Mol Sci 2012;13(5):6204-6219 PMID: 22754359 PMCID: PMC3382761 SCOPUS ID: 2-s2.0-84861548210 07/04/2012 27 Citations

HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice. (Suthaus J, Stuhlmann-Laeisz C, Tompkins VS, Rosean TR, Klapper W, Tosato G, Janz S, Scheller J, Rose-John S) Blood 2012 May 31;119(22):5173-81 PMID: 22490805 PMCID: PMC3370672 SCOPUS ID: 2-s2.0-84861851475 04/12/2012 103 Citations

Global gene expression profiling in mouse plasma cell tumor precursor and bystander cells reveals potential intervention targets for plasma cell neoplasia. (LeGrand J, Park ES, Wang H, Gupta S, Owens JD Jr, Nelson PJ, DuBois W, Bair T, Janz S, Mushinski JF) Blood 2012 Jan 26;119(4):1018-28 PMID: 22147894 PMCID: PMC3271714 SCOPUS ID: 2-s2.0-84863016051 12/08/2011 5 Citations

Antitumor activity of the investigational proteasome inhibitor MLN9708 in mouse models of B-cell and plasma cell malignancies. (Lee EC, Fitzgerald M, Bannerman B, Donelan J, Bano K, Terkelsen J, Bradley DP, Subakan O, Silva MD, Liu R, Pickard M, Li Z, Tayber O, Li P, Hales P, Carsillo M, Neppalli VT, Berger AJ, Kupperman E, Manfredi M, Bolen JB, Van Ness B, Janz S) Clin Cancer Res 2011 Dec 01;17(23):7313-23 PMID: 21903769 PMCID: PMC3443972 SCOPUS ID: 2-s2.0-82555189384 09/10/2011 94 Citations

B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia. (Zhang W, Kater AP, Widhopf GF 2nd, Chuang HY, Enzler T, James DF, Poustovoitov M, Tseng PH, Janz S, Hoh C, Herschman H, Karin M, Kipps TJ) Proc Natl Acad Sci U S A 2010 Nov 02;107(44):18956-60 PMID: 20956327 PMCID: PMC2973856 SCOPUS ID: 2-s2.0-78650481186 10/20/2010 56 Citations

Anaplastic plasmacytoma of mouse--establishing parallels between subtypes of mouse and human plasma cell neoplasia. (de Jong D, Janz S) J Pathol 2010 Jul;221(3):242-7 PMID: 20527018 PMCID: PMC3118561 SCOPUS ID: 2-s2.0-77953496573 06/09/2010 2 Citations

Genetic reporter system for oncogenic Igh-Myc translocations in mice. (Takizawa M, Kim JS, Tessarollo L, McNeil N, Waldschmidt TJ, Casellas R, Ried T, Janz S) Oncogene 2010 Jul 15;29(28):4113-20 PMID: 20453890 PMCID: PMC3108853 SCOPUS ID: 2-s2.0-77954757627 05/11/2010 1 Citation

NF-kappaB/STAT3/PI3K signaling crosstalk in iMyc E mu B lymphoma. (Han SS, Yun H, Son DJ, Tompkins VS, Peng L, Chung ST, Kim JS, Park ES, Janz S) Mol Cancer 2010 Apr 30;9:97 PMID: 20433747 PMCID: PMC2876994 SCOPUS ID: 2-s2.0-77951566551 05/04/2010 97 Citations

Ectopic expression of wild-type FGFR3 cooperates with MYC to accelerate development of B-cell lineage neoplasms. (Zingone A, Cultraro CM, Shin DM, Bean CM, Morse HC 3rd, Janz S, Kuehl WM) Leukemia 2010 Jun;24(6):1171-8 PMID: 20393505 PMCID: PMC3118571 SCOPUS ID: 2-s2.0-77954603996 04/16/2010 20 Citations

IL-6 and MYC collaborate in plasma cell tumor formation in mice. (Rutsch S, Neppalli VT, Shin DM, DuBois W, Morse HC 3rd, Goldschmidt H, Janz S) Blood 2010 Mar 04;115(9):1746-54 PMID: 20018915 PMCID: PMC2832814 SCOPUS ID: 2-s2.0-77950343306 12/19/2009 42 Citations

Prevalence and frequency of circulating t(14;18)-MBR translocation carrying cells in healthy individuals. (Schüler F, Dölken L, Hirt C, Kiefer T, Berg T, Fusch G, Weitmann K, Hoffmann W, Fusch C, Janz S, Rabkin CS, Dölken G) Int J Cancer 2009 Feb 15;124(4):958-63 PMID: 19030176 PMCID: PMC4216731 SCOPUS ID: 2-s2.0-58149461574 11/26/2008 81 Citations

Deregulation of c-Myc Confers distinct survival requirements for memory B cells, plasma cells, and their progenitors. (Khuda SE, Loo WM, Janz S, Van Ness B, Erickson LD) J Immunol 2008 Dec 01;181(11):7537-49 PMID: 19017943 PMCID: PMC2841033 SCOPUS ID: 2-s2.0-71849100851 11/20/2008 22 Citations

Mechanisms and consequences of chromosomal translocation. (Rabkin CS, Janz S) Cancer Epidemiol Biomarkers Prev 2008 Aug;17(8):1849-51 PMID: 18708370 PMCID: PMC2562255 SCOPUS ID: 2-s2.0-54049136580 08/19/2008 1 Citation

t(14;18) Translocations and risk of follicular lymphoma. (Rabkin CS, Hirt C, Janz S, Dölken G) J Natl Cancer Inst Monogr 2008(39):48-51 PMID: 18648003 PMCID: PMC6948841 SCOPUS ID: 2-s2.0-52149096949 07/24/2008 25 Citations

Genetic and environmental cofactors of Myc translocations in plasma cell tumor development in mice. (Janz S) J Natl Cancer Inst Monogr 2008(39):37-40 PMID: 18648000 SCOPUS ID: 2-s2.0-52149120771 07/24/2008 7 Citations

Overview of mechanisms and consequences of chromosomal translocation. (Rabkin CS, Janz S) J Natl Cancer Inst Monogr 2008(39):1 PMID: 18647992 SCOPUS ID: 2-s2.0-52149115623 07/24/2008

Response to Guglielmi et al., "The 3′IgH regulatory region is active at immature stages of B-cell development" [2] (Eckhardt LA, Yan Y, Janz S) Genes Chromosomes and Cancer January 2008;47(1):94 SCOPUS ID: 2-s2.0-36549044897 01/01/2008

AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements. (Kovalchuk AL, duBois W, Mushinski E, McNeil NE, Hirt C, Qi CF, Li Z, Janz S, Honjo T, Muramatsu M, Ried T, Behrens T, Potter M) J Exp Med 2007 Nov 26;204(12):2989-3001 PMID: 17998390 PMCID: PMC2118515 SCOPUS ID: 2-s2.0-36549007391 11/14/2007 43 Citations

Attenuation of WNT signaling by DKK-1 and -2 regulates BMP2-induced osteoblast differentiation and expression of OPG, RANKL and M-CSF. (Fujita K, Janz S) Mol Cancer 2007 Oct 30;6:71 PMID: 17971207 PMCID: PMC2173906 SCOPUS ID: 2-s2.0-37749040562 11/01/2007 152 Citations

Gene expression profiling reveals different pathways related to Abl and other genes that cooperate with c-Myc in a model of plasma cell neoplasia. (Park ES, Shaughnessy JD Jr, Gupta S, Wang H, Lee JS, Woo HG, Zhan F, Owens JD Jr, Potter M, Janz S, Mushinski JF) BMC Genomics 2007 Aug 31;8:302 PMID: 17764563 PMCID: PMC2040348 SCOPUS ID: 2-s2.0-35448946833 09/04/2007 19 Citations

In a model of immunoglobulin heavy-chain (IGH)/MYC translocation, the Igh 3' regulatory region induces MYC expression at the immature stage of B cell development. (Yan Y, Park SS, Janz S, Eckhardt LA) Genes Chromosomes Cancer 2007 Oct;46(10):950-9 PMID: 17639584 PMCID: PMC2742353 SCOPUS ID: 2-s2.0-34548784305 07/20/2007 16 Citations

Distribution of t(14;18)-positive, putative lymphoma precursor cells among B-cell subsets in healthy individuals. (Hirt C, Dölken G, Janz S, Rabkin CS) Br J Haematol 2007 Aug;138(3):349-53 PMID: 17614821 SCOPUS ID: 2-s2.0-34447133546 07/07/2007 33 Citations

A transgenic mouse model of plasma cell malignancy shows phenotypic, cytogenetic, and gene expression heterogeneity similar to human multiple myeloma. (Boylan KL, Gosse MA, Staggs SE, Janz S, Grindle S, Kansas GS, Van Ness BG) Cancer Res 2007 May 01;67(9):4069-78 PMID: 17483317 SCOPUS ID: 2-s2.0-34249311959 05/08/2007 36 Citations

Regulation of AID expression in the immune response. (Crouch EE, Li Z, Takizawa M, Fichtner-Feigl S, Gourzi P, Montaño C, Feigenbaum L, Wilson P, Janz S, Papavasiliou FN, Casellas R) J Exp Med 2007 May 14;204(5):1145-56 PMID: 17452520 PMCID: PMC2118564 SCOPUS ID: 2-s2.0-34249108271 04/25/2007 209 Citations

Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells. (Qi CF, Zhou JX, Lee CH, Naghashfar Z, Xiang S, Kovalchuk AL, Fredrickson TN, Hartley JW, Roopenian DC, Davidson WF, Janz S, Morse HC 3rd) Cancer Res 2007 Mar 15;67(6):2439-47 PMID: 17363561 SCOPUS ID: 2-s2.0-34047272699 03/17/2007 23 Citations

TCL1-induced germinal center B lymphomas in mice (Janz S) Blood 15 September 2006;108(6):1791-1792 SCOPUS ID: 2-s2.0-33748711624 09/15/2006

Distinct MYC thresholds in hematopoietic neoplasia (Janz S) Blood 15 July 2006;108(2):413 SCOPUS ID: 2-s2.0-33745954518 07/15/2006

Myc translocations in B cell and plasma cell neoplasms. (Janz S) DNA Repair (Amst) 2006 Sep 08;5(9-10):1213-24 PMID: 16815105 SCOPUS ID: 2-s2.0-33747893961 07/04/2006 85 Citations

CDDO-Imidazolide inhibits growth and survival of c-Myc-induced mouse B cell and plasma cell neoplasms. (Han SS, Peng L, Chung ST, DuBois W, Maeng SH, Shaffer AL, Sporn MB, Janz S) Mol Cancer 2006 Jun 07;5:22 PMID: 16759389 PMCID: PMC1553469 SCOPUS ID: 2-s2.0-33748131759 06/09/2006 15 Citations

Plasma cell tumour progression in iMycEmu gene-insertion mice. (Kim JS, Han SS, Park SS, McNeil N, Janz S) J Pathol 2006 May;209(1):44-55 PMID: 16482495 SCOPUS ID: 2-s2.0-33645976496 02/17/2006 9 Citations

Molecular and cytological features of the mouse B-cell lymphoma line iMycEmu-1. (Han SS, Shaffer AL, Peng L, Chung ST, Lim JH, Maeng S, Kim JS, McNeil N, Ried T, Staudt LM, Janz S) Mol Cancer 2005 Nov 09;4:40 PMID: 16277667 PMCID: PMC1298327 SCOPUS ID: 2-s2.0-27944461833 11/10/2005 6 Citations

Insertion of Myc into Igh accelerates peritoneal plasmacytomas in mice. (Park SS, Shaffer AL, Kim JS, duBois W, Potter M, Staudt LM, Janz S) Cancer Res 2005 Sep 01;65(17):7644-52 PMID: 16140930 SCOPUS ID: 2-s2.0-24744440161 09/06/2005 21 Citations

Uncovering MYC's full oncogenic potential in the hematopoietic system. (Janz S) Oncogene 2005 May 19;24(22):3541-3 PMID: 15782131 SCOPUS ID: 2-s2.0-19944390643 03/23/2005 8 Citations

Extraosseous IL-6 transgenic mouse plasmacytoma sometimes lacks Myc-activating chromosomal translocation. (McNeil N, Kim JS, Ried T, Janz S) Genes Chromosomes Cancer 2005 Jun;43(2):137-46 PMID: 15751044 SCOPUS ID: 2-s2.0-17644375145 03/08/2005 6 Citations

Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice. (Park SS, Kim JS, Tessarollo L, Owens JD, Peng L, Han SS, Tae Chung S, Torrey TA, Cheung WC, Polakiewicz RD, McNeil N, Ried T, Mushinski JF, Morse HC 3rd, Janz S) Cancer Res 2005 Feb 15;65(4):1306-15 PMID: 15735016 SCOPUS ID: 2-s2.0-13944254718 03/01/2005 99 Citations

Location of Myc, Igh, and Igk on Robertsonian fusion chromosomes is inconsequential for Myc translocations and plasmacytoma development in mice, but Rb(6.15)-carrying tumors prefer Igk-Myc inversions over translocations. (Silva S, Wiener F, Klein G, Janz S) Genes Chromosomes Cancer 2005 Apr;42(4):416-26 PMID: 15645495 SCOPUS ID: 2-s2.0-13944249559 01/13/2005 7 Citations

Deregulated expression of the Myc cellular oncogene drives development of mouse "Burkitt-like" lymphomas from naive B cells. (Zhu D, Qi CF, Morse HC 3rd, Janz S, Stevenson FK) Blood 2005 Mar 01;105(5):2135-7 PMID: 15522957 SCOPUS ID: 2-s2.0-14944339170 11/04/2004 34 Citations

Novel targeted deregulation of c-Myc cooperates with Bcl-X(L) to cause plasma cell neoplasms in mice. (Cheung WC, Kim JS, Linden M, Peng L, Van Ness B, Polakiewicz RD, Janz S) J Clin Invest 2004 Jun;113(12):1763-73 PMID: 15199411 PMCID: PMC420503 SCOPUS ID: 2-s2.0-3042806890 06/17/2004 95 Citations

Selenium deficiency abrogates inflammation-dependent plasma cell tumors in mice. (Felix K, Gerstmeier S, Kyriakopoulos A, Howard OM, Dong HF, Eckhaus M, Behne D, Bornkamm GW, Janz S) Cancer Res 2004 Apr 15;64(8):2910-7 PMID: 15087411 SCOPUS ID: 2-s2.0-1942532136 04/17/2004 31 Citations

Elevated presence of retrotransposons at sites of DNA double strand break repair in mouse models of metabolic oxidative stress and MYC-induced lymphoma. (Rockwood LD, Felix K, Janz S) Mutat Res 2004 Apr 14;548(1-2):117-25 PMID: 15063142 SCOPUS ID: 2-s2.0-1842561717 04/06/2004 21 Citations

Moderate hypermutability of a transgenic lacZ reporter gene in Myc-dependent inflammation-induced plasma cell tumors in mice. (Felix K, Polack A, Pretsch W, Jackson SH, Feigenbaum L, Bornkamm GW, Janz S) Cancer Res 2004 Jan 15;64(2):530-7 PMID: 14744766 SCOPUS ID: 2-s2.0-1642556806 01/28/2004 5 Citations

BCL2 accelerates inflammation-induced BALB/c plasmacytomas and promotes novel tumors with coexisting T(12;15) and T(6;15) translocations. (Silva S, Kovalchuk AL, Kim JS, Klein G, Janz S) Cancer Res 2003 Dec 15;63(24):8656-63 PMID: 14695177 SCOPUS ID: 2-s2.0-0347320792 12/26/2003 26 Citations

COMBO-FISH: specific labeling of nondenatured chromatin targets by computer-selected DNA oligonucleotide probe combinations. (Hausmann M, Winkler R, Hildenbrand G, Finsterle J, Weisel A, Rapp A, Schmitt E, Janz S, Cremer C) Biotechniques 2003 Sep;35(3):564-70, 572-7 PMID: 14513562 SCOPUS ID: 2-s2.0-0042691476 09/30/2003 47 Citations

Paradoxical decrease in mutant frequencies and chromosomal rearrangements in a transgenic lacZ reporter gene in Ku80 null mice deficient in DNA double strand break repair. (Rockwood LD, Nussenzweig A, Janz S) Mutat Res 2003 Aug 28;529(1-2):51-8 PMID: 12943919 SCOPUS ID: 2-s2.0-0041508764 08/29/2003 15 Citations

E mu/S mu transposition into Myc is sometimes a precursor for T(12;15) translocation in mouse B cells. (Kovalchuk AL, Kim JS, Janz S) Oncogene 2003 May 08;22(18):2842-50 PMID: 12743607 SCOPUS ID: 2-s2.0-0037616590 05/14/2003 7 Citations

Lymphoma- and leukemia-associated chromosomal translocations in healthy individuals. (Janz S, Potter M, Rabkin CS) Genes Chromosomes Cancer 2003 Mar;36(3):211-23 PMID: 12557221 SCOPUS ID: 2-s2.0-0037361298 01/31/2003 135 Citations

Redox imbalance and mutagenesis in spleens of mice harboring a hypomorphic allele of Gpdx(a) encoding glucose 6-phosphate dehydrogenase. (Felix K, Rockwood LD, Pretsch W, Bornkamm GW, Janz S) Free Radic Biol Med 2003 Jan 15;34(2):226-32 PMID: 12521604 SCOPUS ID: 2-s2.0-0037438878 01/11/2003 8 Citations

Bcl-2 reduces mutant rates in a transgenic lacZ reporter gene in mouse pre-B lymphocytes. (Felix K, Rolink A, Melchers F, Janz S) Mutat Res 2003 Jan 28;522(1-2):135-44 PMID: 12517419 SCOPUS ID: 2-s2.0-0037469393 01/09/2003 3 Citations

Genomic instability in mouse Burkitt lymphoma is dominated by illegitimate genetic recombinations, not point mutations. (Rockwood LD, Torrey TA, Kim JS, Coleman AE, Kovalchuk AL, Xiang S, Ried T, Morse HC 3rd, Janz S) Oncogene 2002 Oct 17;21(47):7235-40 PMID: 12370814 SCOPUS ID: 2-s2.0-0037126384 10/09/2002 24 Citations

Isotype switch-mediated CH deletions are a recurrent feature of Myc/CH translocations in peritoneal plasmacytomas in mice. (Kovalchuk AL, Janz S) Int J Cancer 2002 Oct 10;101(5):423-6 PMID: 12216069 SCOPUS ID: 2-s2.0-0037057518 09/07/2002 5 Citations

Transgenic shuttle vector assays for determining genetic differences in oxidative B cell mutagenesis in vivo. (Felix K, Rockwood LD, Janz S) Methods Enzymol 2002;353:434-48 PMID: 12078516 SCOPUS ID: 2-s2.0-0036286519 06/25/2002 3 Citations

Moderate G6PD deficiency increases mutation rates in the brain of mice. (Felix K, Rockwood LD, Pretsch W, Nair J, Bartsch H, Bornkamm GW, Janz S) Free Radic Biol Med 2002 Apr 01;32(7):663-73 PMID: 11909700 SCOPUS ID: 2-s2.0-0036532524 03/23/2002 20 Citations

IL-6 transgenic mouse model for extraosseous plasmacytoma. (Kovalchuk AL, Kim JS, Park SS, Coleman AE, Ward JM, Morse HC 3rd, Kishimoto T, Potter M, Janz S) Proc Natl Acad Sci U S A 2002 Feb 05;99(3):1509-14 PMID: 11805288 PMCID: PMC122221 SCOPUS ID: 2-s2.0-0037022341 01/24/2002 113 Citations

Conformational differences in the 3-D nanostructure of the immunoglobulin heavy-chain locus, a hotspot of chromosomal translocations in B lymphocytes. (Esa A, Coleman AE, Edelmann P, Silva S, Cremer CG, Janz S) Cancer Genet Cytogenet 2001 Jun;127(2):168-73 PMID: 11425458 SCOPUS ID: 2-s2.0-0034968320 06/27/2001 23 Citations

Non-Hodgkin lymphomas of mice. (Hori M, Xiang S, Qi CF, Chattopadhyay SK, Fredrickson TN, Hartley JW, Kovalchuk AL, Bornkamm GW, Janz S, Copeland NG, Jenkins NA, Ward JM, Morse HC 3rd) Blood Cells Mol Dis 2001;27(1):217-22 PMID: 11358382 SCOPUS ID: 2-s2.0-0035051756 05/19/2001 12 Citations

Translocation remodeling in the primary BALB/c plasmacytoma TEPC 3610. (Kovalchuk AL, Esa A, Coleman AE, Park SS, Ried T, Cremer CC, Janz S) Genes Chromosomes Cancer 2001 Mar;30(3):283-91 PMID: 11170286 SCOPUS ID: 2-s2.0-0035154325 02/15/2001 10 Citations

Inducible mutagenesis in TEPC 2372, a mouse plasmacytoma cell line that harbors the transgenic shuttle vector lambdaLIZ. (Felix K, Kovalchuk AL, Park SS, Coleman AE, Ramsay ES, Qian M, Kelliher KA, Jones GM, Ried T, Bornkamm GW, Janz S) Mutat Res 2001 Jan 25;473(1):121-36 PMID: 11166031 SCOPUS ID: 2-s2.0-0035945688 02/13/2001 1 Citation

Burkitt lymphoma in the mouse. (Kovalchuk AL, Qi CF, Torrey TA, Taddesse-Heath L, Feigenbaum L, Park SS, Gerbitz A, Klobeck G, Hoertnagel K, Polack A, Bornkamm GW, Janz S, Morse HC 3rd) J Exp Med 2000 Oct 16;192(8):1183-90 PMID: 11034608 PMCID: PMC2195876 SCOPUS ID: 2-s2.0-0034675943 10/18/2000 182 Citations

Chromosomes 1 and 5 harbor plasmacytoma progressor genes in mice. (Coleman AE, Ried T, Janz S) Genes Chromosomes Cancer 2000 Sep;29(1):70-4 PMID: 10918396 SCOPUS ID: 2-s2.0-0033861134 08/05/2000 11 Citations

Lymph nodes and Peyer's patches of IL-6 transgenic BALB/c mice harbor T(12;15) translocated plasma cells that contain illegitimate exchanges between the immunoglobulin heavy-chain mu locus and c-myc. (Kovalchuk AL, Kishimoto T, Janz S) Leukemia 2000 Jun;14(6):1127-35 PMID: 10865979 SCOPUS ID: 2-s2.0-0034081363 06/24/2000 19 Citations

Clonal diversification of primary BALB/c plasmacytomas harboring T(12;15) chromosomal translocations. (Kovalchuk AL, Mushinski EB, Janz S) Leukemia 2000 May;14(5):909-21 PMID: 10803525 SCOPUS ID: 2-s2.0-0034055667 05/10/2000 18 Citations

Cytogenetic analysis of the bipotential murine pre-B cell lymphoma, P388, and its derivative macrophage-like tumor, P388D1, using SKY and CGH. (Coleman AE, Forest ST, McNeil N, Kovalchuk AL, Ried T, Janz S) Leukemia 1999 Oct;13(10):1592-600 PMID: 10516761 SCOPUS ID: 2-s2.0-0032884224 10/12/1999 14 Citations

Elevated mutant frequencies in lymphoid tissues persist throughout plasmacytoma development in BALB/c.lambdaLIZ mice. (Felix K, Kelliher KA, Bornkamm GW, Janz S) Cancer Res 1999 Aug 01;59(15):3621-6 PMID: 10446972 SCOPUS ID: 2-s2.0-0033179682 08/14/1999 10 Citations

Transgenic shuttle vector assays for assessing oxidative B-cell mutagenesis in vivo. (Felix K, Kelliher K, Bornkamm GW, Janz S) Curr Top Microbiol Immunol 1999;246:369-75; discussion 376-7 PMID: 10396077 SCOPUS ID: 2-s2.0-0032962569 07/09/1999

Recurrent non-reciprocal translocations of chromosome 5 in primary T(12;15)-positive BALB/c plasmacytomas. (Coleman AE, Ried T, Janz S) Curr Top Microbiol Immunol 1999;246:175-80; discussion 181 PMID: 10396054 SCOPUS ID: 2-s2.0-0032909685 07/09/1999 4 Citations

Jumping translocation breakpoint regions lead to amplification of rearranged Myc. (Coleman AE, Kovalchuk AL, Janz S, Palini A, Ried T) Blood 1999 Jun 15;93(12):4442-4 PMID: 10391697 SCOPUS ID: 2-s2.0-0033564353 07/03/1999 11 Citations

Association of elevated mutagenesis in the spleen with genetic susceptibility to induced plasmacytoma development in mice. (Felix K, Kelliher K, Bornkamm GW, Janz S) Cancer Res 1998 Apr 15;58(8):1616-9 PMID: 9563470 SCOPUS ID: 2-s2.0-0032522886 05/01/1998 4 Citations

Tetravinyl-tetramethylcyclo-tetrasiloxane (tetravinyl D4) is a mutagen in Rat2lambda lacI fibroblasts. (Felix K, Lin S, Bornkamm GW, Janz S) Carcinogenesis 1998 Feb;19(2):315-20 PMID: 9498283 SCOPUS ID: 2-s2.0-0031927211 03/14/1998 5 Citations

Deletional remodeling of c-myc-deregulating chromosomal translocations. (Kovalchuk AL, Müller JR, Janz S) Oncogene 1997 Nov 06;15(19):2369-77 PMID: 9393881 SCOPUS ID: 2-s2.0-0030687580 12/11/1997 44 Citations

Elevated mutant frequencies in gene lacI in splenic lipopolysaccharide blasts after exposure to activated phagocytes in vitro. (Felix K, Lin S, Janz S) Eur J Immunol 1997 Sep;27(9):2160-4 PMID: 9341754 SCOPUS ID: 2-s2.0-0030870396 10/28/1997 5 Citations

Previously hidden chromosome aberrations in T(12;15)-positive BALB/c plasmacytomas uncovered by multicolor spectral karyotyping. (Coleman AE, Schröck E, Weaver Z, du Manoir S, Yang F, Ferguson-Smith MA, Ried T, Janz S) Cancer Res 1997 Oct 15;57(20):4585-92 PMID: 9377573 SCOPUS ID: 2-s2.0-1842415978 10/23/1997 39 Citations

Monoclonal origin of multicentric Kaposi's sarcoma lesions. (Rabkin CS, Janz S, Lash A, Coleman AE, Musaba E, Liotta L, Biggar RJ, Zhuang Z) N Engl J Med 1997 Apr 03;336(14):988-93 PMID: 9077377 SCOPUS ID: 2-s2.0-0030955108 04/03/1997 210 Citations

In vitro mutagenicity of the plasmacytomagenic agent pristane (2,6,10,14-tetramethylpentadecane). (Felix K, Potter M, Bornkamm GW, Janz S) Cancer Lett 1997 Feb 26;113(1-2):71-6 PMID: 9065804 SCOPUS ID: 2-s2.0-0031586754 02/26/1997 4 Citations

Generation of immunoglobulin/c-myc recombinations in murine Peyer's patch follicles. (Müller JR, Mushinski EB, Jones GM, Williams JA, Janz S, Hausner PF, Potter M) Curr Top Microbiol Immunol 1997;224:251-5 PMID: 9308248 SCOPUS ID: 2-s2.0-0030764805 01/01/1997 4 Citations

Genetic recombinations between c-myc and Igh mu as precursors for recombinations between c-myc and Igh alpha in BALB/c plasmacytomas. (Janz S, Kovalchuk AL, Müller JR, Potter M) Curr Top Microbiol Immunol 1997;224:241-50 PMID: 9308247 SCOPUS ID: 2-s2.0-0030753424 01/01/1997 2 Citations

Migration of cells with immunoglobulin/c-myc recombinations in lymphoid tissues of mice. (Müller JR, Jones GM, Janz S, Potter M) Blood 1997 Jan 01;89(1):291-6 PMID: 8978304 SCOPUS ID: 2-s2.0-0038079015 01/01/1997 29 Citations

Multicolour spectral karyotyping of mouse chromosomes. (Liyanage M, Coleman A, du Manoir S, Veldman T, McCormack S, Dickson RB, Barlow C, Wynshaw-Boris A, Janz S, Wienberg J, Ferguson-Smith MA, Schröck E, Ried T) Nat Genet 1996 Nov;14(3):312-5 PMID: 8896561 SCOPUS ID: 2-s2.0-16144368671 11/01/1996 253 Citations

Detection of immunoglobulin/c-myc recombinations in mice that are resistant to plasmacytoma induction. (Müller JR, Jones GM, Potter M, Janz S) Cancer Res 1996 Jan 15;56(2):419-23 PMID: 8542601 SCOPUS ID: 2-s2.0-0030057747 01/15/1996 25 Citations

DNA sequence analysis of the genetic recombination between Igh6 and Myc in an uncommon BALB/c plasmacytoma, TEPC 1194. (Kovalchuk AL, Potter M, Janz S) Immunogenetics 1996;44(2):151-6 PMID: 8662079 SCOPUS ID: 2-s2.0-0029946076 01/01/1996 6 Citations

Cytotoxicity and membrane damage in vitro by inclusion complexes between gamma-cyclodextrin and siloxanes. (Felix K, Janz S, Pitha J, Williams JA, Mushinski EB, Bornkamm GW, Potter M) Curr Top Microbiol Immunol 1996;210:93-9 PMID: 8565593 SCOPUS ID: 2-s2.0-0030025029 01/01/1996 7 Citations

Completion of the DNA sequence determination of the Igh2 locus of the mouse: the 5'-IA region. (Janz S, Roschke VV) Immunogenetics 1996;43(1-2):101-4 PMID: 8537111 SCOPUS ID: 2-s2.0-0029655832 01/01/1996 1 Citation

Differences between Burkitt's lymphomas and mouse plasmacytomas in the immunoglobulin heavy chain/c-myc recombinations that occur in their chromosomal translocations. (Müller JR, Janz S, Potter M) Cancer Res 1995 Nov 01;55(21):5012-8 PMID: 7585544 SCOPUS ID: 2-s2.0-0028809713 11/01/1995 30 Citations

Persistence of immunoglobulin heavy chain/c-myc recombination-positive lymphocyte clones in the blood of human immunodeficiency virus-infected homosexual men. (Müller JR, Janz S, Goedert JJ, Potter M, Rabkin CS) Proc Natl Acad Sci U S A 1995 Jul 03;92(14):6577-81 PMID: 7604036 PMCID: PMC41561 SCOPUS ID: 2-s2.0-0029056826 07/03/1995 66 Citations

Disposition of the plasmacytomagenic alkane pristane (2,6,10,14-tetramethylpentadecane) in mice. (Janz S, Shacter E) Cancer Biochem Biophys 1995 Jun;15(1):25-34 PMID: 8536217 SCOPUS ID: 2-s2.0-0029310667 06/01/1995 7 Citations

Translocation and activation of protein kinase C by the plasma cell tumor-promoting alkane pristane. (Janz S, Gawrisch K, Lester DS) Cancer Res 1995 Feb 01;55(3):518-24 PMID: 7834620 SCOPUS ID: 2-s2.0-0028959209 02/01/1995 12 Citations

Illegitimate recombinations between c-myc and immunoglobulin loci are remodeled by deletions in mouse plasmacytomas but not in Burkitt's lymphomas. (Müller JR, Janz S, Potter M) Curr Top Microbiol Immunol 1995;194:425-9 PMID: 7895518 SCOPUS ID: 2-s2.0-0027948992 01/01/1995 1 Citation

Genomic instability in B-cells and diversity of recombinations that activate c-myc. (Janz S, Jones GM, Müller JR, Potter M) Curr Top Microbiol Immunol 1995;194:373-80 PMID: 7895512 SCOPUS ID: 2-s2.0-0027988617 01/01/1995 5 Citations

Differences in the molecular structure of c-myc-activating recombinations in murine plasmacytomas and precursor cells. (Müller JR, Potter M, Janz S) Proc Natl Acad Sci U S A 1994 Dec 06;91(25):12066-70 PMID: 7991585 PMCID: PMC45377 SCOPUS ID: 2-s2.0-0027945433 12/06/1994 35 Citations

In vitro cytotoxicity of neutrophil-like human HL-60 cells undergoing an oxidative burst with Escherichia coli reporter strains. (Müller J, Janz S) Toxicol In Vitro 1994 Jun;8(3):437-40 PMID: 20692935 SCOPUS ID: 2-s2.0-0028361237 06/01/1994 1 Citation

Fusion between enveloped viruses and erythrocyte membranes is induced by the isoprenoid alkane pristane (2,6,10,14-tetramethylpentadecane). (Janz S, Shacter E, Herrmann A) Cancer Biochem Biophys 1994 Apr;14(1):1-14 PMID: 7796384 SCOPUS ID: 2-s2.0-0028409867 04/01/1994 3 Citations

Detection of recombinations between c-myc and immunoglobulin switch alpha in murine plasma cell tumors and preneoplastic lesions by polymerase chain reaction. (Janz S, Müller J, Shaughnessy J, Potter M) Proc Natl Acad Sci U S A 1993 Aug 01;90(15):7361-5 PMID: 8346257 PMCID: PMC47137 SCOPUS ID: 2-s2.0-0027179562 08/01/1993 60 Citations

Genotoxicity assessment of waste products of aluminum plasma etching with the SOS chromotest. (Raabe F, Janz S, Wolff G, Merten H, Landrock A, Birkenfeld T, Herzschuh R) Mutat Res 1993 Jul;300(2):99-109 PMID: 7685499 SCOPUS ID: 2-s2.0-0027177009 07/01/1993 6 Citations

Modulation of the H2O2-induced SOS response in Escherichia coli PQ300 by amino acids, metal chelators, antioxidants, and scavengers of reactive oxygen species. (Müller J, Janz S) Environ Mol Mutagen 1993;22(3):157-63 PMID: 8404875 SCOPUS ID: 2-s2.0-0027331518 01/01/1993 22 Citations

Activated murine neutrophils induce unscheduled DNA synthesis in B lymphocytes. (Janz S, Shacter E) Mutat Res 1993 Jan;293(2):173-86 PMID: 7678145 SCOPUS ID: 2-s2.0-0027507188 01/01/1993 13 Citations

The fluidity of DOPC bilayers and membrane fractions prepared from murine plasmacytoma cells is unchanged after incorporation of pristane (2,6,10,14-tetramethylpentadecane) as assessed by fluorescence polarization analysis. (Janz S, Krumbiegel M, Gawrisch K) Cancer Biochem Biophys 1992 Nov;13(2):85-92 PMID: 1343851 SCOPUS ID: 2-s2.0-0026942702 11/01/1992 4 Citations

Assessment of oxidative DNA damage in the oxyR-deficient SOS chromotest strain Escherichia coli PQ300. (Müller J, Janz S) Environ Mol Mutagen 1992;20(4):297-306 PMID: 1425609 SCOPUS ID: 2-s2.0-0026452921 01/01/1992 17 Citations

The uptake of pristane (2,6,10,14-tetramethylpentadecane) into phospholipid bilayers as assessed by NMR, DSC, and tritium labeling methods. (Gawrisch K, Janz S) Biochim Biophys Acta 1991 Dec 09;1070(2):409-18 PMID: 1764453 SCOPUS ID: 2-s2.0-0026038368 12/09/1991 10 Citations

The reaction of pristane (2,6,10,14-tetramethylpentadecane) with radiolytically generated reactive oxygen intermediates results in a stable genotoxic compound as assessed by the SOS chromotest. (Janz S, Brede O, Müller J) Carcinogenesis 1991 Jul;12(7):1241-6 PMID: 2070489 SCOPUS ID: 2-s2.0-0025815903 07/01/1991 2 Citations

A new method for delivering alkanes to mammalian cells: preparation and preliminary characterization of an inclusion complex between beta-cyclodextrin and pristane (2,6,10,14-tetramethylpentadecane). (Janz S, Shacter E) Toxicology 1991;69(3):301-15 PMID: 1949053 SCOPUS ID: 2-s2.0-0026047224 01/01/1991 26 Citations

DNA damage induced by phorbol ester-stimulated neutrophils is augmented by extracellular cofactors. Role of histidine and metals. (Shacter E, Lopez RL, Beecham EJ, Janz S) J Biol Chem 1990 Apr 25;265(12):6693-9 PMID: 2157707 SCOPUS ID: 2-s2.0-0025218710 04/25/1990 54 Citations

Application of an alternative approach for using the SOS chromotest to screen complex indeterminate mixtures. (Janz S, Raabe F, Wolff G) Zentralbl Mikrobiol 1990;145(3):177-82 PMID: 2196748 SCOPUS ID: 2-s2.0-0025140345 01/01/1990 8 Citations

The effect of non-ionic surfactants on the SOS-inducing potency of 4-nitroquinoline-1-oxide in Escherichia coli PQ37. (Raabe F, Janz S, Wolff G) J Basic Microbiol 1990;30(6):435-42 PMID: 2126282 SCOPUS ID: 2-s2.0-0025151497 01/01/1990 4 Citations

[Histologic studies of paraproteinemic nephropathy in BALB/c mice with mineral oil-induced plasmacytoma]. (Janz S, Rassmann B, Raabe F, Storch H) Z Urol Nephrol 1989 Dec;82(12):671-8 PMID: 2629422 SCOPUS ID: 2-s2.0-17344384553 12/01/1989

Gas chromatographic-mass spectrometric investigation of four commercial pristane (2.6.10.14-tetramethylpentadecane) preparations used for plasmacytoma induction in BALB/c mice. (Janz S, Birkenfeld T, Herzschuh R, Storch H) Arch Geschwulstforsch 1989;59(6):415-22 PMID: 2596957 SCOPUS ID: 2-s2.0-0024446035 01/01/1989 3 Citations

[Experimental research on the genotoxicity of various root canal antiseptics in the SOS chromotest]. (Klimm W, Janz S, Gabert A) Zahn Mund Kieferheilkd Zentralbl 1989;77(2):128-30 PMID: 2526434 SCOPUS ID: 2-s2.0-0024570610 01/01/1989 8 Citations

Quantitation of the relationship between tester cell number inoculated and SOS-inducing potency of 4-nitroquinoline-1-oxide (4-NQO) in an automated version of the SOS chromotest. (Janz S, Wolff G, Huttunen T, Raabe F, Storch H) J Basic Microbiol 1989;29(7):403-11 PMID: 2513384 SCOPUS ID: 2-s2.0-0024801510 01/01/1989 14 Citations

Genotoxicity assessment of the plasmacytomagenic agent pristane (2.6.10.14-tetramethylpentadecane) and four related alkanes by the SOS chromotest. (Janz S, Huttunen T, Herzschuh R, Storch H) Arch Geschwulstforsch 1988;58(2):73-8 PMID: 3288166 SCOPUS ID: 2-s2.0-0023907912 01/01/1988 2 Citations

SOS chromotest, a quantitative short-term bacterial assay for the detection of genotoxic compounds in an automated version adapted to Bioscreen Analyzer System. (Janz S, Wolff G, Storch H) Zentralbl Mikrobiol 1988;143(8):645-9 PMID: 3149098 SCOPUS ID: 2-s2.0-0024260443 01/01/1988 14 Citations

Evidence for high purity of a commercial pristane (2,6,10,14-tetramethylpentadecane) preparation used for plasmocytoma induction in BALB/c mice. (Janz S, Herzschuh R, Storch H) Exp Pathol 1987;31(4):253-5 PMID: 3622726 SCOPUS ID: 2-s2.0-0023065709 01/01/1987 1 Citation

Induction of plasma cell tumours with 2,6,10,14-tetramethylpentadecane (pristane) and paraffin oil (paraffinum perliquidum) in BALB/c mice simultaneously exposed to sustained antigenic stimulation with bovine serum albumin (BSA). (Janz S, Püschel W, Raabe F, Storch H) Arch Geschwulstforsch 1987;57(1):25-30 PMID: 3566462 SCOPUS ID: 2-s2.0-0023068685 01/01/1987

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Siegfried Janz MD

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Publications (178)