Faculty Collaboration Database

Increased apoptosis in metastatic human colonic adenocarcinomas. Cancer Biol Ther 2002;1(1):58-63

Date

08/13/2002

Pubmed ID

12170764

DOI

10.4161/cbt.1.1.43

Scopus ID

2-s2.0-0036043771 (requires institutional sign-in at Scopus site)   8 Citations

Abstract

Recent work suggests that apoptosis is disrupted during the progression of many solid tumors. Isogenic metastatic colon adenocarcinoma cells displayed significantly higher levels of staurosporine-induced apoptosis compared to their nonmetastatic counterparts in vitro. In addition, analysis of 15 matched primary tumors and liver metastases demonstrated that the levels of apoptosis were significantly higher in the metastases, and this increased cell death was associated with significantly lower levels of Bcl-2 protein expression. Our data demonstrate that the molecular events associated with acquisition of the metastatic phenotype sensitize colon cancer cells to some pro-apoptotic stimuli.

Author List

Termuhlen PM, Sweeney-Gotsch BM, Berman RS, Ellis LM, Bucana C, Shen Y, Cleary KR, McConkey DJ

MESH terms used to index this publication - Major topics in bold

Adenocarcinoma
Antibodies, Monoclonal
Antineoplastic Agents
Apoptosis
Apoptosis Regulatory Proteins
Colonic Neoplasms
Drug Resistance, Neoplasm
Genes, bcl-2
Humans
Liver Neoplasms
Membrane Glycoproteins
Neoplasm Metastasis
Neoplasm Proteins
Proto-Oncogene Proteins c-bcl-2
Retrospective Studies
Staurosporine
TNF-Related Apoptosis-Inducing Ligand
Tumor Cells, Cultured
Tumor Necrosis Factor-alpha
fas Receptor