Medical College of Wisconsin
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Christian Kastrup PhD

Professor

Institution: Medical College of Wisconsin
Department: Surgery
Division: Trauma and Critical Care

Publications (55)

  • Self-propelling thrombin powder enables hemostasis with no observable recurrent bleeding or thrombosis over 3 days in a porcine model of upper GI bleeding. (Ali-Mohamad N, Cau MF, Zenova V, Baylis JR, Beckett A, McFadden A, Donnellan F, Kastrup CJ) Gastrointest Endosc 2023 Aug;98(2):245-248 PMID: 37061138 SCOPUS ID: 2-s2.0-85164978868 04/16/2023       2 Citations
  • Hemostatic powders for gastrointestinal bleeding: a review of old, new, and emerging agents in a rapidly advancing field. (Jiang SX, Chahal D, Ali-Mohamad N, Kastrup C, Donnellan F) Endosc Int Open 2022 Aug;10(8):E1136-E1146 PMID: 36238531 PMCID: PMC9552790 10/15/2022    
  • Elimination of fibrin polymer formation or crosslinking, but not fibrinogen deficiency, is protective against diet-induced obesity and associated pathologies. (Hur WS, King KC, Patel YN, Nguyen YV, Wei Z, Yang Y, Juang LJ, Leung J, Kastrup CJ, Wolberg AS, Luyendyk JP, Flick MJ) J Thromb Haemost 2022 Dec;20(12):2873-2886 PMID: 36111375 PMCID: PMC9669152 SCOPUS ID: 2-s2.0-85139491210 09/17/2022       4 Citations
  • Liquid-infused microstructured bioadhesives halt non-compressible hemorrhage. (Bao G, Gao Q, Cau M, Ali-Mohamad N, Strong M, Jiang S, Yang Z, Valiei A, Ma Z, Amabili M, Gao ZH, Mongeau L, Kastrup C, Li J) Nat Commun 2022 Aug 26;13(1):5035 PMID: 36028516 PMCID: PMC9418157 SCOPUS ID: 2-s2.0-85137085170 08/27/2022       42 Citations
  • Comparison of DLin-MC3-DMA and ALC-0315 for siRNA Delivery to Hepatocytes and Hepatic Stellate Cells. (Ferraresso F, Strilchuk AW, Juang LJ, Poole LG, Luyendyk JP, Kastrup CJ) Mol Pharm 2022 Jul 04;19(7):2175-2182 PMID: 35642083 PMCID: PMC9621687 SCOPUS ID: 2-s2.0-85132031018 06/02/2022       30 Citations
  • Aortic intimal resident macrophages are essential for maintenance of the non-thrombogenic intravascular state. (Hernandez GE, Ma F, Martinez G, Firozabadi NB, Salvador J, Juang LJ, Leung J, Zhao P, López DA, Ardehali R, Beaudin AE, Kastrup CJ, Pellegrini M, Flick MJ, Iruela-Arispe ML) Nat Cardiovasc Res 2022 Jan;1(1):67-84 PMID: 35599984 PMCID: PMC9121812 SCOPUS ID: 2-s2.0-85133616554 05/24/2022       20 Citations
  • Percutaneous delivery of self-propelling thrombin-containing powder increases survival from noncompressible truncal hemorrhage in a swine model of coagulopathy and hypothermia. (Cau MF, Ali-Mohamad N, Yeh H, Baylis JR, Peng H, Gao HZ, Rezende-Neto J, Grecov D, White NJ, Tenn C, Semple HA, Beckett A, Kastrup CJ) J Trauma Acute Care Surg 2022 Aug 01;93(2S Suppl 1):S86-S93 PMID: 35545803 SCOPUS ID: 2-s2.0-85135375566 05/13/2022       3 Citations
  • Videoconferencing for Large Animal Trauma Experiments During COVID-19: A Cross-Continent Experience. (Ali-Mohamad N, Cau MF, Baylis JR, Semple H, Kastrup CJ, Beckett A) Mil Med 2022 Mar 01 PMID: 35231116 PMCID: PMC9383491 SCOPUS ID: 2-s2.0-85184752039 03/02/2022    
  • Percutaneous delivery of self-propelling hemostatic powder for managing non-compressible abdominal hemorrhage: a proof-of-concept study in swine. (Cau MF, Ali-Mohamad N, Baylis JR, Zenova V, Khavari A, Peng N, McFadden A, Donnellan F, Owen DR, Schaeffer DF, Nagaswami C, Litvinov RI, Weisel JW, Rezende-Neto J, Semple HA, Beckett A, Kastrup CJ) Injury 2022 May;53(5):1603-1609 PMID: 35067343 SCOPUS ID: 2-s2.0-85123176503 01/25/2022       7 Citations
  • Suppression of fibrin(ogen)-driven pathologies in disease models through controlled knockdown by lipid nanoparticle delivery of siRNA. (Juang LJ, Hur WS, Silva LM, Strilchuk AW, Francisco B, Leung J, Robertson MK, Groeneveld DJ, La Prairie B, Chun EM, Cap AP, Luyendyk JP, Palumbo JS, Cullis PR, Bugge TH, Flick MJ, Kastrup CJ) Blood 2022 Mar 03;139(9):1302-1311 PMID: 34958662 PMCID: PMC8900269 SCOPUS ID: 2-s2.0-85125449492 12/28/2021       10 Citations
  • Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier. (Silva LM, Doyle AD, Greenwell-Wild T, Dutzan N, Tran CL, Abusleme L, Juang LJ, Leung J, Chun EM, Lum AG, Agler CS, Zuazo CE, Sibree M, Jani P, Kram V, Martin D, Moss K, Lionakis MS, Castellino FJ, Kastrup CJ, Flick MJ, Divaris K, Bugge TH, Moutsopoulos NM) Science 2021 Dec 24;374(6575):eabl5450 PMID: 34941394 SCOPUS ID: 2-s2.0-85122908098 12/24/2021       81 Citations
  • Hypofibrinogenemia with preserved hemostasis and protection from thrombosis in mice with an Fga truncation mutation. (Hur WS, Paul DS, Bouck EG, Negrón OA, Mwiza JM, Poole LG, Cline-Fedewa HM, Clark EG, Juang LJ, Leung J, Kastrup CJ, Ugarova TP, Wolberg AS, Luyendyk JP, Bergmeier W, Flick MJ) Blood 2022 Mar 03;139(9):1374-1388 PMID: 34905618 PMCID: PMC8900273 SCOPUS ID: 2-s2.0-85125450252 12/15/2021       12 Citations
  • Emerging gene therapies for enhancing the hemostatic potential of platelets. (Leung J, Cau MF, Kastrup CJ) Transfusion 2021 Jul;61 Suppl 1:S275-S285 PMID: 34269451 SCOPUS ID: 2-s2.0-85110365878 07/17/2021       1 Citation
  • Severe upper gastrointestinal bleeding is halted by endoscopically delivered self-propelling thrombin powder: A porcine pilot study. (Ali-Mohamad N, Cau M, Baylis J, Zenova V, Semple H, Beckett A, McFadden A, Donnellan F, Kastrup C) Endosc Int Open 2021 May;9(5):E693-E698 PMID: 33937509 PMCID: PMC8062227 05/04/2021    
  • Nanomedicines for hemorrhage control. (Cau MF, Strilchuk AW, Kastrup CJ) J Thromb Haemost 2021 Apr;19(4):887-891 PMID: 33694243 SCOPUS ID: 2-s2.0-85102580456 03/12/2021       4 Citations
  • The evolution of factor XI and the kallikrein-kinin system. (Ponczek MB, Shamanaev A, LaPlace A, Dickeson SK, Srivastava P, Sun MF, Gruber A, Kastrup C, Emsley J, Gailani D) Blood Adv 2020 Dec 22;4(24):6135-6147 PMID: 33351111 PMCID: PMC7757006 SCOPUS ID: 2-s2.0-85098071612 12/23/2020       28 Citations
  • The adhesion of clots in wounds contributes to hemostasis and can be enhanced by coagulation factor XIII. (Chan KYT, Yong ASM, Wang X, Ringgold KM, St John AE, Baylis JR, White NJ, Kastrup CJ) Sci Rep 2020 Nov 18;10(1):20116 PMID: 33208779 PMCID: PMC7675984 SCOPUS ID: 2-s2.0-85096207089 11/20/2020       8 Citations
  • Post-Translational Modifications of Platelet-Derived Amyloid Precursor Protein by Coagulation Factor XIII-A. (Hur WS, Juang LJ, Mazinani N, Munro L, Jefferies WA, Kastrup CJ) Biochemistry 2020 Nov 24;59(46):4449-4455 PMID: 33161719 SCOPUS ID: 2-s2.0-85096619332 11/10/2020       3 Citations
  • Bleeding is increased in amyloid precursor protein knockout mouse. (Mazinani N, Strilchuk AW, Baylis JR, Hur WS, Jefferies WA, Kastrup CJ) Res Pract Thromb Haemost 2020 Jul;4(5):823-828 PMID: 32685890 PMCID: PMC7354397 SCOPUS ID: 2-s2.0-85096369845 07/21/2020       5 Citations
  • Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiency. (Strilchuk AW, Meixner SC, Leung J, Safikhan NS, Kulkarni JA, Russell HM, van der Meel R, Sutherland MR, Owens AP, Palumbo JS, Conway EM, Pryzdial ELG, Cullis PR, Kastrup CJ) Blood 2020 Dec 17;136(25):2946-2954 PMID: 32678423 PMCID: PMC9710420 SCOPUS ID: 2-s2.0-85096223268 07/18/2020       19 Citations
  • Coagulation factor XII contributes to hemostasis when activated by soil in wounds. (Juang LJ, Mazinani N, Novakowski SK, Prowse ENP, Haulena M, Gailani D, Lavkulich LM, Kastrup CJ) Blood Adv 2020 Apr 28;4(8):1737-1745 PMID: 32339233 PMCID: PMC7189277 SCOPUS ID: 2-s2.0-85084231996 04/28/2020       20 Citations
  • Diatom Frustule Silica Exhibits Superhydrophilicity and Superhemophilicity. (Lee J, Lee HA, Shin M, Juang LJ, Kastrup CJ, Go GM, Lee H) ACS Nano 2020 Apr 28;14(4):4755-4766 PMID: 32207961 SCOPUS ID: 2-s2.0-85084167447 03/26/2020       55 Citations
  • Topical tranexamic acid inhibits fibrinolysis more effectively when formulated with self-propelling particles. (Baylis JR, Lee MM, St John AE, Wang X, Simonson E, Cau M, Kazerooni A, Gusti V, Statz ML, Yoon JSJ, Liggins RT, White NJ, Kastrup CJ) J Thromb Haemost 2019 Oct;17(10):1645-1654 PMID: 31145837 SCOPUS ID: 2-s2.0-85068186945 05/31/2019       8 Citations
  • Coagulation factor XIII-A and activated FXIII-A decrease in some deep vein thrombosis patients following catheter-directed thrombolysis. (Hur WS, Warner H, Machan L, Kastrup CJ) Blood Coagul Fibrinolysis 2019 Jun;30(4):176-180 PMID: 30762590 SCOPUS ID: 2-s2.0-85066852302 02/15/2019    
  • Delivery of mRNA to platelets using lipid nanoparticles. (Novakowski S, Jiang K, Prakash G, Kastrup C) Sci Rep 2019 Jan 24;9(1):552 PMID: 30679556 PMCID: PMC6345896 SCOPUS ID: 2-s2.0-85060537715 01/27/2019       24 Citations
  • Coagulation factor XIIIa cross-links amyloid β into dimers and oligomers and to blood proteins. (Hur WS, Mazinani N, Lu XJD, Yefet LS, Byrnes JR, Ho L, Yeon JH, Filipenko S, Wolberg AS, Jefferies WA, Kastrup CJ) J Biol Chem 2019 Jan 11;294(2):390-396 PMID: 30409906 PMCID: PMC6333891 SCOPUS ID: 2-s2.0-85059908563 11/10/2018       19 Citations
  • Rivaroxaban and apixaban induce clotting factor Xa fibrinolytic activity. (Carter RLR, Talbot K, Hur WS, Meixner SC, Van Der Gugten JG, Holmes DT, Côté HCF, Kastrup CJ, Smith TW, Lee AYY, Pryzdial ELG) J Thromb Haemost 2018 Nov;16(11):2276-2288 PMID: 30176116 SCOPUS ID: 2-s2.0-85054559930 09/04/2018       38 Citations
  • Platelets loaded with liposome-encapsulated thrombin have increased coagulability. (Chan V, Sarkari M, Sunderland R, St John AE, White NJ, Kastrup CJ) J Thromb Haemost 2018 Jun;16(6):1226-1235 PMID: 29573326 SCOPUS ID: 2-s2.0-85047799083 03/25/2018       16 Citations
  • Conceptual and Experimental Tools to Understand Spatial Effects and Transport Phenomena in Nonlinear Biochemical Networks Illustrated with Patchy Switching. (Pompano RR, Chiang AH, Kastrup CJ, Ismagilov RF) Annu Rev Biochem 2017 Jun 20;86:333-356 PMID: 28654324 PMCID: PMC10852032 SCOPUS ID: 2-s2.0-85021678792 06/28/2017       8 Citations
  • Localization of Short-Chain Polyphosphate Enhances its Ability to Clot Flowing Blood Plasma. (Yeon JH, Mazinani N, Schlappi TS, Chan KY, Baylis JR, Smith SA, Donovan AJ, Kudela D, Stucky GD, Liu Y, Morrissey JH, Kastrup CJ) Sci Rep 2017 Feb 10;7:42119 PMID: 28186112 PMCID: PMC5301195 SCOPUS ID: 2-s2.0-85012070573 02/12/2017       11 Citations
  • Thrombolysis by chemically modified coagulation factor Xa. (Pryzdial EL, Meixner SC, Talbot K, Eltringham-Smith LJ, Baylis JR, Lee FM, Kastrup CJ, Sheffield WP) J Thromb Haemost 2016 Sep;14(9):1844-54 PMID: 27359348 PMCID: PMC5576980 SCOPUS ID: 2-s2.0-84988521833 07/01/2016       6 Citations
  • Halting hemorrhage with self-propelling particles and local drug delivery. (Baylis JR, Chan KY, Kastrup CJ) Thromb Res 2016 May;141 Suppl 2(Suppl 2):S36-9 PMID: 27207421 PMCID: PMC5468094 SCOPUS ID: 2-s2.0-84989895870 05/22/2016       27 Citations
  • Self-Propelled Dressings Containing Thrombin and Tranexamic Acid Improve Short-Term Survival in a Swine Model of Lethal Junctional Hemorrhage. (Baylis JR, St John AE, Wang X, Lim EB, Statz ML, Chien D, Simonson E, Stern SA, Liggins RT, White NJ, Kastrup CJ) Shock 2016 Sep;46(3 Suppl 1):123-8 PMID: 27206277 PMCID: PMC4975977 SCOPUS ID: 2-s2.0-84969651727 05/21/2016       21 Citations
  • Adhesion of Blood Clots Can Be Enhanced When Copolymerized with a Macromer That Is Crosslinked by Coagulation Factor XIIIa. (Chan KY, Zhao C, Siren EM, Chan JC, Boschman J, Kastrup CJ) Biomacromolecules 2016 Jun 13;17(6):2248-52 PMID: 27140446 PMCID: PMC5496764 SCOPUS ID: 2-s2.0-84974808859 05/04/2016       13 Citations
  • Self-propelled particles that transport cargo through flowing blood and halt hemorrhage. (Baylis JR, Yeon JH, Thomson MH, Kazerooni A, Wang X, St John AE, Lim EB, Chien D, Lee A, Zhang JQ, Piret JM, Machan LS, Burke TF, White NJ, Kastrup CJ) Sci Adv 2015 Oct;1(9):e1500379 PMID: 26601282 PMCID: PMC4646796 SCOPUS ID: 2-s2.0-85041321205 11/26/2015       151 Citations
  • Controlled Transcription of Exogenous mRNA in Platelets Using Protocells. (Chan V, Novakowski SK, Law S, Klein-Bosgoed C, Kastrup CJ) Angew Chem Int Ed Engl 2015 Nov 09;54(46):13590-3 PMID: 26368852 PMCID: PMC5482712 SCOPUS ID: 2-s2.0-84946501414 09/15/2015       15 Citations
  • Coagulation factor XIIIa is inactivated by plasmin. (Hur WS, Mazinani N, Lu XJ, Britton HM, Byrnes JR, Wolberg AS, Kastrup CJ) Blood 2015 Nov 12;126(20):2329-37 PMID: 26359437 PMCID: PMC4729541 SCOPUS ID: 2-s2.0-84949009516 09/12/2015       33 Citations
  • A biochemical network can control formation of a synthetic material by sensing numerous specific stimuli. (Hun Yeon J, Chan KY, Wong TC, Chan K, Sutherland MR, Ismagilov RF, Pryzdial EL, Kastrup CJ) Sci Rep 2015 May 15;5:10274 PMID: 25975772 PMCID: PMC4432564 SCOPUS ID: 2-s2.0-84929377681 05/16/2015       9 Citations
  • Defects in phosphate acquisition and storage influence virulence of Cryptococcus neoformans. (Kretschmer M, Reiner E, Hu G, Tam N, Oliveira DL, Caza M, Yeon JH, Kim J, Kastrup CJ, Jung WH, Kronstad JW) Infect Immun 2014 Jul;82(7):2697-712 PMID: 24711572 PMCID: PMC4097646 SCOPUS ID: 2-s2.0-84903169822 04/09/2014       42 Citations
  • Painting blood vessels and atherosclerotic plaques with an adhesive drug depot. (Kastrup CJ, Nahrendorf M, Figueiredo JL, Lee H, Kambhampati S, Lee T, Cho SW, Gorbatov R, Iwamoto Y, Dang TT, Dutta P, Yeon JH, Cheng H, Pritchard CD, Vegas AJ, Siegel CD, MacDougall S, Okonkwo M, Thai A, Stone JR, Coury AJ, Weissleder R, Langer R, Anderson DG) Proc Natl Acad Sci U S A 2012 Dec 26;109(52):21444-9 PMID: 23236189 PMCID: PMC3535589 SCOPUS ID: 2-s2.0-84871822549 12/14/2012       111 Citations
  • Stem cell membrane engineering for cell rolling using peptide conjugation and tuning of cell-selectin interaction kinetics. (Cheng H, Byrska-Bishop M, Zhang CT, Kastrup CJ, Hwang NS, Tai AK, Lee WW, Xu X, Nahrendorf M, Langer R, Anderson DG) Biomaterials 2012 Jul;33(20):5004-12 PMID: 22494889 PMCID: PMC3366278 SCOPUS ID: 2-s2.0-84860361008 04/13/2012       88 Citations
  • Rapid discovery of potent siRNA-containing lipid nanoparticles enabled by controlled microfluidic formulation. (Chen D, Love KT, Chen Y, Eltoukhy AA, Kastrup C, Sahay G, Jeon A, Dong Y, Whitehead KA, Anderson DG) J Am Chem Soc 2012 Apr 25;134(16):6948-51 PMID: 22475086 SCOPUS ID: 2-s2.0-84860344186 04/06/2012       290 Citations
  • Remotely activated protein-producing nanoparticles. (Schroeder A, Goldberg MS, Kastrup C, Wang Y, Jiang S, Joseph BJ, Levins CG, Kannan ST, Langer R, Anderson DG) Nano Lett 2012 Jun 13;12(6):2685-9 PMID: 22432731 PMCID: PMC3388722 SCOPUS ID: 2-s2.0-84862298730 03/22/2012       90 Citations
  • Nanoparticulate cellular patches for cell-mediated tumoritropic delivery. (Cheng H, Kastrup CJ, Ramanathan R, Siegwart DJ, Ma M, Bogatyrev SR, Xu Q, Whitehead KA, Langer R, Anderson DG) ACS Nano 2010 Feb 23;4(2):625-31 PMID: 20121215 PMCID: PMC2836800 SCOPUS ID: 2-s2.0-77649170226 02/04/2010       130 Citations
  • Confinement regulates complex biochemical networks: initiation of blood clotting by "diffusion acting". (Shen F, Pompano RR, Kastrup CJ, Ismagilov RF) Biophys J 2009 Oct 21;97(8):2137-45 PMID: 19843446 PMCID: PMC2764071 SCOPUS ID: 2-s2.0-70449091917 10/22/2009       18 Citations
  • Spatial localization of bacteria controls coagulation of human blood by 'quorum acting'. (Kastrup CJ, Boedicker JQ, Pomerantsev AP, Moayeri M, Bian Y, Pompano RR, Kline TR, Sylvestre P, Shen F, Leppla SH, Tang WJ, Ismagilov RF) Nat Chem Biol 2008 Dec;4(12):742-50 PMID: 19031531 PMCID: PMC2651025 SCOPUS ID: 2-s2.0-56249106850 11/26/2008       77 Citations
  • Threshold response of initiation of blood coagulation by tissue factor in patterned microfluidic capillaries is controlled by shear rate. (Shen F, Kastrup CJ, Liu Y, Ismagilov RF) Arterioscler Thromb Vasc Biol 2008 Nov;28(11):2035-41 PMID: 18703776 SCOPUS ID: 2-s2.0-55449124272 08/16/2008       108 Citations
  • Using microfluidics to understand the effect of spatial distribution of tissue factor on blood coagulation. (Shen F, Kastrup CJ, Ismagilov RF) Thromb Res 2008;122 Suppl 1:S27-30 PMID: 18691495 SCOPUS ID: 2-s2.0-48449086175 08/12/2008       16 Citations
  • Effects of shear rate on propagation of blood clotting determined using microfluidics and numerical simulations. (Runyon MK, Kastrup CJ, Johnson-Kerner BL, Ha TG, Ismagilov RF) J Am Chem Soc 2008 Mar 19;130(11):3458-64 PMID: 18302373 SCOPUS ID: 2-s2.0-41449101562 02/28/2008       58 Citations
  • Using chemistry and microfluidics to understand the spatial dynamics of complex biological networks. (Kastrup CJ, Runyon MK, Lucchetta EM, Price JM, Ismagilov RF) Acc Chem Res 2008 Apr;41(4):549-58 PMID: 18217723 PMCID: PMC2593841 SCOPUS ID: 2-s2.0-43649102021 01/26/2008       21 Citations
  • Characterization of the threshold response of initiation of blood clotting to stimulus patch size. (Kastrup CJ, Shen F, Runyon MK, Ismagilov RF) Biophys J 2007 Oct 15;93(8):2969-77 PMID: 17586576 PMCID: PMC1989713 SCOPUS ID: 2-s2.0-35348953113 06/26/2007       40 Citations
  • Propagation of blood clotting in the complex biochemical network of hemostasis is described by a simple mechanism. (Runyon MK, Johnson-Kerner BL, Kastrup CJ, Van Ha TG, Ismagilov RF) J Am Chem Soc 2007 Jun 06;129(22):7014-5 PMID: 17497790 SCOPUS ID: 2-s2.0-34250214157 05/15/2007       38 Citations
  • Response to shape emerges in a complex biochemical network and its simple chemical analogue. (Kastrup CJ, Shen F, Ismagilov RF) Angew Chem Int Ed Engl 2007;46(20):3660-2 PMID: 17407119 SCOPUS ID: 2-s2.0-34250877427 04/05/2007       18 Citations
  • Modular chemical mechanism predicts spatiotemporal dynamics of initiation in the complex network of hemostasis. (Kastrup CJ, Runyon MK, Shen F, Ismagilov RF) Proc Natl Acad Sci U S A 2006 Oct 24;103(43):15747-52 PMID: 17043240 PMCID: PMC1635074 SCOPUS ID: 2-s2.0-33750481224 10/18/2006       68 Citations
  • The aromaticity and Möbius characteristics of carbeno[8]heteroannulenes and triplet state annulenes. (Kastrup CJ, Oldfield SP, Rzepa HS) Chem Commun (Camb) 2002 Mar 21(6):642-3 PMID: 12120163 SCOPUS ID: 2-s2.0-0037149387 07/18/2002       35 Citations
    • Last update: 06/16/2023