Medical College of Wisconsin
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Arshak R. Alexanian VMD, PhD

Arshak R. Alexanian VMD, PhD

Adjunct Associate Professor

Institution: Medical College of Wisconsin
Department: Medicine

Member of the Cardiovascular Center


Publications

  • Specific combinations of the chromatin-modifying enzyme modulators significantly attenuate glioblastoma cell proliferation and viability while exerting minimal effect on normal adult stem cells growth. (Alexanian AR, Huang YW) Tumour Biol 2015 Nov;36(11):9067-72 PMID: 26084611 06/19/2015
  • Epigenetic modulators promote mesenchymal stem cell phenotype switches. (Alexanian AR) Int J Biochem Cell Biol 2015 Jul;64:190-4 PMID: 25936755 05/06/2015
  • Enhanced dopamine release by mesenchymal stem cells reprogrammed neuronally by the modulators of SMAD signaling, chromatin modifying enzymes, and cyclic adenosine monophosphate levels. (Funk RT, Alexanian AR) Transl Res 2013 Nov;162(5):317-23 PMID: 24001408 09/05/2013
  • Enhancing the efficiency of direct reprogramming of human mesenchymal stem cells into mature neuronal-like cells with the combination of small molecule modulators of chromatin modifying enzymes, SMAD signaling and cyclic adenosine monophosphate levels. (Alexanian AR, Liu QS, Zhang Z) Int J Biochem Cell Biol 2013 Aug;45(8):1633-8 PMID: 23665234 05/15/2013
  • Dopaminergic-like cells from epigenetically reprogrammed mesenchymal stem cells. (Zhang Z, Alexanian AR) J Cell Mol Med 2012 Nov;16(11):2708-14 PMID: 22681532 PMCID: PMC4118239 06/12/2012
  • The neural plasticity of early-passage human bone marrow-derived mesenchymal stem cells and their modulation with chromatin-modifying agents. (Zhang Z, Alexanian AR) J Tissue Eng Regen Med 2014 May;8(5):407-13 PMID: 22674835 06/08/2012
  • Transplanted neurally modified bone marrow-derived mesenchymal stem cells promote tissue protection and locomotor recovery in spinal cord injured rats. (Alexanian AR, Fehlings MG, Zhang Z, Maiman DJ) Neurorehabil Neural Repair 2011 Nov-Dec;25(9):873-80 PMID: 21844281 08/17/2011
  • Feline bone marrow-derived mesenchymal stem cells express several pluripotent and neural markers and easily turn into neural-like cells by manipulation with chromatin modifying agents and neural inducing factors. (Zhang Z, Maiman DJ, Kurpad SN, Crowe MJ, Alexanian AR) Cell Reprogram 2011 Oct;13(5):385-90 PMID: 21718099 07/02/2011
  • Survival of neurally induced mesenchymal cells may determine degree of motor recovery in injured spinal cord rats. (Alexanian AR, Kwok WM, Pravdic D, Maiman DJ, Fehlings MG) Restor Neurol Neurosci 2010;28(6):761-7 PMID: 21209491 01/07/2011
  • An efficient method for generation of neural-like cells from adult human bone marrow-derived mesenchymal stem cells. (Alexanian AR) Regen Med 2010 Nov;5(6):891-900 PMID: 21082889 11/19/2010
  • Transplantation of human glial-restricted neural precursors into injured spinal cord promotes functional and sensory recovery without causing allodynia. (Alexanian AR, Svendsen CN, Crowe MJ, Kurpad SN) Cytotherapy 2011 Jan;13(1):61-8 PMID: 20735167 08/26/2010
  • In vitro and in vivo characterization of neurally modified mesenchymal stem cells induced by epigenetic modifiers and neural stem cell environment. (Alexanian AR, Maiman DJ, Kurpad SN, Gennarelli TA) Stem Cells Dev 2008 Dec;17(6):1123-30 PMID: 18484898 05/20/2008
  • Epigenetic modifiers promote efficient generation of neural-like cells from bone marrow-derived mesenchymal cells grown in neural environment. (Alexanian AR) J Cell Biochem 2007 Feb 01;100(2):362-71 PMID: 16924670 08/23/2006
  • Pain with no gain: allodynia following neural stem cell transplantation in spinal cord injury. (Macias MY, Syring MB, Pizzi MA, Crowe MJ, Alexanian AR, Kurpad SN) Exp Neurol 2006 Oct;201(2):335-48 PMID: 16839548 07/15/2006
  • Neural stem cells induce bone-marrow-derived mesenchymal stem cells to generate neural stem-like cells via juxtacrine and paracrine interactions. (Alexanian AR) Exp Cell Res 2005 Nov 01;310(2):383-91 PMID: 16168985 09/20/2005
  • Efficient differentiation and integration of lineage-restricted neural precursors in the traumatically injured adult cat spinal cord. (Alexanian AR, Crowe MJ, Kurpad SN) J Neurosci Methods 2006 Jan 15;150(1):41-6 PMID: 16087243 08/10/2005
  • Quiescent neural cells regain multipotent stem cell characteristics influenced by adult neural stem cells in co-culture. (Alexanian AR, Kurpad SN) Exp Neurol 2005 Jan;191(1):193-7 PMID: 15589526 12/14/2004
  • Differentiating adult hippocampal stem cells into neural crest derivatives. (Alexanian AR, Sieber-Blum M) Neuroscience 2003;118(1):1-5 PMID: 12676130 04/05/2003
  • Calcium-dependent regulation of interactions of caldesmon with calcium-binding proteins found in growth cones of chick forebrain neurons. (Alexanian AR, Bamburg JR, Hidaka H, Mornet D) Cell Mol Neurobiol 2001 Oct;21(5):437-51 PMID: 11860183 02/28/2002
  • Proliferation and regeneration of retrogradely labeled adult rat corticospinal neurons in culture. (Alexanian AR, Nornes HO) Exp Neurol 2001 Aug;170(2):277-82 PMID: 11476593 07/31/2001
  • Reversal of drug resistance in sarcoma-45 by the new calmodulin antagonist--trihydrochloride of [1,2,5-trimethyl-4-phenyl-4-beta-[N-(beta-ethylamino)-N-4'-methoxybe nzy l]-ethylamino] piperidine (AR-2). (Alexanian AR, Arutyunian NS) Invest New Drugs 1999;17(2):105-10 PMID: 10638481 01/19/2000
  • Neuronal survival activity of s100betabeta is enhanced by calcineurin inhibitors and requires activation of NF-kappaB. (Alexanian AR, Bamburg JR) FASEB J 1999 Sep;13(12):1611-20 PMID: 10463953 08/27/1999
  • Antiarrhythmic action of the new calcium antagonist [1,2,5-trimethyl-4-phenyl-4-beta-(N-cyanoethyl-N-4'-methoxybenzyl) -ethylamino]piperidine dihydrochloride. (Alexanian AR, Arutyunian NS, Galoyan AA) Arzneimittelforschung 1996 Dec;46(12):1110-3 PMID: 9006783 12/01/1996
  • Last update: 12/12/2016
    jenkins-FCD Prod-153 3ca6710ea990189ceb85f4312e7298b5922ce1a6