Medical College of Wisconsin
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Daniel M. Lipinski PhD

Daniel M. Lipinski PhD profile photo picture

Associate Professor

Institution: Medical College of Wisconsin
Department: Ophthalmology and Visual Sciences
Program: Research

Publications (36)

  • Porcine Sub-Retinal Pigment Epithelium Deposits: A Model for Dry Age-Related Macular Degeneration With Comparison to Human Drusen. (Shaw EM, Anderson DM, Periasamy R, Schey KL, Curcio CA, Lipinski DM) Invest Ophthalmol Vis Sci 2025 Mar 03;66(3):18 PMID: 40048184 PMCID: PMC11895847 SCOPUS ID: 2-s2.0-86000303608 03/06/2025    
  • The vectors went in two-by-two: Transduction efficiency and tolerability of dual and triple rAAV vector delivery following intravitreal injection for genome-editing applications. (Fehrman RL, Chern KJ, Stoltz KP, Lipinski DM) Exp Eye Res 2025 Feb;251:110223 PMID: 39710097 SCOPUS ID: 2-s2.0-85213252844 12/23/2024       1 Citation
  • Characterization of drusen formation in a primary porcine tissue culture model of dry AMD. (Shaw EM, Tate AJ, Periasamy R, Lipinski DM) Mol Ther Methods Clin Dev 2024 Dec 12;32(4):101331 PMID: 39434920 PMCID: PMC11492580 SCOPUS ID: 2-s2.0-85207665278 10/22/2024       2 Citations
  • Human iPSC-derived photoreceptor transplantation in the cone dominant 13-lined ground squirrel. (Yu CT, Kandoi S, Periasamy R, Reddy LVK, Follett HM, Summerfelt P, Martinez C, Guillaume C, Bowie O, Connor TB, Lipinski DM, Allen KP, Merriman DK, Carroll J, Lamba DA) Stem Cell Reports 2024 Mar 12;19(3):331-342 PMID: 38335965 PMCID: PMC10937153 SCOPUS ID: 2-s2.0-85186065745 02/10/2024       8 Citations
  • Downregulation of lysosomal trafficking in ARPE19 cells leads to decreased transfection efficiency at high passage. (Hood EMS, Lipinski RAJ, Lipinski DM) bioRxiv 2023 Jul 26 PMID: 37546846 PMCID: PMC10402107 08/07/2023    
  • Tolerability and tropism of recombinant adeno-associated virus vectors in the African green monkey (Chlorocebus sabaeus) anterior chamber. (Chern KJ, Issac KZ, Gumbs ZD, O'Connor ME, Lawrence MS, Lipinski DM) Gene Ther 2023 Sep;30(9):714-722 PMID: 37221271 PMCID: PMC11287778 SCOPUS ID: 2-s2.0-85160260133 05/24/2023    
  • Improving retinal vascular endothelial cell tropism through rational rAAV capsid design. (Periasamy R, Patel DD, Boye SL, Boye SE, Lipinski DM) PLoS One 2023;18(5):e0285370 PMID: 37167304 PMCID: PMC10174500 SCOPUS ID: 2-s2.0-85159655750 05/11/2023       1 Citation
  • Isolation, culture, and cryosectioning of primary porcine retinal pigment epithelium on transwell cell culture inserts (Hood EMS, Curcio CA, Lipinski D) STAR Protocols 16 December 2022;3(4) SCOPUS ID: 2-s2.0-85139727880 12/16/2022       9 Citations
  • Prostaglandin-based rAAV-mediated glaucoma gene therapy in Brown Norway rats. (Chern KJ, Nettesheim ER, Reid CA, Li NW, Marcoe GJ, Lipinski DM) Commun Biol 2022 Nov 03;5(1):1169 PMID: 36329259 PMCID: PMC9633612 SCOPUS ID: 2-s2.0-85141145849 11/05/2022       14 Citations
  • Identification of Novel Retinal Pericyte-Targeting rAAV Vectors Through Directed Evolution. (Patel DD, Marsic D, Periasamy R, Zolotukhin S, Lipinski DM) Transl Vis Sci Technol 2022 Aug 01;11(8):28 PMID: 36018583 PMCID: PMC9428359 SCOPUS ID: 2-s2.0-85136924759 08/27/2022       4 Citations
  • rAAV-mediated over-expression of acid ceramidase prevents retinopathy in a mouse model of Farber lipogranulomatosis. (Zhang H, Nagree MS, Liu H, Pan X, Medin JA, Lipinski DM) Gene Ther 2023 Apr;30(3-4):297-308 PMID: 35902747 SCOPUS ID: 2-s2.0-85149011321 07/29/2022       4 Citations
  • Pre-retinal delivery of recombinant adeno-associated virus vector significantly improves retinal transduction efficiency. (Zhang H, Sajdak BS, Merriman DK, Carroll J, Lipinski DM) Mol Ther Methods Clin Dev 2021 Sep 10;22:96-106 PMID: 34485598 PMCID: PMC8390453 SCOPUS ID: 2-s2.0-85122743594 09/07/2021       3 Citations
  • Development of a Preclinical Laser Speckle Contrast Imaging Instrument for Assessing Systemic and Retinal Vascular Function in Small Rodents. (Patel DD, Dhalla AH, Viehland C, Connor TB, Lipinski DM) Transl Vis Sci Technol 2021 Aug 02;10(9):19 PMID: 34403474 PMCID: PMC8374978 SCOPUS ID: 2-s2.0-85114392221 08/18/2021       10 Citations
  • Electroretinogram of the Cone-Dominant Thirteen-Lined Ground Squirrel during Euthermia and Hibernation in Comparison with the Rod-Dominant Brown Norway Rat. (Zhang H, Sajdak BS, Merriman DK, McCall MA, Carroll J, Lipinski DM) Invest Ophthalmol Vis Sci 2020 Jun 03;61(6):6 PMID: 32492111 PMCID: PMC7415905 SCOPUS ID: 2-s2.0-85085963234 06/04/2020       12 Citations
  • Validating a low-cost laser speckle contrast imaging system as a quantitative tool for assessing retinal vascular function. (Patel DD, Lipinski DM) Sci Rep 2020 Apr 28;10(1):7177 PMID: 32346043 PMCID: PMC7188677 SCOPUS ID: 2-s2.0-85083998758 04/30/2020       20 Citations
  • A Comparison of Inducible Gene Expression Platforms: Implications for Recombinant Adeno-Associated Virus (rAAV) Vector-Mediated Ocular Gene Therapy. (Lipinski DM) Adv Exp Med Biol 2019;1185:79-83 PMID: 31884592 SCOPUS ID: 2-s2.0-85077321194 12/31/2019       5 Citations
  • Presynaptic Expression of LRIT3 Transsynaptically Organizes the Postsynaptic Glutamate Signaling Complex Containing TRPM1. (Hasan N, Pangeni G, Cobb CA, Ray TA, Nettesheim ER, Ertel KJ, Lipinski DM, McCall MA, Gregg RG) Cell Rep 2019 Jun 11;27(11):3107-3116.e3 PMID: 31189098 PMCID: PMC6628893 SCOPUS ID: 2-s2.0-85066800714 06/13/2019       37 Citations
  • Acid Ceramidase Deficiency in Mice Leads to Severe Ocular Pathology and Visual Impairment. (Yu FPS, Sajdak BS, Sikora J, Salmon AE, Nagree MS, Gurka J, Kassem IS, Lipinski DM, Carroll J, Medin JA) Am J Pathol 2019 Feb;189(2):320-338 PMID: 30472209 PMCID: PMC6412726 SCOPUS ID: 2-s2.0-85060099082 11/26/2018       19 Citations
  • A Destabilizing Domain Allows for Fast, Noninvasive, Conditional Control of Protein Abundance in the Mouse Eye - Implications for Ocular Gene Therapy. (Datta S, Renwick M, Chau VQ, Zhang F, Nettesheim ER, Lipinski DM, Hulleman JD) Invest Ophthalmol Vis Sci 2018 Oct 01;59(12):4909-4920 PMID: 30347085 PMCID: PMC6181441 SCOPUS ID: 2-s2.0-85055194829 10/23/2018       17 Citations
  • Development of an inducible anti-VEGF rAAV gene therapy strategy for the treatment of wet AMD. (Reid CA, Nettesheim ER, Connor TB, Lipinski DM) Sci Rep 2018 Aug 06;8(1):11763 PMID: 30082848 PMCID: PMC6079038 SCOPUS ID: 2-s2.0-85051247613 08/08/2018       55 Citations
  • Improvement of Photoreceptor Targeting via Intravitreal Delivery in Mouse and Human Retina Using Combinatory rAAV2 Capsid Mutant Vectors. (Reid CA, Ertel KJ, Lipinski DM) Invest Ophthalmol Vis Sci 2017 Dec 01;58(14):6429-6439 PMID: 29260200 PMCID: PMC5736327 SCOPUS ID: 2-s2.0-85038855464 12/21/2017       32 Citations
  • Small and Micro-Scale Recombinant Adeno-Associated Virus Production and Purification for Ocular Gene Therapy Applications. (Reid CA, Lipinski DM) Methods Mol Biol 2018;1715:19-31 PMID: 29188503 SCOPUS ID: 2-s2.0-85036634077 12/01/2017       18 Citations
  • miRNA-mediated post-transcriptional silencing of transgenes leads to increased adeno-associated viral vector yield and targeting specificity. (Reid CA, Boye SL, Hauswirth WW, Lipinski DM) Gene Ther 2017 Aug;24(8):462-469 PMID: 28617420 SCOPUS ID: 2-s2.0-85030779767 06/16/2017       12 Citations
  • Single residue AAV capsid mutation improves transduction of photoreceptors in the Abca4-/- mouse and bipolar cells in the rd1 mouse and human retina ex vivo. (De Silva SR, Charbel Issa P, Singh MS, Lipinski DM, Barnea-Cramer AO, Walker NJ, Barnard AR, Hankins MW, MacLaren RE) Gene Ther 2016 Nov;23(11):767-774 PMID: 27416076 PMCID: PMC5097463 SCOPUS ID: 2-s2.0-84981508189 11/04/2016       26 Citations
  • Systemic Vascular Transduction by Capsid Mutant Adeno-Associated Virus After Intravenous Injection. (Lipinski DM, Reid CA, Boye SL, Peterson JJ, Qi X, Boye SE, Boulton ME, Hauswirth WW) Hum Gene Ther 2015 Nov;26(11):767-76 PMID: 26359319 PMCID: PMC4651034 SCOPUS ID: 2-s2.0-84946906911 09/12/2015       12 Citations
  • CNTF Gene Therapy Confers Lifelong Neuroprotection in a Mouse Model of Human Retinitis Pigmentosa. (Lipinski DM, Barnard AR, Singh MS, Martin C, Lee EJ, Davies WIL, MacLaren RE) Mol Ther 2015 Aug;23(8):1308-1319 PMID: 25896245 PMCID: PMC4539573 SCOPUS ID: 2-s2.0-84938420570 04/22/2015       71 Citations
  • Vesicular stomatitis virus glycoprotein- and Venezuelan equine encephalitis virus-derived glycoprotein-pseudotyped lentivirus vectors differentially transduce corneal endothelium, trabecular meshwork, and human photoreceptors. (Lipinski DM, Barnard AR, Charbel Issa P, Singh MS, De Silva SR, Trabalza A, Eleftheriadou I, Ellison SM, Mazarakis ND, MacLaren RE) Hum Gene Ther 2014 Jan;25(1):50-62 PMID: 24125177 SCOPUS ID: 2-s2.0-84892868349 10/16/2013       23 Citations
  • Functional expression of Rab escort protein 1 following AAV2-mediated gene delivery in the retina of choroideremia mice and human cells ex vivo. (Tolmachova T, Tolmachov OE, Barnard AR, de Silva SR, Lipinski DM, Walker NJ, Maclaren RE, Seabra MC) J Mol Med (Berl) 2013 Jul;91(7):825-37 PMID: 23756766 PMCID: PMC3695676 SCOPUS ID: 2-s2.0-84879842921 06/13/2013       83 Citations
  • Assessment of tropism and effectiveness of new primate-derived hybrid recombinant AAV serotypes in the mouse and primate retina. (Charbel Issa P, De Silva SR, Lipinski DM, Singh MS, Mouravlev A, You Q, Barnard AR, Hankins MW, During MJ, Maclaren RE) PLoS One 2013;8(4):e60361 PMID: 23593201 PMCID: PMC3621895 SCOPUS ID: 2-s2.0-84876013531 04/18/2013       46 Citations
  • Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation. (Singh MS, Charbel Issa P, Butler R, Martin C, Lipinski DM, Sekaran S, Barnard AR, MacLaren RE) Proc Natl Acad Sci U S A 2013 Jan 15;110(3):1101-6 PMID: 23288902 PMCID: PMC3549087 SCOPUS ID: 2-s2.0-84872533232 01/05/2013       218 Citations
  • Clinical applications of retinal gene therapy. (Lipinski DM, Thake M, MacLaren RE) Prog Retin Eye Res 2013 Jan;32:22-47 PMID: 22995954 SCOPUS ID: 2-s2.0-84871388247 09/22/2012       109 Citations
  • Optimization of in vivo confocal autofluorescence imaging of the ocular fundus in mice and its application to models of human retinal degeneration. (Charbel Issa P, Singh MS, Lipinski DM, Chong NV, Delori FC, Barnard AR, MacLaren RE) Invest Ophthalmol Vis Sci 2012 Feb;53(2):1066-75 PMID: 22169101 PMCID: PMC3317405 SCOPUS ID: 2-s2.0-84859913048 12/16/2011       58 Citations
  • Combining M-FISH and Quantum Dot technology for fast chromosomal assignment of transgenic insertions. (Yusuf M, Bauer DL, Lipinski DM, MacLaren RE, Wade-Martins R, Mir KU, Volpi EV) BMC Biotechnol 2011 Dec 13;11:121 PMID: 22165957 PMCID: PMC3266222 SCOPUS ID: 2-s2.0-83255188955 12/15/2011       5 Citations
  • AAV-mediated gene transfer of human X-linked inhibitor of apoptosis protects against oxidative cell death in human RPE cells. (Shan H, Ji D, Barnard AR, Lipinski DM, You Q, Lee EJ, Kamalden TA, Sun X, MacLaren RE) Invest Ophthalmol Vis Sci 2011 Dec 20;52(13):9591-7 PMID: 22039248 SCOPUS ID: 2-s2.0-84863795768 11/01/2011       17 Citations
  • Assessment of cone survival in response to CNTF, GDNF, and VEGF165b in a novel ex vivo model of end-stage retinitis pigmentosa. (Lipinski DM, Singh MS, MacLaren RE) Invest Ophthalmol Vis Sci 2011 Sep 21;52(10):7340-6 PMID: 21873685 SCOPUS ID: 2-s2.0-84856380918 08/30/2011       27 Citations
  • Characterization of a dominant cone degeneration in a green fluorescent protein-reporter mouse with disruption of Loci associated with human dominant retinal dystrophy. (Lipinski DM, Yusuf M, Barnard AR, Damant C, Charbel Issa P, Singh MS, Lee E, Davies WL, Volpi EV, MacLaren RE) Invest Ophthalmol Vis Sci 2011 Aug 22;52(9):6617-23 PMID: 21705682 PMCID: PMC3175985 SCOPUS ID: 2-s2.0-80054790605 06/28/2011       12 Citations
    • Last update: 04/24/2025