Medical College of Wisconsin
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Elizabeth Sweeny PhD

Elizabeth Sweeny PhD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Biochemistry

Member of the Cancer Center
Member of the Cardiovascular Center


Publications (20)

  • GAPDH is involved in the heme-maturation of myoglobin and hemoglobin. (Tupta B, Stuehr E, Sumi MP, Sweeny EA, Smith B, Stuehr DJ, Ghosh A) FASEB J 2022 02;36(2):e22099 PMID: 34972240 SCOPUS ID: 2-s2.0-85123037483 01/01/2022       2 Citations
  • Nitric oxide and heme-NO stimulate superoxide production by NADPH oxidase 5. (Sweeny EA, Hunt AP, Batka AE, Schlanger S, Lehnert N, Stuehr DJ) Free Radic Biol Med 2021 08 20;172:252-263 PMID: 34139309 PMCID: PMC8355125 SCOPUS ID: 2-s2.0-85109100150 06/18/2021    
  • Dynamic regulation of NADPH oxidase 5 by intracellular heme levels and cellular chaperones. (Sweeny EA, Schlanger S, Stuehr DJ) Redox Biol 2020 09;36:101656 PMID: 32738790 PMCID: PMC7394750 SCOPUS ID: 2-s2.0-85088630674 08/02/2020       5 Citations
  • GAPDH delivers heme to soluble guanylyl cyclase. (Dai Y, Sweeny EA, Schlanger S, Ghosh A, Stuehr DJ) J Biol Chem 2020 06 12;295(24):8145-8154 PMID: 32358060 PMCID: PMC7294094 SCOPUS ID: 2-s2.0-85086495703 05/03/2020       18 Citations
  • Structural and mechanistic insights into Hsp104 function revealed by synchrotron X-ray footprinting. (Sweeny EA, Tariq A, Gurpinar E, Go MS, Sochor MA, Kan ZY, Mayne L, Englander SW, Shorter J) J Biol Chem 2020 02 07;295(6):1517-1538 PMID: 31882541 PMCID: PMC7008382 SCOPUS ID: 2-s2.0-85079204211 12/29/2019       8 Citations
  • Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity. (Tariq A, Lin J, Jackrel ME, Hesketh CD, Carman PJ, Mack KL, Weitzman R, Gambogi C, Hernandez Murillo OA, Sweeny EA, Gurpinar E, Yokom AL, Gates SN, Yee K, Sudesh S, Stillman J, Rizo AN, Southworth DR, Shorter J) Cell Rep 2019 08 20;28(8):2080-2095.e6 PMID: 31433984 PMCID: PMC6750954 SCOPUS ID: 2-s2.0-85070688471 08/23/2019       18 Citations
  • Hsp104 and Potentiated Variants Can Operate as Distinct Nonprocessive Translocases. (Durie CL, Lin J, Scull NW, Mack KL, Jackrel ME, Sweeny EA, Castellano LM, Shorter J, Lucius AL) Biophys J 2019 05 21;116(10):1856-1872 PMID: 31027887 PMCID: PMC6531783 SCOPUS ID: 2-s2.0-85064567361 04/28/2019       7 Citations
  • Glyceraldehyde-3-phosphate dehydrogenase is a chaperone that allocates labile heme in cells. (Sweeny EA, Singh AB, Chakravarti R, Martinez-Guzman O, Saini A, Haque MM, Garee G, Dans PD, Hannibal L, Reddi AR, Stuehr DJ) J Biol Chem 2018 09 14;293(37):14557-14568 PMID: 30012884 PMCID: PMC6139559 SCOPUS ID: 2-s2.0-85053291002 07/18/2018       50 Citations
  • Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains. (Guo L, Kim HJ, Wang H, Monaghan J, Freyermuth F, Sung JC, O'Donovan K, Fare CM, Diaz Z, Singh N, Zhang ZC, Coughlin M, Sweeny EA, DeSantis ME, Jackrel ME, Rodell CB, Burdick JA, King OD, Gitler AD, Lagier-Tourenne C, Pandey UB, Chook YM, Taylor JP, Shorter J) Cell 2018 04 19;173(3):677-692.e20 PMID: 29677512 PMCID: PMC5911940 SCOPUS ID: 2-s2.0-85045775165 04/21/2018       218 Citations
  • Hsp90 chaperones hemoglobin maturation in erythroid and nonerythroid cells. (Ghosh A, Garee G, Sweeny EA, Nakamura Y, Stuehr DJ) Proc Natl Acad Sci U S A 2018 02 06;115(6):E1117-E1126 PMID: 29358373 PMCID: PMC5819442 SCOPUS ID: 2-s2.0-85041537342 01/24/2018       24 Citations
  • Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104. (Gates SN, Yokom AL, Lin J, Jackrel ME, Rizo AN, Kendsersky NM, Buell CE, Sweeny EA, Mack KL, Chuang E, Torrente MP, Su M, Shorter J, Southworth DR) Science 2017 07 21;357(6348):273-279 PMID: 28619716 PMCID: PMC5770238 SCOPUS ID: 2-s2.0-85020493156 06/18/2017       160 Citations
  • Avidity for Polypeptide Binding by Nucleotide-Bound Hsp104 Structures. (Weaver CL, Duran EC, Mack KL, Lin J, Jackrel ME, Sweeny EA, Shorter J, Lucius AL) Biochemistry 2017 04 18;56(15):2071-2075 PMID: 28379007 PMCID: PMC5649362 SCOPUS ID: 2-s2.0-85020121050 04/06/2017       7 Citations
  • Formation of Nitrogenase NifDK Tetramers in the Mitochondria of Saccharomyces cerevisiae. (Burén S, Young EM, Sweeny EA, Lopez-Torrejón G, Veldhuizen M, Voigt CA, Rubio LM) ACS Synth Biol 2017 06 16;6(6):1043-1055 PMID: 28221768 PMCID: PMC5477005 SCOPUS ID: 2-s2.0-85020844594 02/22/2017       42 Citations
  • Mechanistic and Structural Insights into the Prion-Disaggregase Activity of Hsp104. (Sweeny EA, Shorter J) J Mol Biol 2016 05 08;428(9 Pt B):1870-85 PMID: 26608812 PMCID: PMC4860052 SCOPUS ID: 2-s2.0-84960926930 11/27/2015       61 Citations
  • The Hsp104 N-terminal domain enables disaggregase plasticity and potentiation. (Sweeny EA, Jackrel ME, Go MS, Sochor MA, Razzo BM, DeSantis ME, Gupta K, Shorter J) Mol Cell 2015 Mar 05;57(5):836-849 PMID: 25620563 PMCID: PMC4623595 SCOPUS ID: 2-s2.0-84924037150 01/27/2015       67 Citations
  • Conserved distal loop residues in the Hsp104 and ClpB middle domain contact nucleotide-binding domain 2 and enable Hsp70-dependent protein disaggregation. (Desantis ME, Sweeny EA, Snead D, Leung EH, Go MS, Gupta K, Wendler P, Shorter J) J Biol Chem 2014 Jan 10;289(2):848-67 PMID: 24280225 PMCID: PMC3887210 SCOPUS ID: 2-s2.0-84891905978 11/28/2013       38 Citations
  • Operational plasticity enables hsp104 to disaggregate diverse amyloid and nonamyloid clients. (DeSantis ME, Leung EH, Sweeny EA, Jackrel ME, Cushman-Nick M, Neuhaus-Follini A, Vashist S, Sochor MA, Knight MN, Shorter J) Cell 2012 Nov 09;151(4):778-793 PMID: 23141537 PMCID: PMC3496281 SCOPUS ID: 2-s2.0-84869017593 11/13/2012       125 Citations
  • Purification of hsp104, a protein disaggregase. (Sweeny EA, DeSantis ME, Shorter J) J Vis Exp 2011 Sep 30(55) PMID: 21989490 PMCID: PMC3230206 SCOPUS ID: 2-s2.0-80053910072 10/13/2011       14 Citations
  • A synergistic small-molecule combination directly eradicates diverse prion strain structures. (Roberts BE, Duennwald ML, Wang H, Chung C, Lopreiato NP, Sweeny EA, Knight MN, Shorter J) Nat Chem Biol 2009 Dec;5(12):936-46 PMID: 19915541 PMCID: PMC2909773 SCOPUS ID: 2-s2.0-73549103148 11/17/2009       80 Citations
  • Prion proteostasis: Hsp104 meets its supporting cast. (Sweeny EA, Shorter J) Prion 2008 Oct-Dec;2(4):135-40 PMID: 19242125 PMCID: PMC2658762 SCOPUS ID: 2-s2.0-63049114323 02/27/2009       40 Citations
  • Last update: 03/11/2022