Guan Chen MD, PhD
Professor
Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Program Development
Member of the Cancer Center
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Research Experience
Cancer Signaling, Ras Oncogenesis, Nuclear ReceptorsPublications
Tyrosine dephosphorylation enhances the therapeutic target activity of epidermal growth factor receptor (EGFR) by disrupting its interaction with estrogen receptor (ER). (Ma S, Yin N, Qi X, Pfister SL, Zhang MJ, Ma R, Chen G) Oncotarget 2015 May 30;6(15):13320-33 PMID: 26079946 PMCID: PMC4537017 06/17/2015 6 Citationsp38γ MAPK Is a Therapeutic Target for Triple-Negative Breast Cancer by Stimulation of Cancer Stem-Like Cell Expansion. (Qi X, Yin N, Ma S, Lepp A, Tang J, Jing W, Johnson B, Dwinell MB, Chitambar CR, Chen G) Stem Cells 2015 Sep;33(9):2738-47 PMID: 26077647 PMCID: PMC4792188 06/17/2015 11 Citationsp38γ MAPK is required for inflammation-associated colon tumorigenesis. (Yin N, Qi X, Tsai S, Lu Y, Basir Z, Oshima K, Thomas JP, Myers CR, Stoner G, Chen G) Oncogene 2016 Feb 25;35(8):1039-48 PMID: 25961922 05/12/2015 10 CitationsIdentification of a ternary protein-complex as a therapeutic target for K-Ras-dependent colon cancer. (Qi X, Xie C, Hou S, Li G, Yin N, Dong L, Lepp A, Chesnik MA, Mirza SP, Szabo A, Tsai S, Basir Z, Wu S, Chen G) Oncotarget 2014 Jun 30;5(12):4269-82 PMID: 24962213 PMCID: PMC4147322 06/26/2014 9 CitationsProtein-tyrosine phosphatase H1 increases breast cancer sensitivity to antiestrogens by dephosphorylating estrogen receptor at Tyr537. (Suresh PS, Ma S, Migliaccio A, Chen G) Mol Cancer Ther 2014 Jan;13(1):230-8 PMID: 24227889 11/15/2013 9 CitationsMK2 Regulates Ras Oncogenesis through Stimulating ROS Production. (Kobayashi Y, Qi X, Chen G) Genes Cancer 2012 Jul;3(7-8):521-30 PMID: 23264852 PMCID: PMC3527985 12/25/2012 p38γ Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response. (Hou S, Suresh PS, Qi X, Lepp A, Mirza SP, Chen G) J Biol Chem 2012 Aug 10;287(33):27895-905 PMID: 22730326 PMCID: PMC3431700 06/26/2012 13 Citationsp38γ mitogen-activated protein kinase (MAPK) confers breast cancer hormone sensitivity by switching estrogen receptor (ER) signaling from classical to nonclassical pathway via stimulating ER phosphorylation and c-Jun transcription. (Qi X, Zhi H, Lepp A, Wang P, Huang J, Basir Z, Chitambar CR, Myers CR, Chen G) J Biol Chem 2012 Apr 27;287(18):14681-91 PMID: 22399296 PMCID: PMC3340246 03/09/2012 18 CitationsPhosphorylation and stabilization of topoisomerase IIα protein by p38γ mitogen-activated protein kinase sensitize breast cancer cells to its poisons. (Qi X, Hou S, Lepp A, Li R, Basir Z, Lou Z, Chen G) J Biol Chem 2011 Oct 14;286(41):35883-90 PMID: 21878638 PMCID: PMC3195563 09/01/2011 13 CitationsPTPH1 cooperates with vitamin D receptor to stimulate breast cancer growth through their mutual stabilization. (Zhi HY, Hou SW, Li RS, Basir Z, Xiang Q, Szabo A, Chen G) Oncogene 2011 Apr 07;30(14):1706-15 PMID: 21119599 PMCID: PMC3072445 12/02/2010 25 CitationsPTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction. (Hou SW, Zhi HY, Pohl N, Loesch M, Qi XM, Li RS, Basir Z, Chen G) Cancer Res 2010 Apr 01;70(7):2901-10 PMID: 20332238 PMCID: PMC2848905 03/25/2010 44 Citationsp38gamma MAPK cooperates with c-Jun in trans-activating matrix metalloproteinase 9. (Loesch M, Zhi HY, Hou SW, Qi XM, Li RS, Basir Z, Iftner T, Cuenda A, Chen G) J Biol Chem 2010 May 14;285(20):15149-58 PMID: 20231272 PMCID: PMC2865276 03/17/2010 55 CitationsThe p38 MAPK stress pathway as a tumor suppressor or more? (Loesch M, Chen G) Front Biosci 2008 May 01;13:3581-93 PMID: 18508457 PMCID: PMC4758212 05/30/2008 57 Citationsp38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response. (Qi X, Pohl NM, Loesch M, Hou S, Li R, Qin JZ, Cuenda A, Chen G) J Biol Chem 2007 Oct 26;282(43):31398-408 PMID: 17724032 08/29/2007 38 CitationsStress-induced c-Jun-dependent Vitamin D receptor (VDR) activation dissects the non-classical VDR pathway from the classical VDR activity. (Li QP, Qi X, Pramanik R, Pohl NM, Loesch M, Chen G) J Biol Chem 2007 Jan 19;282(3):1544-51 PMID: 17121851 11/24/2006 21 Citationsp38gamma mitogen-activated protein kinase integrates signaling crosstalk between Ras and estrogen receptor to increase breast cancer invasion. (Qi X, Tang J, Loesch M, Pohl N, Alkan S, Chen G) Cancer Res 2006 Aug 01;66(15):7540-7 PMID: 16885352 PMCID: PMC2174269 08/04/2006 30 CitationsEssential role of p38gamma in K-Ras transformation independent of phosphorylation. (Tang J, Qi X, Mercola D, Han J, Chen G) J Biol Chem 2005 Jun 24;280(25):23910-7 PMID: 15851477 PMCID: PMC1224721 04/27/2005 43 Citationsp38 MAPK activation selectively induces cell death in K-ras-mutated human colon cancer cells through regulation of vitamin D receptor. (Qi X, Tang J, Pramanik R, Schultz RM, Shirasawa S, Sasazuki T, Han J, Chen G) J Biol Chem 2004 May 21;279(21):22138-44 PMID: 15037631 03/24/2004 48 CitationsEstrogen receptor inhibits c-Jun-dependent stress-induced cell death by binding and modifying c-Jun activity in human breast cancer cells. (Qi X, Borowicz S, Pramanik R, Schultz RM, Han J, Chen G) J Biol Chem 2004 Feb 20;279(8):6769-77 PMID: 14638681 11/26/2003 24 Citationsp38 isoforms have opposite effects on AP-1-dependent transcription through regulation of c-Jun. The determinant roles of the isoforms in the p38 MAPK signal specificity. (Pramanik R, Qi X, Borowicz S, Choubey D, Schultz RM, Han J, Chen G) J Biol Chem 2003 Feb 14;278(7):4831-9 PMID: 12475989 12/12/2002 115 CitationsThe p38 and JNK pathways cooperate to trans-activate vitamin D receptor via c-Jun/AP-1 and sensitize human breast cancer cells to vitamin D(3)-induced growth inhibition. (Qi X, Pramanik R, Wang J, Schultz RM, Maitra RK, Han J, DeLuca HF, Chen G) J Biol Chem 2002 Jul 19;277(29):25884-92 PMID: 11983707 05/02/2002 86 CitationsThe p38 pathway provides negative feedback for Ras proliferative signaling. (Chen G, Hitomi M, Han J, Stacey DW) J Biol Chem 2000 Dec 15;275(50):38973-80 PMID: 10978313 09/09/2000 136 Citations
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