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Jeffrey A. Wesson MD, PhD

Jeffrey A. Wesson MD, PhD profile photo picture

Adjunct Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Nephrology
Program: Administration

View Curriculum Vitae

Research Areas of Interest

  • Calcium Oxalate
  • Chemical Phenomena
  • Crystallization
  • Humans
  • Kidney Calculi
  • Macromolecular Substances
  • Membrane Glycoproteins
  • Osteopontin
  • Particle Size
  • Peptides
  • Polymers
  • Protein Binding
  • Proteome
  • Proteomics
  • Sialoglycoproteins
  • Urinary Calculi
  • Urine

    • Research Experience

  • Adhesiveness
  • Adult
  • Calcium Oxalate
  • Cell Adhesion
  • Chemical Phenomena
  • Crystallization
  • Kidney Calculi
  • Macromolecular Substances
  • Membrane Glycoproteins
  • Microscopy, Atomic Force
  • Osteopontin
  • Particle Size
  • Peptides
  • Polymers
  • Protein Binding
  • Proteome
  • Proteomics
  • Sialoglycoproteins
  • Urinary Calculi
  • Urine

    • Clinical Expertise

  • Calcium Oxalate
  • Crystallization
  • Humans
  • Kidney Calculi
  • Urinary Calculi

    • Methodologies and Techniques

  • Calcium Oxalate
  • Cell Adhesion
  • Chemical Phenomena
  • Crystallization
  • Humans
  • Kidney Calculi
  • Macromolecular Substances
  • Membrane Glycoproteins
  • Microscopy, Atomic Force
  • Osteopontin
  • Particle Size
  • Peptides
  • Polymers
  • Protein Binding
  • Proteome
  • Proteomics
  • Sialoglycoproteins
  • Urinary Calculi
  • Urine

    • Publications (37)

  • Comparison of Calcium Oxalate Stone Matrix Proteomics Data to Predictions from In Vitro Studies of Protein-Crystal Interactions (Wesson JA) Crystal Growth and Design 15 January 2025;25(2):452-461 SCOPUS ID: 2-s2.0-85213288589 01/15/2025    
  • Comparison of cat stone matrix and cat urine proteomes to human calcium oxalate stone matrix and urine proteomes. (Wesson JA, Zenka R, Sherman K, Eisenhauer J, Lulich J, Davis C) Urolithiasis 2024 Sep 13;52(1):130 PMID: 39271505 SCOPUS ID: 2-s2.0-85203993133 09/14/2024       1 Citation
  • Comparison of cat and human calcium oxalate monohydrate kidney stone matrix proteomes. (Wesson JA, Zenka R, Lulich J, Eisenhauer J, Davis C) Urolithiasis 2022 Dec;50(6):653-664 PMID: 36180755 PMCID: PMC10173728 SCOPUS ID: 2-s2.0-85139230911 10/01/2022       4 Citations
  • Protein primary structure correlates with calcium oxalate stone matrix preference. (Tian Y, Tirrell M, Davis C, Wesson JA) PLoS One 2021;16(9):e0257515 PMID: 34555074 PMCID: PMC8459966 SCOPUS ID: 2-s2.0-85115750217 09/24/2021       14 Citations
  • Exploring mechanisms of protein influence on calcium oxalate kidney stone formation. (Berger GK, Eisenhauer J, Vallejos A, Hoffmann B, Wesson JA) Urolithiasis 2021 Aug;49(4):281-290 PMID: 33587148 PMCID: PMC8316271 SCOPUS ID: 2-s2.0-85101461417 02/16/2021       17 Citations
  • Selective protein enrichment in calcium oxalate stone matrix: a window to pathogenesis? (Wesson JA, Kolbach-Mandel AM, Hoffmann BR, Davis C, Mandel NS) Urolithiasis 2019 Dec;47(6):521-532 PMID: 30993355 PMCID: PMC8496971 SCOPUS ID: 2-s2.0-85064686878 04/18/2019       25 Citations
  • Stone former urine proteome demonstrates a cationic shift in protein distribution compared to normal. (Kolbach-Mandel AM, Mandel NS, Hoffmann BR, Kleinman JG, Wesson JA) Urolithiasis 2017 Aug;45(4):337-346 PMID: 28314883 PMCID: PMC5511579 SCOPUS ID: 2-s2.0-85015608912 03/21/2017       22 Citations
  • The role of macromolecules in the formation of kidney stones. (Rimer JD, Kolbach-Mandel AM, Ward MD, Wesson JA) Urolithiasis 2017 Feb;45(1):57-74 PMID: 27913854 PMCID: PMC5253101 SCOPUS ID: 2-s2.0-85000979536 12/04/2016       60 Citations
  • Guaifenesin stone matrix proteomics: a protocol for identifying proteins critical to stone formation. (Kolbach-Mandel AM, Mandel NS, Cohen SR, Kleinman JG, Ahmed F, Mandel IC, Wesson JA) Urolithiasis 2017 Apr;45(2):139-149 PMID: 27435233 PMCID: PMC8496968 SCOPUS ID: 2-s2.0-84978640626 07/21/2016       4 Citations
  • Exploring calcium oxalate crystallization: a constant composition approach. (Kolbach-Mandel AM, Kleinman JG, Wesson JA) Urolithiasis 2015 Oct;43(5):397-409 PMID: 26016572 PMCID: PMC4573792 SCOPUS ID: 2-s2.0-84941997196 05/29/2015       14 Citations
  • Polyisobutylene Urolithiasis Due to Ileal Conduit Urostomy Appliance: An Index Case. (Avallone MA, Kolbach-Mandel AM, Mandel IC, Mandel NS, Dietrich PN, Wesson JA, Davis CM) J Endourol Case Rep 2015;1(1):41-3 PMID: 27579385 PMCID: PMC4996579 01/01/2015    
  • Relative deficiency of acidic isoforms of osteopontin from stone former urine. (Kolbach AM, Afzal O, Halligan B, Sorokina E, Kleinman JG, Wesson JA) Urol Res 2012 Oct;40(5):447-54 PMID: 22322528 PMCID: PMC4978133 SCOPUS ID: 2-s2.0-84867899105 02/11/2012       16 Citations
  • Calcium oxalate monohydrate aggregation induced by aggregation of desialylated tamm-horsfall protein (Viswanathan P, Rimer JD, Kolbach AM, Ward MD, Kleinman JG, Wesson JA) Journal of Urology August 2011;186(2):576 SCOPUS ID: 2-s2.0-79960172731 08/01/2011       1 Citation
  • Calcium oxalate monohydrate aggregation induced by aggregation of desialylated Tamm-Horsfall protein. (Viswanathan P, Rimer JD, Kolbach AM, Ward MD, Kleinman JG, Wesson JA) Urol Res 2011 Aug;39(4):269-82 PMID: 21229239 PMCID: PMC3117096 SCOPUS ID: 2-s2.0-80051784471 01/14/2011       56 Citations
  • Crystal growth inhibitors for the prevention of L-cystine kidney stones through molecular design. (Rimer JD, An Z, Zhu Z, Lee MH, Goldfarb DS, Wesson JA, Ward MD) Science 2010 Oct 15;330(6002):337-341 PMID: 20947757 PMCID: PMC5166609 SCOPUS ID: 2-s2.0-77957948950 10/16/2010       221 Citations
  • Attachment of calcium oxalate monohydrate crystals on patterned surfaces of proteins and lipid bilayers. (An Z, Lee S, Oppenheimer H, Wesson JA, Ward MD) J Am Chem Soc 2010 Sep 29;132(38):13188-90 PMID: 20812679 PMCID: PMC8527957 SCOPUS ID: 2-s2.0-77957109680 09/04/2010       14 Citations
  • Induction of apoptosis with cisplatin enhances calcium oxalate crystal adherence to inner medullary collecting duct cells. (Kleinman JG, Sorokina EA, Wesson JA) Urol Res 2010 Apr;38(2):97-104 PMID: 20077109 SCOPUS ID: 2-s2.0-77953285660 01/16/2010       9 Citations
  • A nephrology consult (Wesson J, Dall A) Neurocritical Care 1 January 2009:381-396 SCOPUS ID: 2-s2.0-84926115326 01/01/2009       1 Citation
  • Pathological biomineralization of calcium oxalate kidney stones (Rimer JD, Wesson JA, Ward MD) Aiche Annual Meeting Conference Proceedings 2008 SCOPUS ID: 2-s2.0-79952309548 12/01/2008    
  • Acidic polyanion poly(acrylic acid) prevents calcium oxalate crystal deposition. (Kleinman JG, Alatalo LJ, Beshensky AM, Wesson JA) Kidney Int 2008 Oct;74(7):919-24 PMID: 18563053 PMCID: PMC2566899 SCOPUS ID: 2-s2.0-51849085221 06/20/2008       21 Citations
  • Pathological biomineralization of kidney stones (Wesson JA, Ward MD) Elements December 2007;3(6):415-421 SCOPUS ID: 2-s2.0-38549087002 01/01/2007       99 Citations
  • Role of crystal surface adhesion in kidney stone disease. (Wesson JA, Ward MD) Curr Opin Nephrol Hypertens 2006 Jul;15(4):386-93 PMID: 16775453 SCOPUS ID: 2-s2.0-33748083647 06/16/2006       46 Citations
  • Crystal surface adhesion explains the pathological activity of calcium oxalate hydrates in kidney stone formation. (Sheng X, Ward MD, Wesson JA) J Am Soc Nephrol 2005 Jul;16(7):1904-8 PMID: 15930089 SCOPUS ID: 2-s2.0-27744447545 06/03/2005       121 Citations
  • Regulation by macromolecules of calcium oxalate crystal aggregation in stone formers. (Wesson JA, Ganne V, Beshensky AM, Kleinman JG) Urol Res 2005 Jun;33(3):206-12 PMID: 15864572 SCOPUS ID: 2-s2.0-21244503882 05/03/2005       57 Citations
  • Adhesion at calcium oxalate crystal surfaces and the effect of urinary constituents. (Sheng X, Jung T, Wesson JA, Ward MD) Proc Natl Acad Sci U S A 2005 Jan 11;102(2):267-72 PMID: 15625112 PMCID: PMC544292 SCOPUS ID: 2-s2.0-12244279575 12/31/2004       194 Citations
  • Pathogenesis, pathophysiology, and classification (Kleinman JG, Wesson JA, Sudakoff GS) Clinical Reviews in Bone and Mineral Metabolism 2004;2(3):187-207 SCOPUS ID: 2-s2.0-26244453903 12/01/2004       1 Citation
  • Osteopontin and calcium stone formation. (Kleinman JG, Wesson JA, Hughes J) Nephron Physiol 2004;98(2):p43-7 PMID: 15499214 SCOPUS ID: 2-s2.0-7544247556 10/23/2004       63 Citations
  • Probing crystallization of calcium oxalate monohydrate and the role of macromolecule additives with in situ atomic force microscopy. (Jung T, Sheng X, Choi CK, Kim WS, Wesson JA, Ward MD) Langmuir 2004 Sep 28;20(20):8587-96 PMID: 15379479 SCOPUS ID: 2-s2.0-5444240364 09/24/2004       144 Citations
  • An acidic peptide sequence of nucleolin-related protein can mediate the attachment of calcium oxalate to renal tubule cells. (Sorokina EA, Wesson JA, Kleinman JG) J Am Soc Nephrol 2004 Aug;15(8):2057-65 PMID: 15284292 SCOPUS ID: 2-s2.0-3543088021 07/31/2004       39 Citations
  • Adhesion between molecules and calcium oxalate crystals: critical interactions in kidney stone formation. (Sheng X, Ward MD, Wesson JA) J Am Chem Soc 2003 Mar 12;125(10):2854-5 PMID: 12617634 SCOPUS ID: 2-s2.0-0037433568 03/06/2003       111 Citations
  • Osteopontin is a critical inhibitor of calcium oxalate crystal formation and retention in renal tubules. (Wesson JA, Johnson RJ, Mazzali M, Beshensky AM, Stietz S, Giachelli C, Liaw L, Alpers CE, Couser WG, Kleinman JG, Hughes J) J Am Soc Nephrol 2003 Jan;14(1):139-47 PMID: 12506146 SCOPUS ID: 2-s2.0-12244271018 12/31/2002       259 Citations
  • Direct visualization of calcium oxalate monohydrate crystallization and dissolution with atomic force microscopy and the role of polymeric additives (Guo S, Ward MD, Wesson JA) Langmuir 28 May 2002;18(11):4284-4291 SCOPUS ID: 2-s2.0-0037188686 05/28/2002       150 Citations
  • Osteopontin--a molecule for all seasons. (Mazzali M, Kipari T, Ophascharoensuk V, Wesson JA, Johnson R, Hughes J) QJM 2002 Jan;95(1):3-13 PMID: 11834767 SCOPUS ID: 2-s2.0-0036180475 02/09/2002       364 Citations
  • Effects of urinary macromolecules on hydroxyapatite crystal formation. (Beshensky AM, Wesson JA, Worcester EM, Sorokina EJ, Snyder CJ, Kleinman JG) J Am Soc Nephrol 2001 Oct;12(10):2108-2116 PMID: 11562409 SCOPUS ID: 2-s2.0-0034823323 09/20/2001       35 Citations
  • Role of anionic proteins in kidney stone formation: interaction between model anionic polypeptides and calcium oxalate crystals. (Wesson JA, Worcester EM, Kleinman JG) J Urol 2000 Apr;163(4):1343-8 PMID: 10737541 SCOPUS ID: 2-s2.0-0034108001 03/29/2000       59 Citations
  • Control of calcium oxalate crystal structure and cell adherence by urinary macromolecules. (Wesson JA, Worcester EM, Wiessner JH, Mandel NS, Kleinman JG) Kidney Int 1998 Apr;53(4):952-7 PMID: 9551403 SCOPUS ID: 2-s2.0-0031959536 04/29/1998       183 Citations
  • Formation of hydrated calcium oxalates in the presence of poly-L-aspartic acid. (Wesson JA, Worcester E) Scanning Microsc 1996;10(2):415-23; 423-4 PMID: 9813620 SCOPUS ID: 2-s2.0-0030316701 01/01/1996       42 Citations
    • Last update: 01/30/2025