Medical College of Wisconsin
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Jenifer Coburn PhD


Institution: Medical College of Wisconsin
Department: Medicine
Division: Infectious Disease
Program: Research

Research Experience

  • Borrelia Infections
  • Spirochaetales Infections
  • Tick-Borne Diseases
  • Publications

  • An extracellular Leptospira interrogans leucine-rich repeat protein binds human E- and VE-cadherins. (Eshghi A, Gaultney RA, England P, Brûlé S, Miras I, Sato H, Coburn J, Bellalou J, Moriarty TJ, Haouz A, Picardeau M) Cell Microbiol 2019 Feb;21(2):e12949 PMID: 30171791 09/02/2018    
  • Characterization of Stress and Innate Immunity Resistance of Wild-Type and Δ. (Curtis MW, Hahn BL, Zhang K, Li C, Robinson RT, Coburn J) Infect Immun 2018 02;86(2) PMID: 29158430 PMCID: PMC5778354 11/22/2017    
  • Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival. (Caine JA, Lin YP, Kessler JR, Sato H, Leong JM, Coburn J) Cell Microbiol 2017 12;19(12) PMID: 28873507 PMCID: PMC5680108 09/06/2017       9 Citations
  • Leptospira interrogans causes quantitative and morphological disturbances in adherens junctions and other biological groups of proteins in human endothelial cells. (Sato H, Coburn J) PLoS Negl Trop Dis 2017 Jul;11(7):e0005830 PMID: 28750011 PMCID: PMC5549773 07/28/2017       4 Citations
  • Multifunctional and Redundant Roles of Outer Surface Proteins in Tissue Adhesion, Colonization, and Complement Evasion. (Caine JA, Coburn J) Front Immunol 2016;7:442 PMID: 27818662 PMCID: PMC5073149 11/08/2016       7 Citations
  • Live Attenuated Borrelia burgdorferi Targeted Mutants in an Infectious Strain Background Protect Mice from Challenge Infection. (Hahn BL, Padmore LJ, Ristow LC, Curtis MW, Coburn J) Clin Vaccine Immunol 2016 08;23(8):725-31 PMID: 27335385 PMCID: PMC4979176 06/24/2016       1 Citations
  • Intravital Imaging of Vascular Transmigration by the Lyme Spirochete: Requirement for the Integrin Binding Residues of the B. burgdorferi P66 Protein. (Kumar D, Ristow LC, Shi M, Mukherjee P, Caine JA, Lee WY, Kubes P, Coburn J, Chaconas G) PLoS Pathog 2015 Dec;11(12):e1005333 PMID: 26684456 PMCID: PMC4686178 12/20/2015       14 Citations
  • A short-term Borrelia burgdorferi infection model identifies tissue tropisms and bloodstream survival conferred by adhesion proteins. (Caine JA, Coburn J) Infect Immun 2015 Aug;83(8):3184-94 PMID: 26015482 PMCID: PMC4496602 05/28/2015       16 Citations
  • Evaluation of cell binding activities of Leptospira ECM adhesins. (Robbins GT, Hahn BL, Evangelista KV, Padmore L, Aranda PS, Coburn J) PLoS Negl Trop Dis 2015 Apr;9(4):e0003712 PMID: 25875373 PMCID: PMC4397020 04/16/2015       13 Citations
  • Host cell heparan sulfate glycosaminoglycans are ligands for OspF-related proteins of the Lyme disease spirochete. (Lin YP, Bhowmick R, Coburn J, Leong JM) Cell Microbiol 2015 Oct;17(10):1464-76 PMID: 25864455 PMCID: PMC4583806 04/14/2015       14 Citations
  • Integrin binding by Borrelia burgdorferi P66 facilitates dissemination but is not required for infectivity. (Ristow LC, Bonde M, Lin YP, Sato H, Curtis M, Wesley E, Hahn BL, Fang J, Wilcox DA, Leong JM, Bergström S, Coburn J) Cell Microbiol 2015 Jul;17(7):1021-36 PMID: 25604835 PMCID: PMC4478124 01/22/2015       16 Citations
  • Glycosaminoglycan binding by Borrelia burgdorferi adhesin BBK32 specifically and uniquely promotes joint colonization. (Lin YP, Chen Q, Ritchie JA, Dufour NP, Fischer JR, Coburn J, Leong JM) Cell Microbiol 2015 Jun;17(6):860-75 PMID: 25486989 PMCID: PMC4437914 12/10/2014       30 Citations
  • Reproducible and quantitative model of infection of Dermacentor variabilis with the live vaccine strain of Francisella tularensis. (Coburn J, Maier T, Casey M, Padmore L, Sato H, Frank DW) Appl Environ Microbiol 2015 Jan;81(1):386-95 PMID: 25362054 PMCID: PMC4272728 11/02/2014       2 Citations
  • Identification of cell-binding adhesins of Leptospira interrogans. (Evangelista KV, Hahn B, Wunder EA Jr, Ko AI, Haake DA, Coburn J) PLoS Negl Trop Dis 2014 Oct;8(10):e3215 PMID: 25275630 PMCID: PMC4183468 10/03/2014       14 Citations
  • Leptospira interrogans binds to cadherins. (Evangelista K, Franco R, Schwab A, Coburn J) PLoS Negl Trop Dis 2014;8(1):e2672 PMID: 24498454 PMCID: PMC3907533 02/06/2014       22 Citations
  • Illuminating the roles of the Borrelia burgdorferi adhesins. (Coburn J, Leong J, Chaconas G) Trends Microbiol 2013 Aug;21(8):372-9 PMID: 23876218 PMCID: PMC3773214 07/24/2013       45 Citations
  • The β₃-integrin ligand of Borrelia burgdorferi is critical for infection of mice but not ticks. (Ristow LC, Miller HE, Padmore LJ, Chettri R, Salzman N, Caimano MJ, Rosa PA, Coburn J) Mol Microbiol 2012 Sep;85(6):1105-18 PMID: 22758390 PMCID: PMC3438374 07/05/2012       36 Citations
  • The Borrelia burgdorferi integrin ligand P66 affects gene expression by human cells in culture. (LaFrance ME, Pierce JV, Antonara S, Coburn J) Infect Immun 2011 Aug;79(8):3249-61 PMID: 21576330 PMCID: PMC3147572 05/18/2011       13 Citations
  • Adhesion mechanisms of Borrelia burgdorferi. (Antonara S, Ristow L, Coburn J) Adv Exp Med Biol 2011;715:35-49 PMID: 21557056 PMCID: PMC4521209 05/11/2011       22 Citations
  • The emergence of severe pulmonary hemorrhagic leptospirosis: questions to consider. (Truong KN, Coburn J) Front Cell Infect Microbiol 2011;1:24 PMID: 22919589 PMCID: PMC3417368 01/01/2011       5 Citations
  • Responses of human endothelial cells to pathogenic and non-pathogenic Leptospira species. (Martinez-Lopez DG, Fahey M, Coburn J) PLoS Negl Trop Dis 2010 Dec 14;4(12):e918 PMID: 21179504 PMCID: PMC3001904 12/24/2010       24 Citations
  • Leptospira as an emerging pathogen: a review of its biology, pathogenesis and host immune responses. (Evangelista KV, Coburn J) Future Microbiol 2010 Sep;5(9):1413-25 PMID: 20860485 PMCID: PMC3037011 09/24/2010       155 Citations
  • Effect of Borrelia burgdorferi OspC at the site of inoculation in mouse skin. (Antonara S, Ristow L, McCarthy J, Coburn J) Infect Immun 2010 Nov;78(11):4723-33 PMID: 20696825 PMCID: PMC2976318 08/11/2010       20 Citations
  • Interaction of Borrelia burgdorferi Hbb with the p66 promoter. (Medrano MS, Policastro PF, Schwan TG, Coburn J) Nucleic Acids Res 2010 Jan;38(2):414-27 PMID: 19910373 PMCID: PMC2811001 11/17/2009       13 Citations
  • Leptospira interrogans binds to human cell surface receptors including proteoglycans. (Breiner DD, Fahey M, Salvador R, Novakova J, Coburn J) Infect Immun 2009 Dec;77(12):5528-36 PMID: 19805539 PMCID: PMC2786458 10/07/2009       31 Citations
  • High prevalence of spirochetosis in cholera patients, Bangladesh. (Nelson EJ, Tanudra A, Chowdhury A, Kane AV, Qadri F, Calderwood SB, Coburn J, Camilli A) Emerg Infect Dis 2009 Apr;15(4):571-3 PMID: 19331734 PMCID: PMC2671413 04/01/2009       9 Citations
  • Borrelia burgdorferi BBB07 interaction with integrin alpha3beta1 stimulates production of pro-inflammatory mediators in primary human chondrocytes. (Behera AK, Durand E, Cugini C, Antonara S, Bourassa L, Hildebrand E, Hu LT, Coburn J) Cell Microbiol 2008 Feb;10(2):320-31 PMID: 17822440 PMCID: PMC2586958 09/08/2007       50 Citations
  • Borrelia burgdorferi adhesins identified using in vivo phage display. (Antonara S, Chafel RM, LaFrance M, Coburn J) Mol Microbiol 2007 Oct;66(1):262-76 PMID: 17784908 PMCID: PMC2651023 09/06/2007       61 Citations
  • Regulators of expression of the oligopeptide permease A proteins of Borrelia burgdorferi. (Medrano MS, Ding Y, Wang XG, Lu P, Coburn J, Hu LT) J Bacteriol 2007 Apr;189(7):2653-9 PMID: 17237172 PMCID: PMC1855802 01/24/2007       35 Citations
  • Elimination of channel-forming activity by insertional inactivation of the p66 gene in Borrelia burgdorferi. (Pinne M, Thein M, Denker K, Benz R, Coburn J, Bergström S) FEMS Microbiol Lett 2007 Jan;266(2):241-9 PMID: 17233736 01/20/2007       25 Citations
  • Short report: Association of macrophage inflammatory response and cell death after in vitro Borrelia burgdorferi infection with arthritis resistance. (Glickstein LJ, Coburn JL) Am J Trop Med Hyg 2006 Nov;75(5):964-7 PMID: 17123997 11/25/2006       9 Citations
  • Identification of a TLR-independent pathway for Borrelia burgdorferi-induced expression of matrix metalloproteinases and inflammatory mediators through binding to integrin alpha 3 beta 1. (Behera AK, Hildebrand E, Uematsu S, Akira S, Coburn J, Hu LT) J Immunol 2006 Jul 01;177(1):657-64 PMID: 16785564 06/21/2006       45 Citations
  • Solving a sticky problem: new genetic approaches to host cell adhesion by the Lyme disease spirochete. (Coburn J, Fischer JR, Leong JM) Mol Microbiol 2005 Sep;57(5):1182-95 PMID: 16101994 08/17/2005       75 Citations
  • Borrelia burgdorferi, an extracellular pathogen, circumvents osteopontin in inducing an inflammatory cytokine response. (Craig-Mylius K, Weber GF, Coburn J, Glickstein L) J Leukoc Biol 2005 May;77(5):710-8 PMID: 15695554 02/08/2005       13 Citations
  • The emergence of Lyme disease. (Steere AC, Coburn J, Glickstein L) J Clin Invest 2004 Apr;113(8):1093-101 PMID: 15085185 PMCID: PMC385417 04/16/2004       509 Citations
  • Characterization of Pseudomonas aeruginosa exoenzyme S as a bifunctional enzyme in J774A.1 macrophages. (Rocha CL, Coburn J, Rucks EA, Olson JC) Infect Immun 2003 Sep;71(9):5296-305 PMID: 12933877 PMCID: PMC187317 08/23/2003       37 Citations
  • Targeted mutation of the outer membrane protein P66 disrupts attachment of the Lyme disease agent, Borrelia burgdorferi, to integrin alphavbeta3. (Coburn J, Cugini C) Proc Natl Acad Sci U S A 2003 Jun 10;100(12):7301-6 PMID: 12748384 PMCID: PMC165870 05/16/2003       72 Citations
  • Regulation of expression of the Borrelia burgdorferi beta(3)-chain integrin ligand, P66, in ticks and in culture. (Cugini C, Medrano M, Schwan TG, Coburn J) Infect Immun 2003 Feb;71(2):1001-7 PMID: 12540584 PMCID: PMC145366 01/24/2003       33 Citations
  • Adhesion mechanisms of the Lyme disease spirochete, Borrelia burgdorferi. (Coburn J) Curr Drug Targets Infect Disord 2001 Aug;1(2):171-9 PMID: 12455413 11/29/2002       15 Citations
  • Borrelia burgdorferi and its tropisms for adhesion molecules in the joint. (Coburn J, Medrano M, Cugini C) Curr Opin Rheumatol 2002 Jul;14(4):394-8 PMID: 12118173 07/16/2002       16 Citations
  • Delineation of Borrelia burgdorferi p66 sequences required for integrin alpha(IIb)beta(3) recognition. (Defoe G, Coburn J) Infect Immun 2001 May;69(5):3455-9 PMID: 11292775 PMCID: PMC98311 04/09/2001       39 Citations
  • Microbiology. Arresting features of bacterial toxins. (Coburn J, Leong JM) Science 2000 Oct 13;290(5490):287-8 PMID: 11183375 02/24/2001    
  • Recognition of multiple antibody epitopes throughout Borrelia burgdorferi p66, a candidate adhesin, in patients with early or late manifestations of Lyme disease. (Ntchobo H, Rothermel H, Chege W, Steere AC, Coburn J) Infect Immun 2001 Mar;69(3):1953-6 PMID: 11179382 PMCID: PMC98111 02/17/2001       17 Citations
  • Platelet activation by a relapsing fever spirochaete results in enhanced bacterium-platelet interaction via integrin alphaIIbbeta3 activation. (Alugupalli KR, Michelson AD, Barnard MR, Robbins D, Coburn J, Baker EK, Ginsberg MH, Schwan TG, Leong JM) Mol Microbiol 2001 Jan;39(2):330-40 PMID: 11136454 01/03/2001       31 Citations
  • Prominent expression of mRNA for proinflammatory cytokines in synovium in patients with juvenile rheumatoid arthritis or chronic Lyme arthritis. (Harjacek M, Diaz-Cano S, Alman BA, Coburn J, Ruthazer R, Wolfe H, Steere AC) J Rheumatol 2000 Feb;27(2):497-503 PMID: 10685820 02/24/2000       43 Citations
  • Lack of Borrelia burgdorferi DNA in synovial samples from patients with antibiotic treatment-resistant Lyme arthritis. (Carlson D, Hernandez J, Bloom BJ, Coburn J, Aversa JM, Steere AC) Arthritis Rheum 1999 Dec;42(12):2705-9 PMID: 10616021 01/01/2000       93 Citations
  • Characterization of a candidate Borrelia burgdorferi beta3-chain integrin ligand identified using a phage display library. (Coburn J, Chege W, Magoun L, Bodary SC, Leong JM) Mol Microbiol 1999 Dec;34(5):926-40 PMID: 10594819 12/14/1999       92 Citations
  • Macrophages and epithelial cells respond differently to the Pseudomonas aeruginosa type III secretion system. (Coburn J, Frank DW) Infect Immun 1999 Jun;67(6):3151-4 PMID: 10338535 PMCID: PMC96636 05/25/1999       57 Citations
  • A natural variant of the cysteine protease virulence factor of group A Streptococcus with an arginine-glycine-aspartic acid (RGD) motif preferentially binds human integrins alphavbeta3 and alphaIIbbeta3. (Stockbauer KE, Magoun L, Liu M, Burns EH Jr, Gubba S, Renish S, Pan X, Bodary SC, Baker E, Coburn J, Leong JM, Musser JM) Proc Natl Acad Sci U S A 1999 Jan 05;96(1):242-7 PMID: 9874803 PMCID: PMC15124 01/06/1999       84 Citations
  • Integrins alpha(v)beta3 and alpha5beta1 mediate attachment of lyme disease spirochetes to human cells. (Coburn J, Magoun L, Bodary SC, Leong JM) Infect Immun 1998 May;66(5):1946-52 PMID: 9573074 PMCID: PMC108148 05/09/1998       95 Citations
  • Different classes of proteoglycans contribute to the attachment of Borrelia burgdorferi to cultured endothelial and brain cells. (Leong JM, Wang H, Magoun L, Field JA, Morrissey PE, Robbins D, Tatro JB, Coburn J, Parveen N) Infect Immun 1998 Mar;66(3):994-9 PMID: 9488387 PMCID: PMC108007 03/06/1998       71 Citations
  • Hemagglutination and proteoglycan binding by the Lyme disease spirochete, Borrelia burgdorferi. (Leong JM, Morrissey PE, Ortega-Barria E, Pereira ME, Coburn J) Infect Immun 1995 Mar;63(3):874-83 PMID: 7532628 PMCID: PMC173084 03/01/1995       74 Citations
  • Diverse Lyme disease spirochetes bind integrin alpha IIb beta 3 on human platelets. (Coburn J, Barthold SW, Leong JM) Infect Immun 1994 Dec;62(12):5559-67 PMID: 7525486 PMCID: PMC303302 12/01/1994       58 Citations
  • Integrin alpha IIb beta 3 mediates binding of the Lyme disease agent Borrelia burgdorferi to human platelets. (Coburn J, Leong JM, Erban JK) Proc Natl Acad Sci U S A 1993 Aug 01;90(15):7059-63 PMID: 8394007 PMCID: PMC47075 08/01/1993       125 Citations
  • The eukaryotic host factor that activates exoenzyme S of Pseudomonas aeruginosa is a member of the 14-3-3 protein family. (Fu H, Coburn J, Collier RJ) Proc Natl Acad Sci U S A 1993 Mar 15;90(6):2320-4 PMID: 8460141 PMCID: PMC46078 03/15/1993       199 Citations
  • Pseudomonas aeruginosa exoenzyme S. (Coburn J) Curr Top Microbiol Immunol 1992;175:133-43 PMID: 1321018 01/01/1992       36 Citations
  • ADP-ribosylation of p21ras and related proteins by Pseudomonas aeruginosa exoenzyme S. (Coburn J, Gill DM) Infect Immun 1991 Nov;59(11):4259-62 PMID: 1937783 PMCID: PMC259026 11/01/1991       85 Citations
  • Pseudomonas aeruginosa exoenzyme S requires a eukaryotic protein for ADP-ribosyltransferase activity. (Coburn J, Kane AV, Feig L, Gill DM) J Biol Chem 1991 Apr 05;266(10):6438-46 PMID: 1901061 04/05/1991       64 Citations
  • Several GTP-binding proteins, including p21c-H-ras, are preferred substrates of Pseudomonas aeruginosa exoenzyme S. (Coburn J, Wyatt RT, Iglewski BH, Gill DM) J Biol Chem 1989 May 25;264(15):9004-8 PMID: 2498323 05/25/1989       89 Citations
  • Exoenzyme S of Pseudomonas aeruginosa ADP-ribosylates the intermediate filament protein vimentin. (Coburn J, Dillon ST, Iglewski BH, Gill DM) Infect Immun 1989 Mar;57(3):996-8 PMID: 2492977 PMCID: PMC313212 03/01/1989       66 Citations
  • ADP-ribosylation of membrane proteins by bacterial toxins in the presence of NAD glycohydrolase. (Gill DM, Coburn J) Biochim Biophys Acta 1988 Apr 28;954(1):65-72 PMID: 2833927 04/28/1988       13 Citations
  • Assay and purification of cytosolic factor required for cholera toxin activity. (Woolkalis M, Gill DM, Coburn J) Methods Enzymol 1988;165:246-9 PMID: 2852765 01/01/1988       1 Citations
  • ADP-ribosylation by cholera toxin: functional analysis of a cellular system that stimulates the enzymic activity of cholera toxin fragment A1. (Gill DM, Coburn J) Biochemistry 1987 Oct 06;26(20):6364-71 PMID: 3322378 10/06/1987       35 Citations
  • The differential effects of GABA-transaminase inactivation in the chick retina and brain. (Rando RR, Coburn J, Parkinson D) J Neurochem 1982 Oct;39(4):1147-51 PMID: 7119785 10/01/1982       4 Citations
  • Last update: 03/15/2019
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