Medical College of Wisconsin
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Kathleen M. Bone PhD

Kathleen M. Bone PhD profile photo picture

Associate Professor

Institution: Medical College of Wisconsin
Department: Pathology
Division: Administration

View Curriculum Vitae

Clinical Expertise

  • Chromosome Aberrations
  • Chromosomes, Human
  • Cytogenetic Analysis
  • Cytogenetics
  • DNA
  • DNA Mismatch Repair
  • DNA Repair
  • Genetic Services
  • Genetic Techniques
  • Genetic Testing
  • Genetics
  • Genetics, Medical
  • Genomic Imprinting
  • Human Genetics
  • Microarray Analysis
  • Molecular Biology
  • Oncogenes
  • Polymerase Chain Reaction
  • Receptor Protein-Tyrosine Kinases
  • Sex Chromosomes

    • Publications (21)

  • Fate control engagement augments NK cell responses in LV/hu-IL-12 transduced sarcoma. (Rademacher MJ, Faber ML, Bone KM, Medin JA, Schloemer NJ) Exp Mol Pathol 2024 May 09;137:104898 PMID: 38729059 SCOPUS ID: 2-s2.0-85192295267 05/11/2024    
  • Chapter: Ring Chromosome 4. (Bone, KM, Chernos, J, Thomas, MA) Human Ring Chromosomes: A practical guide for clinicians and families. Part II Constitutional Ring Chromosomes. In review. 03/30/2023    
  • Detection of chromosomal alteration after infusion of gene-edited allogeneic CAR T cells. (Sasu BJ, Opiteck GJ, Gopalakrishnan S, Kaimal V, Furmanak T, Huang D, Goswami A, He Y, Chen J, Nguyen A, Balakumaran A, Shah NN, Hamadani M, Bone KM, Prashad S, Bowen MA, Pertel T, Embree HD, Gidwani SG, Chang D, Moore A, Leonard M, Amado RG) Mol Ther 2023 Mar 01;31(3):676-685 PMID: 36518079 PMCID: PMC10014221 SCOPUS ID: 2-s2.0-85145741279 12/16/2022       5 Citations
  • Atypical Presentation in Sclerosing Epithelioid Fibrosarcoma: A Case Report (Miller LJ, Saterbak A, Parsons LN, Singh R, Bone KM.) AJCP 9 Nov 2022; 158 (Supplement_1):S38-S39:doi: 10.1093/ajcp/aqac126.072 11/09/2022    
  • Effects of EWSR1 Amplification on the Clinical and Histologic Behavior of Non-Ewing Sarcoma Soft Tissue Tumors (Miller LJ, Bodnar C, Parsons LN, Singh R, Bone KM.) JMD [Internet] 2022 Oct. 24(10, Supplement) S1-S154.doi: 10.1016/S1525-1578(22)00284-7 10/24/2022    
  • Correction: Parashar et al. Patient-Derived Ovarian Cancer Spheroids Rely on PI3K-AKT Signaling Addiction for Cancer Stemness and Chemoresistance. Cancers 2022, 14, 958. (Parashar D, Geethadevi A, Mittal S, McAlarnen LA, George J, Kadamberi IP, Gupta P, Uyar DS, Hopp EE, Drendel H, Bishop EA, Bradley WH, Bone KM, Rader JS, Pradeep S, Chaluvally-Raghavan P) Cancers (Basel) 2022 May 16;14(10) PMID: 35626175 PMCID: PMC9140135 SCOPUS ID: 2-s2.0-85129951244 05/29/2022       1 Citation
  • Parashar D, Geethadevi A, Mittal S, McAlarnen LA, George J, Kadamberi IP, Gupta P, Uyar DS, Hopp EE, Drendel H, Bishop EA, Bradley WH, Bone KM, Rader JS, Pradeep S, Chaluvally-Raghavan P. (Correction: Parashar et al. Patient-Derived Ovarian Cancer Spheroids Rely on PI3K-AKT Signaling Addiction for Cancer Stemness and Chemoresistance) Cancers (Basel) 2022 May 16;14(10):2443. PMCID: PMC9140135 05/16/2022    
  • Pediatric Donor Cell Acute Lymphoblastic Leukemia Following Bone Marrow Transplant for GATA2 Mutation. (Scheuermann A, Moskop A, Hopp A, Bone K, Drendel HM, Talano J, Harker-Murray P, Astle J) J Pediatr Hematol Oncol 2022 Jul 01;44(5):268-270 PMID: 35235548 SCOPUS ID: 2-s2.0-85129146818 03/03/2022       3 Citations
  • Patient-Derived Ovarian Cancer Spheroids Rely on PI3K-AKT Signaling Addiction for Cancer Stemness and Chemoresistance. (Parashar D, Geethadevi A, Mittal S, McAlarnen LA, George J, Kadamberi IP, Gupta P, Uyar DS, Hopp EE, Drendel H, Bishop EA, Bradley WH, Bone KM, Rader JS, Pradeep S, Chaluvally-Raghavan P) Cancers (Basel) 2022 Feb 15;14(4) PMID: 35205706 PMCID: PMC8870411 SCOPUS ID: 2-s2.0-85124460063 02/26/2022       12 Citations
  • It Takes a Village: Providing International Pediatric Pathology Services in a Resource-Limited Setting. (Hopp AM, Tetzlaff JE, Kopidlansky K, Leventaki V, Parsons LN, Bone K, Drendel HM, Sreynich K, Lyvannak S, Heng S, Chanpheaktra N, Putchhat H, Khauv P, Camitta BM, Jarzembowski JA) Am J Clin Pathol 2022 Jul 01;158(1):81-95 PMID: 35050350 SCOPUS ID: 2-s2.0-85133980519 01/21/2022    
  • A complex KMT2A::AFF3 fusion resulting from a three-way chromosomal rearrangement in pediatric B lymphoblastic leukemia. (Miller LJ, Leventaki V, Harker-Murray PD, Drendel HM, Bone KM) Cancer Genet 2022 Apr;262-263:43-46 PMID: 34995897 SCOPUS ID: 2-s2.0-85122276846 01/08/2022    
  • Fine-needle aspiration diagnosis of clonal extramedullary hematopoiesis in a case of myeloproliferative neoplasm. (Shponka V, Bone K, Nomani L, Hunt B) Diagn Cytopathol 2022 Feb;50(2):E43-E46 PMID: 34617678 SCOPUS ID: 2-s2.0-85116487437 10/08/2021    
  • Failure of NIPT to detect constitutional chromoanasynthesis involving chromosome 21 in a case of fetal hydrops-A case report. (Bone K, MacPherson MJ, Chernos J, Lauzon J) Clin Case Rep 2019 Nov;7(11):2165-2168 PMID: 31788271 PMCID: PMC6878046 SCOPUS ID: 2-s2.0-85073956306 12/04/2019       4 Citations
  • Mosaic trisomy 1q: a recurring chromosome anomaly that is a diagnostic challenge and is associated with a Fryns-like phenotype. (Bone KM, Chernos JE, Perrier R, Innes AM, Bernier FP, McLeod R, Thomas MA) Prenat Diagn 2017 Jun;37(6):602-610 PMID: 28437579 SCOPUS ID: 2-s2.0-85019577249 04/25/2017       5 Citations
  • A Novel Genetic Syndrome Caused by Haploinsufficiency of CHD2, a Regulator of Chromatin Structure (Bone, K., Argiropoulos, B.) J Down Syndr Chr Abnorm 2016 Jan 7;2:104, doi:10.4172/2472-1115.1000104 01/07/2016    
  • NPM-ALK mediates phosphorylation of MSH2 at tyrosine 238, creating a functional deficiency in MSH2 and the loss of mismatch repair. (Bone KM, Wang P, Wu F, Wu C, Li L, Bacani JT, Andrew SE, Lai R) Blood Cancer J 2015 May 15;5(5):e311 PMID: 25978431 PMCID: PMC4476014 SCOPUS ID: 2-s2.0-84989896192 05/16/2015       9 Citations
  • STAT1 is phosphorylated and downregulated by the oncogenic tyrosine kinase NPM-ALK in ALK-positive anaplastic large-cell lymphoma. (Wu C, Molavi O, Zhang H, Gupta N, Alshareef A, Bone KM, Gopal K, Wu F, Lewis JT, Douglas DN, Kneteman NM, Lai R) Blood 2015 Jul 16;126(3):336-45 PMID: 25921060 SCOPUS ID: 2-s2.0-84937784820 04/30/2015       22 Citations
  • Aberrant expression and biological significance of Sox2, an embryonic stem cell transcriptional factor, in ALK-positive anaplastic large cell lymphoma. (Gelebart P, Hegazy SA, Wang P, Bone KM, Anand M, Sharon D, Hitt M, Pearson JD, Ingham RJ, Ma Y, Lai R) Blood Cancer J 2012 Aug 10;2(8):e82 PMID: 22885405 PMCID: PMC3432482 SCOPUS ID: 2-s2.0-84865987684 08/14/2012       37 Citations
  • Identification of two novel phenotypically distinct breast cancer cell subsets based on Sox2 transcription activity. (Wu F, Zhang J, Wang P, Ye X, Jung K, Bone KM, Pearson JD, Ingham RJ, McMullen TP, Ma Y, Lai R) Cell Signal 2012 Nov;24(11):1989-98 PMID: 22800865 SCOPUS ID: 2-s2.0-84865325894 07/18/2012       43 Citations
  • Fusion tyrosine kinase NPM-ALK Deregulates MSH2 and suppresses DNA mismatch repair function novel insights into a potent oncoprotein. (Young LC, Bone KM, Wang P, Wu F, Adam BA, Hegazy S, Gelebart P, Holovati J, Li L, Andrew SE, Lai R) Am J Pathol 2011 Jul;179(1):411-21 PMID: 21703420 PMCID: PMC3123797 SCOPUS ID: 2-s2.0-80052489979 06/28/2011       12 Citations
  • The canonical NF-kappaB pathway is required for formation of luminal mammary neoplasias and is activated in the mammary progenitor population. (Pratt MA, Tibbo E, Robertson SJ, Jansson D, Hurst K, Perez-Iratxeta C, Lau R, Niu MY) Oncogene 2009 Jul 30;28(30):2710-22 PMID: 19483731 SCOPUS ID: 2-s2.0-68149164966 06/02/2009       71 Citations
    • Last update: 05/12/2024