Medical College of Wisconsin
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Kenneth Brockman PhD

Kenneth Brockman PhD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Microbiology and Immunology

Member of the Center for Immunology

Research Experience

  • Achromobacter
  • Adhesins, Bacterial
  • Bacteria
  • Bacteria, Anaerobic
  • Biofilms
  • Chinchilla
  • Cystic Fibrosis
  • Haemophilus Infections
  • Macrophages
  • Mucus
  • Neutrophils
  • Otitis Media
  • Pneumonia, Bacterial

    • Methodologies and Techniques

  • Biofilms
  • Chinchilla
  • DNA Modification Methylases
  • Disease Models, Animal
  • Epigenomics
  • Mice
  • Mutation
  • Primary Cell Culture
  • Real-Time Polymerase Chain Reaction
  • Sequence Analysis, RNA

    • Publications (28)

  • High-depth RNA-Seq data sets to investigate the differences in gene expression mediated by phasevarions in non-typeable Haemophilus influenzae. (Atack JM, Brockman KL, Bakaletz LO, Jennings MP) Microbiol Resour Announc 2023 Dec 14;12(12):e0078523 PMID: 37991358 PMCID: PMC10720539 SCOPUS ID: 2-s2.0-85180072653 11/22/2023    
  • Phase variable acetylation of lipooligosaccharide modifies antibody production and opsonophagocytic killing of non-typeable Haemophilus influenzae (Wills BM, Garai P, Dickinson Q, Meyer JG, Brockman KL) iScience 20 October 2023;26(10) SCOPUS ID: 2-s2.0-85170435505 10/20/2023    
  • Phase variable acetylation of lipooligosaccharide modifies antibody production and opsonophagocytic killing of non-typeable Haemophilus influenzae. (Wills BM, Garai P, Dickinson Q, Meyer JG, Brockman KL) iScience 2023 Oct 20;26(10):107785 PMID: 37727736 PMCID: PMC10505976 SCOPUS ID: 2-s2.0-85170435505 09/20/2023    
  • Identification of Virulence Factors Involved in a Murine Model of Severe Achromobacter xylosoxidans Infection. (Wills BM, Garai P, Riegert MO, Sanchez FT, Pickrum AM, Frank DW, Brockman KL) Infect Immun 2023 Jul 18;91(7):e0003723 PMID: 37255468 PMCID: PMC10353400 SCOPUS ID: 2-s2.0-85165519693 05/31/2023       3 Citations
  • Adherence of Nontypeable Haemophilus influenzae to Cells and Substrates of the Airway Is Differentially Regulated by Individual ModA Phasevarions. (Garai P, Atack JM, Wills BM, Jennings MP, Bakaletz LO, Brockman KL) Microbiol Spectr 2023 Feb 14;11(1):e0409322 PMID: 36511712 PMCID: PMC9927368 SCOPUS ID: 2-s2.0-85148113631 12/14/2022       3 Citations
  • The In Vitro Replication Cycle of Achromobacter xylosoxidans and Identification of Virulence Genes Associated with Cytotoxicity in Macrophages. (Pickrum AM, Riegert MO, Wells C, Brockman K, Frank DW) Microbiol Spectr 2022 Aug 31;10(4):e0208322 PMID: 35856670 PMCID: PMC9430717 SCOPUS ID: 2-s2.0-85137137821 07/21/2022       5 Citations
  • Characterization of the Phase-Variable Autotransporter Lav Reveals a Role in Host Cell Adherence and Biofilm Formation in Nontypeable Haemophilus influenzae. (Phillips ZN, Garai P, Tram G, Martin G, Van Den Bergh A, Husna AU, Staples M, Grimwood K, Jennison AV, Guillon P, von Itzstein M, Jennings MP, Brockman KL, Atack JM) Infect Immun 2022 Apr 21;90(4):e0056521 PMID: 35258316 PMCID: PMC9022572 SCOPUS ID: 2-s2.0-85128634430 03/09/2022       2 Citations
  • A Bacterial Epigenetic Switch in Non-typeable Haemophilus influenzae Modifies Host Immune Response During Otitis Media. (Robledo-Avila FH, Ruiz-Rosado JD, Partida-Sanchez S, Brockman KL) Front Cell Infect Microbiol 2020;10:512743 PMID: 33194779 PMCID: PMC7644868 SCOPUS ID: 2-s2.0-85095581955 11/17/2020       10 Citations
  • The Nontypeable Haemophilus influenzae Major Adhesin Hia Is a Dual-Function Lectin That Binds to Human-Specific Respiratory Tract Sialic Acid Glycan Receptors. (Atack JM, Day CJ, Poole J, Brockman KL, Timms JRL, Winter LE, Haselhorst T, Bakaletz LO, Barenkamp SJ, Jennings MP) mBio 2020 Nov 03;11(6) PMID: 33144377 PMCID: PMC7642680 SCOPUS ID: 2-s2.0-85095613918 11/05/2020       10 Citations
  • A Bacterial Epigenetic Switch in Non-typeable Haemophilus influenzae Modifies Host Immune Response During Otitis Media (Robledo-Avila FH, Ruiz-Rosado JdD, Partida-Sanchez S, Brockman KL) Frontiers in Cellular and Infection Microbiology 23 October 2020;10 SCOPUS ID: 2-s2.0-85095581955 10/23/2020       10 Citations
  • The TRPM2 Ion Channel Regulates Inflammatory Functions of Neutrophils During Listeria monocytogenes Infection. (Robledo-Avila FH, Ruiz-Rosado JD, Brockman KL, Partida-Sánchez S) Front Immunol 2020;11:97 PMID: 32117251 PMCID: PMC7010865 SCOPUS ID: 2-s2.0-85079677223 03/03/2020       16 Citations
  • The TRPM2 Ion Channel Regulates Inflammatory Functions of Neutrophils During Listeria monocytogenes Infection (Robledo-Avila FH, Ruiz-Rosado JdD, Brockman KL, Partida-Sánchez S) Frontiers in Immunology 4 February 2020;11 SCOPUS ID: 2-s2.0-85079677223 02/04/2020       16 Citations
  • Regulation and Maturation of the Shewanella oneidensis Sulfite Reductase SirA. (Brockman KL, Shirodkar S, Croft TJ, Banerjee R, Saffarini DA) Sci Rep 2020 Jan 22;10(1):953 PMID: 31969587 PMCID: PMC6976685 SCOPUS ID: 2-s2.0-85078139745 01/24/2020       5 Citations
  • Panel 7 - Pathogenesis of otitis media - a review of the literature between 2015 and 2019. (Thornton RB, Hakansson A, Hood DW, Nokso-Koivisto J, Preciado D, Riesbeck K, Richmond PC, Su YC, Swords WE, Brockman KL) Int J Pediatr Otorhinolaryngol 2020 Mar;130 Suppl 1:109838 PMID: 31879085 PMCID: PMC7062565 SCOPUS ID: 2-s2.0-85076859531 12/28/2019       9 Citations
  • Streptococcus oralis subsp. dentisani Produces Monolateral Serine-Rich Repeat Protein Fibrils, One of Which Contributes to Saliva Binding via Sialic Acid. (Ronis A, Brockman K, Singh AK, Gaytán MO, Wong A, McGrath S, Owen CD, Magrini V, Wilson RK, van der Linden M, King SJ) Infect Immun 2019 Oct;87(10) PMID: 31308084 PMCID: PMC6759294 SCOPUS ID: 2-s2.0-85072508552 07/17/2019       13 Citations
  • Biofilm biology and vaccine strategies for otitis media due to nontypeable Haemophilus influenzae. (Novotny LA, Brockman KL, Mokrzan EM, Jurcisek JA, Bakaletz LO) J Pediatr Infect Dis 2019 Feb;14(2):69-77 PMID: 30853830 PMCID: PMC6402341 SCOPUS ID: 2-s2.0-85049831489 03/12/2019       15 Citations
  • Antibodies against the Majority Subunit (PilA) of the Type IV Pilus of Nontypeable Haemophilus influenzae Disperse Moraxella catarrhalis from a Dual-Species Biofilm. (Mokrzan EM, Novotny LA, Brockman KL, Bakaletz LO) mBio 2018 Dec 11;9(6) PMID: 30538189 PMCID: PMC6299487 SCOPUS ID: 2-s2.0-85058590472 12/13/2018       29 Citations
  • Epigenetic Regulation Alters Biofilm Architecture and Composition in Multiple Clinical Isolates of Nontypeable Haemophilus influenzae. (Brockman KL, Azzari PN, Branstool MT, Atack JM, Schulz BL, Jen FE, Jennings MP, Bakaletz LO) mBio 2018 Sep 18;9(5) PMID: 30228240 PMCID: PMC6143736 SCOPUS ID: 2-s2.0-85055490499 09/20/2018       27 Citations
  • Dysregulated Calcium Homeostasis in Cystic Fibrosis Neutrophils Leads to Deficient Antimicrobial Responses. (Robledo-Avila FH, Ruiz-Rosado JD, Brockman KL, Kopp BT, Amer AO, McCoy K, Bakaletz LO, Partida-Sanchez S) J Immunol 2018 Oct 01;201(7):2016-2027 PMID: 30120123 PMCID: PMC6143431 SCOPUS ID: 2-s2.0-85053469523 08/19/2018       36 Citations
  • The HMW2 adhesin of non-typeable Haemophilus influenzae is a human-adapted lectin that mediates high-affinity binding to 2-6 linked N-acetylneuraminic acid glycans. (Atack JM, Day CJ, Poole J, Brockman KL, Bakaletz LO, Barenkamp SJ, Jennings MP) Biochem Biophys Res Commun 2018 Sep 05;503(2):1103-1107 PMID: 29944882 PMCID: PMC6095747 SCOPUS ID: 2-s2.0-85048968279 06/27/2018       17 Citations
  • Nontypeable Haemophilus influenzae releases DNA and DNABII proteins via a T4SS-like complex and ComE of the type IV pilus machinery. (Jurcisek JA, Brockman KL, Novotny LA, Goodman SD, Bakaletz LO) Proc Natl Acad Sci U S A 2017 Aug 08;114(32):E6632-E6641 PMID: 28696280 PMCID: PMC5559034 SCOPUS ID: 2-s2.0-85026867309 07/12/2017       50 Citations
  • The ModA2 Phasevarion of nontypeable Haemophilus influenzae Regulates Resistance to Oxidative Stress and Killing by Human Neutrophils. (Brockman KL, Branstool MT, Atack JM, Robledo-Avila F, Partida-Sanchez S, Jennings MP, Bakaletz LO) Sci Rep 2017 Jun 09;7(1):3161 PMID: 28600561 PMCID: PMC5466613 SCOPUS ID: 2-s2.0-85020676207 06/11/2017       25 Citations
  • ModA2 Phasevarion Switching in Nontypeable Haemophilus influenzae Increases the Severity of Experimental Otitis Media. (Brockman KL, Jurcisek JA, Atack JM, Srikhanta YN, Jennings MP, Bakaletz LO) J Infect Dis 2016 Sep 01;214(5):817-24 PMID: 27288538 PMCID: PMC4978376 SCOPUS ID: 2-s2.0-84988912794 06/12/2016       31 Citations
  • A biphasic epigenetic switch controls immunoevasion, virulence and niche adaptation in non-typeable Haemophilus influenzae. (Atack JM, Srikhanta YN, Fox KL, Jurcisek JA, Brockman KL, Clark TA, Boitano M, Power PM, Jen FE, McEwan AG, Grimmond SM, Smith AL, Barenkamp SJ, Korlach J, Bakaletz LO, Jennings MP) Nat Commun 2015 Jul 28;6:7828 PMID: 26215614 PMCID: PMC4525171 SCOPUS ID: 2-s2.0-84938068933 07/29/2015       92 Citations
  • Shewanella oneidensis and extracellular electron transfer to metal oxides (Saffarini D, Brockman K, Beliav A, Bouhenni R, Shirodkar S) Bacteria-Metal Interactions 1 January 2015:21-40 SCOPUS ID: 2-s2.0-84944627798 01/01/2015       10 Citations
  • The role of Shewanella oneidensis MR-1 outer surface structures in extracellular electron transfer (Bouhenni RA, Vora GJ, Biffinger JC, Shirodkar S, Brockman K, Ray R, Wu P, Johnson BJ, Biddle EM, Marshall MJ, Fitzgerald LA, Little BJ, Fredrickson JK, Beliaev AS, Ringeisen BR, Saffarini DA) Electroanalysis April 2010;22(7-8):856-864 SCOPUS ID: 2-s2.0-77951013534 01/01/2010       92 Citations
  • Comparing current generation from Shewanella oneidensis MR-1 and candidate nanowire deletion mutants in a microbial fuel cell (Biffinger JC, Fitzgerald LA, Vora Ricky Ray GJ, Wu P, Baldwin JW, Little BJ, Bouhenni R, Shirodkar S, Brockman K, Saffarini D, Ringeisen BR) ACS National Meeting Book of Abstracts 2009 SCOPUS ID: 2-s2.0-78649780228 12/01/2009       1 Citation
  • Involvement of a membrane-bound class III adenylate cyclase in regulation of anaerobic respiration in Shewanella oneidensis MR-1. (Charania MA, Brockman KL, Zhang Y, Banerjee A, Pinchuk GE, Fredrickson JK, Beliaev AS, Saffarini DA) J Bacteriol 2009 Jul;191(13):4298-306 PMID: 19395492 PMCID: PMC2698484 SCOPUS ID: 2-s2.0-67649392523 04/28/2009       61 Citations
    • Last update: 01/17/2024