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Michael T. Zimmermann PhD

Michael T. Zimmermann PhD

Director, Assistant Professor

Institution: Medical College of Wisconsin
Department: Clinical and Translational Science Institute
Program: Governance

Member of the Genomic Sciences and Precision Medicine Center (GSPMC)


Publications

  • Novel BRAF alteration in desmoplastic infantile ganglioglioma with response to targeted therapy. (Blessing MM, Blackburn PR, Balcom JR, Krishnan C, Harrod VL, Zimmermann MT, Barr Fritcher EG, Zysk CD, Jackson RA, Nair AA, Jenkins RB, Halling KC, Kipp BR, Ida CM) Acta Neuropathol Commun 2018 Nov 05;6(1):118 PMID: 30396366 PMCID: PMC6219207 11/07/2018    
  • Apolipoprotein CII Amyloidosis Associated With p.Lys41Thr Mutation. (Sethi S, Dasari S, Plaisier E, Ronco P, Nasr SH, Brocheriou I, Theis JD, Vrana JA, Zimmermann MT, Quint PS, McPhail ED, Kurtin PJ) Kidney Int Rep 2018 Sep;3(5):1193-1201 PMID: 30197986 PMCID: PMC6127408 09/11/2018    
  • Protein modeling and clinical description of a novel in-frame GLB1 deletion causing GM1 gangliosidosis type II. (Richter JE Jr, Zimmermann MT, Blackburn PR, Mohammad AN, Klee EW, Pollard LM, Macmurdo CF, Atwal PS, Caulfield TR) Mol Genet Genomic Med 2018 11;6(6):1229-1235 PMID: 30187681 PMCID: PMC6305665 09/07/2018    
  • A Patient With Hereditary ATTR and a Novel AGel p.Ala578Pro Amyloidosis. (Sridharan M, Highsmith WE, Kurtin PJ, Zimmermann MT, Theis JD, Dasari S, Dingli D) Mayo Clin Proc 2018 Nov;93(11):1678-1682 PMID: 30093168 08/11/2018       1 Citations
  • Assessing Human Genetic Variations in Glucose Transporter SLC2A10 and Their Role in Altering Structural and Functional Properties. (Zimmermann MT, Urrutia R, Cousin MA, Oliver GR, Klee EW) Front Genet 2018;9:276 PMID: 30090112 PMCID: PMC6068234 08/10/2018    
  • Correction to: the impact of pharmacokinetic gene profiles across human cancers. (Zimmermann MT, Therneau TM, Kocher JA) BMC Cancer 2018 07 18;18(1):743 PMID: 30021563 PMCID: PMC6050650 07/20/2018    
  • Even pore-localizing missense variants at highly conserved sites in -encoded K7.1 channels may have wild-type function and not cause type 1 long QT syndrome: Do not rely solely on the genetic test company's interpretation. (Paquin A, Ye D, Tester DJ, Kapplinger JD, Zimmermann MT, Ackerman MJ) HeartRhythm Case Rep 2018 Feb;4(2):37-44 PMID: 29876285 PMCID: PMC5988472 06/08/2018    
  • The impact of pharmacokinetic gene profiles across human cancers. (Zimmermann MT, Therneau TM, Kocher JA) BMC Cancer 2018 May 21;18(1):577 PMID: 29783934 PMCID: PMC5963084 05/23/2018       1 Citations
  • Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas. (Knijnenburg TA, Wang L, Zimmermann MT, Chambwe N, Gao GF, Cherniack AD, Fan H, Shen H, Way GP, Greene CS, Liu Y, Akbani R, Feng B, Donehower LA, Miller C, Shen Y, Karimi M, Chen H, Kim P, Jia P, Shinbrot E, Zhang S, Liu J, Hu H, Bailey MH, Yau C, Wolf D, Zhao Z, Weinstein JN, Li L, Ding L, Mills GB, Laird PW, Wheeler DA, Shmulevich I, Cancer Genome Atlas Research Network, Monnat RJ Jr, Xiao Y, Wang C) Cell Rep 2018 Apr 03;23(1):239-254.e6 PMID: 29617664 PMCID: PMC5961503 04/05/2018       20 Citations
  • Transcriptomic signatures of cellular and humoral immune responses in older adults after seasonal influenza vaccination identified by data-driven clustering. (Voigt EA, Grill DE, Zimmermann MT, Simon WL, Ovsyannikova IG, Kennedy RB, Poland GA) Sci Rep 2018 01 15;8(1):739 PMID: 29335477 PMCID: PMC5768803 01/18/2018       1 Citations
  • Novel variants likely disrupt DNA binding: molecular modeling in two cases, review of published cases, genotype-phenotype correlation, and phenotypic expansion of the Bosch-Boonstra-Schaaf optic atrophy syndrome. (Kaiwar C, Zimmermann MT, Ferber MJ, Niu Z, Urrutia RA, Klee EW, Babovic-Vuksanovic D) Cold Spring Harb Mol Case Stud 2017 Nov;3(6) PMID: 28963436 PMCID: PMC5701304 10/01/2017    
  • Functional validation reveals the novel missense V419L variant in associated with Loeys-Dietz syndrome (LDS) impairs canonical TGF-β signaling. (Cousin MA, Zimmermann MT, Mathison AJ, Blackburn PR, Boczek NJ, Oliver GR, Lomberk GA, Urrutia RA, Deyle DR, Klee EW) Cold Spring Harb Mol Case Stud 2017 07;3(4) PMID: 28679693 PMCID: PMC5495030 07/07/2017    
  • Novel de novo variant in is likely to impact DNA binding in a patient with a neurodevelopmental disorder and expanded phenotypes: patient report, in silico functional assessment, and review of published cases. (Blackburn PR, Barnett SS, Zimmermann MT, Cousin MA, Kaiwar C, Pinto E Vairo F, Niu Z, Ferber MJ, Urrutia RA, Selcen D, Klee EW, Pichurin PN) Cold Spring Harb Mol Case Stud 2017 05;3(3):a001743 PMID: 28487885 PMCID: PMC5411688 05/11/2017    
  • Integration of Immune Cell Populations, mRNA-Seq, and CpG Methylation to Better Predict Humoral Immunity to Influenza Vaccination: Dependence of mRNA-Seq/CpG Methylation on Immune Cell Populations. (Zimmermann MT, Kennedy RB, Grill DE, Oberg AL, Goergen KM, Ovsyannikova IG, Haralambieva IH, Poland GA) Front Immunol 2017;8:445 PMID: 28484452 PMCID: PMC5399034 05/10/2017    
  • Genome-wide associations of CD46 and IFI44L genetic variants with neutralizing antibody response to measles vaccine. (Haralambieva IH, Ovsyannikova IG, Kennedy RB, Larrabee BR, Zimmermann MT, Grill DE, Schaid DJ, Poland GA) Hum Genet 2017 04;136(4):421-435 PMID: 28289848 PMCID: PMC5433429 03/16/2017       4 Citations
  • Molecular modeling and molecular dynamic simulation of the effects of variants in the TGFBR2 kinase domain as a paradigm for interpretation of variants obtained by next generation sequencing. (Zimmermann MT, Urrutia R, Oliver GR, Blackburn PR, Cousin MA, Bozeck NJ, Klee EW) PLoS One 2017;12(2):e0170822 PMID: 28182693 PMCID: PMC5300139 02/10/2017       5 Citations
  • Novel Pathogenic Variant in TGFBR2 Confirmed by Molecular Modeling Is a Rare Cause of Loeys-Dietz Syndrome. (Zimmermann MT, Urrutia RA, Blackburn PR, Cousin MA, Boczek NJ, Klee EW, Macmurdo C, Atwal PS) Case Rep Genet 2017;2017:7263780 PMID: 28163941 PMCID: PMC5253504 02/07/2017    
  • A Novel Kleefstra Syndrome-associated Variant That Affects the Conserved TPL Motif within the Ankyrin Repeat of EHMT1 Leads to Abnormal Protein Folding. (Blackburn PR, Tischer A, Zimmermann MT, Kemppainen JL, Sastry S, Knight Johnson AE, Cousin MA, Boczek NJ, Oliver G, Misra VK, Gavrilova RH, Lomberk G, Auton M, Urrutia R, Klee EW) J Biol Chem 2017 03 03;292(9):3866-3876 PMID: 28057753 PMCID: PMC5339767 01/07/2017    
  • Hereditary Lysozyme Amyloidosis Variant p.Leu102Ser Associates with Unique Phenotype. (Nasr SH, Dasari S, Mills JR, Theis JD, Zimmermann MT, Fonseca R, Vrana JA, Lester SJ, McLaughlin BM, Gillespie R, Highsmith WE Jr, Lee JJ, Dispenzieri A, Kurtin PJ) J Am Soc Nephrol 2017 Feb;28(2):431-438 PMID: 28049649 PMCID: PMC5280032 01/05/2017       4 Citations
  • The development of non-coding RNA ontology. (Huang J, Eilbeck K, Smith B, Blake JA, Dou D, Huang W, Natale DA, Ruttenberg A, Huan J, Zimmermann MT, Jiang G, Lin Y, Wu B, Strachan HJ, de Silva N, Kasukurthi MV, Jha VK, He Y, Zhang S, Wang X, Liu Z, Borchert GM, Tan M) Int J Data Min Bioinform 2016;15(3):214-232 PMID: 27990175 PMCID: PMC5156483 12/19/2016    
  • A novel ANO3 variant identified in a 53-year-old woman presenting with hyperkinetic dysarthria, blepharospasm, hyperkinesias, and complex motor tics. (Blackburn PR, Zimmermann MT, Gass JM, Harris KG, Cousin MA, Boczek NJ, Ross OA, Klee EW, Brazis PW, Van Gerpen JA, Atwal PS) BMC Med Genet 2016 Dec 05;17(1):93 PMID: 27919237 PMCID: PMC5139108 12/07/2016       2 Citations
  • Immunosenescence-Related Transcriptomic and Immunologic Changes in Older Individuals Following Influenza Vaccination. (Kennedy RB, Ovsyannikova IG, Haralambieva IH, Oberg AL, Zimmermann MT, Grill DE, Poland GA) Front Immunol 2016;7:450 PMID: 27853459 PMCID: PMC5089977 11/18/2016    
  • Functional characterization of a GFAP variant of uncertain significance in an Alexander disease case within the setting of an individualized medicine clinic. (Boczek NJ, Sigafoos AN, Zimmermann MT, Maus RL, Cousin MA, Blackburn PR, Urrutia R, Clark KJ, Patterson MC, Wick MJ, Klee EW) Clin Case Rep 2016 09;4(9):885-95 PMID: 27648269 PMCID: PMC5018595 09/21/2016    
  • Single-sample expression-based chemo-sensitivity score improves survival associations independently from genomic mutations for ovarian cancer Patients. (Zimmermann MT, Jiang G, Wang C) AMIA Jt Summits Transl Sci Proc 2016;2016:94-100 PMID: 27570657 PMCID: PMC5001782 08/30/2016    
  • Gene signatures associated with adaptive humoral immunity following seasonal influenza A/H1N1 vaccination. (Ovsyannikova IG, Salk HM, Kennedy RB, Haralambieva IH, Zimmermann MT, Grill DE, Oberg AL, Poland GA) Genes Immun 2016 Dec;17(7):371-379 PMID: 27534615 PMCID: PMC5133148 08/19/2016       5 Citations
  • Whole Transcriptome Profiling Identifies CD93 and Other Plasma Cell Survival Factor Genes Associated with Measles-Specific Antibody Response after Vaccination. (Haralambieva IH, Zimmermann MT, Ovsyannikova IG, Grill DE, Oberg AL, Kennedy RB, Poland GA) PLoS One 2016;11(8):e0160970 PMID: 27529750 PMCID: PMC4987012 08/17/2016       5 Citations
  • Gene signatures related to HAI response following influenza A/H1N1 vaccine in older individuals. (Ovsyannikova IG, Oberg AL, Kennedy RB, Zimmermann MT, Haralambieva IH, Goergen KM, Grill DE, Poland GA) Heliyon 2016 May;2(5):e00098 PMID: 27441275 PMCID: PMC4946173 07/22/2016    
  • "The molecule's the thing:" the promise of molecular modeling and dynamic simulations in aiding the prioritization and interpretation of genomic testing results. (Oliver GR, Zimmermann MT, Klee EW, Urrutia RA) F1000Res 2016;5:766 PMID: 27408685 PMCID: PMC4920209 07/14/2016    
  • Transcriptional signatures of influenza A/H1N1-specific IgG memory-like B cell response in older individuals. (Haralambieva IH, Ovsyannikova IG, Kennedy RB, Zimmermann MT, Grill DE, Oberg AL, Poland GA) Vaccine 2016 07 25;34(34):3993-4002 PMID: 27317456 PMCID: PMC5520794 06/19/2016       9 Citations
  • Novel Type of Renal Amyloidosis Derived from Apolipoprotein-CII. (Nasr SH, Dasari S, Hasadsri L, Theis JD, Vrana JA, Gertz MA, Muppa P, Zimmermann MT, Grogg KL, Dispenzieri A, Sethi S, Highsmith WE Jr, Merlini G, Leung N, Kurtin PJ) J Am Soc Nephrol 2017 Feb;28(2):439-445 PMID: 27297947 PMCID: PMC5280007 06/15/2016       22 Citations
  • Recursive Indirect-Paths Modularity (RIP-M) for Detecting Community Structure in RNA-Seq Co-expression Networks. (Rahmani B, Zimmermann MT, Grill DE, Kennedy RB, Oberg AL, White BC, Poland GA, McKinney BA) Front Genet 2016;7:80 PMID: 27242890 PMCID: PMC4861003 06/01/2016    
  • De novo RRAGC mutation activates mTORC1 signaling in syndromic fetal dilated cardiomyopathy. (Long PA, Zimmermann MT, Kim M, Evans JM, Xu X, Olson TM) Hum Genet 2016 08;135(8):909-917 PMID: 27234373 PMCID: PMC4947566 05/29/2016       6 Citations
  • The Non-Coding RNA Ontology (NCRO): a comprehensive resource for the unification of non-coding RNA biology. (Huang J, Eilbeck K, Smith B, Blake JA, Dou D, Huang W, Natale DA, Ruttenberg A, Huan J, Zimmermann MT, Jiang G, Lin Y, Wu B, Strachan HJ, He Y, Zhang S, Wang X, Liu Z, Borchert GM, Tan M) J Biomed Semantics 2016;7:24 PMID: 27152146 PMCID: PMC4857245 05/07/2016       8 Citations
  • System-Wide Associations between DNA-Methylation, Gene Expression, and Humoral Immune Response to Influenza Vaccination. (Zimmermann MT, Oberg AL, Grill DE, Ovsyannikova IG, Haralambieva IH, Kennedy RB, Poland GA) PLoS One 2016;11(3):e0152034 PMID: 27031986 PMCID: PMC4816338 04/01/2016       10 Citations
  • Ribosome Mechanics Informs about Mechanism. (Zimmermann MT, Jia K, Jernigan RL) J Mol Biol 2016 Feb 27;428(5 Pt A):802-810 PMID: 26687034 PMCID: PMC4789072 12/22/2015       5 Citations
  • Whole-exome analysis reveals novel somatic genomic alterations associated with outcome in immunochemotherapy-treated diffuse large B-cell lymphoma. (Novak AJ, Asmann YW, Maurer MJ, Wang C, Slager SL, Hodge LS, Manske M, Price-Troska T, Yang ZZ, Zimmermann MT, Nowakowski GS, Ansell SM, Witzig TE, McPhail E, Ketterling R, Feldman AL, Dogan A, Link BK, Habermann TM, Cerhan JR) Blood Cancer J 2015 Aug 28;5:e346 PMID: 26314988 PMCID: PMC4558593 09/01/2015       27 Citations
  • Adverse Drug Events-based Tumor Stratification for Ovarian Cancer Patients Receiving Platinum Therapy. (Wang C, Zimmermann MT, Chute CG, Jiang G) AMIA Jt Summits Transl Sci Proc 2015;2015:51-5 PMID: 26306234 PMCID: PMC4525249 08/26/2015    
  • Drug Normalization for Cancer Therapeutic and Druggable Genome Target Discovery. (Jiang G, Sohn S, Zimmermann MT, Wang C, Liu H, Chute CG) AMIA Jt Summits Transl Sci Proc 2015;2015:72-6 PMID: 26306243 PMCID: PMC4525232 08/26/2015    
  • A Semantic Web-based System for Mining Genetic Mutations in Cancer Clinical Trials. (Priya S, Jiang G, Dasari S, Zimmermann MT, Wang C, Heflin J, Chute CG) AMIA Jt Summits Transl Sci Proc 2015;2015:142-6 PMID: 26306257 PMCID: PMC4525254 08/26/2015    
  • Structural origins of misfolding propensity in the platelet adhesive von Willebrand factor A1 domain. (Zimmermann MT, Tischer A, Whitten ST, Auton M) Biophys J 2015 Jul 21;109(2):398-406 PMID: 26200876 PMCID: PMC4621621 07/23/2015       6 Citations
  • Recessive MYH6 Mutations in Hypoplastic Left Heart With Reduced Ejection Fraction. (Theis JL, Zimmermann MT, Evans JM, Eckloff BW, Wieben ED, Qureshi MY, O'Leary PW, Olson TM) Circ Cardiovasc Genet 2015 Aug;8(4):564-71 PMID: 26085007 06/19/2015       20 Citations
  • PANDA: pathway and annotation explorer for visualizing and interpreting gene-centric data. (Hart SN, Moore RM, Zimmermann MT, Oliver GR, Egan JB, Bryce AH, Kocher JA) PeerJ 2015;3:e970 PMID: 26038725 PMCID: PMC4451017 06/04/2015    
  • MACE: model based analysis of ChIP-exo. (Wang L, Chen J, Wang C, Uusküla-Reimand L, Chen K, Medina-Rivera A, Young EJ, Zimmermann MT, Yan H, Sun Z, Zhang Y, Wu ST, Huang H, Wilson MD, Kocher JP, Li W) Nucleic Acids Res 2014 Nov 10;42(20):e156 PMID: 25249628 PMCID: PMC4227761 09/25/2014       32 Citations
  • TNNI3K mutation in familial syndrome of conduction system disease, atrial tachyarrhythmia and dilated cardiomyopathy. (Theis JL, Zimmermann MT, Larsen BT, Rybakova IN, Long PA, Evans JM, Middha S, de Andrade M, Moss RL, Wieben ED, Michels VV, Olson TM) Hum Mol Genet 2014 Nov 01;23(21):5793-804 PMID: 24925317 PMCID: PMC4189907 06/14/2014       14 Citations
  • Understanding protein-nanoparticle interaction: a new gateway to disease therapeutics. (Giri K, Shameer K, Zimmermann MT, Saha S, Chakraborty PK, Sharma A, Arvizo RR, Madden BJ, Mccormick DJ, Kocher JP, Bhattacharya R, Mukherjee P) Bioconjug Chem 2014 Jun 18;25(6):1078-90 PMID: 24831101 PMCID: PMC4128259 05/17/2014       26 Citations
  • Elastic network models capture the motions apparent within ensembles of RNA structures. (Zimmermann MT, Jernigan RL) RNA 2014 Jun;20(6):792-804 PMID: 24759093 PMCID: PMC4024634 04/25/2014       14 Citations
  • Clinical proteome informatics workbench detects pathogenic mutations in hereditary amyloidoses. (Dasari S, Theis JD, Vrana JA, Zenka RM, Zimmermann MT, Kocher JP, Highsmith WE Jr, Kurtin PJ, Dogan A) J Proteome Res 2014 May 02;13(5):2352-8 PMID: 24650283 03/22/2014       21 Citations
  • Factors correlating with significant differences between X-ray structures of myoglobin. (Rashin AA, Domagalski MJ, Zimmermann MT, Minor W, Chruszcz M, Jernigan RL) Acta Crystallogr D Biol Crystallogr 2014 Feb;70(Pt 2):481-91 PMID: 24531482 PMCID: PMC3940193 02/18/2014       5 Citations
  • Adverse Drug Event-based Stratification of Tumor Mutations: A Case Study of Breast Cancer Patients Receiving Aromatase Inhibitors. (Wang C, Zimmermann MT, Prodduturi N, Chute CG, Jiang G) AMIA Annu Symp Proc 2014;2014:1160-9 PMID: 25954427 PMCID: PMC4419882 01/01/2014       1 Citations
  • Computational and experimental characterization of RNA cubic nanoscaffolds. (Afonin KA, Kasprzak W, Bindewald E, Puppala PS, Diehl AR, Hall KT, Kim TJ, Zimmermann MT, Jernigan RL, Jaeger L, Shapiro BA) Methods 2014 May 15;67(2):256-65 PMID: 24189588 PMCID: PMC4007386 11/06/2013       23 Citations
  • Revealing rotational modes of functionalized gold nanorods on live cell membranes. (Gu Y, Sun W, Wang G, Zimmermann MT, Jernigan RL, Fang N) Small 2013 Mar 11;9(5):785-92 PMID: 23124917 11/06/2012       20 Citations
  • A computational investigation on the connection between dynamics properties of ribosomal proteins and ribosome assembly. (Burton B, Zimmermann MT, Jernigan RL, Wang Y) PLoS Comput Biol 2012;8(5):e1002530 PMID: 22654657 PMCID: PMC3359968 06/02/2012       13 Citations
  • Combining statistical potentials with dynamics-based entropies improves selection from protein decoys and docking poses. (Zimmermann MT, Leelananda SP, Kloczkowski A, Jernigan RL) J Phys Chem B 2012 Jun 14;116(23):6725-31 PMID: 22490366 04/12/2012    
  • The importance of slow motions for protein functional loops. (Skliros A, Zimmermann MT, Chakraborty D, Saraswathi S, Katebi AR, Leelananda SP, Kloczkowski A, Jernigan RL) Phys Biol 2012 Feb 07;9(1):014001 PMID: 22314977 PMCID: PMC3783528 02/09/2012    
  • MAVENs: motion analysis and visualization of elastic networks and structural ensembles. (Zimmermann MT, Kloczkowski A, Jernigan RL) BMC Bioinformatics 2011 Jun 28;12:264 PMID: 21711533 PMCID: PMC3213244 06/30/2011       28 Citations
  • Free energies for coarse-grained proteins by integrating multibody statistical contact potentials with entropies from elastic network models. (Zimmermann MT, Leelananda SP, Gniewek P, Feng Y, Jernigan RL, Kloczkowski A) J Struct Funct Genomics 2011 Jul;12(2):137-47 PMID: 21674234 PMCID: PMC3227679 06/16/2011       11 Citations
  • Human telomerase model shows the role of the TEN domain in advancing the double helix for the next polymerization step. (Steczkiewicz K, Zimmermann MT, Kurcinski M, Lewis BA, Dobbs D, Kloczkowski A, Jernigan RL, Kolinski A, Ginalski K) Proc Natl Acad Sci U S A 2011 Jun 07;108(23):9443-8 PMID: 21606328 PMCID: PMC3111281 05/25/2011       32 Citations
  • Crystal structure of the CusBA heavy-metal efflux complex of Escherichia coli. (Su CC, Long F, Zimmermann MT, Rajashankar KR, Jernigan RL, Yu EW) Nature 2011 Feb 24;470(7335):558-62 PMID: 21350490 PMCID: PMC3078058 02/26/2011       113 Citations
  • Immunoglobulin Structure Exhibits Control over CDR Motion. (Zimmermann MT, Skliros A, Kloczkowski A, Jernigan RL) Immunome Res 2011;7(5) PMID: 25191522 PMCID: PMC4151861 01/01/2011    
  • Crystal structures of the CusA efflux pump suggest methionine-mediated metal transport. (Long F, Su CC, Zimmermann MT, Boyken SE, Rajashankar KR, Jernigan RL, Yu EW) Nature 2010 Sep 23;467(7314):484-8 PMID: 20865003 PMCID: PMC2946090 09/25/2010       121 Citations
  • Last update: 12/17/2018
    jenkins-FCD Prod-300 626508253d14e4184314fb9f66322a03a5906796