Medical College of Wisconsin
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Peter J. Newman PhD


Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Pharmacology

Member of the Cancer Center
Member of the Cardiovascular Center


  • Integrin-αIIbβ3-mediated outside-in signalling activates a negative feedback pathway to suppress platelet activation. (Dai B, Wu P, Xue F, Yang R, Yu Z, Dai K, Ruan C, Liu G, Newman PJ, Gao C) Thromb Haemost 2016 10 28;116(5):918-930 PMID: 27465472 10/30/2016       2 Citations
  • The Role of Sialylated Glycans in Human Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1)-mediated Trans Homophilic Interactions and Endothelial Cell Barrier Function. (Lertkiatmongkol P, Paddock C, Newman DK, Zhu J, Thomas MJ, Newman PJ) J Biol Chem 2016 Dec 09;291(50):26216-26225 PMID: 27793989 PMCID: PMC5207088 10/30/2016       7 Citations
  • Antiendothelial αvβ3 Antibodies Are a Major Cause of Intracranial Bleeding in Fetal/Neonatal Alloimmune Thrombocytopenia. (Santoso S, Wihadmadyatami H, Bakchoul T, Werth S, Al-Fakhri N, Bein G, Kiefel V, Zhu J, Newman PJ, Bayat B, Sachs UJ) Arterioscler Thromb Vasc Biol 2016 08;36(8):1517-24 PMID: 27283740 PMCID: PMC5140275 06/11/2016       19 Citations
  • Endothelial functions of platelet/endothelial cell adhesion molecule-1 (CD31). (Lertkiatmongkol P, Liao D, Mei H, Hu Y, Newman PJ) Curr Opin Hematol 2016 May;23(3):253-9 PMID: 27055047 PMCID: PMC4986701 04/08/2016       21 Citations
  • Structural basis for PECAM-1 homophilic binding. (Paddock C, Zhou D, Lertkiatmongkol P, Newman PJ, Zhu J) Blood 2016 Feb 25;127(8):1052-61 PMID: 26702061 PMCID: PMC4768429 12/25/2015       14 Citations
  • CRISPR/Cas9-mediated conversion of human platelet alloantigen allotypes. (Zhang N, Zhi H, Curtis BR, Rao S, Jobaliya C, Poncz M, French DL, Newman PJ) Blood 2016 Feb 11;127(6):675-80 PMID: 26634302 PMCID: PMC4751021 12/05/2015       11 Citations
  • Platelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin αIIbβ3 and Lyn Kinase. (Zhi H, Dai J, Liu J, Zhu J, Newman DK, Gao C, Newman PJ) PLoS One 2015;10(8):e0135738 PMID: 26291522 PMCID: PMC4546160 08/21/2015       10 Citations
  • Restoration of responsiveness of phospholipase Cγ2-deficient platelets by enforced expression of phospholipase Cγ1. (Zheng Y, Adams T, Zhi H, Yu M, Wen R, Newman PJ, Wang D, Newman DK) PLoS One 2015;10(3):e0119739 PMID: 25793864 PMCID: PMC4368822 03/21/2015       5 Citations
  • Regulation of endothelial cell barrier function by antibody-driven affinity modulation of platelet endothelial cell adhesion molecule-1 (PECAM-1). (Mei H, Campbell JM, Paddock CM, Lertkiatmongkol P, Mosesson MW, Albrecht R, Newman PJ) J Biol Chem 2014 Jul 25;289(30):20836-44 PMID: 24936065 PMCID: PMC4110291 06/18/2014       19 Citations
  • PECAM-1: regulator of endothelial junctional integrity. (Privratsky JR, Newman PJ) Cell Tissue Res 2014 Mar;355(3):607-19 PMID: 24435645 PMCID: PMC3975704 01/18/2014       71 Citations
  • Platelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of sitosterolemia. (Kanaji T, Kanaji S, Montgomery RR, Patel SB, Newman PJ) Blood 2013 Oct 10;122(15):2732-42 PMID: 23926302 PMCID: PMC3795464 08/09/2013       20 Citations
  • Inhibition of HPA-1a alloantibody-mediated platelet destruction by a deglycosylated anti-HPA-1a monoclonal antibody in mice: toward targeted treatment of fetal-alloimmune thrombocytopenia. (Bakchoul T, Greinacher A, Sachs UJ, Krautwurst A, Renz H, Harb H, Bein G, Newman PJ, Santoso S) Blood 2013 Jul 18;122(3):321-7 PMID: 23645838 PMCID: PMC3716199 05/07/2013       20 Citations
  • Immunoreceptor tyrosine-based inhibitory motif (ITIM)-mediated inhibitory signaling is regulated by sequential phosphorylation mediated by distinct nonreceptor tyrosine kinases: a case study involving PECAM-1. (Tourdot BE, Brenner MK, Keough KC, Holyst T, Newman PJ, Newman DK) Biochemistry 2013 Apr 16;52(15):2597-608 PMID: 23418871 PMCID: PMC3666314 02/20/2013       18 Citations
  • Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo. (Zhi H, Rauova L, Hayes V, Gao C, Boylan B, Newman DK, McKenzie SE, Cooley BC, Poncz M, Newman PJ) Blood 2013 Mar 07;121(10):1858-67 PMID: 23264598 PMCID: PMC3591804 12/25/2012       46 Citations
  • Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function. (Kuckleburg CJ, Newman PJ) Arterioscler Thromb Vasc Biol 2013 Feb;33(2):275-84 PMID: 23202369 PMCID: PMC3562705 12/04/2012       15 Citations
  • Cadherin 6 has a functional role in platelet aggregation and thrombus formation. (Dunne E, Spring CM, Reheman A, Jin W, Berndt MC, Newman DK, Newman PJ, Ni H, Kenny D) Arterioscler Thromb Vasc Biol 2012 Jul;32(7):1724-31 PMID: 22539596 PMCID: PMC4155514 04/28/2012       21 Citations
  • Proteinase 3 contributes to transendothelial migration of NB1-positive neutrophils. (Kuckleburg CJ, Tilkens SB, Santoso S, Newman PJ) J Immunol 2012 Mar 01;188(5):2419-26 PMID: 22266279 PMCID: PMC3288489 01/24/2012       39 Citations
  • GPIbα regulates platelet size by controlling the subcellular localization of filamin. (Kanaji T, Ware J, Okamura T, Newman PJ) Blood 2012 Mar 22;119(12):2906-13 PMID: 22174152 PMCID: PMC3327465 12/17/2011       27 Citations
  • PECAM-1 dampens cytokine levels during LPS-induced endotoxemia by regulating leukocyte trafficking. (Privratsky JR, Tilkens SB, Newman DK, Newman PJ) Life Sci 2012 Jan 30;90(5-6):177-84 PMID: 22119535 PMCID: PMC3264774 11/29/2011       7 Citations
  • Relative contribution of PECAM-1 adhesion and signaling to the maintenance of vascular integrity. (Privratsky JR, Paddock CM, Florey O, Newman DK, Muller WA, Newman PJ) J Cell Sci 2011 May 01;124(Pt 9):1477-85 PMID: 21486942 PMCID: PMC3078814 04/14/2011       43 Citations
  • Residues within a lipid-associated segment of the PECAM-1 cytoplasmic domain are susceptible to inducible, sequential phosphorylation. (Paddock C, Lytle BL, Peterson FC, Holyst T, Newman PJ, Volkman BF, Newman DK) Blood 2011 Jun 02;117(22):6012-23 PMID: 21464369 PMCID: PMC3112045 04/06/2011       23 Citations
  • Heparin promotes platelet responsiveness by potentiating αIIbβ3-mediated outside-in signaling. (Gao C, Boylan B, Fang J, Wilcox DA, Newman DK, Newman PJ) Blood 2011 May 05;117(18):4946-52 PMID: 21368290 PMCID: PMC3100701 03/04/2011       60 Citations
  • Lyn and PECAM-1 function as interdependent inhibitors of platelet aggregation. (Ming Z, Hu Y, Xiang J, Polewski P, Newman PJ, Newman DK) Blood 2011 Apr 07;117(14):3903-6 PMID: 21297004 PMCID: PMC3083302 02/08/2011       28 Citations
  • Last update: 07/13/2010
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