Medical College of Wisconsin
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Qing-song Liu PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Program Development

Member of the Neuroscience Research Center


  • Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes. (Lee SH, Shin SM, Zhong P, Kim HT, Kim DI, Kim JM, Do Heo W, Kim DW, Yeo CY, Kim CH, Liu QS) Nat Commun 2018 08 24;9(1):3434 PMID: 30143647 PMCID: PMC6109165 08/26/2018    
  • HCN2 channels in the ventral tegmental area regulate behavioral responses to chronic stress. (Zhong P, Vickstrom CR, Liu X, Hu Y, Yu L, Yu HG, Liu QS) Elife 2018 01 02;7 PMID: 29256865 PMCID: PMC5749952 12/20/2017       3 Citations
  • Resveratrol modulates cocaine-induced inhibitory synaptic plasticity in VTA dopamine neurons by inhibiting phosphodiesterases (PDEs). (Li Y, Yu L, Zhao L, Zeng F, Liu QS) Sci Rep 2017 Nov 15;7(1):15657 PMID: 29142291 PMCID: PMC5688096 11/17/2017    
  • Stress Promotes Drug Seeking Through Glucocorticoid-Dependent Endocannabinoid Mobilization in the Prelimbic Cortex. (McReynolds JR, Doncheck EM, Li Y, Vranjkovic O, Graf EN, Ogasawara D, Cravatt BF, Baker DA, Liu QS, Hillard CJ, Mantsch JR) Biol Psychiatry 2017 Oct 06 PMID: 29100630 PMCID: PMC5889367 11/05/2017    
  • VTA mTOR Signaling Regulates Dopamine Dynamics, Cocaine-Induced Synaptic Alterations, and Reward. (Liu X, Li Y, Yu L, Vickstrom CR, Liu QS) Neuropsychopharmacology 2018 04;43(5):1066-1077 PMID: 29039413 PMCID: PMC5854804 10/19/2017       3 Citations
  • Phosphodiesterase 4 inhibitors and drugs of abuse: current knowledge and therapeutic opportunities. (Olsen CM, Liu QS) Front Biol (Beijing) 2016 Oct;11(5):376-386 PMID: 28974957 PMCID: PMC5617368 10/05/2017    
  • Serotonin in the Frontal Cortex: A Potential Therapeutic Target for Neurological Disorders. (Lu H, Liu QS) Biochem Pharmacol (Los Angel) 2017 Feb;6(1) PMID: 28758051 PMCID: PMC5531193 08/02/2017    
  • PDE4 Inhibition Restores the Balance Between Excitation and Inhibition in VTA Dopamine Neurons Disrupted by Repeated In Vivo Cocaine Exposure. (Liu X, Zhong P, Vickstrom C, Li Y, Liu QS) Neuropsychopharmacology 2017 Sep;42(10):1991-1999 PMID: 28497801 PMCID: PMC5561351 05/13/2017       3 Citations
  • The Epac-Phospholipase Cε Pathway Regulates Endocannabinoid Signaling and Cocaine-Induced Disinhibition of Ventral Tegmental Area Dopamine Neurons. (Tong J, Liu X, Vickstrom C, Li Y, Yu L, Lu Y, Smrcka AV, Liu QS) J Neurosci 2017 03 15;37(11):3030-3044 PMID: 28209735 PMCID: PMC5354337 02/18/2017       4 Citations
  • Coordinated regulation of endocannabinoid-mediated retrograde synaptic suppression in the cerebellum by neuronal and astrocytic monoacylglycerol lipase. (Liu X, Chen Y, Vickstrom CR, Li Y, Viader A, Cravatt BF, Liu QS) Sci Rep 2016 10 24;6:35829 PMID: 27775008 PMCID: PMC5075776 10/25/2016    
  • Pituitary Adenylate-Cyclase Activating Polypeptide Regulates Hunger- and Palatability-Induced Binge Eating. (Hurley MM, Maunze B, Block ME, Frenkel MM, Reilly MJ, Kim E, Chen Y, Li Y, Baker DA, Liu QS, Choi S) Front Neurosci 2016;10:383 PMID: 27597817 PMCID: PMC4993128 09/07/2016    
  • Medical Marijuana-Opportunities and Challenges. (Liu QS) Biochem Pharmacol (Los Angel) 2016 Jun;5(3) PMID: 27441101 PMCID: PMC4948749 07/22/2016    
  • Neuronal and Astrocytic Monoacylglycerol Lipase Limit the Spread of Endocannabinoid Signaling in the Cerebellum. (Chen Y, Liu X, Vickstrom CR, Liu MJ, Zhao L, Viader A, Cravatt BF, Liu QS) eNeuro 2016 May-Jun;3(3) PMID: 27182552 PMCID: PMC4865651 05/18/2016       4 Citations
  • Epac Signaling Is Required for Cocaine-Induced Change in AMPA Receptor Subunit Composition in the Ventral Tegmental Area. (Liu X, Chen Y, Tong J, Reynolds AM, Proudfoot SC, Qi J, Penzes P, Lu Y, Liu QS) J Neurosci 2016 04 27;36(17):4802-15 PMID: 27122037 PMCID: PMC4846675 04/29/2016       6 Citations
  • Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition. (Ogasawara D, Deng H, Viader A, Baggelaar MP, Breman A, den Dulk H, van den Nieuwendijk AM, Soethoudt M, van der Wel T, Zhou J, Overkleeft HS, Sanchez-Alavez M, Mori S, Nguyen W, Conti B, Liu X, Chen Y, Liu QS, Cravatt BF, van der Stelt M) Proc Natl Acad Sci U S A 2016 Jan 05;113(1):26-33 PMID: 26668358 PMCID: PMC4711871 12/17/2015       31 Citations
  • Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action. (Viader A, Blankman JL, Zhong P, Liu X, Schlosburg JE, Joslyn CM, Liu QS, Tomarchio AJ, Lichtman AH, Selley DE, Sim-Selley LJ, Cravatt BF) Cell Rep 2015 Aug 04;12(5):798-808 PMID: 26212325 PMCID: PMC4526356 07/28/2015       33 Citations
  • Leptin attenuates the detrimental effects of β-amyloid on spatial memory and hippocampal later-phase long term potentiation in rats. (Tong JQ, Zhang J, Hao M, Yang J, Han YF, Liu XJ, Shi H, Wu MN, Liu QS, Qi JS) Horm Behav 2015 Jul;73:125-30 PMID: 26135065 07/03/2015       11 Citations
  • Full Fatty Acid Amide Hydrolase Inhibition Combined with Partial Monoacylglycerol Lipase Inhibition: Augmented and Sustained Antinociceptive Effects with Reduced Cannabimimetic Side Effects in Mice. (Ghosh S, Kinsey SG, Liu QS, Hruba L, McMahon LR, Grim TW, Merritt CR, Wise LE, Abdullah RA, Selley DE, Sim-Selley LJ, Cravatt BF, Lichtman AH) J Pharmacol Exp Ther 2015 Aug;354(2):111-20 PMID: 25998048 PMCID: PMC4518073 05/23/2015       18 Citations
  • BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain dopamine neurons. (Zhong P, Liu Y, Hu Y, Wang T, Zhao YP, Liu QS) J Neurosci 2015 Mar 11;35(10):4469-81 PMID: 25762688 PMCID: PMC4355208 03/13/2015       20 Citations
  • S-SCAM, a rare copy number variation gene, induces schizophrenia-related endophenotypes in transgenic mouse model. (Zhang N, Zhong P, Shin SM, Metallo J, Danielson E, Olsen CM, Liu QS, Lee SH) J Neurosci 2015 Feb 04;35(5):1892-904 PMID: 25653350 PMCID: PMC4315826 02/06/2015       4 Citations
  • Blockade of 2-arachidonoylglycerol hydrolysis produces antidepressant-like effects and enhances adult hippocampal neurogenesis and synaptic plasticity. (Zhang Z, Wang W, Zhong P, Liu SJ, Long JZ, Zhao L, Gao HQ, Cravatt BF, Liu QS) Hippocampus 2015 Jan;25(1):16-26 PMID: 25131612 PMCID: PMC4517601 08/19/2014       26 Citations
  • Cyclin-dependent kinase 5 in the ventral tegmental area regulates depression-related behaviors. (Zhong P, Liu X, Zhang Z, Hu Y, Liu SJ, Lezama-Ruiz M, Joksimovic M, Liu QS) J Neurosci 2014 Apr 30;34(18):6352-66 PMID: 24790206 PMCID: PMC4004818 05/03/2014       24 Citations
  • Monoacylglycerol lipase inhibition blocks chronic stress-induced depressive-like behaviors via activation of mTOR signaling. (Zhong P, Wang W, Pan B, Liu X, Zhang Z, Long JZ, Zhang HT, Cravatt BF, Liu QS) Neuropsychopharmacology 2014 Jun;39(7):1763-76 PMID: 24476943 PMCID: PMC4023150 01/31/2014       46 Citations
  • Endocannabinoid signaling in the etiology and treatment of major depressive illness. (Hillard CJ, Liu QS) Curr Pharm Des 2014;20(23):3795-811 PMID: 24180398 PMCID: PMC4002665 11/05/2013       20 Citations
  • CaMKII activity in the ventral tegmental area gates cocaine-induced synaptic plasticity in the nucleus accumbens. (Liu X, Liu Y, Zhong P, Wilkinson B, Qi J, Olsen CM, Bayer KU, Liu QS) Neuropsychopharmacology 2014 Mar;39(4):989-99 PMID: 24154664 PMCID: PMC3924533 10/25/2013       13 Citations
  • Melatonin protects against amyloid-β-induced impairments of hippocampal LTP and spatial learning in rats. (Liu XJ, Yuan L, Yang D, Han WN, Li QS, Yang W, Liu QS, Qi JS) Synapse 2013 Sep;67(9):626-36 PMID: 23620224 04/27/2013       29 Citations
  • Metabotropic glutamate receptor I (mGluR1) antagonism impairs cocaine-induced conditioned place preference via inhibition of protein synthesis. (Yu F, Zhong P, Liu X, Sun D, Gao HQ, Liu QS) Neuropsychopharmacology 2013 Jun;38(7):1308-21 PMID: 23348064 PMCID: PMC3656374 01/26/2013       29 Citations
  • Phosphodiesterase 4 inhibition impairs cocaine-induced inhibitory synaptic plasticity and conditioned place preference. (Zhong P, Wang W, Yu F, Nazari M, Liu X, Liu QS) Neuropsychopharmacology 2012 Oct;37(11):2377-87 PMID: 22713909 PMCID: PMC3442353 06/21/2012       22 Citations
  • Acute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD. (Han J, Kesner P, Metna-Laurent M, Duan T, Xu L, Georges F, Koehl M, Abrous DN, Mendizabal-Zubiaga J, Grandes P, Liu Q, Bai G, Wang W, Xiong L, Ren W, Marsicano G, Zhang X) Cell 2012 Mar 02;148(5):1039-50 PMID: 22385967 03/06/2012       198 Citations
  • Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice. (Pan B, Wang W, Zhong P, Blankman JL, Cravatt BF, Liu QS) J Neurosci 2011 Sep 21;31(38):13420-30 PMID: 21940435 PMCID: PMC3371386 09/24/2011       93 Citations
  • Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum. (Zhong P, Pan B, Gao XP, Blankman JL, Cravatt BF, Liu QS) J Physiol 2011 Oct 15;589(Pt 20):4847-55 PMID: 21911610 PMCID: PMC3224879 09/14/2011       38 Citations
  • Extracellular signal-regulated kinase signaling in the ventral tegmental area mediates cocaine-induced synaptic plasticity and rewarding effects. (Pan B, Zhong P, Sun D, Liu QS) J Neurosci 2011 Aug 03;31(31):11244-55 PMID: 21813685 PMCID: PMC3153072 08/05/2011       39 Citations
  • Recruitment of prefrontal cortical endocannabinoid signaling by glucocorticoids contributes to termination of the stress response. (Hill MN, McLaughlin RJ, Pan B, Fitzgerald ML, Roberts CJ, Lee TT, Karatsoreos IN, Mackie K, Viau V, Pickel VM, McEwen BS, Liu QS, Gorzalka BB, Hillard CJ) J Neurosci 2011 Jul 20;31(29):10506-15 PMID: 21775596 PMCID: PMC3179266 07/22/2011       162 Citations
  • Excitatory-inhibitory imbalance in hypoglossal neurons during the critical period of postnatal development in the rat. (Gao XP, Liu QS, Liu Q, Wong-Riley MT) J Physiol 2011 Apr 15;589(Pt 8):1991-2006 PMID: 21486774 PMCID: PMC3090599 04/14/2011       24 Citations
  • Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system. (Schlosburg JE, Blankman JL, Long JZ, Nomura DK, Pan B, Kinsey SG, Nguyen PT, Ramesh D, Booker L, Burston JJ, Thomas EA, Selley DE, Sim-Selley LJ, Liu QS, Lichtman AH, Cravatt BF) Nat Neurosci 2010 Sep;13(9):1113-9 PMID: 20729846 PMCID: PMC2928870 08/24/2010       339 Citations
  • Deficiency in endocannabinoid signaling in the nucleus accumbens induced by chronic unpredictable stress. (Wang W, Sun D, Pan B, Roberts CJ, Sun X, Hillard CJ, Liu QS) Neuropsychopharmacology 2010 Oct;35(11):2249-61 PMID: 20664582 PMCID: PMC3055309 07/29/2010       58 Citations
  • Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling. (Pan B, Wang W, Long JZ, Sun D, Hillard CJ, Cravatt BF, Liu QS) J Pharmacol Exp Ther 2009 Nov;331(2):591-7 PMID: 19666749 PMCID: PMC2775254 08/12/2009       108 Citations
  • D2 dopamine receptor activation facilitates endocannabinoid-mediated long-term synaptic depression of GABAergic synaptic transmission in midbrain dopamine neurons via cAMP-protein kinase A signaling. (Pan B, Hillard CJ, Liu QS) J Neurosci 2008 Dec 24;28(52):14018-30 PMID: 19109485 PMCID: PMC2656602 12/26/2008       88 Citations
  • Endocannabinoid signaling mediates cocaine-induced inhibitory synaptic plasticity in midbrain dopamine neurons. (Pan B, Hillard CJ, Liu QS) J Neurosci 2008 Feb 06;28(6):1385-97 PMID: 18256258 02/08/2008       100 Citations
  • Astrocyte activation of presynaptic metabotropic glutamate receptors modulates hippocampal inhibitory synaptic transmission. (Liu QS, Xu Q, Kang J, Nedergaard M) Neuron Glia Biol 2004 Nov;1(4):307-16 PMID: 16755304 PMCID: PMC1474019 06/07/2006    
  • BDNF-dependent synaptic sensitization in midbrain dopamine neurons after cocaine withdrawal. (Pu L, Liu QS, Poo MM) Nat Neurosci 2006 May;9(5):605-7 PMID: 16633344 04/25/2006       97 Citations
  • Repeated cocaine exposure in vivo facilitates LTP induction in midbrain dopamine neurons. (Liu QS, Pu L, Poo MM) Nature 2005 Oct 13;437(7061):1027-31 PMID: 16222299 PMCID: PMC1457101 10/14/2005       221 Citations
  • P2X7 receptor inhibition improves recovery after spinal cord injury. (Wang X, Arcuino G, Takano T, Lin J, Peng WG, Wan P, Li P, Xu Q, Liu QS, Goldman SA, Nedergaard M) Nat Med 2004 Aug;10(8):821-7 PMID: 15258577 07/20/2004       382 Citations
  • Astrocyte-mediated activation of neuronal kainate receptors. (Liu QS, Xu Q, Arcuino G, Kang J, Nedergaard M) Proc Natl Acad Sci U S A 2004 Mar 02;101(9):3172-7 PMID: 14766987 PMCID: PMC365762 02/10/2004       154 Citations
  • Signaling at the gliovascular interface. (Simard M, Arcuino G, Takano T, Liu QS, Nedergaard M) J Neurosci 2003 Oct 08;23(27):9254-62 PMID: 14534260 10/10/2003       403 Citations
  • Potentiation of alpha7-containing nicotinic acetylcholine receptors by select albumins. (Conroy WG, Liu QS, Nai Q, Margiotta JF, Berg DK) Mol Pharmacol 2003 Feb;63(2):419-28 PMID: 12527814 01/16/2003       28 Citations
  • Nicotinic regulation of CREB activation in hippocampal neurons by glutamatergic and nonglutamatergic pathways. (Hu M, Liu QS, Chang KT, Berg DK) Mol Cell Neurosci 2002 Dec;21(4):616-25 PMID: 12504594 12/31/2002       90 Citations
  • beta -Amyloid peptide blocks the response of alpha 7-containing nicotinic receptors on hippocampal neurons. (Liu Q, Kawai H, Berg DK) Proc Natl Acad Sci U S A 2001 Apr 10;98(8):4734-9 PMID: 11274373 PMCID: PMC31903 03/29/2001       257 Citations
  • Selective modulation of excitatory transmission by mu-opioid receptor activation in rat supraoptic neurons. (Liu QS, Han S, Jia YS, Ju G) J Neurophysiol 1999 Dec;82(6):3000-5 PMID: 10601435 12/22/1999       20 Citations
  • Actin filaments and the opposing actions of CaM kinase II and calcineurin in regulating alpha7-containing nicotinic receptors on chick ciliary ganglion neurons. (Liu Qs, Berg DK) J Neurosci 1999 Dec 01;19(23):10280-8 PMID: 10575025 11/27/1999       50 Citations
  • Extracellular calcium regulates responses of both alpha3- and alpha7-containing nicotinic receptors on chick ciliary ganglion neurons. (Liu QS, Berg DK) J Neurophysiol 1999 Sep;82(3):1124-32 PMID: 10482732 09/14/1999       35 Citations
  • Kainate acts at presynaptic receptors to increase GABA release from hypothalamic neurons. (Liu QS, Patrylo PR, Gao XB, van den Pol AN) J Neurophysiol 1999 Aug;82(2):1059-62 PMID: 10444697 08/13/1999       37 Citations
  • Last update: 12/02/2018
    jenkins-FCD Prod-300 626508253d14e4184314fb9f66322a03a5906796