Medical College of Wisconsin
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Sang H. Lee PhD

Sang H. Lee PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Program Development

Member of the Neuroscience Research Center


  • Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes. (Lee SH, Shin SM, Zhong P, Kim HT, Kim DI, Kim JM, Do Heo W, Kim DW, Yeo CY, Kim CH, Liu QS) Nat Commun 2018 08 24;9(1):3434 PMID: 30143647 PMCID: PMC6109165 08/26/2018    
  • Targeted knockout of a chemokine-like gene increases anxiety and fear responses. (Choi JH, Jeong YM, Kim S, Lee B, Ariyasiri K, Kim HT, Jung SH, Hwang KS, Choi TI, Park CO, Huh WK, Carl M, Rosenfeld JA, Raskin S, Ma A, Gecz J, Kim HG, Kim JS, Shin HC, Park DS, Gerlai R, Jamieson BB, Kim JS, Iremonger KJ, Lee SH, Shin HS, Kim CH) Proc Natl Acad Sci U S A 2018 01 30;115(5):E1041-E1050 PMID: 29339520 PMCID: PMC5798319 01/18/2018       2 Citations
  • Ottogi Inhibits Wnt/β-catenin Signaling by Regulating Cell Membrane Trafficking of Frizzled8. (Kim HT, Lee MS, Jeong YM, Ro H, Kim DI, Shin YH, Kim JE, Hwang KS, Choi JH, Bahn M, Lee JJ, Lee SH, Bae YK, Lee JS, Choi JK, Kim NS, Yeo CY, Kim CH) Sci Rep 2017 Oct 16;7(1):13278 PMID: 29038508 PMCID: PMC5643531 10/19/2017    
  • S-SCAM, a rare copy number variation gene, induces schizophrenia-related endophenotypes in transgenic mouse model. (Zhang N, Zhong P, Shin SM, Metallo J, Danielson E, Olsen CM, Liu QS, Lee SH) J Neurosci 2015 Feb 04;35(5):1892-904 PMID: 25653350 PMCID: PMC4315826 02/06/2015       4 Citations
  • SynPAnal: software for rapid quantification of the density and intensity of protein puncta from fluorescence microscopy images of neurons. (Danielson E, Lee SH) PLoS One 2014;9(12):e115298 PMID: 25531531 PMCID: PMC4274056 12/23/2014       19 Citations
  • GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling. (Shin SM, Zhang N, Hansen J, Gerges NZ, Pak DT, Sheng M, Lee SH) Nat Neurosci 2012 Dec;15(12):1655-66 PMID: 23143515 PMCID: PMC3804128 11/13/2012       64 Citations
  • Role of TARP interaction in S-SCAM-mediated regulation of AMPA receptors. (Danielson E, Metallo J, Lee SH) Channels (Austin) 2012 Sep-Oct;6(5):393-7 PMID: 22878254 PMCID: PMC3508780 08/11/2012       5 Citations
  • S-SCAM/MAGI-2 is an essential synaptic scaffolding molecule for the GluA2-containing maintenance pool of AMPA receptors. (Danielson E, Zhang N, Metallo J, Kaleka K, Shin SM, Gerges N, Lee SH) J Neurosci 2012 May 16;32(20):6967-80 PMID: 22593065 PMCID: PMC3365591 05/18/2012       24 Citations
  • Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation. (Evers DM, Matta JA, Hoe HS, Zarkowsky D, Lee SH, Isaac JT, Pak DT) Nat Neurosci 2010 Oct;13(10):1199-207 PMID: 20802490 PMCID: PMC2947592 08/31/2010       43 Citations
  • The role of CaMKII as an F-actin-bundling protein crucial for maintenance of dendritic spine structure. (Okamoto K, Narayanan R, Lee SH, Murata K, Hayashi Y) Proc Natl Acad Sci U S A 2007 Apr 10;104(15):6418-23 PMID: 17404223 PMCID: PMC1851051 04/04/2007       183 Citations
  • Molecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2. (Kastning K, Kukhtina V, Kittler JT, Chen G, Pechstein A, Enders S, Lee SH, Sheng M, Yan Z, Haucke V) Proc Natl Acad Sci U S A 2007 Feb 20;104(8):2991-6 PMID: 17289840 PMCID: PMC1815294 02/10/2007       60 Citations
  • Differential roles of Rap1 and Rap2 small GTPases in neurite retraction and synapse elimination in hippocampal spiny neurons. (Fu Z, Lee SH, Simonetta A, Hansen J, Sheng M, Pak DT) J Neurochem 2007 Jan;100(1):118-31 PMID: 17227435 01/18/2007       59 Citations
  • Subunit rules governing the sorting of internalized AMPA receptors in hippocampal neurons. (Lee SH, Simonetta A, Sheng M) Neuron 2004 Jul 22;43(2):221-36 PMID: 15260958 07/21/2004       197 Citations
  • Tyrosine phosphorylation of GluR2 is required for insulin-stimulated AMPA receptor endocytosis and LTD. (Ahmadian G, Ju W, Liu L, Wyszynski M, Lee SH, Dunah AW, Taghibiglou C, Wang Y, Lu J, Wong TP, Sheng M, Wang YT) EMBO J 2004 Mar 10;23(5):1040-50 PMID: 14976558 PMCID: PMC380981 02/21/2004       189 Citations
  • AMPA receptor trafficking and synaptic plasticity: major unanswered questions. (Sheng M, Hyoung Lee S) Neurosci Res 2003 Jun;46(2):127-34 PMID: 12767475 05/28/2003       64 Citations
  • Clathrin adaptor AP2 and NSF interact with overlapping sites of GluR2 and play distinct roles in AMPA receptor trafficking and hippocampal LTD. (Lee SH, Liu L, Wang YT, Sheng M) Neuron 2002 Nov 14;36(4):661-74 PMID: 12441055 11/21/2002       309 Citations
  • Mlo, a modulator of plant defense and cell death, is a novel calmodulin-binding protein. Isolation and characterization of a rice Mlo homologue. (Kim MC, Lee SH, Kim JK, Chun HJ, Choi MS, Chung WS, Moon BC, Kang CH, Park CY, Yoo JH, Kang YH, Koo SC, Koo YD, Jung JC, Kim ST, Schulze-Lefert P, Lee SY, Cho MJ) J Biol Chem 2002 May 31;277(22):19304-14 PMID: 11904292 03/21/2002       91 Citations
  • Identification of calmodulin isoform-specific binding peptides from a phage-displayed random 22-mer peptide library. (Choi JY, Lee SH, Park CY, Heo WD, Kim JC, Kim MC, Chung WS, Moon BC, Cheong YH, Kim CY, Yoo JH, Koo JC, Ok HM, Chi SW, Ryu SE, Lee SY, Lim CO, Cho MJ) J Biol Chem 2002 Jun 14;277(24):21630-8 PMID: 11901148 03/20/2002    
  • Biochemical and morphological characterization of an intracellular membrane compartment containing AMPA receptors. (Lee SH, Valtschanoff JG, Kharazia VN, Weinberg R, Sheng M) Neuropharmacology 2001 Nov;41(6):680-92 PMID: 11640922 10/20/2001       51 Citations
  • AMPA receptor trafficking and the control of synaptic transmission. (Sheng M, Lee SH) Cell 2001 Jun 29;105(7):825-8 PMID: 11439178 07/06/2001       148 Citations
  • A novel cold-inducible zinc finger protein from soybean, SCOF-1, enhances cold tolerance in transgenic plants. (Kim JC, Lee SH, Cheong YH, Yoo CM, Lee SI, Chun HJ, Yun DJ, Hong JC, Lee SY, Lim CO, Cho MJ) Plant J 2001 Feb;25(3):247-59 PMID: 11208017 02/24/2001       222 Citations
  • Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization. (Lin JW, Ju W, Foster K, Lee SH, Ahmadian G, Wyszynski M, Wang YT, Sheng M) Nat Neurosci 2000 Dec;3(12):1282-90 PMID: 11100149 12/02/2000       380 Citations
  • Identification of a calmodulin-regulated soybean Ca(2+)-ATPase (SCA1) that is located in the plasma membrane. (Chung WS, Lee SH, Kim JC, Heo WD, Kim MC, Park CY, Park HC, Lim CO, Kim WB, Harper JF, Cho MJ) Plant Cell 2000 Aug;12(8):1393-407 PMID: 10948258 PMCID: PMC149111 08/19/2000       74 Citations
  • Differential regulation of Ca2+/calmodulin-dependent enzymes by plant calmodulin isoforms and free Ca2+ concentration. (Lee SH, Johnson JD, Walsh MP, Van Lierop JE, Sutherland C, Xu A, Snedden WA, Kosk-Kosicka D, Fromm H, Narayanan N, Cho MJ) Biochem J 2000 Aug 15;350 Pt 1:299-306 PMID: 10926857 PMCID: PMC1221255 08/06/2000       75 Citations
  • Growth of the NMDA receptor industrial complex. (Sheng M, Lee SH) Nat Neurosci 2000 Jul;3(7):633-5 PMID: 10862688 06/22/2000       43 Citations
  • Development of neuron-neuron synapses. (Lee SH, Sheng M) Curr Opin Neurobiol 2000 Feb;10(1):125-31 PMID: 10679427 02/19/2000       84 Citations
  • Competitive binding of calmodulin isoforms to calmodulin-binding proteins: implication for the function of calmodulin isoforms in plants. (Lee SH, Kim MC, Heo WD, Kim JC, Chung WS, Park CY, Park HC, Cheong YH, Kim CY, Lee KJ, Bahk JD, Lee SY, Cho MJ) Biochim Biophys Acta 1999 Aug 17;1433(1-2):56-67 PMID: 10446359 08/14/1999       44 Citations
  • Involvement of specific calmodulin isoforms in salicylic acid-independent activation of plant disease resistance responses. (Heo WD, Lee SH, Kim MC, Kim JC, Chung WS, Chun HJ, Lee KJ, Park CY, Park HC, Choi JY, Cho MJ) Proc Natl Acad Sci U S A 1999 Jan 19;96(2):766-71 PMID: 9892708 PMCID: PMC15211 01/20/1999       186 Citations
  • Reciprocal regulation of mammalian nitric oxide synthase and calcineurin by plant calmodulin isoforms. (Cho MJ, Vaghy PL, Kondo R, Lee SH, Davis JP, Rehl R, Heo WD, Johnson JD) Biochemistry 1998 Nov 10;37(45):15593-7 PMID: 9843363 12/08/1998       43 Citations
  • A new class II rice chitinase, Rcht2, whose induction by fungal elicitor is abolished by protein phosphatase 1 and 2A inhibitor. (Kim CY, Gal SW, Choe MS, Jeong SY, Lee SI, Cheong YH, Lee SH, Choi YJ, Han CD, Kang KY, Cho MJ) Plant Mol Biol 1998 Jun;37(3):523-34 PMID: 9617819 06/09/1998       36 Citations
  • Differential activation of NAD kinase by plant calmodulin isoforms. The critical role of domain I. (Lee SH, Seo HY, Kim JC, Heo WD, Chung WS, Lee KJ, Kim MC, Cheong YH, Choi JY, Lim CO, Cho MJ) J Biol Chem 1997 Apr 04;272(14):9252-9 PMID: 9083059 04/04/1997       64 Citations
  • Identification of a novel divergent calmodulin isoform from soybean which has differential ability to activate calmodulin-dependent enzymes. (Lee SH, Kim JC, Lee MS, Heo WD, Seo HY, Yoon HW, Hong JC, Lee SY, Bahk JD, Hwang I) J Biol Chem 1995 Sep 15;270(37):21806-12 PMID: 7665602 09/15/1995       120 Citations
  • Plasticity of hypothalamic motivational systems. (Wise RA) Science 1969 Aug 29;165(3896):929-30 PMID: 5798319 08/29/1969       14 Citations
  • Last update: 01/18/2019
    jenkins-FCD Prod-300 626508253d14e4184314fb9f66322a03a5906796