Medical College of Wisconsin
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Sang H. Lee PhD

Sang H. Lee PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Program Development

Member of the Neuroscience Research Center


  • S-SCAM, a rare copy number variation gene, induces schizophrenia-related endophenotypes in transgenic mouse model. (Zhang N, Zhong P, Shin SM, Metallo J, Danielson E, Olsen CM, Liu QS, Lee SH) J Neurosci 2015 Feb 04;35(5):1892-904 PMID: 25653350 PMCID: PMC4315826 02/06/2015
  • SynPAnal: software for rapid quantification of the density and intensity of protein puncta from fluorescence microscopy images of neurons. (Danielson E, Lee SH) PLoS One 2014;9(12):e115298 PMID: 25531531 PMCID: PMC4274056 12/23/2014
  • GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling. (Shin SM, Zhang N, Hansen J, Gerges NZ, Pak DT, Sheng M, Lee SH) Nat Neurosci 2012 Dec;15(12):1655-66 PMID: 23143515 PMCID: PMC3804128 11/13/2012
  • Role of TARP interaction in S-SCAM-mediated regulation of AMPA receptors. (Danielson E, Metallo J, Lee SH) Channels (Austin) 2012 Sep-Oct;6(5):393-7 PMID: 22878254 PMCID: PMC3508780 08/11/2012
  • S-SCAM/MAGI-2 is an essential synaptic scaffolding molecule for the GluA2-containing maintenance pool of AMPA receptors. (Danielson E, Zhang N, Metallo J, Kaleka K, Shin SM, Gerges N, Lee SH) J Neurosci 2012 May 16;32(20):6967-80 PMID: 22593065 PMCID: PMC3365591 05/18/2012
  • Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation. (Evers DM, Matta JA, Hoe HS, Zarkowsky D, Lee SH, Isaac JT, Pak DT) Nat Neurosci 2010 Oct;13(10):1199-207 PMID: 20802490 PMCID: PMC2947592 08/31/2010
  • The role of CaMKII as an F-actin-bundling protein crucial for maintenance of dendritic spine structure. (Okamoto K, Narayanan R, Lee SH, Murata K, Hayashi Y) Proc Natl Acad Sci U S A 2007 Apr 10;104(15):6418-23 PMID: 17404223 PMCID: PMC1851051 04/04/2007
  • Molecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2. (Kastning K, Kukhtina V, Kittler JT, Chen G, Pechstein A, Enders S, Lee SH, Sheng M, Yan Z, Haucke V) Proc Natl Acad Sci U S A 2007 Feb 20;104(8):2991-6 PMID: 17289840 PMCID: PMC1815294 02/10/2007
  • Differential roles of Rap1 and Rap2 small GTPases in neurite retraction and synapse elimination in hippocampal spiny neurons. (Fu Z, Lee SH, Simonetta A, Hansen J, Sheng M, Pak DT) J Neurochem 2007 Jan;100(1):118-31 PMID: 17227435 01/18/2007
  • Subunit rules governing the sorting of internalized AMPA receptors in hippocampal neurons. (Lee SH, Simonetta A, Sheng M) Neuron 2004 Jul 22;43(2):221-36 PMID: 15260958 07/21/2004
  • Tyrosine phosphorylation of GluR2 is required for insulin-stimulated AMPA receptor endocytosis and LTD. (Ahmadian G, Ju W, Liu L, Wyszynski M, Lee SH, Dunah AW, Taghibiglou C, Wang Y, Lu J, Wong TP, Sheng M, Wang YT) EMBO J 2004 Mar 10;23(5):1040-50 PMID: 14976558 PMCID: PMC380981 02/21/2004
  • Clathrin adaptor AP2 and NSF interact with overlapping sites of GluR2 and play distinct roles in AMPA receptor trafficking and hippocampal LTD. (Lee SH, Liu L, Wang YT, Sheng M) Neuron 2002 Nov 14;36(4):661-74 PMID: 12441055 11/21/2002
  • Biochemical and morphological characterization of an intracellular membrane compartment containing AMPA receptors. (Lee SH, Valtschanoff JG, Kharazia VN, Weinberg R, Sheng M) Neuropharmacology 2001 Nov;41(6):680-92 PMID: 11640922 10/20/2001
  • AMPA receptor trafficking and the control of synaptic transmission. (Sheng M, Lee SH) Cell 2001 Jun 29;105(7):825-8 PMID: 11439178 07/06/2001
  • Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization. (Lin JW, Ju W, Foster K, Lee SH, Ahmadian G, Wyszynski M, Wang YT, Sheng M) Nat Neurosci 2000 Dec;3(12):1282-90 PMID: 11100149 12/02/2000
  • Growth of the NMDA receptor industrial complex. (Sheng M, Lee SH) Nat Neurosci 2000 Jul;3(7):633-5 PMID: 10862688 06/22/2000
  • Development of neuron-neuron synapses. (Lee SH, Sheng M) Curr Opin Neurobiol 2000 Feb;10(1):125-31 PMID: 10679427 02/19/2000
  • Last update: 05/15/2015
    jenkins-FCD Prod-38 cbde4bce27d896c78ced066bd23fa5cbe01e29f9