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Hepatic angiosarcoma occurring after cyclophosphamide therapy: case report and review of the literature. Am J Clin Oncol 2000 Dec;23(6):581-3

Date

02/24/2001

Pubmed ID

11202801

DOI

10.1097/00000421-200012000-00010

Scopus ID

2-s2.0-0034444567 (requires institutional sign-in at Scopus site)   16 Citations

Abstract

A 54-year-old man with polyarteritis nodosa developed acute onset of right upper quadrant abdominal pain associated with a large liver mass. Transvenous liver biopsy revealed hepatic angiosarcoma, a rare liver tumor classically associated with environmental toxins. He had been treated with oral cyclophosphamide for 13 years. A review of the literature revealed two other cases of hepatic angiosarcoma in patients after long-term cyclophosphamide treatment. We propose that cyclophosphamide be added to the list of exposures potentially associated with hepatic angiosarcoma.

Author List

Rosenthal AK, Klausmeier M, Cronin ME, McLaughlin JK

Author

Ann K. Rosenthal MD Associate Dean, Chief, Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Cyclophosphamide
Hemangiosarcoma
Humans
Immunosuppressive Agents
Liver Neoplasms
Male
Middle Aged
Polyarteritis Nodosa