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Ann K. Rosenthal MD

Associate Dean, Chief, Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Rheumatology
Program: Administration

Member of the Cardiovascular Center
Member of the Center for Immunology

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Publications (121)

Daniel J McCarty, MD: A Giant of Rheumatology (Rosenthal AK, Csuka ME, Halverson P) Rheumatic Disease Clinics of North America February 2024;50(1):15-23 SCOPUS ID: 2-s2.0-85169505673 02/01/2024

Fractures in Patients With Acute Calcium Pyrophosphate Crystal Arthritis Versus Matched Comparators in a Large Cohort Study (Tedeschi SK, Hayashi K, Rosenthal A, Gill M, Marrugo J, Fukui S, Gravallese E, Solomon DH) Arthritis and Rheumatology 2024 SCOPUS ID: 2-s2.0-85184424992 01/01/2024

Daniel J McCarty, MD: A Giant of Rheumatology. (Rosenthal AK, Csuka ME, Halverson P) Rheum Dis Clin North Am 2024 Feb;50(1):15-23 PMID: 37973282 SCOPUS ID: 2-s2.0-85169505673 11/17/2023

The 2023 ACR/EULAR classification criteria for calcium pyrophosphate deposition disease. (Abhishek A, Tedeschi SK, Pascart T, Latourte A, Dalbeth N, Neogi T, Fuller A, Rosenthal A, Becce F, Bardin T, Ea HK, Filippou G, Fitzgerald J, Iagnocco A, Lioté F, McCarthy GM, Ramonda R, Richette P, Sivera F, Andrés M, Cipolletta E, Doherty M, Pascual E, Perez-Ruiz F, So A, Jansen TL, Kohler MJ, Stamp LK, Yinh J, Adinolfi A, Arad U, Aung T, Benillouche E, Bortoluzzi A, Dau J, Maningding E, Fang MA, Figus FA, Filippucci E, Haslett J, Janssen M, Kaldas M, Kimoto M, Leamy K, Navarro GM, Sarzi-Puttini P, Scirè C, Silvagni E, Sirotti S, Stack JR, Truong L, Xie C, Yokose C, Hendry AM, Terkeltaub R, Taylor WJ, Choi HK) Ann Rheum Dis 2023 Oct;82(10):1248-1257 PMID: 37495237 PMCID: PMC10529191 SCOPUS ID: 2-s2.0-85166439712 07/27/2023 6 Citations

The 2023 ACR/EULAR Classification Criteria for Calcium Pyrophosphate Deposition Disease. (Abhishek A, Tedeschi SK, Pascart T, Latourte A, Dalbeth N, Neogi T, Fuller A, Rosenthal A, Becce F, Bardin T, Ea HK, Filippou G, FitzGerald J, Iagnocco A, Lioté F, McCarthy GM, Ramonda R, Richette P, Sivera F, Andres M, Cipolletta E, Doherty M, Pascual E, Perez-Ruiz F, So A, Jansen TL, Kohler MJ, Stamp LK, Yinh J, Adinolfi A, Arad U, Aung T, Benillouche E, Bortoluzzi A, Dau J, Maningding E, Fang MA, Figus FA, Filippucci E, Haslett J, Janssen M, Kaldas M, Kimoto M, Leamy K, Navarro GM, Sarzi-Puttini P, Scirè C, Silvagni E, Sirotti S, Stack JR, Truong L, Xie C, Yokose C, Hendry AM, Terkeltaub R, Taylor WJ, Choi HK) Arthritis Rheumatol 2023 Oct;75(10):1703-1713 PMID: 37494275 PMCID: PMC10543651 SCOPUS ID: 2-s2.0-85165999744 07/26/2023 9 Citations

CPPD and Other Microcrystalline Disorders (Rosenthal AK, Andres M, Abhishek A, Terkeltaub R) A Clinician's Pearls and Myths in Rheumatology: Second Edition 1 January 2023:531-543 SCOPUS ID: 2-s2.0-85171002900 01/01/2023

Pathologic biomineralization: part II: mineralizing extracellular vesicles in osteoarthritis (Rosenthal AK) Mineralizing Vesicles: From Biochemical and Biophysical Properties to Their Roles in Physiology and Disease 1 January 2023:81-94 SCOPUS ID: 2-s2.0-85189575395 01/01/2023

Patient and healthcare team recommended medication adherence strategies for hydroxychloroquine: results of a qualitative study informing intervention development (Garg S, Chewning B, Gazeley D, Gomez S, Kaitz N, Weber AC, Rosenthal A, Bartels C) Lupus Science and Medicine 1 August 2022;9(1) SCOPUS ID: 2-s2.0-85135964467 08/01/2022 4 Citations

Identification of Common Pathogenic Pathways Involved in Hemochromatosis Arthritis and Calcium Pyrophosphate Deposition Disease: a Review. (Mitton-Fitzgerald E, Gohr CM, Williams CM, Rosenthal AK) Curr Rheumatol Rep 2022 Feb;24(2):40-45 PMID: 35143028 SCOPUS ID: 2-s2.0-85124724073 02/11/2022 3 Citations

Basic Calcium Phosphate-Associated Arthritis (Rosenthal AK, Baynes K) Rare Diseases of the Immune System 2022:63-74 SCOPUS ID: 2-s2.0-85135585381 01/01/2022

Analytic Methods to Detect Articular Basic Calcium Phosphate Crystals (Rosenthal AK) Synovial Fluid Analysis and the Evaluation of Patients with Arthritis 1 January 2022:125-132 SCOPUS ID: 2-s2.0-85160145215 01/01/2022 3 Citations

Pathogenesis of calcium pyrophosphate deposition disease. (Williams CJ, Rosenthal AK) Best Pract Res Clin Rheumatol 2021 Dec;35(4):101718 PMID: 34696986 SCOPUS ID: 2-s2.0-85117751817 10/27/2021 9 Citations

Cardiovascular Disease Risk in Calcium Pyrophosphate Deposition Disease: A Nationwide Study of Veterans. (Bashir M, Sherman KA, Solomon DH, Rosenthal A, Tedeschi SK) Arthritis Care Res (Hoboken) 2023 Feb;75(2):277-282 PMID: 34523251 PMCID: PMC8918431 SCOPUS ID: 2-s2.0-85137128656 09/16/2021 3 Citations

Calcium pyrophosphate crystal size and characteristics. (Zell M, Aung T, Kaldas M, Rosenthal AK, Bai B, Liu T, Ozcan A, FitzGerald JD) Osteoarthr Cartil Open 2021 Mar;3(1) PMID: 34386778 PMCID: PMC8356773 SCOPUS ID: 2-s2.0-85118587719 08/14/2021 6 Citations

Inorganic pyrophosphate is reduced in patients with systemic sclerosis. (Hsu VM, Kozák E, Li Q, Bocskai M, Schlesinger N, Rosenthal A, McClure ST, Kovács L, Bálint L, Szamosi S, Szücs G, Carns M, Aren K, Goldberg I, Váradi A, Varga J) Rheumatology (Oxford) 2022 Mar 02;61(3):1158-1165 PMID: 34152415 PMCID: PMC9052889 SCOPUS ID: 2-s2.0-85120604264 06/22/2021 10 Citations

Towards development of core domain sets for short term and long term studies of calcium pyrophosphate crystal deposition (CPPD) disease: A framework paper by the OMERACT CPPD working group. (Cai K, Fuller A, Zhang Y, Hensey O, Grossberg D, Christensen R, Shea B, Singh JA, McCarthy GM, Rosenthal AK, Filippou G, Taylor WJ, Diaz-Torne C, Stamp LK, Edwards NL, Pascart T, Becce F, Nielsen SM, Tugwell P, Beaton D, Abhishek A, Tedeschi SK, Dalbeth N) Semin Arthritis Rheum 2021 Aug;51(4):946-950 PMID: 34140183 PMCID: PMC8981257 SCOPUS ID: 2-s2.0-85107905472 06/19/2021 6 Citations

Identifying Potential Classification Criteria for Calcium Pyrophosphate Deposition Disease: Item Generation and Item Reduction. (Tedeschi SK, Pascart T, Latourte A, Godsave C, Kundakci B, Naden RP, Taylor WJ, Dalbeth N, Neogi T, Perez-Ruiz F, Rosenthal A, Becce F, Pascual E, Andres M, Bardin T, Doherty M, Ea HK, Filippou G, FitzGerald J, Guitierrez M, Iagnocco A, Jansen TL, Kohler MJ, Lioté F, Matza M, McCarthy GM, Ramonda R, Reginato AM, Richette P, Singh JA, Sivera F, So A, Stamp LK, Yinh J, Yokose C, Terkeltaub R, Choi H, Abhishek A) Arthritis Care Res (Hoboken) 2022 Oct;74(10):1649-1658 PMID: 33973414 PMCID: PMC8578594 SCOPUS ID: 2-s2.0-85134627915 05/12/2021 21 Citations

Calcium pyrophosphate deposition and crowned dens syndrome. (Rosenthal AK) Cleve Clin J Med 2021 Apr 01;88(4):206-207 PMID: 33795241 SCOPUS ID: 2-s2.0-85103807676 04/03/2021 3 Citations

The value of anti-CarP and anti-PAD4 as markers of rheumatoid arthritis in ACPA/RF negative rheumatoid arthritis patients. (Kolarz B, Ciesla M, Rosenthal AK, Dryglewska M, Majdan M) Ther Adv Musculoskelet Dis 2021;13:1759720X21989868 PMID: 33628335 PMCID: PMC7882754 SCOPUS ID: 2-s2.0-85100969705 02/26/2021 18 Citations

Effects of the TNFRSF11B Mutation Associated With Calcium Pyrophosphate Deposition Disease in Osteoclastogenesis in a Murine Model. (Mitton-Fitzgerald E, Gohr CM, Williams CJ, Ortiz A, Mbalaviele G, Rosenthal AK) Arthritis Rheumatol 2021 Aug;73(8):1543-1549 PMID: 33559312 PMCID: PMC8324507 SCOPUS ID: 2-s2.0-85107541732 02/10/2021 7 Citations

Management of calcium pyrophosphate crystal deposition disease: A systematic review. (Parperis K, Papachristodoulou E, Kakoullis L, Rosenthal AK) Semin Arthritis Rheum 2021 Feb;51(1):84-94 PMID: 33360232 SCOPUS ID: 2-s2.0-85098070174 12/29/2020 23 Citations

Hypermethylation of the miR-155 gene in the whole blood and decreased plasma level of miR-155 in rheumatoid arthritis. (Kolarz B, Ciesla M, Dryglewska M, Rosenthal AK, Majdan M) PLoS One 2020;15(6):e0233897 PMID: 32484820 PMCID: PMC7266293 SCOPUS ID: 2-s2.0-85085854712 06/03/2020 12 Citations

2020 American College of Rheumatology Guideline for the Management of Gout (FitzGerald JD, Dalbeth N, Mikuls T, Brignardello-Petersen R, Guyatt G, Abeles AM, Gelber AC, Harrold LR, Khanna D, King C, Levy G, Libbey C, Mount D, Pillinger MH, Rosenthal A, Singh JA, Sims JE, Smith BJ, Wenger NS, Bae SS, Danve A, Khanna PP, Kim SC, Lenert A, Poon S, Qasim A, Sehra ST, Sharma TSK, Toprover M, Turgunbaev M, Zeng L, Zhang MA, Turner AS, Neogi T) Arthritis Care and Research 1 June 2020;72(6):744-760 SCOPUS ID: 2-s2.0-85084419186 06/01/2020 445 Citations

2020 American College of Rheumatology Guideline for the Management of Gout. (FitzGerald JD, Dalbeth N, Mikuls T, Brignardello-Petersen R, Guyatt G, Abeles AM, Gelber AC, Harrold LR, Khanna D, King C, Levy G, Libbey C, Mount D, Pillinger MH, Rosenthal A, Singh JA, Sims JE, Smith BJ, Wenger NS, Bae SS, Danve A, Khanna PP, Kim SC, Lenert A, Poon S, Qasim A, Sehra ST, Sharma TSK, Toprover M, Turgunbaev M, Zeng L, Zhang MA, Turner AS, Neogi T) Arthritis Rheumatol 2020 Jun;72(6):879-895 PMID: 32390306 SCOPUS ID: 2-s2.0-85084483852 05/12/2020 217 Citations

Investigating lupus retention in care to inform interventions for disparities reduction: an observational cohort study. (Bartels CM, Rosenthal A, Wang X, Ahmad U, Chang I, Ezeh N, Garg S, Schletzbaum M, Kind A) Arthritis Res Ther 2020 Feb 22;22(1):35 PMID: 32087763 PMCID: PMC7036188 SCOPUS ID: 2-s2.0-85079916252 02/24/2020 14 Citations

Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of gout. (Bursill D, Taylor WJ, Terkeltaub R, Abhishek A, So AK, Vargas-Santos AB, Gaffo AL, Rosenthal A, Tausche AK, Reginato A, Manger B, Sciré C, Pineda C, van Durme C, Lin CT, Yin C, Albert DA, Biernat-Kaluza E, Roddy E, Pascual E, Becce F, Perez-Ruiz F, Sivera F, Lioté F, Schett G, Nuki G, Filippou G, McCarthy G, da Rocha Castelar Pinheiro G, Ea HK, Tupinambá HA, Yamanaka H, Choi HK, Mackay J, ODell JR, Vázquez Mellado J, Singh JA, Fitzgerald JD, Jacobsson LTH, Joosten L, Harrold LR, Stamp L, Andrés M, Gutierrez M, Kuwabara M, Dehlin M, Janssen M, Doherty M, Hershfield MS, Pillinger M, Edwards NL, Schlesinger N, Kumar N, Slot O, Ottaviani S, Richette P, MacMullan PA, Chapman PT, Lipsky PE, Robinson P, Khanna PP, Gancheva RN, Grainger R, Johnson RJ, Te Kampe R, Keenan RT, Tedeschi SK, Kim S, Choi SJ, Fields TR, Bardin T, Uhlig T, Jansen T, Merriman T, Pascart T, Neogi T, Klück V, Louthrenoo W, Dalbeth N) Ann Rheum Dis 2019 Nov;78(11):1592-1600 PMID: 31501138 PMCID: PMC7288724 SCOPUS ID: 2-s2.0-85072260058 09/11/2019 71 Citations

Patient Perspectives on Smoking Cessation and Interventions in Rheumatology Clinics. (Wattiaux A, Bettendorf B, Block L, Gilmore-Bykovskyi A, Ramly E, Piper ME, Rosenthal A, Sadusky J, Cox E, Chewning B, Bartels CM) Arthritis Care Res (Hoboken) 2020 Mar;72(3):369-377 PMID: 30768768 PMCID: PMC6697238 SCOPUS ID: 2-s2.0-85079537636 02/16/2019 15 Citations

Chemical characterization of Maltese-cross birefringent particles in synovial fluid samples collected from symptomatic joints (Li B, Singer N, Rosenthal A, Unal M, Haggins D, Yeni YN, Akkus O) Revue du Rhumatisme (Edition Francaise) January 2019;86(1):108-111 SCOPUS ID: 2-s2.0-85040986504 01/01/2019

Chemical characterization of Maltese-cross birefringent particles in synovial fluid samples collected from symptomatic joints (Li B, Singer N, Rosenthal A, Unal M, Haggins D, Yeni YN, Akkus O) Joint Bone Spine July 2018;85(4):501-503 SCOPUS ID: 2-s2.0-85034602511 07/01/2018 3 Citations

Gout, Hyperuricemia, and Crystal-Associated Disease Network Consensus Statement Regarding Labels and Definitions for Disease Elements in Gout. (Bursill D, Taylor WJ, Terkeltaub R, Kuwabara M, Merriman TR, Grainger R, Pineda C, Louthrenoo W, Edwards NL, Andrés M, Vargas-Santos AB, Roddy E, Pascart T, Lin CT, Perez-Ruiz F, Tedeschi SK, Kim SC, Harrold LR, McCarthy G, Kumar N, Chapman PT, Tausche AK, Vazquez-Mellado J, Gutierrez M, da Rocha Castelar-Pinheiro G, Richette P, Pascual E, Fisher MC, Burgos-Vargas R, Robinson PC, Singh JA, Jansen TL, Saag KG, Slot O, Uhlig T, Solomon DH, Keenan RT, Scire CA, Biernat-Kaluza E, Dehlin M, Nuki G, Schlesinger N, Janssen M, Stamp LK, Sivera F, Reginato AM, Jacobsson L, Lioté F, Ea HK, Rosenthal A, Bardin T, Choi HK, Hershfield MS, Czegley C, Choi SJ, Dalbeth N) Arthritis Care Res (Hoboken) 2019 Mar;71(3):427-434 PMID: 29799677 PMCID: PMC6252290 SCOPUS ID: 2-s2.0-85053427249 05/26/2018 68 Citations

Review: Unmet Needs and the Path Forward in Joint Disease Associated With Calcium Pyrophosphate Crystal Deposition. (Abhishek A, Neogi T, Choi H, Doherty M, Rosenthal AK, Terkeltaub R) Arthritis Rheumatol 2018 Aug;70(8):1182-1191 PMID: 29609209 PMCID: PMC6105380 SCOPUS ID: 2-s2.0-85050607535 04/03/2018 40 Citations

Mutations in osteoprotegerin account for the CCAL1 locus in calcium pyrophosphate deposition disease. (Williams CJ, Qazi U, Bernstein M, Charniak A, Gohr C, Mitton-Fitzgerald E, Ortiz A, Cardinal L, Kaell AT, Rosenthal AK) Osteoarthritis Cartilage 2018 Jun;26(6):797-806 PMID: 29578045 PMCID: PMC6293976 SCOPUS ID: 2-s2.0-85044857768 03/27/2018 17 Citations

Concurrence of rheumatoid arthritis and calcium pyrophosphate deposition disease: A case collection and review of the literature. (Sabchyshyn V, Konon I, Ryan LM, Rosenthal AK) Semin Arthritis Rheum 2018 Aug;48(1):9-11 PMID: 29338885 PMCID: PMC6240440 SCOPUS ID: 2-s2.0-85040444231 01/18/2018 16 Citations

Basic calcium phosphate crystal-associated musculoskeletal syndromes: an update. (Rosenthal AK) Curr Opin Rheumatol 2018 Mar;30(2):168-172 PMID: 29227355 PMCID: PMC6241512 SCOPUS ID: 2-s2.0-85042427521 12/12/2017 19 Citations

Calcium Pyrophosphate Deposition Disease and Associated Medical Comorbidities: A National Cross-Sectional Study of US Veterans. (Kleiber Balderrama C, Rosenthal AK, Lans D, Singh JA, Bartels CM) Arthritis Care Res (Hoboken) 2017 Sep;69(9):1400-1406 PMID: 27898996 PMCID: PMC5472491 SCOPUS ID: 2-s2.0-85027505435 11/30/2016 49 Citations

Erosive osteoarthritis: A systematic analysis of definitions used in the literature. (Gazeley DJ, Yeturi S, Patel PJ, Rosenthal AK) Semin Arthritis Rheum 2017 Feb;46(4):395-403 PMID: 27692966 PMCID: PMC6278834 SCOPUS ID: 2-s2.0-85008686874 10/04/2016 22 Citations

Pauci-Immune Crescentic Glomerulonephritis in Connective Tissue Disease. (Yeturi S, Cronin M, Robin A, Lorna C, Rosenthal AK) Case Rep Rheumatol 2016;2016:9070487 PMID: 27504208 PMCID: PMC4967670 08/10/2016

Calcium Pyrophosphate Deposition Disease. (Rosenthal AK, Ryan LM) N Engl J Med 2016 Jun 30;374(26):2575-84 PMID: 27355536 PMCID: PMC6240444 SCOPUS ID: 2-s2.0-84976480156 06/30/2016 241 Citations

The Role of ANK in Calcium Pyrophosphate Deposition Disease. (Mitton-Fitzgerald E, Gohr CM, Bettendorf B, Rosenthal AK) Curr Rheumatol Rep 2016 May;18(5):25 PMID: 27032788 PMCID: PMC5453179 SCOPUS ID: 2-s2.0-84962758314 04/02/2016 21 Citations

Editorial introductions (Saag K, Rosenthal AK, McInnes I) Current Opinion in Rheumatology 1 March 2016;28(2):v-vi SCOPUS ID: 2-s2.0-84957642398 03/01/2016

Editorial: Decreasing Crystal-Induced Consternation: New Methods of Crystal Identification. (Rosenthal AK, Pascual E) Arthritis Rheumatol 2016 Jul;68(7):1574-7 PMID: 26882418 SCOPUS ID: 2-s2.0-84976524882 02/18/2016 4 Citations

Articular cartilage vesicles and calcium crystal deposition diseases. (Rosenthal AK) Curr Opin Rheumatol 2016 Mar;28(2):127-32 PMID: 26814404 PMCID: PMC6240443 SCOPUS ID: 2-s2.0-84957634988 01/28/2016 20 Citations

Validation of administrative codes for calcium pyrophosphate deposition: a Veterans Administration study. (Bartels CM, Singh JA, Parperis K, Huber K, Rosenthal AK) J Clin Rheumatol 2015 Jun;21(4):189-92 PMID: 26010181 PMCID: PMC4694041 SCOPUS ID: 2-s2.0-84936949452 05/27/2015 17 Citations

Autophagy modulates articular cartilage vesicle formation in primary articular chondrocytes. (Rosenthal AK, Gohr CM, Mitton-Fitzgerald E, Grewal R, Ninomiya J, Coyne CB, Jackson WT) J Biol Chem 2015 May 22;290(21):13028-38 PMID: 25869133 PMCID: PMC4505557 SCOPUS ID: 2-s2.0-84930004979 04/15/2015 28 Citations

The adverse effects of diabetes on osteoarthritis: update on clinical evidence and molecular mechanisms. (King KB, Rosenthal AK) Osteoarthritis Cartilage 2015 Jun;23(6):841-50 PMID: 25837996 PMCID: PMC5530368 SCOPUS ID: 2-s2.0-84929707100 04/04/2015 88 Citations

Imaging of calcium pyrophosphate deposition disease. (Miksanek J, Rosenthal AK) Curr Rheumatol Rep 2015 Mar;17(3):20 PMID: 25761927 PMCID: PMC5471493 SCOPUS ID: 2-s2.0-84924787445 03/13/2015 47 Citations

Lysophosphatidic acid mediates fibrosis in injured joints by regulating collagen type I biosynthesis. (Wu L, Petrigliano FA, Ba K, Lee S, Bogdanov J, McAllister DR, Adams JS, Rosenthal AK, Van Handel B, Crooks GM, Lin Y, Evseenko D) Osteoarthritis Cartilage 2015 Feb;23(2):308-18 PMID: 25464168 PMCID: PMC4465392 SCOPUS ID: 2-s2.0-84921051997 12/03/2014 27 Citations

Clodronate exerts an anabolic effect on articular chondrocytes mediated through the purinergic receptor pathway. (Rosa RG, Collavino K, Lakhani A, Delve E, Weber JF, Rosenthal AK, Waldman SD) Osteoarthritis Cartilage 2014 Sep;22(9):1327-36 PMID: 25042551 PMCID: PMC5452978 SCOPUS ID: 2-s2.0-85027958792 07/22/2014 21 Citations

Nonpharmacologic and pharmacologic management of CPP crystal arthritis and BCP arthropathy and periarticular syndromes. (Rosenthal AK, Ryan LM) Rheum Dis Clin North Am 2014 May;40(2):343-56 PMID: 24703351 PMCID: PMC6240445 SCOPUS ID: 2-s2.0-84898599073 04/08/2014 15 Citations

Shoulder symptoms and function in geriatric patients. (Burner T, Abbott D, Huber K, Stout M, Fleming R, Wessel B, Massey E, Rosenthal A, Burns E) J Geriatr Phys Ther 2014;37(4):154-8 PMID: 24534849 PMCID: PMC4460823 SCOPUS ID: 2-s2.0-84925679835 02/19/2014 13 Citations

Upregulation of ANK protein expression in joint tissue in calcium pyrophosphate dihydrate crystal deposition disease. (Uzuki M, Sawai T, Ryan LM, Rosenthal AK, Masuda I) J Rheumatol 2014 Jan;41(1):65-74 PMID: 24293574 PMCID: PMC6240442 SCOPUS ID: 2-s2.0-84891775364 12/03/2013 14 Citations

The progressive ankylosis gene product ANK regulates extracellular ATP levels in primary articular chondrocytes. (Rosenthal AK, Gohr CM, Mitton-Fitzgerald E, Lutz MK, Dubyak GR, Ryan LM) Arthritis Res Ther 2013 Oct 17;15(5):R154 PMID: 24286344 PMCID: PMC3978574 SCOPUS ID: 2-s2.0-84885537495 11/30/2013 35 Citations

Hyperglycemia reduces proteoglycan levels in tendons. (Burner T, Gohr C, Mitton-Fitzgerald E, Rosenthal AK) Connect Tissue Res 2012;53(6):535-41 PMID: 22891926 SCOPUS ID: 2-s2.0-84869827564 08/16/2012 48 Citations

Crystal arthritis: calcium pyrophosphate deposition-nothing 'pseudo' about it! (Rosenthal AK, Ryan LM) Nat Rev Rheumatol 2011 May;7(5):257-8 PMID: 21532639 SCOPUS ID: 2-s2.0-79955571641 05/03/2011 8 Citations

Proteomic analysis of articular cartilage vesicles from normal and osteoarthritic cartilage. (Rosenthal AK, Gohr CM, Ninomiya J, Wakim BT) Arthritis Rheum 2011 Feb;63(2):401-11 PMID: 21279997 PMCID: PMC3038242 SCOPUS ID: 2-s2.0-79551658047 02/01/2011 66 Citations

Crystals, inflammation, and osteoarthritis. (Rosenthal AK) Curr Opin Rheumatol 2011 Mar;23(2):170-3 PMID: 21169842 PMCID: PMC3154781 SCOPUS ID: 2-s2.0-79951575788 12/21/2010 71 Citations

Proteomic analysis of articular cartilage vesicles from normal and osteoarthritic cartilage. (Rosenthal AK, Gohr CM, Ninomiya J, Wakim BT) Arthritis Rheum 2010 Oct 27: PMID: 20981819 10/29/2010

Purine receptors modulate chondrocyte extracellular inorganic pyrophosphate production. (Rosenthal AK, Hempel D, Kurup IV, Masuda I, Ryan LM) Osteoarthritis Cartilage 2010 Nov;18(11):1496-501 PMID: 20709180 PMCID: PMC2975862 SCOPUS ID: 2-s2.0-78149415406 08/17/2010 25 Citations

Parallel regulation of extracellular ATP and inorganic pyrophosphate: roles of growth factors, transduction modulators, and ANK. (Costello JC, Rosenthal AK, Kurup IV, Masuda I, Medhora M, Ryan LM) Connect Tissue Res 2011 Apr;52(2):139-46 PMID: 20604715 SCOPUS ID: 2-s2.0-79952310245 07/08/2010 60 Citations

Changing trends in serious extra-articular manifestations of rheumatoid arthritis among United State veterans over 20 years. (Bartels CM, Bell CL, Shinki K, Rosenthal A, Bridges AJ) Rheumatology (Oxford) 2010 Sep;49(9):1670-5 PMID: 20463190 PMCID: PMC2919197 SCOPUS ID: 2-s2.0-77955752827 05/14/2010 59 Citations

Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease (Rosenthal AK, Terkeltaub RA) A Clinician's Pearls and Myths in Rheumatology 2009:369-376 SCOPUS ID: 2-s2.0-84889975592 12/01/2009 1 Citation

Type II collagen levels correlate with mineralization by articular cartilage vesicles. (Jubeck B, Muth E, Gohr CM, Rosenthal AK) Arthritis Rheum 2009 Sep;60(9):2741-6 PMID: 19714645 PMCID: PMC2749926 SCOPUS ID: 2-s2.0-69449107152 08/29/2009 15 Citations

Decline in rheumatoid vasculitis prevalence among US veterans: a retrospective cross-sectional study. (Bartels C, Bell C, Rosenthal A, Shinki K, Bridges A) Arthritis Rheum 2009 Sep;60(9):2553-7 PMID: 19714622 PMCID: PMC2867593 SCOPUS ID: 2-s2.0-69449106760 08/29/2009 32 Citations

Articular cartilage vesicles contain RNA. (Mitton E, Gohr CM, McNally MT, Rosenthal AK) Biochem Biophys Res Commun 2009 Oct 23;388(3):533-8 PMID: 19679100 PMCID: PMC2754773 SCOPUS ID: 2-s2.0-69549117350 08/15/2009 21 Citations

Osteoarthritis: The need for innovative therapeutic interventions (Rosenthal AK) Current Rheumatology Reviews 2009;5(1):3-7 SCOPUS ID: 2-s2.0-65949086181 06/01/2009 1 Citation

Dexamethasone promotes calcium pyrophosphate dihydrate crystal formation by articular chondrocytes. (Fahey M, Mitton E, Muth E, Rosenthal AK) J Rheumatol 2009 Jan;36(1):163-9 PMID: 19132782 PMCID: PMC2640436 SCOPUS ID: 2-s2.0-58149526653 01/10/2009 15 Citations

Calcium crystals and arthritis: what is new under polarizing light? (Rosenthal AK) J Clin Rheumatol 2009 Feb;15(1):42-5 PMID: 19131764 SCOPUS ID: 2-s2.0-67650337450 01/10/2009 2 Citations

Advanced glycation end products increase transglutaminase activity in primary porcine tenocytes. (Rosenthal AK, Gohr CM, Mitton E, Monnier V, Burner T) J Investig Med 2009 Feb;57(2):460-6 PMID: 19127169 PMCID: PMC6240446 SCOPUS ID: 2-s2.0-85047684563 01/08/2009 25 Citations

Diabetes and rheumatic diseases. (Burner TW, Rosenthal AK) Curr Opin Rheumatol 2009 Jan;21(1):50-4 PMID: 19077719 SCOPUS ID: 2-s2.0-58149236804 12/17/2008 83 Citations

Less common arthropathies D. neuropathic arthropathy (Rosenthal AK) Primer on the Rheumatic Diseases: Thirteenth Edition 2008:488-491 SCOPUS ID: 2-s2.0-84892323229 12/01/2008

Feasibility of a tetracycline-binding method for detecting synovial fluid basic calcium phosphate crystals. (Rosenthal AK, Fahey M, Gohr C, Burner T, Konon I, Daft L, Mattson E, Hirschmugl C, Ryan LM, Simkin P) Arthritis Rheum 2008 Oct;58(10):3270-4 PMID: 18821676 PMCID: PMC2574625 SCOPUS ID: 2-s2.0-54949138028 09/30/2008 17 Citations

Promotion of articular cartilage matrix vesicle mineralization by type I collagen. (Jubeck B, Gohr C, Fahey M, Muth E, Matthews M, Mattson E, Hirschmugl C, Rosenthal AK) Arthritis Rheum 2008 Sep;58(9):2809-17 PMID: 18759309 PMCID: PMC6290924 SCOPUS ID: 2-s2.0-51849094455 09/02/2008 41 Citations

Characterization of articular calcium-containing crystals by synchrotron FTIR. (Rosenthal AK, Mattson E, Gohr CM, Hirschmugl CJ) Osteoarthritis Cartilage 2008 Nov;16(11):1395-402 PMID: 18472285 PMCID: PMC2574906 SCOPUS ID: 2-s2.0-53849090623 05/13/2008 33 Citations

Association between crystals and cartilage degeneration in the ankle. (Muehleman C, Li J, Aigner T, Rappoport L, Mattson E, Hirschmugl C, Masuda K, Rosenthal AK) J Rheumatol 2008 Jun;35(6):1108-17 PMID: 18412302 PMCID: PMC6240447 SCOPUS ID: 2-s2.0-44949242602 04/17/2008 65 Citations

Calcific tendonitis : a model. (Gohr CM, Fahey M, Rosenthal AK) Connect Tissue Res 2007;48(6):286-91 PMID: 18075814 SCOPUS ID: 2-s2.0-37349074048 12/14/2007 20 Citations

The role of noncollagenous proteins in mineralization (Rosenthal AK) Current Opinion in Orthopaedics September 2007;18(5):449-453 SCOPUS ID: 2-s2.0-34547881856 09/01/2007 9 Citations

Update in calcium deposition diseases. (Rosenthal AK) Curr Opin Rheumatol 2007 Mar;19(2):158-62 PMID: 17278931 SCOPUS ID: 2-s2.0-33846849168 02/07/2007 56 Citations

Osteopontin promotes pathologic mineralization in articular cartilage. (Rosenthal AK, Gohr CM, Uzuki M, Masuda I) Matrix Biol 2007 Mar;26(2):96-105 PMID: 17123806 PMCID: PMC1852442 SCOPUS ID: 2-s2.0-33846627260 11/25/2006 58 Citations

Calcium crystal deposition and osteoarthritis. (Rosenthal AK) Rheum Dis Clin North Am 2006 May;32(2):401-12, vii PMID: 16716886 SCOPUS ID: 2-s2.0-33646545703 05/24/2006 42 Citations

The serine protease inhibitor trappin-2 is present in cartilage and synovial fluid in osteoarthritis. (Jaovisidha K, Etim A, Yamakawa K, Masuda I, Gohr CM, Wakim BT, Boonapatcharoen N, Ninomiya J, Rosenthal AK) J Rheumatol 2006 Feb;33(2):318-25 PMID: 16465664 SCOPUS ID: 2-s2.0-32144440435 02/09/2006 10 Citations

Extracellular matrix changes regulate calcium crystal formation in articular cartilage. (Kalya S, Rosenthal AK) Curr Opin Rheumatol 2005 May;17(3):325-9 PMID: 15838245 SCOPUS ID: 2-s2.0-18144397783 04/20/2005 24 Citations

Transglutaminase contributes to CPPD crystal formation in osteoarthritis. (Heinkel D, Gohr CM, Uzuki M, Rosenthal AK) Front Biosci 2004 Sep 01;9:3257-61 PMID: 15353354 SCOPUS ID: 2-s2.0-17644417961 09/09/2004 19 Citations

Current Opinion in Rheumatology: Editorial introductions (Matteson EL, Burmester GR, Rosenthal AK) Current Opinion in Rheumatology May 2004;16(3) SCOPUS ID: 2-s2.0-1942435938 05/01/2004

Crystal arthropathies and other unpopular rheumatic diseases. (Rosenthal AK) Curr Opin Rheumatol 2004 May;16(3):262 PMID: 15103254 SCOPUS ID: 2-s2.0-1942499787 04/23/2004 5 Citations

Regulation of transglutaminase activity in articular chondrocytes through thrombin receptor-mediated factor XIII synthesis. (Rosenthal AK, Mosesson MW, Gohr CM, Masuda I, Heinkel D, Seibenlist KR) Thromb Haemost 2004 Mar;91(3):558-68 PMID: 14983233 SCOPUS ID: 2-s2.0-1642346951 02/26/2004 11 Citations

Thyroxine stimulates transglutaminase activity in articular chondrocytes. (Rosenthal AK, Heinkel D, Gohr CM) Osteoarthritis Cartilage 2003 Jun;11(6):463-70 PMID: 12801486 SCOPUS ID: 2-s2.0-0037668879 06/13/2003 14 Citations

Metabolism of extracellular pyrophosphate. (Ryan LM, Rosenthal AK) Curr Opin Rheumatol 2003 May;15(3):311-4 PMID: 12707586 SCOPUS ID: 2-s2.0-0038746715 04/23/2003 24 Citations

Transforming growth factor-beta levels in synovial fluid of osteoarthritis with or without calcium pyrophosphate dihydrate crystals. (Punzi L, Oliviero F, Ramonda R) J Rheumatol 2003 Feb;30(2):420; author reply 420-1 PMID: 12583352 SCOPUS ID: 2-s2.0-12244307898 02/14/2003 18 Citations

Calcium crystals in osteoarthritis. (Jaovisidha K, Rosenthal AK) Curr Opin Rheumatol 2002 May;14(3):298-302 PMID: 11981330 SCOPUS ID: 2-s2.0-0036229809 05/01/2002 27 Citations

Transglutaminase participates in the incorporation of latent TGFbeta into the extracellular matrix of aging articular chondrocytes. (Le M, Gohr CM, Rosenthal AK) Connect Tissue Res 2001;42(4):245-53 PMID: 11913769 SCOPUS ID: 2-s2.0-0035215305 03/27/2002 17 Citations

The high prevalence of pathologic calcium crystals in pre-operative knees. (Derfus BA, Kurian JB, Butler JJ, Daft LJ, Carrera GF, Ryan LM, Rosenthal AK) J Rheumatol 2002 Mar;29(3):570-4 PMID: 11908575 SCOPUS ID: 2-s2.0-0036197813 03/23/2002 163 Citations

Efficacy and safety of tenecteplase in combination with enoxaparin, abciximab, or unfractionated heparin: the ASSENT-3 randomised trial in acute myocardial infarction. (Assessment of the Safety and Efficacy of a New Thrombolytic Regimen (ASSENT)-3 Investigators) Lancet 2001 Aug 25;358(9282):605-13 PMID: 11530146 SCOPUS ID: 2-s2.0-0035949117 09/01/2001 803 Citations

The transglutaminase, Factor XIIIA, is present in articular chondrocytes. (Rosenthal AK, Masuda I, Gohr CM, Derfus BA, Le M) Osteoarthritis Cartilage 2001 Aug;9(6):578-81 PMID: 11520172 SCOPUS ID: 2-s2.0-0034848832 08/25/2001 40 Citations

Transforming growth factor beta-1 stimulates articular chondrocyte elaboration of matrix vesicles capable of greater calcium pyrophosphate precipitation. (Derfus BA, Camacho NP, Olmez U, Kushnaryov VM, Westfall PR, Ryan LM, Rosenthal AK) Osteoarthritis Cartilage 2001 Apr;9(3):189-94 PMID: 11300741 SCOPUS ID: 2-s2.0-0035032346 04/13/2001 21 Citations

Pathogenesis of calcium pyrophosphate crystal deposition disease. (Rosenthal AK) Curr Rheumatol Rep 2001 Feb;3(1):17-23 PMID: 11177767 SCOPUS ID: 2-s2.0-0035260412 03/20/2001 14 Citations

Identification of crystals in synovial fluids and joint tissues. (Rosenthal AK, Mandel N) Curr Rheumatol Rep 2001 Feb;3(1):11-6 PMID: 11177766 SCOPUS ID: 2-s2.0-0035256833 03/20/2001 31 Citations

Hepatic angiosarcoma occurring after cyclophosphamide therapy: case report and review of the literature. (Rosenthal AK, Klausmeier M, Cronin ME, McLaughlin JK) Am J Clin Oncol 2000 Dec;23(6):581-3 PMID: 11202801 SCOPUS ID: 2-s2.0-0034444567 02/24/2001 16 Citations

Participation of transglutaminase in the activation of latent transforming growth factor beta1 in aging articular cartilage. (Rosenthal AK, Gohr CM, Henry LA, Le M) Arthritis Rheum 2000 Aug;43(8):1729-33 PMID: 10943862 SCOPUS ID: 2-s2.0-0033869479 08/16/2000 44 Citations

Connective tissue disease and other related rheumatic conditions among patients with finger and hand and temporomandibular joint prostheses in Denmark. (Fryzek JP, Mellemkjaer L, Friis S, McLaughlin JK, Rosenthal AK, Blot WJ, Olsen JH) J Rheumatol 2000 Jun;27(6):1434-6 PMID: 10852266 SCOPUS ID: 2-s2.0-0034082190 06/14/2000 1 Citation

Formation of calcium pyrophosphate crystals: biologic implications. (Rosenthal AK) Curr Opin Rheumatol 2000 May;12(3):219-22 PMID: 10803752 SCOPUS ID: 2-s2.0-0034058308 05/10/2000 8 Citations

Thyroid hormones induce features of the hypertrophic phenotype and stimulate correlates of CPPD crystal formation in articular chondrocytes. (Rosenthal AK, Henry LA) J Rheumatol 1999 Feb;26(2):395-401 PMID: 9972975 SCOPUS ID: 2-s2.0-0032903995 02/11/1999 40 Citations

Calcium crystal-associated arthritides. (Rosenthal AK) Curr Opin Rheumatol 1998 May;10(3):273-7 PMID: 9608333 SCOPUS ID: 2-s2.0-0031861132 06/03/1998 18 Citations

Transglutaminase activity in aging articular chondrocytes and articular cartilage vesicles. (Rosenthal AK, Derfus BA, Henry LA) Arthritis Rheum 1997 May;40(5):966-70 PMID: 9153560 SCOPUS ID: 2-s2.0-0030916270 05/01/1997 68 Citations

Retinoic acid stimulates pyrophosphate elaboration by cartilage and chondrocytes. (Rosenthal AK, Henry LA) Calcif Tissue Int 1996 Aug;59(2):128-33 PMID: 8687982 SCOPUS ID: 2-s2.0-0029683759 08/01/1996 15 Citations

Hemochromatosis-like arthropathy in diabetes mellitus without hemochromatosis. (McCarthy GM, Rosenthal AK, Carrera GF) J Rheumatol 1996 Aug;23(8):1453-6 PMID: 8856631 SCOPUS ID: 2-s2.0-0029740699 08/01/1996 7 Citations

Incidence of cancer among patients with systemic sclerosis. (Rosenthal AK, McLaughlin JK, Gridley G, Nyrén O) Cancer 1995 Sep 01;76(5):910-4 PMID: 8625197 SCOPUS ID: 2-s2.0-0029121828 09/01/1995 183 Citations

Treatment of refractory crystal-associated arthritis. (Rosenthal AK, Ryan LM) Rheum Dis Clin North Am 1995 Feb;21(1):151-61 PMID: 7732165 SCOPUS ID: 2-s2.0-0028861779 02/01/1995 34 Citations

Insulin-like growth factor-1 suppresses pyrophosphate elaboration by transforming growth factor beta1-stimulated chondrocytes and cartilage. (Olmez U, Ryan LM, Kurup IV, Rosenthal AK) Osteoarthritis Cartilage 1994 Sep;2(3):149-54 PMID: 11550674 SCOPUS ID: 2-s2.0-0028023246 09/01/1994 34 Citations

Ageing increases growth factor-induced inorganic pyrophosphate elaboration by articular cartilage. (Rosenthal AK, Ryan LM) Mech Ageing Dev 1994 Jul;75(1):35-44 PMID: 9128752 SCOPUS ID: 2-s2.0-0028146172 07/01/1994 21 Citations

Probenecid inhibits transforming growth factor-beta 1 induced pyrophosphate elaboration by chondrocytes. (Rosenthal AK, Ryan LM) J Rheumatol 1994 May;21(5):896-900 PMID: 7520501 SCOPUS ID: 2-s2.0-0028237430 05/01/1994 43 Citations

Adenocarcinoma of the lung associated with eosinophilia and hidebound skin. (Henry DW, Rosenthal A, McCarty DJ) J Rheumatol 1994 May;21(5):972-3 PMID: 8064750 SCOPUS ID: 2-s2.0-0028321921 05/01/1994 6 Citations

Scleroderma and malignancy: an epidemiological study. (Rosenthal AK, McLaughlin JK, Linet MS, Persson I) Ann Rheum Dis 1993 Jul;52(7):531-3 PMID: 8346981 PMCID: PMC1005093 SCOPUS ID: 2-s2.0-0027220102 07/01/1993 101 Citations

A comparison of the effect of transforming growth factor beta 1 on pyrophosphate elaboration from various articular tissues. (Rosenthal AK, McCarty BA, Cheung HS, Ryan LM) Arthritis Rheum 1993 Apr;36(4):539-42 PMID: 7681284 SCOPUS ID: 2-s2.0-0027461107 04/01/1993 35 Citations

Transforming growth factor beta 1 stimulates inorganic pyrophosphate elaboration by porcine cartilage. (Rosenthal AK, Cheung HS, Ryan LM) Arthritis Rheum 1991 Jul;34(7):904-11 PMID: 1647773 SCOPUS ID: 2-s2.0-0025780585 07/01/1991 68 Citations

Diagnosis, pathogenesis, and management of reflex sympathetic dystrophy syndrome. (Rosenthal AK, Wortmann RL) Compr Ther 1991 Jun;17(6):46-50 PMID: 1934988 SCOPUS ID: 2-s2.0-0026181284 06/01/1991 14 Citations

Stimulation of pyrophosphate production in articular cartilage by a platelet-derived factor is independent of mitogenesis. (Rosenthal AK, Cheung HS, Ryan LM) J Lab Clin Med 1990 Mar;115(3):352-5 PMID: 2155981 SCOPUS ID: 2-s2.0-0025231561 03/01/1990 3 Citations

Stimulation of inorganic pyrophosphate elaboration by cultured cartilage and chondrocytes. (Ryan LM, Kurup I, Rosenthal AK, McCarty DJ) Arch Biochem Biophys 1989 Aug 01;272(2):393-9 PMID: 2546499 SCOPUS ID: 2-s2.0-0024384618 08/01/1989 7 Citations

Augmentation of inorganic pyrophosphate elaboration in cartilage by serum factors. (Rosenthal AK, Cheung HS, Ryan LM) Arch Biochem Biophys 1989 Aug 01;272(2):386-92 PMID: 2546498 SCOPUS ID: 2-s2.0-0024365598 08/01/1989 4 Citations

Arthritis associated with calcium oxalate crystals in an anephric patient treated with peritoneal dialysis. (Rosenthal A, Ryan LM, McCarty DJ) JAMA 1988 Sep 02;260(9):1280-2 PMID: 3404640 SCOPUS ID: 2-s2.0-0023762168 09/02/1988 17 Citations

Lymphomatoid granulomatosis associated with a carotid sinus fistula: response to cytotoxic therapy. (Rosenthal AK, Rowe JM) Am J Med 1987 Aug;83(2):381-2 PMID: 3618648 SCOPUS ID: 2-s2.0-0023634171 08/01/1987 1 Citation

Pharmacological modification of immunoregulatory T lymphocytes . II. Modulation of T lymphocyte cell surface characteristics. (Birch RE, Rosenthal AK, Polmar SH) Clin Exp Immunol 1982 Apr;48(1):231-8 PMID: 6177462 PMCID: PMC1536581 SCOPUS ID: 2-s2.0-0020047793 04/01/1982 41 Citations

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Profiles for MCW, MU, MSOE, UWM, BCW, CW, Froedtert, and VA Faculty

Ann K. Rosenthal MD

Associate Dean, Chief, Professor

Publications (121)