Two cases of transfusion-transmitted Anaplasma phagocytophilum. Am J Clin Pathol 2012 Apr;137(4):562-5
Date
03/21/2012Pubmed ID
22431531DOI
10.1309/AJCP4E4VQQQOZIAQScopus ID
2-s2.0-84860590931 (requires institutional sign-in at Scopus site) 48 CitationsAbstract
Anaplasma phagocytophilum, the causative agent of human granulocytic anaplasmosis, is an obligate intracellular bacterium most commonly acquired from tick bites. High seroprevalence rates in endemic regions suggest that transfusion transmission of A phagocytophilum would be a common event; however, only 2 cases have previously been reported. The exact cause of this discrepancy is not known. Whole blood leukocyte-reduction methods used by many blood centers are thought to reduce the risk of transfusion transmission of many pathogens, including A phagocytophilum. We report 2 additional cases of transfusion-transmitted A phagocytophilum in which leukocyte reduction of all transfused units failed to prevent microbial transmission.
Author List
Annen K, Friedman K, Eshoa C, Horowitz M, Gottschall J, Straus TAuthors
Kenneth D. Friedman MD Professor in the Medicine department at Medical College of WisconsinMary M. Horowitz MD, MS Professor in the Medicine department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Aged, 80 and overAnaplasma phagocytophilum
Ehrlichiosis
Female
Humans
Middle Aged
Transfusion Reaction
