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Two cases of transfusion-transmitted Anaplasma phagocytophilum. Am J Clin Pathol 2012 Apr;137(4):562-5 PMID: 22431531

Pubmed ID





Anaplasma phagocytophilum, the causative agent of human granulocytic anaplasmosis, is an obligate intracellular bacterium most commonly acquired from tick bites. High seroprevalence rates in endemic regions suggest that transfusion transmission of A phagocytophilum would be a common event; however, only 2 cases have previously been reported. The exact cause of this discrepancy is not known. Whole blood leukocyte-reduction methods used by many blood centers are thought to reduce the risk of transfusion transmission of many pathogens, including A phagocytophilum. We report 2 additional cases of transfusion-transmitted A phagocytophilum in which leukocyte reduction of all transfused units failed to prevent microbial transmission.

Author List

Annen K, Friedman K, Eshoa C, Horowitz M, Gottschall J, Straus T


Mary M. Horowitz MD, MS Center Director, Professor in the Medicine department at Medical College of Wisconsin


2-s2.0-84860590931   29 Citations

MESH terms used to index this publication - Major topics in bold

Aged, 80 and over
Anaplasma phagocytophilum
Middle Aged
Transfusion Reaction
jenkins-FCD Prod-331 a335b1a6d1e9c32173c9534e6f6ff51494143916