Regio- and stereoselective ruthenium-catalyzed hydrovinylation of 1,3-dienes: application to the generation of a 20(S) steroidal side chain. Org Lett 2003 May 01;5(9):1567-9
Date
04/26/2003Pubmed ID
12713325DOI
10.1021/ol030031+Scopus ID
2-s2.0-0041764978 (requires institutional sign-in at Scopus site) 48 CitationsAbstract
The addition of ethylene to 1,3-dienes and 1-vinylcycloalkenes, catalyzed by two ruthenium complexes, proceeds in a regioselective fashion to afford 3-methyl-1,4-dienes as products. For a steroidal-based 1-vinylcycloalkene, the addition is stereospecific, giving a product with a 20(S) configuration. [reaction: see text]
Author List
He Z, Yi CS, Donaldson WAAuthors
William Donaldson PhD Professor in the Department of Chemistry department at Marquette UniversityChae Yi PhD Professor, Inorganic and Organometallic Chemistry, Homogeneous Catalysis in the Chemistry department at Marquette University
MESH terms used to index this publication - Major topics in bold
AlkadienesCatalysis
Cyclization
Ethylenes
Organometallic Compounds
Ruthenium
Stereoisomerism
Steroids
Vinyl Compounds
