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Regio- and stereoselective ruthenium-catalyzed hydrovinylation of 1,3-dienes: application to the generation of a 20(S) steroidal side chain. Org Lett 2003 May 01;5(9):1567-9

Date

04/26/2003

Pubmed ID

12713325

DOI

10.1021/ol030031+

Abstract

The addition of ethylene to 1,3-dienes and 1-vinylcycloalkenes, catalyzed by two ruthenium complexes, proceeds in a regioselective fashion to afford 3-methyl-1,4-dienes as products. For a steroidal-based 1-vinylcycloalkene, the addition is stereospecific, giving a product with a 20(S) configuration. [reaction: see text]

Author List

He Z, Yi CS, Donaldson WA

Authors

William Donaldson PhD Professor in the Department of Chemistry department at Marquette University
Chae Yi PhD Professor, Inorganic and Organometallic Chemistry, Homogeneous Catalysis in the Chemistry department at Marquette University




MESH terms used to index this publication - Major topics in bold

Alkadienes
Catalysis
Cyclization
Ethylenes
Organometallic Compounds
Ruthenium
Stereoisomerism
Steroids
Vinyl Compounds
jenkins-FCD Prod-399 190a069c593fb5498b7fcd942f44b7bc9cdc7ea1