Medical College of Wisconsin
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Ventral midline blanching in the setting of segmental infantile hemangiomas: clinical observations and pathogenetic implications. Pediatr Dermatol 2015 Mar-Apr;32(2):180-7 PMID: 25529105

Pubmed ID





Areas of blanched skin in children may be seen as an independent finding or in association with vascular birthmarks. We performed a retrospective chart review to identify and describe infants with areas of ventral midline blanching in the presence of segmental infantile hemangiomas. We identified nine full-term infants with partial or full segmental hemangiomas and areas of midline ventral blanching. Additional ventral wall defects were seen in five patients. Six had cardiac anomalies and six had intracranial anomalies. Five were diagnosed with definite PHACE (posterior fossa, hemangioma, arterial, cardiac, and eye abnormalities) syndrome and three had possible PHACE syndrome. Eight were complicated by ulceration. Treatment varied according to the case. Ventral blanching, even in the absence of overt midline defects, can be seen in infants with segmental hemangiomas at risk for PHACE syndrome. We hypothesize that midline blanching may represent a minor manifestation of a developmental ventral defect.

Author List

Feigenbaum DF, Sybert VP, Vanderhooft SL, Siegel D, Drolet BA, Frieden IJ, Mathes EF


Dawn Siegel MD Associate Professor in the Dermatology department at Medical College of Wisconsin


2-s2.0-84925355171   1 Citations

MESH terms used to index this publication - Major topics in bold

Aortic Coarctation
Eye Abnormalities
Hemangioma, Capillary
Infant, Newborn
Neoplastic Syndromes, Hereditary
Neurocutaneous Syndromes
Retrospective Studies
Risk Assessment
Sampling Studies
Skin Abnormalities
Skin Neoplasms
jenkins-FCD Prod-321 98992d628744e349846c2f62ac68f241d7e1ea70