Adhesion mechanisms of Borrelia burgdorferi. Adv Exp Med Biol 2011;715:35-49
Date
05/11/2011Pubmed ID
21557056Pubmed Central ID
PMC4521209DOI
10.1007/978-94-007-0940-9_3Scopus ID
2-s2.0-79960126040 (requires institutional sign-in at Scopus site) 38 CitationsAbstract
The Borrelia are widely distributed agents of Lyme disease and Relapsing Fever. All are vector-borne zoonotic pathogens, have segmented genomes, and enigmatic mechanisms of pathogenesis. Adhesion to mammalian and tick substrates is one pathogenic mechanism that has been widely studied. At this point, the primary focus of research in this area has been on Borrelia burgdorferi, one agent of Lyme disease, but many of the adhesins of B. burgdorferi are conserved in other Lyme disease agents, and some are conserved in the Relapsing Fever Borrelia. B. burgdorferi adhesins that mediate attachment to cell-surface molecules may influence the host response to the bacteria, while adhesins that mediate attachment to soluble proteins or extracellular matrix components may cloak the bacterial surface from recognition by the host immune system as well as facilitate colonization of tissues. While targeted mutations in the genes encoding some adhesins have been shown to affect the infectivity and pathogenicity of B. burgdorferi, much work remains to be done to understand the roles of the adhesins in promoting the persistent infection required to maintain the bacteria in reservoir hosts.
Author List
Antonara S, Ristow L, Coburn JAuthor
Jenifer Coburn PhD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Adhesins, BacterialAnimals
Arthropods
Bacterial Adhesion
Borrelia burgdorferi
Decorin
Disease Reservoirs
Glycosaminoglycans
Host-Pathogen Interactions
Humans
Integrins
Laminin
Lyme Disease
Receptors, Cell Surface
