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Mesh term Integrins

Browse to parent terms:
Receptors, Immunologic

Description

A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.


Browse to child terms:
Integrin alpha Chains
Integrin beta Chains
Receptors, Cytoadhesin
Receptors, Fibrinogen
Receptors, Fibronectin
Receptors, Leukocyte-Adhesion
Receptors, Very Late Antigen


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View this term at the NCBI website
jenkins-FCD Prod-486 e3098984f26de787f5ecab75090d0a28e7f4f7c0