Application of an alternative approach for using the SOS chromotest to screen complex indeterminate mixtures. Zentralbl Mikrobiol 1990;145(3):177-82
Date
01/01/1990Pubmed ID
2196748Abstract
We report on the application of an alternative approach to screen two complex indeterminate mixtures for genotoxic activity with the SOS chromotest, a simple quantitative colorimetric short-term bacterial genotoxicity assay. Considering the mixtures as a complex matrix, we evaluated the shape of the dose response curve of the direct acting reference genotoxin 4-nitroquinoline-1-oxide (4-NQO) with and without the matrix and found for one mixture a previously unrecognized genotoxic potential.
Author List
Janz S, Raabe F, Wolff GAuthor
Siegfried Janz MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
ColorimetryDNA Repair
Dose-Response Relationship, Drug
Escherichia coli
Genes, Bacterial
Industrial Waste
Regression Analysis
