Medical College of Wisconsin
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Application of an alternative approach for using the SOS chromotest to screen complex indeterminate mixtures. Zentralbl Mikrobiol 1990;145(3):177-82

Date

01/01/1990

Pubmed ID

2196748

Abstract

We report on the application of an alternative approach to screen two complex indeterminate mixtures for genotoxic activity with the SOS chromotest, a simple quantitative colorimetric short-term bacterial genotoxicity assay. Considering the mixtures as a complex matrix, we evaluated the shape of the dose response curve of the direct acting reference genotoxin 4-nitroquinoline-1-oxide (4-NQO) with and without the matrix and found for one mixture a previously unrecognized genotoxic potential.

Author List

Janz S, Raabe F, Wolff G

Author

Siegfried Janz MD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Colorimetry
DNA Repair
Dose-Response Relationship, Drug
Escherichia coli
Genes, Bacterial
Industrial Waste
Regression Analysis
SOS Response (Genetics)
jenkins-FCD Prod-400 0f9a74600e4e79798f8fa6f545ea115f3dd948b2