Medical College of Wisconsin
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Application of an alternative approach for using the SOS chromotest to screen complex indeterminate mixtures. Zentralbl Mikrobiol 1990;145(3):177-82



Pubmed ID



We report on the application of an alternative approach to screen two complex indeterminate mixtures for genotoxic activity with the SOS chromotest, a simple quantitative colorimetric short-term bacterial genotoxicity assay. Considering the mixtures as a complex matrix, we evaluated the shape of the dose response curve of the direct acting reference genotoxin 4-nitroquinoline-1-oxide (4-NQO) with and without the matrix and found for one mixture a previously unrecognized genotoxic potential.

Author List

Janz S, Raabe F, Wolff G


Siegfried Janz MD Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

DNA Repair
Dose-Response Relationship, Drug
Escherichia coli
Genes, Bacterial
Industrial Waste
Regression Analysis
jenkins-FCD Prod-461 7d7c6113fc1a2757d2947d29fae5861c878125ab