Airflow limitation in a collapsible model of the human pharynx: physical mechanisms studied with fluid-structure interaction simulations and experiments. Physiol Rep 2019 May;7(10):e14099
Date
05/23/2019Pubmed ID
31116516Pubmed Central ID
PMC6530458DOI
10.14814/phy2.14099Scopus ID
2-s2.0-85066466799 (requires institutional sign-in at Scopus site) 24 CitationsAbstract
The classical Starling Resistor model has been the paradigm of airway collapse in obstructive sleep apnea (OSA) for the last 30 years. Its theoretical framework is grounded on the wave-speed flow limitation (WSFL) theory. Recent observations of negative effort dependence in OSA patients violate the predictions of the WSFL theory. Fluid-structure interaction (FSI) simulations are emerging as a technique to quantify how the biomechanical properties of the upper airway determine the shape of the pressure-flow curve. This study aimed to test two predictions of the WSFL theory, namely (1) the pressure profile upstream from the choke point becomes independent of downstream pressure during flow limitation and (2) the maximum flowrate in a collapsible tube is
Author List
Le TB, Moghaddam MG, Woodson BT, Garcia GJMAuthors
Guilherme Garcia PhD Assistant Professor in the Biomedical Engineering department at Medical College of WisconsinB Tucker Woodson MD Chief, Professor in the Otolaryngology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Airway ObstructionAirway Resistance
Biomechanical Phenomena
Compliance
Computer Simulation
Elastic Modulus
Female
Humans
Magnetic Resonance Imaging
Middle Aged
Models, Anatomic
Models, Biological
Pharynx
Pressure
Respiration
Rheology
Sleep Apnea, Obstructive