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Guilherme Garcia PhD

Guilherme Garcia PhD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Biomedical Engineering
Program: Biomedical Engineering Program


Research Experience

  • Airway Resistance
  • Computational Biology
  • Computer Simulation
  • Cystic Fibrosis
  • Electrophysiology
  • Mucociliary Clearance
  • Nasal Cavity
  • Nasal Obstruction
  • Nasal Sprays
  • Nose
  • Respiratory Mechanics
  • Sleep Apnea, Obstructive
  • Systems Biology
  • Epithelial Electrophysiology
  • Fluid Dynamics
  • Computational Fluid Dynamics
  • Signalling Pathways
  • Fluid Mechanics
  • Nasal Physiology
  • Publications (65)

  • Large eddy simulations of airflow and particle deposition in pulsating bi-directional nasal drug delivery (Farnoud A, Tofighian H, Baumann I, Garcia GJM, Schmid O, Gutheil E, Rashidi MM) Physics of Fluids 1 October 2020;32(10) SCOPUS ID: 2-s2.0-85094614898 10/01/2020    
  • Rhinomanometry Versus Computational Fluid Dynamics: Correlated, but Different Techniques. (Cherobin GB, Voegels RL, Pinna FR, Gebrim EMMS, Bailey RS, Garcia GJM) Am J Rhinol Allergy 2020 Aug 17:1945892420950157 PMID: 32806938 08/19/2020    
  • Numerical evaluation of spray position for improved nasal drug delivery. (Basu S, Holbrook LT, Kudlaty K, Fasanmade O, Wu J, Burke A, Langworthy BW, Farzal Z, Mamdani M, Bennett WD, Fine JP, Senior BA, Zanation AM, Ebert CS Jr, Kimple AJ, Thorp BD, Frank-Ito DO, Garcia GJM, Kimbell JS) Sci Rep 2020 06 29;10(1):10568 PMID: 32601278 PMCID: PMC7324389 SCOPUS ID: 2-s2.0-85087009445 07/01/2020       1 Citation
  • Narrowed Posterior Nasal Airway Limits Efficacy of Anterior Septoplasty. (Campbell DA, Moghaddam MG, Rhee JS, Garcia GJM) Facial Plast Surg Aesthet Med 2020 May 29 PMID: 32471319 05/31/2020    
  • Virtual septoplasty: a method to predict surgical outcomes for patients with nasal airway obstruction. (Moghaddam MG, Garcia GJM, Frank-Ito DO, Kimbell JS, Rhee JS) Int J Comput Assist Radiol Surg 2020 Apr;15(4):725-735 PMID: 32078099 PMCID: PMC7148186 SCOPUS ID: 2-s2.0-85079604195 02/23/2020       1 Citation
  • The collapsing anatomical structure is not always the primary site of flow limitation in obstructive sleep apnea. (Garcia GJM, Woodson BT) J Clin Sleep Med 2020 03 15;16(3):345-346 PMID: 32003741 PMCID: PMC7075099 SCOPUS ID: 2-s2.0-85082145879 02/01/2020    
  • lapdMouse: a data archive for advancing computational models of inhaled aerosol dosimetry. (Garcia GJM) J Appl Physiol (1985) 2020 02 01;128(2):307-308 PMID: 31971472 PMCID: PMC7052587 SCOPUS ID: 2-s2.0-85079350652 01/24/2020    
  • Clinical Importance of Nasal Air Conditioning: A Review of the Literature. (Newsome H, L Lin E, Poetker DM, Garcia GJM) Am J Rhinol Allergy 2019 Nov;33(6):763-769 PMID: 31291132 SCOPUS ID: 2-s2.0-85068817020 07/11/2019       3 Citations
  • Normative ranges of nasal airflow variables in healthy adults. (Borojeni AAT, Garcia GJM, Moghaddam MG, Frank-Ito DO, Kimbell JS, Laud PW, Koenig LJ, Rhee JS) Int J Comput Assist Radiol Surg 2020 Jan;15(1):87-98 PMID: 31267334 PMCID: PMC6939154 SCOPUS ID: 2-s2.0-85069642677 07/04/2019       7 Citations
  • Airflow limitation in a collapsible model of the human pharynx: physical mechanisms studied with fluid-structure interaction simulations and experiments. (Le TB, Moghaddam MG, Woodson BT, Garcia GJM) Physiol Rep 2019 05;7(10):e14099 PMID: 31116516 PMCID: PMC6530458 SCOPUS ID: 2-s2.0-85066466799 05/23/2019       3 Citations
  • A hierarchical stepwise approach to evaluate nasal patency after virtual surgery for nasal airway obstruction. (Frank-Ito DO, Kimbell JS, Borojeni AAT, Garcia GJM, Rhee JS) Clin Biomech (Bristol, Avon) 2019 01;61:172-180 PMID: 30594764 PMCID: PMC6813815 SCOPUS ID: 2-s2.0-85058820393 12/31/2018       6 Citations
  • Sensitivity of nasal airflow variables computed via computational fluid dynamics to the computed tomography segmentation threshold. (Cherobin GB, Voegels RL, Gebrim EMMS, Garcia GJM) PLoS One 2018;13(11):e0207178 PMID: 30444909 PMCID: PMC6239298 SCOPUS ID: 2-s2.0-85056695624 11/18/2018       5 Citations
  • Radiologic changes in the aging nasal cavity. (Ganjaei KG, Soler ZM, Mappus ED, Worley ML, Rowan NR, Garcia GJM, Matthews LJ, Dubno JR, Eckert MA, Schlosser RJ) Rhinology 2019 Apr 01;57(2):117-124 PMID: 30352446 PMCID: PMC6543530 SCOPUS ID: 2-s2.0-85064239455 10/24/2018    
  • Upper airway reconstruction using long-range optical coherence tomography: Effects of airway curvature on airflow resistance. (Kimbell JS, Basu S, Garcia GJM, Frank-Ito DO, Lazarow F, Su E, Protsenko D, Chen Z, Rhee JS, Wong BJ) Lasers Surg Med 2019 02;51(2):150-160 PMID: 30051633 PMCID: PMC6424583 SCOPUS ID: 2-s2.0-85051074999 07/28/2018       5 Citations
  • Novel Radiographic Assessment of the Cribriform Plate. (Ganjaei KG, Soler ZM, Mappus ED, Taylor RJ, Worley ML, Mulligan JK, Mattos JL, Rowan NR, Garcia GJM, Dubno JR, Eckert MA, Matthews LJ, Schlosser RJ) Am J Rhinol Allergy 2018 May;32(3):175-180 PMID: 29660990 PMCID: PMC6346299 SCOPUS ID: 2-s2.0-85052494063 04/18/2018       4 Citations
  • Simulating airway collapse in obstructive sleep apnea using fluid-structure interaction methodologies (Le TB, Garcia GJM) Frontiers in Biomedical Devices, BIOMED - 2018 Design of Medical Devices Conference, DMD 2018 2018 SCOPUS ID: 2-s2.0-85049631725 01/01/2018    
  • Relationship between degree of obstruction and airflow limitation in subglottic stenosis. (Lin EL, Bock JM, Zdanski CJ, Kimbell JS, Garcia GJM) Laryngoscope 2018 07;128(7):1551-1557 PMID: 29171660 PMCID: PMC5967982 SCOPUS ID: 2-s2.0-85035021303 11/25/2017       3 Citations
  • Ideal Particle Sizes for Inhaled Steroids Targeting Vocal Granulomas: Preliminary Study Using Computational Fluid Dynamics. (Perkins EL, Basu S, Garcia GJM, Buckmire RA, Shah RN, Kimbell JS) Otolaryngol Head Neck Surg 2018 03;158(3):511-519 PMID: 29160160 PMCID: PMC5832637 SCOPUS ID: 2-s2.0-85042882945 11/22/2017       11 Citations
  • Virtual Surgery for the Nasal Airway: A Preliminary Report on Decision Support and Technology Acceptance. (Vanhille DL, Garcia GJM, Asan O, Borojeni AAT, Frank-Ito DO, Kimbell JS, Pawar SS, Rhee JS) JAMA Facial Plast Surg 2018 Jan 01;20(1):63-69 PMID: 29049474 PMCID: PMC5833667 SCOPUS ID: 2-s2.0-85040970438 10/20/2017       12 Citations
  • Advances in Technology for Functional Rhinoplasty: The Next Frontier. (Pawar SS, Garcia GJ, Rhee JS) Facial Plast Surg Clin North Am 2017 May;25(2):263-270 PMID: 28340656 SCOPUS ID: 2-s2.0-85013123054 03/28/2017       2 Citations
  • Correlation between Subjective Nasal Patency and Intranasal Airflow Distribution. (Casey KP, Borojeni AA, Koenig LJ, Rhee JS, Garcia GJ) Otolaryngol Head Neck Surg 2017 04;156(4):741-750 PMID: 28139171 PMCID: PMC6062004 SCOPUS ID: 2-s2.0-85018974018 02/01/2017       19 Citations
  • Estimates of nasal airflow at the nasal cycle mid-point improve the correlation between objective and subjective measures of nasal patency. (Gaberino C, Rhee JS, Garcia GJ) Respir Physiol Neurobiol 2017 04;238:23-32 PMID: 28089607 PMCID: PMC5316304 SCOPUS ID: 2-s2.0-85009224928 01/17/2017       12 Citations
  • LVAD Outflow Graft Angle and Thrombosis Risk. (Aliseda A, Chivukula VK, Mcgah P, Prisco AR, Beckman JA, Garcia GJ, Mokadam NA, Mahr C) ASAIO J 2017 Jan/Feb;63(1):14-23 PMID: 28033200 PMCID: PMC5201113 SCOPUS ID: 2-s2.0-85008473978 12/30/2016       26 Citations
  • Impact of LVAD Implantation Site on Ventricular Blood Stagnation. (Prisco AR, Aliseda A, Beckman JA, Mokadam NA, Mahr C, Garcia GJM) ASAIO J 2017 Jul/Aug;63(4):392-400 PMID: 28009715 PMCID: PMC5478478 SCOPUS ID: 2-s2.0-85007273939 12/24/2016       11 Citations
  • Correlation of Nasal Mucosal Temperature With Subjective Nasal Patency in Healthy Individuals. (Bailey RS, Casey KP, Pawar SS, Garcia GJ) JAMA Facial Plast Surg 2017 Jan 01;19(1):46-52 PMID: 27918749 PMCID: PMC5247324 SCOPUS ID: 2-s2.0-85012894185 12/06/2016       11 Citations
  • Creation of an idealized nasopharynx geometry for accurate computational fluid dynamics simulations of nasal airflow in patient-specific models lacking the nasopharynx anatomy. (A T Borojeni A, Frank-Ito DO, Kimbell JS, Rhee JS, Garcia GJM) Int J Numer Method Biomed Eng 2017 05;33(5) PMID: 27525807 PMCID: PMC5311034 SCOPUS ID: 2-s2.0-84988423783 08/16/2016       11 Citations
  • Impact of Middle versus Inferior Total Turbinectomy on Nasal Aerodynamics. (Dayal A, Rhee JS, Garcia GJ) Otolaryngol Head Neck Surg 2016 09;155(3):518-25 PMID: 27165673 PMCID: PMC5010478 SCOPUS ID: 2-s2.0-84984924081 05/12/2016       41 Citations
  • The relationship between nasal resistance to airflow and the airspace minimal cross-sectional area. (Garcia GJM, Hariri BM, Patel RG, Rhee JS) J Biomech 2016 06 14;49(9):1670-1678 PMID: 27083059 PMCID: PMC4885785 SCOPUS ID: 2-s2.0-84964330707 04/17/2016       19 Citations
  • Response to Dr Chung's Question on Simulating the Nasal Cycle with Computational Fluid Dynamics. (Garcia GJ, Patel RG, Frank-Ito DO, Kimbell JS, Rhee JS) Otolaryngol Head Neck Surg 2015 Aug;153(2):308-9 PMID: 26198862 PMCID: PMC4745903 SCOPUS ID: 2-s2.0-84937680302 07/23/2015       1 Citation
  • Olfactory deposition of inhaled nanoparticles in humans. (Garcia GJ, Schroeter JD, Kimbell JS) Inhal Toxicol 2015;27(8):394-403 PMID: 26194036 PMCID: PMC4745908 SCOPUS ID: 2-s2.0-84939235361 07/22/2015       54 Citations
  • Identifying patients who may benefit from inferior turbinate reduction using computer simulations. (Hariri BM, Rhee JS, Garcia GJ) Laryngoscope 2015 Dec;125(12):2635-41 PMID: 25963247 PMCID: PMC4641847 SCOPUS ID: 2-s2.0-84929245157 05/13/2015       28 Citations
  • Simulating the nasal cycle with computational fluid dynamics. (Patel RG, Garcia GJ, Frank-Ito DO, Kimbell JS, Rhee JS) Otolaryngol Head Neck Surg 2015 Feb;152(2):353-60 PMID: 25450411 PMCID: PMC4402730 SCOPUS ID: 2-s2.0-84922255976 12/03/2014       29 Citations
  • Predicting postsurgery nasal physiology with computational modeling: current challenges and limitations. (Frank-Ito DO, Kimbell JS, Laud P, Garcia GJ, Rhee JS) Otolaryngol Head Neck Surg 2014 Nov;151(5):751-9 PMID: 25168451 PMCID: PMC4405156 SCOPUS ID: 2-s2.0-84908672297 08/30/2014       26 Citations
  • Effects of airway surface liquid height on the kinetics of extracellular nucleotides in airway epithelia. (Amarante TD, da Silva JK, Garcia GJ) J Theor Biol 2014 Dec 21;363:427-35 PMID: 25159000 SCOPUS ID: 2-s2.0-84907536913 08/28/2014       1 Citation
  • The N-terminal domain allosterically regulates cleavage and activation of the epithelial sodium channel. (Kota P, Buchner G, Chakraborty H, Dang YL, He H, Garcia GJ, Kubelka J, Gentzsch M, Stutts MJ, Dokholyan NV) J Biol Chem 2014 Aug 15;289(33):23029-42 PMID: 24973914 PMCID: PMC4132802 SCOPUS ID: 2-s2.0-84905986076 06/30/2014       11 Citations
  • A systematic review of patient-reported nasal obstruction scores: defining normative and symptomatic ranges in surgical patients. (Rhee JS, Sullivan CD, Frank DO, Kimbell JS, Garcia GJ) JAMA Facial Plast Surg 2014 May-Jun;16(3):219-25; quiz 232 PMID: 24604253 PMCID: PMC4072745 SCOPUS ID: 2-s2.0-84901722311 03/08/2014       96 Citations
  • In reference to Regional peak mucosal cooling predicts the perception of nasal patency. (Garcia GJ, Kimbell JS, Frank-Ito DO) Laryngoscope 2014 May;124(5):E210 PMID: 24443036 PMCID: PMC3996834 SCOPUS ID: 2-s2.0-84899439399 01/21/2014    
  • Perception of better nasal patency correlates with increased mucosal cooling after surgery for nasal obstruction. (Sullivan CD, Garcia GJ, Frank-Ito DO, Kimbell JS, Rhee JS) Otolaryngol Head Neck Surg 2014 Jan;150(1):139-47 PMID: 24154749 PMCID: PMC3917722 10/25/2013    
  • Changes in nasal airflow and heat transfer correlate with symptom improvement after surgery for nasal obstruction. (Kimbell JS, Frank DO, Laud P, Garcia GJ, Rhee JS) J Biomech 2013 Oct 18;46(15):2634-43 PMID: 24063885 PMCID: PMC3959863 SCOPUS ID: 2-s2.0-84884979625 09/26/2013       56 Citations
  • Biophysical model of ion transport across human respiratory epithelia allows quantification of ion permeabilities. (Garcia GJ, Boucher RC, Elston TC) Biophys J 2013 Feb 05;104(3):716-26 PMID: 23442922 PMCID: PMC3566454 SCOPUS ID: 2-s2.0-84873395144 02/28/2013       11 Citations
  • A mechanochemical model for auto-regulation of lung airway surface layer volume. (Herschlag G, Garcia GJ, Button B, Tarran R, Lindley B, Reinhardt B, Elston TC, Forest MG) J Theor Biol 2013 May 21;325:42-51 PMID: 23415939 PMCID: PMC3631568 SCOPUS ID: 2-s2.0-84875258088 02/19/2013       7 Citations
  • Computed nasal resistance compared with patient-reported symptoms in surgically treated nasal airway passages: a preliminary report. (Kimbell JS, Garcia GJ, Frank DO, Cannon DE, Pawar SS, Rhee JS) Am J Rhinol Allergy 2012 May-Jun;26(3):e94-8 PMID: 22643935 PMCID: PMC3490502 SCOPUS ID: 2-s2.0-84862167892 05/31/2012       40 Citations
  • Computed nasal resistance compared with patient-reported symptoms in surgically treated nasal airway passages: A preliminary report. (Kimbell JS, Garcia GJM, Frank DO, Cannon DE, Pawar SS, Rhee JS) Am J Rhinol Allergy 2012 May 01;26(3):94-98 PMID: 29025472 05/01/2012    
  • Computational model for the regulation of extracellular ATP and adenosine in airway epithelia. (Garcia GJ, Picher M, Zuo P, Okada SF, Lazarowski ER, Button B, Boucher RC, Elston TC) Subcell Biochem 2011;55:51-74 PMID: 21560044 SCOPUS ID: 2-s2.0-84930200581 05/12/2011       6 Citations
  • Toward personalized nasal surgery using computational fluid dynamics. (Rhee JS, Pawar SS, Garcia GJ, Kimbell JS) Arch Facial Plast Surg 2011 Sep-Oct;13(5):305-10 PMID: 21502467 PMCID: PMC3560572 SCOPUS ID: 2-s2.0-80155135811 04/20/2011       61 Citations
  • Effects of Surface Smoothness on Inertial Particle Deposition in Human Nasal Models. (Schroeter JD, Garcia GJ, Kimbell JS) J Aerosol Sci 2011 Jan 01;42(1):52-63 PMID: 21339833 PMCID: PMC3039423 02/23/2011    
  • Objective measures in aesthetic and functional nasal surgery: perspectives on nasal form and function. (Pawar SS, Garcia GJ, Kimbell JS, Rhee JS) Facial Plast Surg 2010 Aug;26(4):320-7 PMID: 20665410 PMCID: PMC3073127 SCOPUS ID: 2-s2.0-77955018407 07/29/2010       43 Citations
  • Septal deviation and nasal resistance: an investigation using virtual surgery and computational fluid dynamics. (Garcia GJ, Rhee JS, Senior BA, Kimbell JS) Am J Rhinol Allergy 2010 Jan-Feb;24(1):e46-53 PMID: 20109325 SCOPUS ID: 2-s2.0-75749152943 01/30/2010       82 Citations
  • A computational fluid dynamics approach to assess interhuman variability in hydrogen sulfide nasal dosimetry. (Schroeter JD, Garcia GJ, Kimbell JS) Inhal Toxicol 2010 Mar;22(4):277-86 PMID: 20064104 SCOPUS ID: 2-s2.0-77149161402 01/13/2010       22 Citations
  • Septal deviation and nasal resistance: An investigation using virtual surgery and computational fluid dynamics. (Garcia GJM, Rhee JS, Senior BA, Kimbell JS) Am J Rhinol Allergy 2010 Jan 01;24(1):46-53 PMID: 29025514 01/01/2010    
  • Deposition of inhaled nanoparticles in the rat nasal passages: dose to the olfactory region. (Garcia GJ, Kimbell JS) Inhal Toxicol 2009 Dec;21(14):1165-75 PMID: 19831956 SCOPUS ID: 2-s2.0-75349091411 10/17/2009       46 Citations
  • Dosimetry of nasal uptake of water-soluble and reactive gases: a first study of interhuman variability. (Garcia GJ, Schroeter JD, Segal RA, Stanek J, Foureman GL, Kimbell JS) Inhal Toxicol 2009 Jun;21(7):607-18 PMID: 19459775 SCOPUS ID: 2-s2.0-70350589079 05/23/2009       51 Citations
  • Interindividual variability in nasal filtration as a function of nasal cavity geometry. (Garcia GJ, Tewksbury EW, Wong BA, Kimbell JS) J Aerosol Med Pulm Drug Deliv 2009 Jun;22(2):139-55 PMID: 19422314 SCOPUS ID: 2-s2.0-67549099256 05/09/2009       66 Citations
  • Visualization of nasal airflow patterns in a patient affected with atrophic rhinitis using particle image velocimetry (Garcia GJM, Mitchell G, Bailie N, Thornhill D, Watterson J, Kimbell JS) Journal of Physics: Conference Series 1 October 2007;85(1) SCOPUS ID: 2-s2.0-36448963149 10/01/2007    
  • Atrophic rhinitis: a CFD study of air conditioning in the nasal cavity. (Garcia GJ, Bailie N, Martins DA, Kimbell JS) J Appl Physiol (1985) 2007 Sep;103(3):1082-92 PMID: 17569762 SCOPUS ID: 2-s2.0-34548442846 06/16/2007       147 Citations
  • Three-dimensional mapping of ozone-induced injury in the nasal airways of monkeys using magnetic resonance imaging and morphometric techniques. (Carey SA, Minard KR, Trease LL, Wagner JG, Garcia GJ, Ballinger CA, Kimbell JS, Plopper CG, Corley RA, Postlethwait EM, Harkema JR, Einstein DR) Toxicol Pathol 2007 Jan;35(1):27-40 PMID: 17325970 SCOPUS ID: 2-s2.0-33847312157 02/28/2007       30 Citations
  • Allometric scaling laws of metabolism (da Silva JKL, Garcia GJM, Barbosa LA) Physics of Life Reviews December 2006;3(4):229-261 SCOPUS ID: 2-s2.0-33751203844 12/01/2006    
  • Interspecific allometry of bone dimensions: A review of the theoretical models (Garcia GJM, da Silva JKL) Physics of Life Reviews September 2006;3(3):188-209 SCOPUS ID: 2-s2.0-33749636870 09/01/2006    
  • The scaling of maximum and basal metabolic rates of mammals and birds (Barbosa LA, Garcia GJM, Da Silva JKL) Physica A: Statistical Mechanics and its Applications 1 January 2006;359(1-4):547-554 SCOPUS ID: 2-s2.0-27344456831 01/01/2006    
  • Absorbing-state phase transitions with extremal dynamics. (Dickman R, Garcia GJ) Phys Rev E Stat Nonlin Soft Matter Phys 2005 Jun;71(6 Pt 2):066113 PMID: 16089826 08/11/2005    
  • Asymmetric dynamics and critical behavior in the Bak-Sneppen model (Garcia GJM, Dickman R) Physica A: Statistical Mechanics and its Applications 1 November 2004;342(3-4):516-528 SCOPUS ID: 2-s2.0-4544301270 11/01/2004    
  • On the thresholds, probability densities, and critical exponents of Bak-Sneppen-like models (Garcia GJM, Dickman R) Physica A: Statistical Mechanics and its Applications 15 October 2004;342(1-2 SPEC. ISS.):164-170 SCOPUS ID: 2-s2.0-4644342025 10/15/2004    
  • On the scaling of mammalian long bones. (Garcia GJ, da Silva JK) J Exp Biol 2004 Apr;207(Pt 9):1577-84 PMID: 15037651 SCOPUS ID: 2-s2.0-2342572412 03/24/2004       31 Citations
  • On singular probability densities generated by extremal dynamics (Garcia GJM, Dickman R) Physica A: Statistical Mechanics and its Applications 1 February 2004;332(1-4):318-336 SCOPUS ID: 2-s2.0-0346846410 02/01/2004    
  • Long-bone allometry of terrestrial mammals and the geometric-shape and elastic-force constraints of bone evolution. (Kokshenev VB, Silva JK, Garcia GJ) J Theor Biol 2003 Oct 21;224(4):551-6 PMID: 12957126 SCOPUS ID: 2-s2.0-0041381340 09/06/2003       9 Citations
  • Last update: 11/05/2020
    jenkins-FCD Prod-484 8aa07fc50b7f6d102f3dda2f4c7056ff84294d1d