Faculty Collaboration Database

Intracranial Extraskeletal Mesenchymal Chondrosarcoma: Case Report and Review of the Literature of Reported Cases in Adults and Children. World Neurosurg 2019 Sep;129:302-310

Date

06/04/2019

Pubmed ID

31158544

DOI

10.1016/j.wneu.2019.05.221

Scopus ID

2-s2.0-85068562842 (requires institutional sign-in at Scopus site)   6 Citations

Abstract

BACKGROUND: Intracranial extraskeletal mesenchymal chondrosarcoma is a rare, malignant variant of chondrosarcoma that is characterized by undifferentiated mesenchymal cells interspersed with pockets of mature hyaline cartilage.

CASE DESCRIPTION: In this study, we report a 23-year-old female patient who underwent multiple craniotomies for tumor resection, as well as adjuvant radiotherapy and chemotherapy. We review the literature for reported cases and discuss the histopathologic features, radiologic findings, therapeutic approaches, and outcomes associated with this rare tumor.

CONCLUSIONS: Intracranial extra-skeletal mesenchymal chondrosarcomas are very aggressive tumors, and their management should emphasize attempting gross total resection followed by adjuvant treatment modalities, including radiation therapy and/or chemotherapy.

Author List

Shabani S, Kaushal M, Kaufman B, Knipstein J, Lawlor MW, Lew S, Foy A

Authors

Andrew Foy MD Associate Professor in the Neurosurgery department at Medical College of Wisconsin
Michael W. Lawlor MD, PhD Adjunct Professor in the Pathology department at Medical College of Wisconsin
Sean Lew MD Chief, Professor in the Neurosurgery department at Medical College of Wisconsin
Saman Shabani MD Assistant Professor in the Neurosurgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Brain Neoplasms
Chondrosarcoma, Mesenchymal
Combined Modality Therapy
Female
Humans
Young Adult