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Contrast agent-enhanced magnetic resonance imaging of skeletal muscle damage in animal models of muscular dystrophy. Magn Reson Med 2000 Oct;44(4):655-9

Date

10/12/2000

Pubmed ID

11025524

DOI

10.1002/1522-2594(200010)44:4<655::aid-mrm22>3.0.co;2-t

Abstract

Membrane lesions play an early role in the pathogenesis of muscular dystrophy. Using a new albumin-targeted contrast agent (MS-325), sarcolemmal integrity of two animal models for muscular dystrophy was studied by MRI. Intravenously injected MS-325 does not enter skeletal muscle of normal mice. However, mdx and Sgca-null mutant mice, animal models for Duchenne and sarcoglycan-deficient limb-girdle muscular dystrophy, respectively, showed significant accumulation of MS-325 in skeletal muscle. The results suggest that contrast agent-enhanced MRI could serve as a common, noninvasive imaging procedure for evaluating the localization, extent, and mechanisms of skeletal muscle damage in muscular dystrophy. Furthermore, this method is expected to facilitate assessment of therapeutic approaches in these diseases.

Author List

Straub V, Donahue KM, Allamand V, Davisson RL, Kim YR, Campbell KP

Author

Kathleen M. Schmainda PhD Professor in the Biophysics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Contrast Media
Female
Gadolinium
Magnetic Resonance Imaging
Male
Mice
Mice, Inbred C57BL
Mice, Inbred mdx
Mice, Mutant Strains
Muscle, Skeletal
Muscular Dystrophy, Animal
Organometallic Compounds