Faculty Collaboration Database

Generalized lymphadenopathy and T cell abnormalities in hemophilia A. J Pediatr 1983 Jul;103(1):18-22

Date

07/01/1983

Pubmed ID

6223133

DOI

10.1016/s0022-3476(83)80768-9

Scopus ID

2-s2.0-0020526898 (requires institutional sign-in at Scopus site)   37 Citations

Abstract

Two patients with hemophilia A had generalized lymphadenopathy, lymphopenia, elevated IgG values, depressed T4 (helper) lymphocytes, elevated T8 (suppressor) lymphocytes, and abnormally low T4/T8 ratios. One of the patients, who also had hepatosplenomegaly, underwent cervical lymph node biopsy; the node contained 43% T8-lymphocytes, a marked elevation over the small fraction of T8 cells usually found in lymph nodes. These patients may have a form of the acquired immune deficiency syndrome described in male homosexuals, Haitians, intravenous drug abusers, and recently, in patients with hemophilia. We studied T cell phenotypes in 43 patients with hemophilia. Fourteen of 28 patients given commercial factor VIII concentrates had abnormal T4/T8 ratios; none of nine patients who used cryoprecipitate had abnormal values. T4 helper cells were significantly lower, T8 suppressor cells significantly elevated, and T4/T8 ratios significantly lower in the lyophilized concentrate users and in patients with hemophilia as a total group. The type of therapeutic factor VIII replacement may alter the risk of developing T4/T8 abnormalities or AIDS.

Author List

Gill JC, Menitove JE, Wheeler D, Aster RH, Montgomery RR

Author

Robert R. Montgomery MD Adjunct Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Acquired Immunodeficiency Syndrome
Child
Factor VIII
Fibrinogen
Hemophilia A
Humans
Leukocyte Count
Lymphatic Diseases
Male
T-Lymphocytes, Helper-Inducer
T-Lymphocytes, Regulatory