Faculty Collaboration Database

Generalized lymphadenopathy and T cell abnormalities in hemophilia A. J Pediatr 1983 Jul;103(1):18-22

Date

07/01/1983

Pubmed ID

6223133

DOI

10.1016/s0022-3476(83)80768-9

Scopus ID

2-s2.0-0020526898 (requires institutional sign-in at Scopus site)   37 Citations

Abstract

Two patients with hemophilia A had generalized lymphadenopathy, lymphopenia, elevated IgG values, depressed T4 (helper) lymphocytes, elevated T8 (suppressor) lymphocytes, and abnormally low T4/T8 ratios. One of the patients, who also had hepatosplenomegaly, underwent cervical lymph node biopsy; the node contained 43% T8-lymphocytes, a marked elevation over the small fraction of T8 cells usually found in lymph nodes. These patients may have a form of the acquired immune deficiency syndrome described in male homosexuals, Haitians, intravenous drug abusers, and recently, in patients with hemophilia. We studied T cell phenotypes in 43 patients with hemophilia. Fourteen of 28 patients given commercial factor VIII concentrates had abnormal T4/T8 ratios; none of nine patients who used cryoprecipitate had abnormal values. T4 helper cells were significantly lower, T8 suppressor cells significantly elevated, and T4/T8 ratios significantly lower in the lyophilized concentrate users and in patients with hemophilia as a total group. The type of therapeutic factor VIII replacement may alter the risk of developing T4/T8 abnormalities or AIDS.

Author List

Gill JC, Menitove JE, Wheeler D, Aster RH, Montgomery RR

MESH terms used to index this publication - Major topics in bold

Acquired Immunodeficiency Syndrome
Child
Factor VIII
Fibrinogen
Hemophilia A
Humans
Leukocyte Count
Lymphatic Diseases
Male
T-Lymphocytes, Helper-Inducer
T-Lymphocytes, Regulatory