Pediatric Atorvastatin in Diabetes Trial (PADIT): a pilot study to determine the effect of atorvastatin on arterial stiffness and endothelial function in children with type 1 diabetes mellitus. J Pediatr Endocrinol Metab 2009 Jan;22(1):65-8
Date
04/07/2009Pubmed ID
19344076Pubmed Central ID
PMC3621084DOI
10.1515/jpem.2009.22.1.65Scopus ID
2-s2.0-61849164951 (requires institutional sign-in at Scopus site) 37 CitationsAbstract
Fifty-one children with type 1 diabetes mellitus (DM1) participated in a double blinded, randomized, cross-over pilot study to determine whether 12 weeks of daily atorvastatin (20 mg daily) would reduce arterial stiffness and improve endothelial function. Secondary analysis demonstrated potential reduction of arterial stiffness following atorvastatin therapy (p = 0.06). Additional long-term prospective studies with larger numbers of patients are needed.
Author List
Haller MJ, Stein JM, Shuster JJ, Theriaque D, Samyn MM, Pepine C, Silverstein JHAuthor
Margaret Mary Samyn MD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Anticholesteremic Agents
Child
Cross-Over Studies
Diabetes Mellitus, Type 1
Diabetic Angiopathies
Double-Blind Method
Endothelium, Vascular
Female
Heptanoic Acids
Humans
Male
Patient Compliance
Peripheral Vascular Diseases
Pilot Projects
Placebos
Pyrroles
Radial Artery
Vascular Resistance
Young Adult
