Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Cushing's syndrome of nonpituitary causes. Curr Opin Endocrinol Diabetes Obes 2009 Aug;16(4):308-15

Date

06/06/2009

Pubmed ID

19491665

DOI

10.1097/MED.0b013e32832d8950

Scopus ID

2-s2.0-67651083828   11 Citations

Abstract

PURPOSE OF REVIEW: Cushing's syndrome is being recognized with greater frequency and in patients with milder disease. Many of these individuals have nonpituitary causes of their hypercortisolism. This review discusses the classification, presentation, diagnosis, and therapy of patients with Cushing's syndrome from nonpituitary causes.

RECENT FINDINGS: Many previously unrecognized or poorly understood causes of Cushing's syndrome have been elucidated. It is now appreciated that essentially any form of exogenous glucocorticoid is capable of causing Cushing's syndrome. Additionally, new findings have led to a more complete understanding of bilateral nodular adrenal disease.

SUMMARY: The diagnosis of patients with less profound cortisol excess has increased the prevalence of Cushing's syndrome and made nonpituitary causes more common. As a result, clinicians must be cognizant of such patients and pursue the diagnosis when appropriate.

Author List

Carroll TB, Findling JW

Authors

Ty Carroll MD Staff Physician in the Multi-Specialty department at Medical College of Wisconsin
James W. Findling MD Staff Physician in the Multi-Specialty department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Cushing Syndrome
Glucocorticoids
Humans
Hydrocortisone