Faculty Collaboration Database

Possible role of prostaglandins in the effects of the cannabinoids on adenylate cyclase activity. Eur J Pharmacol 1983 Jul 15;91(1):21-7

Date

07/15/1983

Pubmed ID

6311573

DOI

10.1016/0014-2999(83)90357-6

Scopus ID

2-s2.0-0020595620 (requires institutional sign-in at Scopus site)   21 Citations

Abstract

In vitro, the cannabinoids delta 9-tetrahydrocannabinol (delta 9-THC), 11-OH-delta 9-THC, cannabidiol and cannabinol all increased adenylate cyclase activity in mouse cerebral cortical homogenates. Levonantradol, a synthetic cannabinoid analog, also increased adenylate cyclase activity while its optical isomer dextronantradol did not. The increases in enzyme activity produced by the active compounds were biphasic with significant increases at 10 microM and/or 30 microM concentrations with return to control levels at 100 microM. The increases did not occur in the absence of added GTP nor did delta 9-THC have any effect on fluoride-stimulation of adenylate cyclase activity. The prostaglandin synthetase inhibitors acetyl salicylic acid and indomethacin and the phospholipase A2 inhibitor quinacrine all abolished the increase in adenylate cyclase activity produced by delta 9-THC, suggesting the involvement of prostaglandins in this cannabinoid action.

Author List

Hillard CJ, Bloom AS

Author

Cecilia J. Hillard PhD Associate Dean, Center Director, Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adenosine Triphosphate
Adenylyl Cyclases
Animals
Aspirin
Cannabinoids
Dronabinol
Guanosine Triphosphate
Indomethacin
Male
Mice
Mice, Inbred ICR
Phospholipases A
Phospholipases A2
Prostaglandins
Quinacrine